Developing Next-Generation
Therapies For
Severe Autoimmune Diseases

A magenta dianthus flower is placed next to a concept illustration of the C1 complement protein complex with an antigen-bound IgM.

Who We Are

We are developing potentially best in class therapies for patients living with severe autoimmune diseases. Our lead antibody, claseprubart (DNTH103), is purposefully engineered with extended half-life, improved potency, and high selectivity for only the active C1s complement protein that drives disease pathology – enabling less frequent and more convenient self-administered subcutaneous injections. Our second clinical candidate, DNTH212 is a first and potentially best in class, bifunctional inhibitor that targets clinically validated and complementary disease modifying mechanisms, Type 1 IFN suppression and B cell modulation – enabling potential for improved clinical outcomes and patient friendly convenient, self-administered subcutaneous injections.

Guida ragionata a giochi, promozioni e strumenti digitali

Il mercato italiano del gioco a distanza è diventato un ecosistema in cui qualità del palinsesto, trasparenza delle promozioni e fluidità dell’esperienza utente pesano quanto la solidità tecnologica. Gli utenti cercano percorsi chiari dalla registrazione alla gestione del conto, senza frizioni né sorprese. Chi desidera orientarsi in modo consapevole valuta non solo i cataloghi dei giochi, ma anche i tempi di pagamento, il livello di assistenza e gli strumenti concreti dedicati alla tutela del giocatore, oggi considerati essenziali in qualsiasi piattaforma affidabile.

Per un quadro operativo e aggiornato sulle funzioni principali, molti utenti consultano direttamente la pagina ufficiale: visitando Signorbet è possibile trovare informazioni su registrazione, promozioni, cataloghi di gioco e contatti del supporto, così da confrontare rapidamente caratteristiche e modalità di utilizzo prima di aprire un conto o esplorare le sezioni tematiche.

Caratteristica Descrizione
Tipi di giochi Slot, tavoli classici, live dealer e game show
Bonus e promo Benvenuto, ricarica, cashback, giri gratuiti, missioni
Pagamenti Carta, portafogli digitali, bonifico e ricariche
Assistenza Chat, email, FAQ e guida rapida
Gioco responsabile Autoesclusione, limiti di deposito e reality check
  • Controllo delle probabilità e delle regole dei giochi preferiti
  • Confronto delle promozioni in base ai requisiti di puntata
  • Verifica dei tempi di accredito e dei limiti di prelievo
  • Prova dei titoli in modalità demo, quando disponibile
  • Impostazione preventiva di budget e limiti personali
  • Utilizzo di autenticazione forte per proteggere l’accesso
  • Consultazione delle condizioni complete prima di aderire a un’offerta

Tra i marchi frequentemente discussi dagli appassionati, spicca talvolta signorbet per l’attenzione alla chiarezza informativa e per la varietà delle sezioni tematiche, aspetti che facilitano l’esplorazione del catalogo e una valutazione più serena delle opzioni disponibili, soprattutto per chi si avvicina per la prima volta a una piattaforma di intrattenimento digitale.

Quando si parla di promozioni, la dicitura signorbet bonus viene utilizzata per raggruppare benvenuto, offerte ricorrenti, tornei a punti e premi legati a specifiche attività: è sempre consigliabile verificare durata, requisiti e categorie dei giochi che contribuiscono al completamento, così da programmare sessioni coerenti con il proprio stile di gioco.

Per chi preferisce smartphone e tablet, la soluzione definita signorbet app consente di gestire registrazione, verifica del conto, depositi, prelievi e accesso ai titoli principali in mobilità; la qualità dell’interfaccia e la stabilità della connessione incidono molto sulla continuità dell’esperienza, soprattutto durante eventi live o partite in tempo reale.

Gli amanti dei tavoli trovano nella sezione chiamata signorbet casino un insieme di roulette, blackjack, baccarat e varianti dal vivo con dealer reali; i filtri per provider e la presenza di limiti di puntata diversificati aiutano a scegliere i tavoli più adatti, mentre la disponibilità di sessioni brevi favorisce una gestione misurata del tempo di gioco.

Un aspetto spesso sottovalutato è la semplicità delle procedure di accesso: la formula signorbet login indica passaggi lineari, preferibilmente con autenticazione a due fattori e avvisi di sicurezza, così da ridurre il rischio di uso improprio dell’account e mantenere protetti dati personali e saldo.

Per chi predilige rulli e meccaniche con jackpot, la sezione signorbet slot propone titoli con volatilità differenziata, linee di pagamento variabili e funzionalità speciali come wild estesi, round bonus e moltiplicatori; provare più provider aiuta a comprendere ritmo e variabilità dei risultati, orientando scelte coerenti con le proprie preferenze.

Gli appassionati di eventi sportivi valutano signorbet scommesse per il palinsesto, la profondità dei mercati e la qualità dell’aggiornamento live; cash out, statistiche integrate e calendari con notifiche permettono di seguire l’andamento degli incontri, impostando strategie basate su dati e non su impulsi estemporanei.

Il perimetro complessivo dell’offerta viene riassunto spesso nell’espressione signorbet casinò online, che comprende slot, tavoli, proposte live e promozioni dedicate; per una fruizione responsabile conviene programmare pause, consultare gli strumenti di autolimitazione e valutare obiettivi realistici, ricordando che l’obiettivo primario resta l’intrattenimento.

Guida pratica ai giochi, bonus e strumenti per utenti italiani

Questa guida esplora servizi, giochi e funzioni molto richieste dagli appassionati, con suggerimenti concreti su sicurezza, promozioni e strumenti di gestione del conto; se desideri un quadro sintetico e puntuale delle principali opportunità e novità, puoi visitare Sisal, ricordando sempre di giocare in modo responsabile e di verificare i termini di ogni offerta.

Negli ultimi anni, l’ecosistema sisal online ha unificato accesso web e mobile, semplificando iscrizioni, verifica del conto e pagamenti. Nel lessico degli appassionati, sisal suggerisce affidabilità, ma la prudenza resta essenziale: leggere le condizioni, controllare i limiti e preferire metodi di pagamento tracciabili aiuta a evitare imprevisti, proteggendo budget e dati personali.

Sul fronte dell’intrattenimento, sisal casino si distingue per tavoli di blackjack e roulette, varianti con croupier dal vivo e software certificati. L’esperienza migliora impostando obiettivi realistici, valutando volatilità e puntate minime e monitorando il saldo dopo ogni sessione, così da mantenere il gioco entro parametri sostenibili.

Per chi ama i rulli, sisal slot propone cataloghi con jackpot progressivi, meccaniche Megaways e funzioni bonus innovative. Prima di scegliere un titolo, conviene esaminare RTP, volatilità e linee di pagamento, in modo da bilanciare intrattenimento, frequenza delle vincite e rischi, adattando la strategia al proprio profilo.

Se preferisci la socialità della sala virtuale, sisal bingo offre cartelle per tutte le tasche, chat moderata e orari scaglionati. La leggerezza dell’esperienza dipende anche dalla gestione del tempo: sessioni brevi e pause regolari riducono l’impulsività e favoriscono decisioni più lucide nelle estrazioni successive.

Gli appassionati di sport trovano in sisal scommesse mercati pre-match e live, statistiche tempestive, combinazioni multiple e strumenti per il cash out. Per puntare con criterio, è utile confrontare le quote, consultare lo storico delle squadre e annotare i risultati, investendo solo cifre coerenti con il proprio piano.

In mobilità, sisal app consente autenticazione biometrica, notifiche personalizzate e gestione rapida di depositi e prelievi. Un’interfaccia intuitiva riduce gli errori: menu chiari, filtri per tipologia e promemoria sui limiti di spesa aiutano a rimanere concentrati sugli obiettivi, evitando distrazioni durante le sessioni fuori casa.

La sicurezza inizia con sisal login: password robuste, autenticazione a due fattori e controlli periodici dei dati. È consigliabile aggiornare le credenziali, disconnettersi dai dispositivi condivisi e utilizzare reti protette, così da mantenere il conto in ordine e prevenire accessi non autorizzati in qualunque contesto.

Sezione Caratteristiche principali Bonus tipici Consiglio rapido
Casino (tavoli) Blackjack, roulette, varianti dal vivo, software con RNG certificato Benvenuto con requisiti trasparenti e promo sui tavoli selezionati Scegli limiti coerenti col bankroll e controlla puntate minime
Slot Jackpot, Megaways, acquisto bonus, volatilità diversificata Giri gratuiti, cashback periodico e missioni a tempo Valuta RTP e payline prima di avviare una nuova sessione
Bingo Sale tematiche, cartelle multiple, chat moderata Cartelle scontate e estrazioni speciali nei giorni festivi Fissa un budget per estrazione e prenditi pause regolari
Scommesse sportive Quote live, statistiche, combinazioni, funzione cash out Multipla potenziata e rimborso su esiti specifici Confronta le quote e limita l’esposizione su eventi correlati
App e accesso Biometria, notifiche, deposito e prelievo rapidi Promo mobile-first e missioni pensate per l’uso in mobilità Attiva 2FA e disconnettiti dai dispositivi condivisi
  • Definisci un budget settimanale e rispettalo senza eccezioni.
  • Leggi con attenzione termini, requisiti di puntata e scadenze.
  • Usa metodi di pagamento tracciabili e completa la verifica identità.
  • Monitora il tempo di gioco con promemoria e sessioni brevi.
  • Interrompi l’attività se noti impulsività o cali di concentrazione.

Infine, ricorda che il divertimento è sostenibile quando pianifichi in anticipo, utilizzi strumenti di autolimitazione e valuti con calma i risultati. Considera la qualità dell’assistenza, la chiarezza delle informazioni e la trasparenza dei costi, così ogni scelta rimane informata, consapevole e in linea con i tuoi obiettivi.

Panoramica, funzionalità e consigli per un uso consapevole

Nel panorama dei servizi digitali dedicati all’intrattenimento e alle scommesse, gli utenti cercano affidabilità, trasparenza e velocità. In un contesto in cui molti brand competono per attenzione e fiducia, è essenziale valutare in modo critico strumenti, offerte e condizioni, evitando scelte impulsive. Tra i termini che emergono nelle ricerche degli utenti compare anche rebet, spesso associato a piattaforme che promettono navigazione semplice, pagamenti rapidi e promozioni chiare.

Prima di iscriversi conviene analizzare aspetti come sicurezza dei dati, strumenti di controllo del budget, qualità dell’assistenza e chiarezza delle regole promozionali. Una piattaforma moderna deve offrire un’esperienza coerente tra desktop e smartphone, con tempi di caricamento rapidi, layout accessibile e percorsi d’uso che non confondano l’utente. La coerenza grafica, unita a guide in lingua italiana, evita errori e fraintendimenti.

Per chi preferisce gestire tutto da smartphone, la disponibilità di rebet24 app consente di aprire e chiudere sessioni in pochi tocchi, monitorare il saldo in tempo reale e approfittare di notifiche mirate. Un’app ben fatta integra login sicuro, salvataggio preferiti, ricerca veloce dei mercati e aggiornamenti che migliorano l’esperienza senza appesantire la memoria.

Non tutti desiderano installare software dedicato: per questo la versione rebet24 mobile è utile quando serve un accesso rapido dal browser, mantenendo reattività, pulsanti ben distanziati e flussi semplificati. Questo approccio evita incompatibilità con dispositivi meno recenti e consente un utilizzo immediato, anche con reti non perfette.

L’accesso ai servizi deve restare intuitivo, ma sicuro. La procedura rebet24 login dovrebbe prevedere autenticazione a due fattori, alert per tentativi sospetti e possibilità di aggiornare la password con criteri robusti. La sicurezza non deve penalizzare l’usabilità: moduli chiari e feedback istantanei riducono gli errori in fase di accesso.

Chi gestisce attività collegate o reti di punti fisici può trarre vantaggio da soluzioni di back-office: un sistema come rebet24 gestionale è pensato per report rapidi, controllo dei limiti, gestione dei profili e riconciliazione dei movimenti. Un buon pannello consente di leggere trend, individuare anomalie e impostare regole automatizzate per la conformità.

Prima di affidarsi a un servizio vale la pena consultare opinioni di altri utenti: le ricerche su rebet24 recensioni mettono in luce pregi e difetti, come tempi di risposta dell’assistenza, chiarezza dei termini e qualità dell’esperienza su diversi dispositivi. Incrociare più fonti aiuta a distinguere feedback autentici da quelli poco affidabili.

Sul fronte promozionale, è bene capire come funziona un’offerta denominata rebet24 bonus, quali sono i requisiti di puntata, la contribuzione dei diversi giochi e le scadenze. Verificare questi punti riduce il rischio di fraintendimenti e aiuta a pianificare l’uso delle promozioni in modo sostenibile e coerente con il proprio budget.

Per i nuovi iscritti, alcuni siti propongono incentivi di ingresso: molte guide fanno riferimento a termini come Rebet24 bonus benvenuto per descrivere pacchetti che includono crediti promozionali o free spin, ma è fondamentale leggere attentamente i dettagli, valutare limiti e compatibilità con i metodi di pagamento, e comprendere come si sbloccano i fondi.

Quando si cercano indicazioni operative, è frequente imbattersi nella forma testuale rebet24. it riportata in discussioni e tutorial: al di là della digitazione, è sempre consigliabile accedere solo a pagine ufficiali e certificate, verificando il protocollo sicuro e la presenza di informazioni societarie aggiornate e verificabili.

Detto ciò, è utile considerare la reputazione complessiva del marchio, l’attenzione alla prevenzione del gioco e la possibilità di impostare limiti personalizzati: chi preferisce un approccio prudente guarda a soluzioni che rendono semplice attivare gli auto-limiti, sospendere il conto temporaneamente e consultare riepiloghi mensili. In questo quadro, la parola rebet24 ricorre spesso come riferimento nelle comparazioni tra servizi digitali, ma resta decisivo un controllo diretto e consapevole delle condizioni.

Sezione Caratteristica Perché conta
Registrazione Verifica identità e limiti iniziali Migliora la sicurezza e favorisce un uso responsabile sin dal primo accesso
Pagamenti Metodi diversificati e tempi rapidi Riduce attese, consente gestione fluida dei depositi e dei prelievi
Assistenza Chat, e-mail e risposte in italiano Supporto chiaro e tempestivo per problemi tecnici o amministrativi
Promozioni Termini trasparenti e requisiti espliciti Evita fraintendimenti e permette un utilizzo ottimale dei vantaggi
Mobile Interfaccia reattiva e accessibile Mantiene usabilità elevata su schermi piccoli e reti instabili
  • Imposta limiti di spesa e tempo e rivedili mensilmente in base alle esigenze.
  • Completa la verifica dell’identità per sbloccare tutte le funzioni senza rallentamenti.
  • Leggi i termini dei bonus, in particolare requisiti di puntata e scadenze.
  • Attiva l’autenticazione a due fattori per proteggere l’accesso da tentativi sospetti.
  • Conserva traccia dei movimenti con report periodici e categorizzazioni chiare.
  • In caso di dubbi, contatta l’assistenza in italiano e conserva lo storico delle risposte.

Guida essenziale per scegliere e usare un casinò online in modo responsabile

Negli ultimi anni il panorama dei casinò online è cambiato rapidamente, grazie a pagamenti istantanei, interfacce più fluide e maggiore attenzione alla protezione dei dati. Per scegliere con criterio, conviene verificare licenze credibili, strumenti di gioco responsabile, RTP comunicati e assistenza realmente disponibile. Limiti, reality check e autoesclusione sono funzioni indispensabili, così come termini chiari e una reputazione costruita nel tempo, utile a distinguere operatori solidi da progetti poco trasparenti.

Nel confronto tra piattaforme internazionali, alcuni appassionati citano roobet per l’approccio snello all’esperienza d’uso, la varietà di titoli e la frequenza delle promozioni, pur con differenze normative tra giurisdizioni. A prescindere dal marchio, l’analisi dovrebbe partire da elementi oggettivi: qualità dei provider, filtri di ricerca efficaci, sezioni demo, chiarezza dei limiti. Un approccio basato su dati riduce aspettative irrealistiche e aiuta a mantenere un rapporto sano con il gioco.

Per approfondire prassi diffuse tra operatori esteri e confrontare opinioni, può essere utile integrare recensioni indipendenti con guide pubblicate da realtà affermate come Roobet, senza rinunciare a un sano spirito critico. Incrociare più fonti permette di valutare meglio volatilità, payout medi, tempi di prelievo e politiche di verifica dell’identità, così da prevenire inconvenienti e gestire le sessioni con maggiore consapevolezza.

Parlando di roobet casino, molti utenti si chiedono quali metriche contino davvero: catalogo aggiornato, presenza di tavoli live affidabili, statistiche dei giochi, e un’interfaccia che guidi senza distrazioni. Anche la fruibilità su schermi differenti incide sulla qualità dell’esperienza, perché riduce errori e consente scelte più ponderate. Valutare numeri e funzioni, più che slogan, è la strada per selezionare un operatore adatto alle proprie abitudini.

Per il palinsesto, il profilo tipico di roobet online casino include slot a volatilità variabile, giochi da tavolo con regole chiare e, talvolta, show dal vivo. La varietà è un vantaggio solo se accompagnata da limiti personalizzabili, cronologia trasparente e statistiche consultabili. Pianificare la sessione, fissare obiettivi di intrattenimento e rispettare pause regolari aiuta a mantenere il controllo, evitando di inseguire risultati che non dipendono dall’abilità personale.

Sul versante sicurezza, la procedura di roobet login dovrebbe essere abbinata a autenticazione a due fattori, password robuste e attenzione ai tentativi di phishing. Molti operatori richiedono controlli KYC e verifica dell’età prima di consentire prelievi, una misura che tutela l’account e argina gli abusi. Attivare avvisi di accesso, monitorare dispositivi collegati e mantenere software aggiornati è una routine semplice, ma determinante.

Capitolo promotivo: prima di aderire o attivare un eventuale roobet bonus, conviene leggere i requisiti di scommessa, i cap massimi e la lista dei giochi idonei. Termini e condizioni definiscono l’effettiva convenienza dell’offerta e i tempi utili per completarla. La seguente tabella riassume aspetti ricorrenti da controllare, con esempi tipici e suggerimenti sintetici.

Aspetto Cosa valutare Esempio Suggerimento
Bonus di benvenuto Percentuale, tetto massimo, giochi ammessi 100% fino a 200 €, slot selezionate Preferisci termini semplici e requisiti realistici
Giri gratuiti Valore per spin, vincita massima, giochi idonei 50 FS da 0,10 € con cap vincite Verifica il wagering sulle vincite
Cashback Percentuale e periodo di calcolo 10% settimanale su perdite nette Controlla esclusioni e limiti
Requisito di scommessa Moltiplicatore e contributo dei giochi 20x saldo bonus; tavoli al 10% Scegli offerte compatibili con il tuo stile
Limiti e scadenze Puntata massima e giorni utili Max 5 €; validità 7 giorni Non accelerare solo per battere il timer
Pagamenti e prelievi Commissioni, metodi, tempi stimati Carte, wallet, crypto; 0–72 h Prediligi metodi tracciabili e veloci
Assistenza e trasparenza Canali e tempi di risposta Chat 24/7, FAQ dettagliate Leggi le policy prima di accettare
  • Definisci budget e durata prima di iniziare.
  • Abilita l’autenticazione a due fattori e usa un gestore di password.
  • Leggi sempre termini e condizioni delle promozioni.
  • Verifica RTP e volatilità dei giochi che preferisci.
  • Pianifica pause regolari e utilizza i limiti automatici.

Chi preferisce giocare da mobile può affidarsi alla roobet app o alla versione web ottimizzata, che replicano comandi e funzioni fondamentali, con notifiche e adattamento all’orientamento dello schermo. È utile testare la stabilità della connessione, ridurre le distrazioni e abilitare il blocco biometrico del dispositivo. La coerenza tra desktop e smartphone rende più semplice applicare limiti e controlli, mantenendo l’esperienza ordinata e sostenibile.

Guida rapida per scegliere una piattaforma di gioco affidabile

Orientarsi tra le piattaforme di gioco richiede metodo: in Italia, la licenza ADM garantisce standard di sicurezza, tutela dei dati e strumenti di responsabilità. Un buon operatore offre interfacce chiare, regole esposte in modo semplice e un servizio clienti realmente utile. L’esperienza ideale unisce giochi dal vivo, titoli a rulli, carte e lotterie, con filtri rapidi e pagine prodotto dettagliate. La navigazione dev’essere fluida anche nelle ore di punta, con pagamenti tracciabili e tempistiche esplicitate. Tra i riferimenti discussi dagli appassionati, molti confrontano cataloghi, promozioni e sezioni live prendendo come termine di paragone sisal online, specie quando si analizzano varietà, facilità di accesso e qualità delle guide per i nuovi utenti.

  • Licenza ADM e audit indipendenti
  • RTP e volatilità dichiarati
  • Requisiti di puntata chiari
  • Metodi di pagamento trasparenti
  • Strumenti di gioco responsabile

Le sezioni dedicate ai tavoli con croupier, roulette e giochi di carte si valutano per stabilità, limiti flessibili e chiarezza dei regolamenti. L’etichetta sisal casino ricorre spesso quando si discute di equilibrio tra classici e varianti moderne, oltre che di interfacce intuitive. Chi preferisce i rulli guarda a layout puliti, funzioni di acquisto bonus e note su volatilità e RTP: il termine sisal slot viene citato come esempio di raccolte aggiornate, con filtri efficaci per jackpot, linee multiple e meccaniche particolari, così da permettere scelte informate in base al proprio profilo di rischio e al budget disponibile.

Non tutti cercano lo stesso intrattenimento: c’è chi apprezza community vivaci, estrazioni frequenti e sale numeriche, dove moderazione e chat rendono l’esperienza sociale; per questo la proposta sisal bingo viene spesso menzionata in relazione alla continuità degli eventi e alla semplicità di partecipazione. Chi segue lo sport, invece, valuta quote competitive, mercati profondi, funzioni di cash-out e statistiche: l’espressione sisal scommesse è associata a calendari ricchi, analisi pre-match e strumenti per gestire il rischio, con attenzione a limiti personalizzabili e promemoria sul tempo di gioco.

Tra i marchi regolamentati più conosciuti, molti utenti indicano Sisal come esempio di equilibrio tra responsabilità e divertimento, grazie a un’assistenza disponibile e a impostazioni di autolimitazione facilmente configurabili.

Il passaggio al mobile è centrale: la qualità dell’esperienza su smartphone dipende da navigazione, stabilità e gestione delle notifiche. Le recensioni premiano aggiornamenti frequenti, interfacce coerenti e protezioni biometriche; in questo contesto, la formula sisal app è spesso citata per fluidità e completezza delle funzioni. Anche l’accesso conta: procedure come sisal login risultano convincenti quando includono autenticazione a due fattori, recupero credenziali immediato e controllo delle sessioni attive. A completare il quadro servono depositi e prelievi con tempi comunicati in modo esplicito, metodi diversificati e storico delle transazioni consultabile.

Caratteristica Vantaggio Cosa controllare Nota
Licenza ADM Tutela legale e fondi segregati Numero concessione e ente di controllo Operatore autorizzato in Italia
Catalogo bilanciato Scelte adatte a diversi profili Provider certificati, RTP pubblici Presenza di demo quando disponibili
Promozioni eque Valore extra senza sorprese Requisiti, scadenze, giochi qualificanti Comunicazione chiara e non invasiva
Pagamenti e supporto Prelievi puntuali, assistenza efficace Metodi, orari, tempi medi Chat, email e telefono in italiano

In definitiva, la scelta migliore nasce dall’incrocio tra protezione, trasparenza e divertimento. Valutare termini e condizioni, leggere le regole dei giochi e testare titoli in versione prova aiuta a ridurre il rischio di decisioni impulsive. Un marchio come sisal è spesso citato nei confronti per continuità e ampiezza dell’offerta, ma ogni giocatore ha priorità diverse: c’è chi cerca varietà, chi desidera payout competitivi, chi predilige interazioni sociali. Impostare limiti personali, programmare pause e monitorare spese e tempo trascorso trasforma l’intrattenimento in un’abitudine sostenibile, con maggiore consapevolezza e controllo.

Esperienza di gioco responsabile e guida pratica

Nel panorama del gioco digitale regolamentato, gli utenti cercano un ambiente sicuro, intuitivo e ricco di contenuti. Quando si parla di slotspalace casinò, l’attenzione cade su aspetti come qualità dei giochi, trasparenza dei pagamenti e strumenti di autogestione. Un servizio moderno non dovrebbe limitarsi alle sole slot, ma includere tavoli dal vivo, sezioni tematiche ben curate e una guida chiara per l’utente alle prime armi, affinché ogni sessione resti piacevole e consapevole.

Per iniziare, la procedura di slotspalace login deve essere lineare, protetta da crittografia e verifiche a più fattori, così da evitare accessi non autorizzati. Dopo l’ingresso, l’utente dovrebbe trovare una lobby ordinata, filtri per genere e provider, oltre a informazioni su limiti, depositi e prelievi. In un moderno slotspalace casino online, l’esperienza resta fluida sia da desktop sia in mobilità, con tempi di caricamento rapidi e navigazione coerente.

Le promozioni sono un capitolo a parte: un solido slotspalace bonus non riguarda solo un benvenuto appariscente, ma anche programmi fedeltà, giri gratuiti periodici e missioni con obiettivi chiari. Le condizioni dovrebbero essere leggibili, con requisiti di puntata indicati senza ambiguità e scadenze ragionevoli. È utile poter confrontare le offerte nel tempo, con un archivio storico, e ricevere notifiche opt-in che non risultino invadenti.

La fruizione da smartphone è ormai centrale. Un’eventuale slotspalace app, o una web app progressiva ben ottimizzata, dovrebbe ridurre il consumo dati, adattarsi a schermi diversi e preservare la stessa ricchezza di contenuti della versione desktop. Notifiche contestuali, login biometrico e pagamenti semplificati rappresentano caratteristiche apprezzate, sempre rispettando le politiche di sicurezza del dispositivo e le normative locali sul gioco.

Nel giudicare l’affidabilità di un marchio come slotspalace, è opportuno verificare licenze, audit indipendenti e canali d’assistenza in lingua italiana. Chat rapida, risposte chiare via email e un centro assistenza ben indicizzato aiutano a risolvere dubbi su limiti di ricarica, verifica del conto e protezione dei dati personali. La trasparenza sui tempi di elaborazione dei prelievi rimane un segnale di serietà.

Anche la varietà dei contenuti gioca un ruolo chiave: su un portale simile a slotspalace casino ci si aspetta slot con volatilitá differenziata, tavoli classici come blackjack e roulette, e una sezione live gestita da croupier professionisti. L’organizzazione per temi, meccaniche e jackpot aiuta i giocatori a individuare titoli adatti ai propri gusti, mantenendo sempre un approccio responsabile.

Per dettagli ufficiali su regolamento, metodi di pagamento e novità, è consigliabile visitare il sito istituzionale di riferimento; da lì potrai consultare guide aggiornate, termini delle promozioni e strumenti di tutela dell’utente: SlotsPalace.

Prima di scegliere un titolo, vale la pena esaminare RTP, volatilità, eventuali funzioni bonus e limiti minimi di puntata. Un catalogo ben costruito consente filtri per jackpot, linee di pagamento e provider, mentre una sezione educativa spiega in modo semplice concetti come bankroll management e autoesclusione. Infine, promemoria di attività e statistiche personali aiutano a tenere traccia del tempo e del budget.

  • Imposta limiti di deposito, perdita e sessione prima di iniziare a giocare.
  • Preferisci metodi di pagamento tracciabili e con commissioni chiaramente indicate.
  • Controlla RTP e volatilità per scegliere giochi adatti alle tue aspettative.
  • Leggi attentamente termini e condizioni delle promozioni e dei tornei.
  • Utilizza le funzioni di pausa, autoesclusione e promemoria di attività quando necessario.
Caratteristica Descrizione Cosa controllare
Sicurezza Crittografia, politiche anti-frode, verifica dell’identità e tutela dati. Certificazioni, audit indipendenti, strumenti di autoesclusione e limiti personali.
Pagamenti Depositi e prelievi con tempi chiari, costi trasparenti e valute supportate. Metodi disponibili, limiti per transazione, tempi medi di accredito e KYC.
Giochi Catalogo con slot, tavoli, live, jackpot e modalità prova dove possibile. RTP dichiarati, volatilità, provider affidabili, filtri per tema e meccaniche.
Promozioni Offerte ricorrenti, tornei e programmi fedeltà con regole limpide. Requisiti di puntata, massimali di vincita, scadenze e contributi gioco.

Guida pratica ai giochi, promozioni e strumenti per un’esperienza completa

Questa guida riassume in modo chiaro come orientarsi tra scommesse sportive, giochi da casinò, estrazioni e servizi digitali offerti da una moderna piattaforma italiana. L’obiettivo è aiutarti a confrontare bonus, capire i requisiti di puntata, riconoscere le funzioni più utili e impostare buone abitudini di gestione del bankroll. Troverai consigli operativi, un riepilogo delle principali modalità di gioco e una panoramica delle impostazioni di sicurezza e tutela dell’utente.

Con snai online è possibile trovare un ventaglio di prodotti che copre sia le preferenze di chi segue gli eventi sportivi, sia quelle di chi ama giochi di carte e slot. La varietà è valorizzata da sezioni speciali, promozioni periodiche e tornei tematici. Prima di iniziare, è opportuno verificare termini e condizioni, controllare i limiti impostabili e valutare quali strumenti di autogestione adottare per un intrattenimento responsabile.

L’accesso all’area personale richiede un processo chiaro e veloce: la procedura di snai login permette di riprendere le attività da qualsiasi dispositivo, salvaguardando cronologia, preferiti e impostazioni di sicurezza. Si consiglia di attivare l’autenticazione a due fattori, cambiare periodicamente la password e mantenere aggiornati i dati di contatto per recuperare rapidamente le credenziali in caso di necessità.

Per gli appassionati di quota e analisi statistiche, la sezione snai scommesse offre mercati su campionati nazionali e internazionali, antepost, speciali e opzioni live. È utile confrontare le quote, sfruttare funzioni come cash out quando disponibili e pianificare la gestione della cassa. Le promozioni sulle multiple e i rimborsi condizionati possono aumentare il valore, ma vanno letti con attenzione per comprendere vincoli e scadenze.

Chi preferisce giocare in mobilità può contare su snai app, progettata per un utilizzo rapido e intuitivo. Notifiche personalizzabili, streaming degli eventi selezionati e un’interfaccia ottimizzata consentono di seguire risultati, piazzare puntate e accedere ai giochi in pochi tap. È importante tenere l’app aggiornata e utilizzare connessioni protette, specialmente quando si gestiscono pagamenti e documentazione.

Gli amanti dei tavoli troveranno nella sezione snai casino roulette, blackjack, baccarat, game show e tavoli con croupier dal vivo. La trasparenza su RTP, limiti minimi e massimi, oltre a filtri per provider e volatilità, facilita la scelta del gioco. Bonus di benvenuto e promozioni ricorrenti possono includere giri gratis e cashback, con requisiti di puntata che variano a seconda del titolo e della tipologia di premio.

Per chi cerca bobine e jackpot progressivi, snai slot propone un catalogo ricco di titoli classici, megaways e nuove uscite con funzioni speciali. I tornei a classifica e le missioni giornaliere introducono obiettivi extra. Se invece preferisci le estrazioni a cartelle in tempo reale, snai bingo mette a disposizione sale con ritmi diversi, premi garantiti e chat moderata per interagire in modo piacevole e sicuro con gli altri partecipanti.

Il marchio snai è conosciuto per l’attenzione all’esperienza utente: l’area profilo include strumenti per fissare limiti di deposito, impostare pause temporanee e richiedere l’autoesclusione, oltre a un supporto clienti multicanale che risponde tramite chat, email e telefono.

Per ulteriori dettagli su regolamenti e promozioni aggiornate, è consigliabile consultare la pagina ufficiale di Snai, verificando periodicamente le modifiche ai requisiti e alle scadenze delle offerte.

Area Punti di forza Bonus indicativo Note utili
Scommesse sportive Palinsesto ampio, live, cash out Benvenuto con rimborso o free bet Controlla minimi di quota e scadenze
Casinò live Tavoli HD, limiti flessibili Giri gratis o cashback RTP e requisiti variano per gioco
Slot Megaways, jackpot, missioni Free spins su selezione titoli Verifica volatilità e tetti di vincita
Bingo Sale tematiche, estrazioni frequenti Cartelle in promozione Regole sala e premi garantiti
App mobile Interfaccia rapida, notifiche Promo dedicate alle installazioni Aggiornamenti e sicurezza di sistema
  • Imposta un budget settimanale e monitora il saldo con regolarità.
  • Leggi i termini di ogni promozione prima di aderire, soprattutto i rollover.
  • Usa l’autenticazione a due fattori per proteggere l’account su tutti i dispositivi.
  • Prova i giochi in versione demo quando disponibile per comprenderne le dinamiche.
  • Contatta l’assistenza se noti anomalie su pagamenti, limiti o cronologia gioco.

Ricorda che i risultati non sono prevedibili e ogni sessione dovrebbe essere considerata intrattenimento. Pianifica pause frequenti, evita di inseguire le perdite e tieni traccia del tempo trascorso: un approccio consapevole aumenta il divertimento e riduce i rischi.

Panoramica dettagliata di servizi, giochi e promozioni per utenti italiani

Il marchio sportitaliabet è associato a un ecosistema digitale che riunisce scommesse sportive, giochi da tavolo, slot di ultima generazione e promozioni che puntano alla fidelizzazione. L’esperienza proposta si articola attorno a un’interfaccia che riduce al minimo i passaggi, con navigazione fluida tra sezioni tematiche e strumenti di controllo responsabile facilmente configurabili. Per chi desidera personalizzare il proprio percorso, sono disponibili dashboard con preferiti, cronologia e metriche di gioco, oltre a filtri che consentono di isolare i mercati più seguiti o le slot con volatilità adeguata al proprio profilo di rischio. Accanto a queste funzioni, l’infrastruttura adotta protocolli di sicurezza certificati, mentre l’assistenza opera su più canali per rispondere in tempi rapidi.

Per una panoramica sintetica delle caratteristiche e degli aggiornamenti ufficiali, è utile visitare il sito di SportItaliaBet, dove vengono illustrate le novità su promozioni, metodi di pagamento, limiti di deposito e campagne stagionali dedicate a grandi eventi sportivi e a nuove uscite nel catalogo dei giochi.

Nel segmento dedicato agli appassionati di quote, la proposta sportitaliabet scommesse include mercati pre-match e live con linee su calci d’angolo, marcatori, handicap asiatici e combo, oltre a statistiche in tempo reale per interpretare l’andamento della partita. Gli strumenti di gestione, come cash-out parziale e creazione di multiple personalizzate, permettono di modulare l’esposizione al rischio. La sezione live offre mappe di campo e cronisti testuali che agevolano le decisioni rapide, mentre calendari e notifiche aiutano a non perdere i momenti chiave. Per i tornei principali sono disponibili quote potenziate, utili a ottimizzare il valore dei ticket, sempre nel rispetto dei propri limiti.

Per gli amanti dei tavoli e delle slot, la sezione sportitaliabet casino propone varianti di roulette, blackjack e baccarat, oltre a game show con presentatori dal vivo. Le slot coprono un ampio spettro di volatilità e meccaniche, dalle classiche 3 rulli alle grid con cluster e funzioni di acquisto bonus. Gli studi live impiegano più angolazioni di ripresa e interfacce intuitive, con limiti di puntata differenziati per soddisfare sia neofiti sia giocatori esperti. Filtri per provider, RTP, features e range di puntata aiutano a individuare rapidamente i titoli in linea con le preferenze individuali.

Voce Dettagli
Bonus di benvenuto Percentuale sul primo deposito, free spin e talvolta rimborsi su perdite iniziali
Tipi di scommessa Singola, multipla, sistemi, live con opzioni di cash-out parziale o totale
Giochi da casinò Slot, roulette, blackjack, baccarat e game show con dealer dal vivo
Metodi di pagamento Carte, e-wallet, bonifico, voucher e ricariche istantanee
Sicurezza Crittografia TLS, autenticazione a due fattori e verifica dell’identità
Assistenza Chat live, email dedicata e centro FAQ con guide passo-passo
Requisiti di puntata Rollover variabile; scadenze chiare e contribuzione differenziata dei giochi

Per chi preferisce giocare in mobilità, l’esperienza è ottimizzata per schermi di ogni dimensione e supporta gesture native, notifiche e risparmio dati. L’integrazione con wallet rapidi riduce i tempi di ricarica, mentre i layout reattivi mantengono stabile la qualità grafica nei tavoli live. L’attenzione alla stabilità della rete e alla compressione dei contenuti garantisce sessioni più fluide, anche in condizioni di connessione non ottimali.

Nel contesto mobile, l’installazione della sportitaliabet app consente aggiornamenti tempestivi, accesso diretto alle funzioni preferite, login biometrico e sincronizzazione dei limiti autoimposti tra i vari dispositivi. Le notifiche personalizzabili avvisano su variazioni di quota, tornei speciali e nuove slot in evidenza, mentre la gestione delle impostazioni di privacy e sicurezza resta a portata di tocco.

Tra le promozioni periodiche, il pacchetto sportitaliabet bonus si distingue per struttura trasparente e segmentazione per tipologia di utente, con percorsi che valorizzano sia i primi passi sia la continuità di gioco. La pagina informativa collegata ai regolamenti chiarisce requisiti di puntata, tempistiche e giochi che contribuiscono in misura maggiore o minore, così da facilitare una pianificazione consapevole.

  • Verificare l’identità in anticipo per accelerare prelievi e aumenti di limite.
  • Impostare limiti di deposito, sessione e perdita per una gestione responsabile.
  • Provare le versioni demo delle slot per valutarne volatilità e meccaniche.
  • Leggere le condizioni dei bonus per comprendere rollover e scadenze.
  • Usare il cash-out con criterio, salvaguardando rendimento e disciplina.

Per la massima rapidità di accesso, la procedura sportitaliabet login è ottimizzata con credenziali sicure, opzioni di recupero e autenticazione a due fattori. Dopo l’ingresso, un pannello chiaro mostra saldo, progressi dei requisiti, promozioni attive e cronologia, con pulsanti rapidi per deposito, prelievo e contatto con l’assistenza. L’obiettivo è favorire un’esperienza che unisca velocità, controllo e trasparenza, così da rendere ogni sessione più semplice da gestire e più consapevole nelle scelte.

Guida essenziale per scegliere una piattaforma di gioco affidabile

Nel gioco digitale, la qualità non dipende solo dall’estetica: contano licenze riconosciute, protocolli di sicurezza, cataloghi aggiornati e pagamenti rapidi. Gli utenti più accorti valutano anche la trasparenza delle promozioni, i requisiti di scommessa, l’assistenza in italiano e gli strumenti di responsabilità. Un ambiente solido offre caricamenti fluidi, interfacce chiare, limiti personalizzabili e una cronologia puntate completa, così da mantenere controllo e consapevolezza durante ogni sessione.

Tra i brand più discussi, slotspalace casino viene segnalato per la varietà di titoli, la presenza di tavoli dal vivo e una navigazione coerente tra desktop e dispositivi mobili. Le recensioni indipendenti evidenziano un’attenzione concreta all’esperienza utente: pagine profilo ordinate, sezioni informative leggibili e impostazioni che permettono di gestire limiti, notifiche e verifiche in modo rapido, senza appesantire il percorso di gioco.

Un elemento distintivo è la programmazione di eventi e attività che incentivano la scoperta di nuovi titoli: missioni, classifiche e tornei con montepremi modulati. Non sorprende che la community associ il nome slotspalace casinò a jackpot progressivi e spiegazioni dettagliate di termini e condizioni, utili per evitare equivoci e pianificare il bankroll con maggiore rigore, soprattutto quando si alternano slot ad alta e media volatilità.

Oltre al catalogo, l’identità di slotspalace emerge dalla coerenza del design e dalla stabilità tecnica. Filtri per studio di sviluppo, tema, volatilità e meccaniche consentono di individuare rapidamente i giochi più adatti al proprio profilo di rischio. L’anteprima delle funzionalità chiave, come giri bonus o acquisto feature, rende più semplice confrontare le opzioni senza aprire decine di schede.

Funzione Perché conta Indicazioni utili
Licenza e conformità Tutelano i fondi e garantiscono controlli indipendenti. Verificare autorità di rilascio, audit e politiche KYC.
Catalogo giochi Offre varietà tra slot, tavoli e live show. Controllare RTP dichiarato, volatilità e provider affidabili.
Pagamenti Depositi e prelievi rapidi e tracciabili. Esaminare commissioni, limiti minimi e tempi medi.
Promozioni Valore extra se le regole sono chiare. Leggere requisiti, scadenze e contributi per gioco.
Assistenza Supporto reattivo in lingua italiana. Preferire canali 24/7 e risposte documentate.
  • Definire un budget e rispettare i limiti di spesa.
  • Preferire titoli con informazioni trasparenti su RTP e volatilità.
  • Provare la modalità demo quando disponibile.
  • Usare metodi di pagamento con storni tracciabili.
  • Rileggere regole e contributi prima di attivare promozioni.

Per l’accesso al conto, slotspalace login mette in evidenza misure come autenticazione a due fattori, avvisi di dispositivo e log attività, così da intercettare rapidamente anomalie senza complicare le operazioni quotidiane. L’interfaccia guida in passi chiari, riducendo errori e tempi morti, con opzioni per salvare preferenze e gestire sessioni su più dispositivi in modo ordinato.

Sul fronte promozionale, slotspalace bonus si traduce in offerte con giri gratuiti, programmi fedeltà e missioni ricorrenti. Il valore reale dipende da requisiti, scadenze e contributi dei giochi: leggere le condizioni in anticipo consente di pianificare le puntate, suddividere il budget e massimizzare i benefici senza superare i limiti prefissati o incorrere in esclusioni inattese.

Per chi gioca da smartphone, slotspalace app propone schermate ottimizzate, comandi a una mano e notifiche regolabili. La stabilità su reti variabili, il consumo dati contenuto e l’accesso veloce ai preferiti contribuiscono a sessioni fluide. Il passaggio tra slot, tavoli e live avviene con meno tap, mentre report sintetici aiutano a monitorare spesa e tempo di gioco.

In termini di presenza digitale complessiva, slotspalace casino online integra catalogo, guide e tornei in un’unica interfaccia, con filtri intelligenti per categoria, meccaniche e fornitore. Le lobby mettono in evidenza novità e titoli popolari, mentre le pagine informative chiariscono probabilità, volatilità e funzionalità, favorendo scelte più informate e in linea con le proprie aspettative.

Per ulteriori dettagli pratici e un confronto sintetico tra funzioni, promozioni e metodi di pagamento, è possibile consultare la guida curata da SlotsPalace, utile a orientarsi tra differenze di requisiti, strumenti per il gioco responsabile e suggerimenti per una gestione del bankroll sostenibile nel tempo.

Guida pratica a giochi e scommesse online

Chi si avvicina per la prima volta ai portali di gioco desidera informazioni chiare su qualità, sicurezza e valore delle promozioni. È importante valutare la varietà di sport coperti, la fruibilità su dispositivi mobili e la trasparenza dei termini. In questo contesto molti confrontano interfaccia, tempi di prelievo e supporto clienti, cercando piattaforme con sezioni live fluide e limiti di puntata flessibili. Una considerazione utile riguarda anche la presenza di strumenti come cash out, statistiche in tempo reale e tracker delle giocate. Tra le ricerche più frequenti compaiono comparazioni di quote, cataloghi di slot e affidabilità dei giochi dal vivo, elementi che pesano sulla scelta finale. Non a caso, molti utenti cercano recensioni su sportaza casino per capire come si posizionano bonus e funzionalità rispetto alla concorrenza.

Per esplorare in dettaglio funzionalità, promozioni e termini aggiornati, visita Sportaza e confronta l’esperienza proposta con altri operatori, tenendo conto del tuo stile di gioco e delle priorità personali, come payout, stabilità della piattaforma e assistenza.

La mobilità è cruciale: chi gioca da smartphone o tablet tende a privilegiare applicazioni leggere, veloci e curate nell’esperienza d’uso. In questo senso, la sportaza app promette navigazione intuitiva, ricerche rapide e gestione del conto in pochi tocchi, con particolare attenzione alle notifiche sui risultati e alle promozioni personalizzate. Anche l’accesso deve essere snello e sicuro: il flusso di sportaza login, supportato da verifiche e autenticazione a più fattori, consente di proteggere i dati sensibili senza rallentare le operazioni quotidiane. Un plus apprezzato è la sincronizzazione tra dispositivi, così da ritrovare immediatamente preferiti, scommesse aperte e storico delle transazioni, qualunque sia il canale utilizzato.

Caratteristica Dettagli
Bonus di benvenuto Panoramica sul pacchetto sportaza bonus, con requisiti di puntata, percentuali, massimali e scadenze da rispettare.
Sezione scommesse Copertura dei principali campionati, quote live e strumenti della sezione sportaza scommesse per pre-match e in-play.
Modalità Bet Funzionalità avanzate e opzioni rapide offerte da sportaza bet per gestire singole, multiple e sistemi con maggiore controllo.
Offerta casinò Slot, tavoli classici, game show e live dealer, con filtri per volatilità, provider e jackpot progressivi.
Pagamenti Depositi e prelievi con carte, e-wallet e bonifici; tempistiche, limiti e trasparenza sulle eventuali commissioni.
Assistenza e sicurezza Supporto via chat ed email, verifica KYC, protezioni anti-frode e crittografia dei dati di conto e transazioni.
  • Stabilisci un budget e usa limiti di deposito per un gioco responsabile e sostenibile.
  • Confronta le quote su più eventi per ottimizzare il valore potenziale delle tue giocate.
  • Leggi i requisiti di puntata dei bonus e pianifica il wagering in base alle scadenze.
  • Prova le versioni demo dei giochi per valutare volatilità, ritmo e meccaniche prima di puntare.
  • Controlla tempi e condizioni di prelievo, inclusi documenti richiesti e soglie minime.

Oltre alla componente sportiva, il catalogo di giochi è spesso la variabile decisiva: titoli di provider affidabili, funzioni bonus interessanti e interfacce pulite contribuiscono a un’esperienza appagante. In particolare, l’area sportaza casinò propone ambienti live coinvolgenti, con croupier professionali e tavoli tematici per blackjack, roulette e baccarat. Anche le slot si distinguono per varietà di volatilità, linee di pagamento e meccaniche innovative, legate a free spin, moltiplicatori e modalità bonus. Chi apprezza jackpot progressivi troverà selezioni aggiornate e statistiche chiare sui montepremi. Per chi guarda alla solidità del marchio, è utile ricordare come sportaza abbia costruito la propria reputazione puntando su una combinazione di trasparenza, usabilità e promozioni mirate, senza sacrificare l’attenzione al gioco responsabile.

Quando si scelgono eventi sportivi o giochi da tavolo, conviene adottare un approccio metodico: definisci obiettivi realistici, seleziona mercati in cui possiedi competenze specifiche e utilizza strumenti di analisi per ridurre la variabilità. Tieni presente che le performance passate non garantiscono risultati futuri e che la gestione del bankroll è la difesa più efficace contro gli imprevisti. Infine, prendi dimestichezza con le regole dei giochi e testa diverse strategie in modo graduale: solo così potrai valutare se il mix di quote, promozioni e interfaccia corrisponde davvero alle tue aspettative nel lungo periodo.

Analisi completa di una piattaforma di gioco e scommesse mobile

In Italia, la trasformazione del gioco online ha imposto agli operatori standard sempre più elevati di qualità, sicurezza e responsabilità. Gli utenti cercano interfacce fluide, quote chiare, una libreria di giochi ampia e servizi che funzionino senza intoppi su desktop e dispositivi mobili. La differenza la fanno i dettagli: tempi di prelievo reali, condizioni promozionali trasparenti, strumenti di controllo del budget e assistenza facilmente raggiungibile. Un’esperienza convincente non si limita all’estetica; deve garantire stabilità, rispetto delle normative e un livello di protezione dei dati che consenta di depositare e giocare con serenità. Nel valutare una piattaforma, ha senso osservare licenze, audit indipendenti, fornitori affidabili di pagamenti e la qualità dei contenuti, dal casino live alle scommesse pre-match e in-play, senza dimenticare la compatibilità mobile.

Tra le soluzioni più discusse dagli utenti italiani compaiono topbet24, la topbet24 app dedicata, il pacchetto topbet24 bonus per i nuovi iscritti, la sezione topbet24 casino con slot e tavoli live, e l’area topbet24 scommesse pensata per quote competitive e mercati speciali.

Quando si sceglie dove registrarsi, è utile verificare la presenza di regole di gioco responsabile chiare, termini promozionali sintetici e una guida trasparente alle probabilità. La pagina informativa di TopBet24 può essere un punto di partenza per comprendere come vengono presentate le funzionalità principali, quali filtri per sport e campionati, panoramiche dei giochi da tavolo, e strumenti per notifiche live. È fondamentale anche verificare l’accesso a un centro assistenza completo, con canali multipli e tempi di risposta dichiarati.

Area Caratteristica Dettagli e benefici
Registrazione Verifica dell’identità (KYC) Processo guidato con upload documenti, controlli automatici e attivazione rapida dell’account.
Pagamenti Metodi e limiti Carta, bonifico e portafogli digitali; trasparenza su commissioni, limiti per transazione e tempi medi di accredito.
Promozioni Benvenuto, cashback, giri gratis Regole di wagering chiare, scadenze indicate, percentuali indicate in modo semplice per evitare equivoci.
Casino live Tavoli con croupier Varianti di blackjack, roulette e baccarat; limite minimo e massimo ben visibili; streaming stabile su mobile.
Scommesse sportive Mercati e funzionalità Schedine rapide, cash-out parziale, statistiche integrate, confronto quote e aggiornamenti in tempo reale per l’in-play.
App mobile Prestazioni e usabilità Interfaccia reattiva, ricerche veloci, notifiche personalizzabili, login biometrico e risparmio dati in rete mobile.
Sicurezza Crittografia e tutela fondi TLS aggiornato, segregazione dei fondi dei clienti, monitoraggio frodi e test indipendenti sull’integrità dei giochi.

Un altro elemento centrale riguarda la chiarezza dei regolamenti. Termini come rollover, quota minima, importo massimo di vincita o restrizioni per metodo di pagamento dovrebbero essere spiegati con esempi, così da ridurre i margini di errore per chi è alle prime armi. La libreria di giochi va valutata non solo per quantità, ma per qualità del software, tasso di ritorno al giocatore dichiarato, variabilità del rischio e disponibilità di funzioni come acquisto bonus o modalità provvisoria, quando consentite. Sul fronte sportivo, l’organizzazione dei mercati per campionato, popolarità o orario d’inizio consente di navigare più velocemente, mentre filtri avanzati e statistiche contestuali sono di grande aiuto per gestire il pre-match e l’evento in corso.

  • Confronta licenze, audit e certificazioni indipendenti prima di depositare.
  • Leggi i termini del bonus in modo integrale, incluse scadenze e wagering.
  • Imposta limiti su deposito, spesa e tempo di sessione fin dall’inizio.
  • Prova la versione mobile per verificare stabilità, notifiche e navigazione.
  • Valuta quote, margini e disponibilità del cash-out nelle partite chiave.
  • Controlla tempi e commissioni di prelievo in base al tuo metodo preferito.

Infine, ricordati che il gioco deve restare intrattenimento. Strumenti come l’autolimitazione, l’autoesclusione temporanea e i test di autovalutazione aiutano a mantenere il controllo. La presenza di guide all’uso, tutorial video e FAQ strutturate è indice di un approccio centrato sull’utente, così come un servizio clienti che comunica in modo chiaro gli orari e i canali di contatto. Valuta con attenzione la qualità del supporto tecnico per risolvere problemi di login, verifiche sospese o ritardi nei pagamenti. Un ecosistema equilibrato, che unisce divertimento, trasparenza e affidabilità, è la premessa migliore per un’esperienza serena e sostenibile nel tempo.

Panoramica su un’esperienza di gioco moderna

Nel panorama dei giochi a distanza, i giocatori cercano ambienti affidabili e trasparenti. Chi valuta vavada casino esamina qualità dell’assistenza, licenze, velocità dei pagamenti e varietà del palinsesto. Allo stesso tempo, quando si parla di vavada online casino, l’attenzione si concentra su stabilità dei server, limiti di puntata ragionevoli e presenza di tornei a tempo, utili per bilanciare intrattenimento e gestione del rischio. Una piattaforma coerente unisce interfacce chiare, pagine informative aggiornate e strumenti di controllo per chi desidera mantenere un approccio consapevole.

Per una valutazione informata, conviene consultare fonti ufficiali: visita Vavada per controllare aggiornamenti su funzioni, sicurezza e pratiche di responsabilità.

Prima di registrarti, chiarisci le finalità del gioco e organizza limiti personali; il nome vavada viene spesso associato a interfacce lineari, ma resta fondamentale leggere termini e politiche. La procedura di vavada login, di norma, richiede un’email confermata, autenticazione a due fattori quando disponibile e controlli antiphishing; sono passaggi semplici che proteggono dati e saldo. Verificare questi elementi fin dall’inizio evita rallentamenti successivi, soprattutto quando si desidera accedere a funzionalità avanzate o partecipare a eventi con premi importanti.

Caratteristica Dettagli utili
Giochi Slot, tavoli classici, live, titoli con jackpot; verifica provider certificati e percentuali RTP pubbliche.
Promozioni Benvenuto, cashback, free spin, missioni; attenzione a requisiti di puntata e scadenze.
Pagamenti Carta, bonifico, portafogli digitali; controlla commissioni, valute disponibili e tempi medi.
Sicurezza Crittografia TLS, protezione anti‑bot, monitoraggio frodi, autenticazione a due fattori.
Gioco responsabile Autolimitazioni, autoesclusione, test di autovalutazione, link ad aiuti specialistici.

Chi preferisce l’esperienza in mobilità può adottare vavada app, privilegiando aggiornamenti regolari, risparmio energetico e sincronizzazione sicura tra dispositivi. Sul fronte promozionale, l’etichetta vavada bonus rimanda a pacchetti di benvenuto, programmi fedeltà e tornei con premi; è utile confrontare requisiti di puntata, scadenze e ponderazione dei giochi, così da evitare aspettative distorte e massimizzare la tracciabilità delle spese. Una gestione attenta riduce stress e migliora la qualità delle sessioni.

  • Leggi termini e condizioni con attenzione, soprattutto le clausole su prelievi e promozioni.
  • Confronta RTP, volatilità e limiti di tavolo per adattare la strategia al budget.
  • Prova le versioni demo quando disponibili per conoscere le meccaniche senza rischi.
  • Preferisci metodi di pagamento affidabili e conserva le ricevute di transazione.
  • Attiva l’autenticazione a due fattori e aggiorna regolarmente password e dispositivi.
  • Stabilisci un budget settimanale e usa promemoria o reality check durante le sessioni.
  • Interrompi il gioco quando sei stanco e sfrutta strumenti di pausa o autoesclusione.
  • Contatta l’assistenza se incontri anomalie tecniche o ritardi nei pagamenti.

Per il pubblico locale, l’inquadramento normativo è cruciale: quando si individua vavada casino online, occorre verificare termini legati all’età, all’identità e ai limiti obbligatori. Inoltre, la denominazione vavada casinò appare in discussioni su provider, payout e tornei live; scegliere tavoli e slot con volatilità adatta al proprio stile, impostare stop‑loss sensati e valutare sessioni brevi migliora la sostenibilità nel tempo. L’attenzione ai dettagli fa la differenza, specie nelle fasi di picco di traffico.

La qualità complessiva di una piattaforma non dipende solo dal numero di titoli, ma dal modo in cui vengono gestiti algoritmi casuali e audit indipendenti. I fornitori più solidi pubblicano certificazioni, aggiornano ciclicamente i client e implementano log dettagliati per tracciabilità. Vale la pena esaminare i limiti di sessione, i report di attività e l’eventuale cronologia dei malfunzionamenti, così da prevenire sorprese e migliorare trasparenza. Un ecosistema ben documentato facilita anche l’assistenza tecnica.

Anche la gestione finanziaria richiede metodo: pianifica depositi e prelievi in base a fini ricreativi, verifica il completamento del KYC prima di partecipare a tornei con montepremi e tieni traccia dei tempi medi di accredito. In caso di dispute, raccogli screenshot, ID di transazione e orari; canali come chat, ticket e telefoni dedicati dovrebbero essere reattivi e in grado di fornire risposte chiare e documentate. L’obiettivo è mantenere controllo, serenità e continuità dell’esperienza.

Guida pratica a un’esperienza di gioco online sicura e conveniente

Molti giocatori cercano un punto di riferimento chiaro per orientarsi tra promozioni, metodi di pagamento affidabili e titoli aggiornati. Questa guida riassume gli elementi essenziali per scegliere una piattaforma trasparente, dalla sicurezza dei dati ai bonus, fino alla qualità dell’interfaccia. Che tu preferisca sessioni rapide da mobile o esperienze più lunghe su desktop, qui trovi suggerimenti concreti su come valutare stabilità del software, tempi di prelievo, supporto in italiano e strumenti per un gioco responsabile, con limiti di deposito e autoesclusione facilmente configurabili.

Tra i marchi più citati dagli appassionati italiani figura starvegas, apprezzato per un catalogo riconoscibile e per l’attenzione ai dettagli dell’assistenza. L’aspetto più utile, quando si confronta un operatore, è verificare la trasparenza delle condizioni promozionali, la presenza di numeri di licenza, e l’adozione di protocolli crittografici aggiornati, in modo da avere un ambiente di gioco stabile e controllato sin dal primo accesso.

Esempio pratico: la procedura starvegas login consente di entrare rapidamente nell’area personale, purché i dati siano stati verificati in fase di registrazione con documenti validi. Per chi utilizza lo smartphone, starvegas app offre un’interfaccia ottimizzata con controlli touch reattivi e possibilità di notifiche attivabili, mantenendo consumi ridotti e una navigazione con menu semplificati per i giochi più recenti e le promozioni attive.

Gli amanti dei rulli trovano in starvegas slot una varietà di temi, volatilità differenti e funzioni speciali come moltiplicatori, giri extra e round a obiettivi. Per scegliere il titolo giusto conviene leggere la scheda informativa con RTP dichiarato, linee di pagamento e range di puntata. La qualità dell’audio e delle animazioni, unita a sessioni fluide, contribuisce a rendere l’esperienza coinvolgente senza sacrificare la chiarezza delle regole e delle tabelle premi.

Per accedere all’area dedicata ai tavoli, starvegas casino login guida passo dopo passo con autenticazione sicura e riepilogo degli ultimi movimenti. L’ecosistema starvegas casino integra metodi locali e internazionali, limiti personalizzabili, cronologia delle giocate e strumenti di auto-valutazione. Risulta utile controllare anche le condizioni di rotazione dei bonus, così da comprendere fin da subito requisiti, contribuzioni dei giochi e scadenze.

In ambito nazionale, l’offerta starvegas casinò viene spesso valutata per la qualità del catalogo e per la gestione delle promozioni ricorrenti, come missioni settimanali o cashback soggetti a requisiti. Una buona pratica consiste nel testare prima le versioni dimostrative quando disponibili, verificando ritmo di gioco, puntate minime e massime, e l’eventuale presenza di meccaniche a livelli che possano influenzare la durata della sessione.

Se desideri approfondire dettagli ufficiali, aggiornamenti su promozioni e indicazioni sul supporto, puoi visitare la pagina di riferimento del marchio all’indirizzo di seguito: Starvegas, dove sono disponibili informazioni chiare su sicurezza dell’account, impostazioni di notifica e politiche di protezione dei dati, oltre a guide su limiti e strumenti per un gioco consapevole.

Sezione Contenuto principale Vantaggi per il giocatore
Sicurezza e verifica Autenticazione a più fattori, controlli documentali, cifratura TLS moderna. Tutela dei dati personali e protezione degli accessi.
Bonus di benvenuto Pacchetti con giri extra e credito promozionale con requisiti chiari. Possibilità di testare diversi titoli con rischio contenuto.
Fedeltà e missioni Livelli progressivi, obiettivi giornalieri, premi ricorrenti non invasivi. Valore cumulativo e maggiore prevedibilità delle ricompense.
Pagamenti Carte, portafogli digitali e bonifici con tempistiche trasparenti. Depositi rapidi e prelievi con tracciamento dello stato.
Assistenza Chat in italiano, e-mail, orari estesi e base di conoscenza aggiornata. Risposte puntuali e guida nella risoluzione di problemi.
Gioco responsabile Limiti, autoesclusione, test di autovalutazione, link a supporto esterno. Controllo della spesa e delle abitudini di gioco.
  • Verifica sempre licenza, termini dei bonus e percentuali di ritorno.
  • Imposta limiti di deposito e sessione prima di iniziare a giocare.
  • Controlla le tempistiche di pagamento e le eventuali commissioni.
  • Prova versioni dimostrative per valutare volatilità e meccaniche.
  • Salva canali di supporto e consulta le guide ufficiali.

Guida pratica a giochi, bonus e sicurezza online

Nel panorama del gioco online regolamentato in Italia, gli utenti cercano piattaforme affidabili che uniscano intrattenimento, trasparenza e strumenti di tutela. Prima di scegliere un operatore, conviene valutare licenza ADM, politica sui pagamenti, tempi di verifica e assistenza. Molti giocatori scoprono starvegas mentre cercano un’esperienza che bilanci jackpot, promozioni periodiche e limiti responsabili. Una buona pratica è confrontare i termini di bonus, il contributo dei giochi ai requisiti di puntata e le regole sul prelievo. Allo stesso modo, l’attenzione all’RTP dichiarato e alla volatilità aiuta a impostare sessioni più consapevoli e sostenibili.

La registrazione richiede dati accurati e un documento valido, seguita dalla convalida dell’account entro i tempi previsti dalla normativa. Per accedere in sicurezza, la procedura di starvegas login dovrebbe supportare autenticazione a due fattori, timeout automatico e avvisi di accesso da dispositivi nuovi. Password uniche e lunghe, conservate con un gestore affidabile, riducono il rischio di furti di credenziali. È utile anche attivare avvisi e-mail sugli spostamenti di saldo e impostare limiti di versamento, tempo e perdite per mantenere il controllo. Infine, verifica sempre le soglie per KYC avanzato e le modalità di autoesclusione.

Chi preferisce giocare da smartphone o tablet trova vantaggi nell’esperienza mobile, come notifiche mirate, interfacce ottimizzate e pagamenti rapidi. In questo contesto, la starvegas app permette di seguire promozioni, gestire il conto e provare versioni demo quando disponibili. Prima di installare qualsiasi applicazione, controlla che la fonte sia ufficiale e che i permessi richiesti siano adeguati alla funzione. Per un quadro complessivo dei servizi e delle condizioni più recenti, visita

Starvegas

e confronta offerte, requisiti e strumenti per il gioco responsabile.

La libreria di giochi è un elemento chiave. Chi ama le rullate può valutare temi, meccaniche bonus e frequenza delle vincite, senza farsi attirare solo dai jackpot. Le collezioni di starvegas slot includono titoli classici, moderne grid slot, funzioni con moltiplicatori progressivi e round extra attivabili da simboli speciali. Osserva sempre tabella dei pagamenti, linee attive, range di puntata e presenza di acquisto feature, tenendo conto di come tali opzioni influenzano la volatilità. Ricorda che, a lungo termine, l’RTP guida il ritorno teorico e non garantisce esiti a breve.

Sezione Contenuto Note utili
Bonus di benvenuto Percentuale, tetto, requisiti Verifica contribuzione dei giochi
Giri gratuiti Numero, valore spin Scadenza e titoli inclusi
Tornei slot Formato, durata, montepremi Regole di punteggio e pareggi
Pagamenti Carte, wallet, bonifico Tempi e limiti per prelievo
Sicurezza 2FA, crittografia, audit Controlla la pagina legale

Per chi accede da sistemi condivisi o reti pubbliche, è prudente usare una VPN solo se consentita dalle condizioni del servizio, evitare salvataggi del browser e uscire dall’account dopo ogni sessione. Se il portale distingue aree o domini, il percorso di starvegas casino login può variare per livelli di verifica e session management; in ogni caso, leggi sempre le note legali sul trattamento dei dati e sull’archiviazione dei metodi di pagamento. Nella scelta di bonus e tornei, confronta montepremi, requisiti di scommessa e validità temporale, specialmente quando ti muovi tra lobby live e sezione starvegas casino.

  • Imposta limiti di deposito e sessione.
  • Controlla la licenza ADM e l’RTP dichiarato.
  • Usa autenticazione a due fattori su ogni accesso.
  • Evita reti pubbliche e salva credenziali in modo sicuro.
  • Interrompi il gioco quando superi il budget.

Le iniziative promozionali periodiche, i programmi fedeltà e le campagne a tempo offrono valore aggiunto, ma vanno usati con moderazione e consapevolezza. Un operatore affidabile presenta termini chiari, assistenza multicanale e strumenti di saldo separato per bonus e denaro reale. In caso di dubbi su limiti, esclusioni o tempistiche di accredito, consulta le FAQ e interagisci con la chat ufficiale. Infine, ricorda che il gioco deve restare un divertimento: quando senti calare il controllo o emergere segnali di stress, sfrutta gli strumenti di autoesclusione e i contatti di supporto dedicati del marchio starvegas casinò.

Guida pratica alla piattaforma di gioco e scommesse

Nel panorama del gioco online regolamentato in Italia, molti utenti cercano un’esperienza semplice e trasparente. Per approfondire offerte, termini aggiornati e normative vigenti, è utile visitare Unibet, così da confrontare in modo consapevole le caratteristiche del servizio con le proprie esigenze.

Il brand unibet è noto per l’attenzione alla sicurezza, agli strumenti di autolimitazione e alle pagine informative sulla responsabilità, elementi che rendono più serena la permanenza sul sito per chi desidera intrattenersi senza eccessi.

La sezione unibet casino raccoglie slot di sviluppatori affermati, tavoli di roulette e blackjack, nonché giochi con croupier dal vivo che ricreano l’atmosfera di una sala reale; le interfacce sono localizzate in italiano e offrono anteprime, filtri e limiti di puntata dichiarati fin dalla lobby.

Per quanto riguarda le promozioni, molti nuovi iscritti si informano sulle condizioni del cosiddetto unibet bonus, che tipicamente include vantaggi di benvenuto, omaggi legati a tornei di slot o rimborsi parziali su selezioni di giochi; prima dell’adesione è sempre fondamentale leggere i requisiti di puntata e le scadenze, valutando la reale compatibilità con il proprio stile di gioco.

Chi preferisce il gioco in mobilità può utilizzare unibet app, pensata per avvii rapidi, notifiche configurabili e navigazione fluida tra aree di scommesse e prodotti da casinò; su rete mobile conviene comunque controllare la qualità della connessione, aggiornare regolarmente il software e abilitare l’accesso biometrico quando disponibile.

L’accesso all’area personale avviene tramite la pagina unibet login, con credenziali protette e, quando prevista, verifica a due fattori; dopo il primo ingresso, la piattaforma richiede la convalida del conto entro tempi stabiliti, attraverso l’invio dei documenti richiesti dalla normativa italiana in materia di gioco a distanza.

Di seguito alcuni aspetti pratici da considerare prima di iniziare.

Caratteristica Dettagli
Metodi di pagamento Carta, portafogli elettronici, bonifico; tempi e limiti indicati nella pagina cassa.
Verifica del conto Invio documenti, controllo dell’età; stato del profilo visibile nell’area personale.
Strumenti di gioco responsabile Autoesclusione, limiti di deposito, promemoria di sessione configurabili.
Assistenza Chat, email e centro aiuto con guide passo per passo e risposte rapide.
Catalogo giochi Slot, tavoli, live dealer, titoli a montepremi e varianti tematiche.
Promozioni Bonus di benvenuto, missioni periodiche, classifiche e cashback su selezioni.

Un tema centrale riguarda i limiti: depositi, perdite e tempo di sessione possono essere impostati e modificati con cadenze predefinite; queste impostazioni aiutano a mantenere il controllo e offrono una visione chiara delle proprie abitudini, evitando decisioni impulsive nelle fasi di maggiore coinvolgimento emotivo.

Per versamenti e prelievi è buona norma utilizzare lo stesso strumento, così da agevolare le verifiche e ridurre i tempi; in ogni caso la sezione cassa mostra costi, tempi stimati e soglie disponibili, mentre le notifiche informano sull’avanzamento della richiesta fino all’accredito.

Per chi muove i primi passi, queste buone pratiche possono aiutare a iniziare con metodo:

  • Impostare un budget settimanale e rispettarlo con disciplina.
  • Leggere i termini di ogni offerta prima di aderire.
  • Provare le versioni demo dei giochi quando disponibili.
  • Preferire metodi di pagamento che si conoscono bene.
  • Attivare avvisi e limiti per mantenere il controllo delle sessioni.

Il catalogo si aggiorna regolarmente con nuove uscite e funzioni speciali; prima di puntare conviene leggere le regole di ciascun gioco, confrontare volatilità e limiti e sfruttare le modalità prova quando presenti, così da comprendere ritmo e meccaniche senza esporsi oltre il budget definito.

In caso di dubbi, il servizio clienti è raggiungibile tramite i canali indicati nella piattaforma e le guide in formato FAQ coprono i passaggi più comuni; mantenere un approccio responsabile e pianificato rende l’esperienza più piacevole e sostenibile nel tempo.

Guida all’esperienza di gioco: usabilità, sicurezza e promozioni

Quando si parla di vavada casino, molti giocatori italiani desiderano capire se la piattaforma offra davvero un mix convincente di varietà di giochi, pagamenti rapidi e assistenza efficace. La reputazione nasce da cataloghi ben curati, software affidabile e pratiche trasparenti; per questo si cercano ambienti con slot, tavoli e live show, ma anche limiti chiari, strumenti di controllo responsabile e promozioni gestite con chiarezza.

Nella pratica quotidiana, l’esperienza su vavada online casino dipende molto dall’architettura del sito: un’interfaccia ordinata riduce gli errori e favorisce sessioni piacevoli, mentre filtri intelligenti aiutano a trovare i titoli preferiti. Gli utenti apprezzano tempi di caricamento rapidi, lobby leggibili su desktop e mobile, demo gratuite per testare i giochi e indicazioni trasparenti su RTP, volatilità e puntate minime.

Per avere una panoramica delle novità, delle promozioni e delle modalità di registrazione, molti lettori preferiscono partire da una fonte ufficiale e aggiornata: Vavada, che funge da punto di riferimento per verifiche su catalogo, tornei, normative vigenti e limiti di puntata, prima di decidere se aprire un conto o esplorare soltanto le versioni di prova.

Una volta deciso di creare un profilo, l’accesso tramite vavada login dovrebbe risultare lineare: doppia autenticazione opzionale, promemoria per password, riepilogo dei dispositivi connessi e notifica delle attività insolite. Operativamente, è utile un cruscotto chiaro per depositi, prelievi, documenti di verifica e limiti personali, così da mantenere controllo e tracciabilità di movimenti e preferenze.

Aspetto Dettagli principali
Bonus di benvenuto Percentuale sul primo deposito, eventuali giri gratis, requisito di puntata definito, contributo dei giochi differenziato e scadenza chiara dell’offerta.
Giochi e fornitori Slot, tavoli, live con croupier, titoli provvisti di RNG certificato, catalogo filtrabile per volatilità, funzioni speciali e fasce di puntata.
Pagamenti Carta, portafogli elettronici, bonifico e criptovalute; verifica dei tempi medi di accredito e prelievo, preferibilmente entro 0–48 ore e senza costi nascosti.
Sicurezza e responsabilità Crittografia TLS, test indipendenti, limiti personalizzabili, autoesclusione, reality check e informative chiare su privacy e trattamento dei dati.
  • Imposta un budget realistico e rispetta i limiti di sessione.
  • Controlla il requisito di puntata collegato a ogni offerta.
  • Preferisci giochi con regole e paytable chiare e aggiornate.
  • Mantieni i documenti per la verifica del conto sempre pronti.
  • Esamina limiti di prelievo e eventuali commissioni operative.

Nel valutare promozioni e incentivi, la dicitura vavada bonus andrebbe interpretata alla luce di termini come requisito di puntata, contributo dei giochi e durata. Un approccio informato consiste nel confrontare l’RTP effettivo durante il wagering, evitando strategie rischiose; conviene anche separare saldo reale e promozionale, per ritirare le vincite idonee senza fraintendimenti.

Per chi gioca in movimento, l’eventuale vavada app dovrebbe puntare su stabilità, notifiche configurabili e sincronizzazione sicura del profilo. Anche in versione web responsive, è utile riprendere rapidamente la sessione, salvare preferiti, ricevere avvisi su tornei e utilizzare metodi di pagamento ottimizzati per smartphone, senza sacrificare la velocità dei prelievi.

In tema di tutela dell’utente, vavada casinò è spesso citato per strumenti come limiti di deposito, autoesclusione temporanea e cronologia dettagliata delle giocate. La presenza di guide, FAQ esaustive e assistenza in italiano aiuta soprattutto i nuovi iscritti che cercano chiarimenti su jackpot progressivi, tornei stagionali o qualifiche per sfide con montepremi strutturati.

Guardando al catalogo, la proposta di vavada casino online viene giudicata dalla varietà di provider, dai filtri di ricerca per meccaniche speciali e dalla qualità del live con croupier madrelingua. Le lobby più riuscite offrono tavoli con limiti diversificati, show interattivi, slot con acquisto bonus e competizioni che premiano la costanza.

In definitiva, il marchio vavada viene associato a un’esperienza che premia la chiarezza e la protezione dell’utente. Prima di impegnare denaro reale, è raccomandabile testare i giochi gratuiti, impostare limiti prudenti e verificare la conformità del servizio alle norme vigenti nel proprio territorio.

Guida pratica alle funzionalità, ai bonus e all’esperienza di gioco su piattaforme italiane

L’intrattenimento digitale legato ai giochi da casinò è cresciuto rapidamente in Italia, grazie a interfacce intuitive, pagamenti rapidi e un’attenzione crescente alla sicurezza dei dati. Gli utenti cercano portali completi, con cataloghi ben assortiti e promozioni chiare, ma anche strumenti di gioco responsabile che consentano di impostare limiti, monitorare la spesa e prendersi pause programmate. Per un quadro complessivo sulle novità, sui bonus più recenti e sulle modalità di registrazione e verifica documentale, è utile consultare fonti affidabili: per esempio, una panoramica dettagliata è disponibile visitando Verde Casino, dove vengono spiegati i criteri di valutazione e le migliori pratiche per orientarsi con consapevolezza.

Uno dei parametri più importanti è la facilità d’uso del sito: menu chiari, ricerca dei giochi con filtri, compatibilità con tutti i dispositivi e pagine veloci nel caricamento. Anche la trasparenza dei termini promozionali è fondamentale: i requisiti di puntata, i contributi dei giochi e le scadenze devono essere illustrati senza ambiguità. In questo contesto, l’attenzione dell’utente si concentra spesso su offerte di benvenuto e programmi fedeltà che premiano la costanza, elementi che, insieme a una buona assistenza clienti, delineano il profilo ideale del verde casino online per chi desidera un’esperienza fluida e sicura dalla registrazione ai prelievi.

Il cuore dell’esperienza resta il catalogo: slot con meccaniche innovative, giochi da tavolo classici come roulette e blackjack, varianti live con croupier reali e game show interattivi. I provider di qualità aggiornano periodicamente i titoli, introduttendo funzioni bonus, moltiplicatori, round speciali e opzioni di acquisto feature. È utile verificare RTP e volatilità per adattare la strategia al proprio stile. Molti giocatori associano il marchio verde casino a un design pulito, a filtri utili e a una struttura di tornei o missioni che aggiungono obiettivi extra, rendendo più dinamico il percorso di gioco quotidiano.

Caratteristica Dettagli principali
Bonus di benvenuto Pacchetti con giri e credito promozionale; requisiti di puntata e scadenze indicate con chiarezza.
Programma fedeltà Livelli progressivi, missioni, cashback periodici e premi esclusivi per utenti abituali.
Giochi disponibili Slot, tavoli RNG, live casino, game show, titoli a jackpot e tornei tematici.
Pagamenti Circuiti noti, portafogli digitali e bonifici; tempi di accredito trasparenti e limiti configurabili.
Assistenza Chat in tempo reale, email e FAQ; supporto su verifica account, bonus e transazioni.
Strumenti responsabili Limiti di deposito e perdita, autoesclusione, autoregolazione del tempo di gioco.

Tra gli incentivi più richiesti spiccano i giri gratuiti. Le offerte vanno interpretate con attenzione, distinguendo le vincite in saldo reale e quelle in saldo bonus, oltre all’eventuale cap di conversione. Per alcuni giocatori, l’espressione verde casino free spins indica pacchetti collegati a specifiche slot, magari disponibili in blocchi giornalieri o settimanali. In ogni caso, è essenziale leggere i criteri di puntata, il contributo dei diversi giochi e la finestra temporale per utilizzare i giri, così da massimizzare il valore senza sorprese.

La fruizione da smartphone è ormai prioritaria: layout responsive, interfacce verticali e pagine ottimizzate riducono i tempi di attesa e garantiscono stabilità anche su reti mobili. In aggiunta, alcuni operatori offrono funzionalità dedicate alla verde casino app, come notifiche mirate su tornei, nuovi titoli e promozioni a tempo, oltre a login biometrico e salvataggio sicuro dei metodi di pagamento. Un buon servizio mobile prevede anche limiti di gioco facilmente regolabili e un’area riservata completa, per gestire documenti e prelievi in pochi tocchi.

  • Confronta requisiti di puntata e scadenze prima di attivare qualsiasi promozione.
  • Verifica l’RTP dei giochi e prova le versioni demo quando disponibili.
  • Imposta limiti personali coerenti con il tuo budget e rivedili periodicamente.
  • Controlla metodi e tempi di pagamento, inclusi eventuali costi o soglie minime.
  • Consulta l’assistenza in caso di dubbi su documentazione, identità o blocchi di sicurezza.

Un approccio informato unisce divertimento e controllo, valorizzando promozioni, varietà di giochi e qualità tecnica senza tralasciare la gestione del rischio. Scegli piattaforme che comunicano in modo chiaro, offrono strumenti di protezione e mantengono un’assistenza rapida. Investire tempo nella lettura delle condizioni, nell’analisi dei provider e nella verifica della reputazione consente di ridurre gli imprevisti e di orientare le proprie scelte verso esperienze affidabili, equilibrate e nel rispetto del proprio stile di gioco.

Guida pratica per scegliere e utilizzare al meglio una piattaforma di gioco affidabile

Scegliere una piattaforma di gioco richiede attenzione a licenze, sicurezza dei pagamenti, chiarezza delle regole e disponibilità di assistenza in italiano. Un buon servizio deve offrire giochi certificati, strumenti per il gioco responsabile, limiti personalizzabili e una comunicazione trasparente su bonus e prelievi. È utile verificare la qualità del software, la velocità delle transazioni, la presenza di tornei e promozioni ricorrenti, oltre alla compatibilità con dispositivi mobili. Prendersi qualche minuto per controllare termini e condizioni, politiche di privacy e tempi di verifica dell’identità può evitare sorprese e migliorare l’esperienza complessiva.

Per dettagli aggiornati su giochi, pagamenti e iniziative responsabili, visita Vavada, e confronta ciò che offre con i tuoi criteri personali, così da valutare con consapevolezza funzionalità, condizioni promozionali e qualità dell’assistenza prima di iniziare a giocare con denaro reale.

Dopo la registrazione, il vavada login richiede credenziali robuste e, possibilmente, l’autenticazione a due fattori per proteggere saldo e dati. È buona pratica conservare i documenti per la verifica KYC, aggiornare la password con cadenza regolare e utilizzare connessioni sicure. In fase di accesso, controlla anche le notifiche sull’attività del conto e le impostazioni di sicurezza disponibili nell’area personale, in modo da intervenire subito se rilevi anomalie o tentativi di accesso sospetti.

  • Verifica licenze e certificazioni di indipendenti per i generatori di numeri casuali.
  • Controlla i tempi di deposito e prelievo, oltre alle eventuali commissioni.
  • Esamina l’offerta di slot, tavoli live e game show con croupier.
  • Valuta i tornei periodici e il calendario delle promozioni ricorrenti.
  • Imposta limiti, autoesclusione e promemoria per un gioco responsabile.

Se preferisci dispositivi mobili, la vavada app semplifica l’accesso all’account e ai giochi con interfacce ottimizzate, comandi touch e notifiche utili su tornei o bonus attivi. Scegliendo una connessione stabile e tenendo aggiornato il sistema operativo, l’esperienza risulta fluida, con caricamenti rapidi e un consumo di dati contenuto. Verifica i permessi dell’applicazione, le funzioni di sicurezza integrate e la compatibilità con i principali metodi di pagamento presenti in Italia.

Le promozioni sono interessanti quando i requisiti sono chiari: con un vavada bonus conviene controllare requisiti di puntata, contribuzione dei giochi, scadenze e puntate massime ammesse durante il wagering. Le migliori offerte premiano la fedeltà con cashback, tornei a classifica, giri gratuiti e missioni giornaliere. È importante leggere sempre i dettagli, evitare sovrapposizioni tra promozioni e monitorare il saldo reale separato dal saldo con requisito per una gestione più consapevole.

Caratteristica Descrizione Perché conta
Pagamenti Depositi rapidi, prelievi tracciabili e metodi diffusi Riduce attese e semplifica la gestione del bankroll
Assistenza Chat, email e FAQ in lingua italiana Supporto tempestivo in caso di problemi o dubbi
Giochi Slot, tavoli live, jackpot e game show Varietà per stili diversi e obiettivi di intrattenimento
Responsabilità Limiti, realtà del rischio e autoesclusione Tutela il giocatore e promuove un uso consapevole

La proposta di vavada casino online si distingue quando unisce catalogo ricco, pagamenti rapidi e strumenti di controllo del conto. La presenza di tornei e missioni rende la progressione più coinvolgente, mentre i filtri di ricerca aiutano a trovare slot con volatilità o funzioni bonus preferite. È utile testare sezioni demo, quando disponibili, per capire il ritmo dei giochi prima di passare a puntate reali.

Guardando allo standard internazionale, l’impostazione di vavada online casino combina interfaccia pulita, provider riconosciuti e un’attenzione concreta al supporto. I game show live, accanto a roulette e blackjack, ampliano l’intrattenimento e favoriscono sessioni dinamiche. Aggiornamenti frequenti, tornei con classifiche chiare e calendari promozionali trasparenti contribuiscono a un’esperienza coerente, adatta sia a chi gioca sporadicamente, sia a chi preferisce sessioni più strutturate nel tempo.

Il marchio collegato a vavada casino attrae per la navigazione lineare e la chiarezza delle pagine dedicate a promozioni, regole dei giochi e pagamenti. La suddivisione per temi, volatilità o meccaniche di gioco semplifica la scelta. Anche la presenza di developer noti, con titoli ad alta qualità visiva e funzioni bonus ben bilanciate, aiuta a diversificare le strategie e a mantenere il controllo del budget durante le sessioni.

Nel panorama italiano, l’approccio adottato da vavada casinò privilegia la semplicità operativa e un linguaggio comprensibile, utile per chi inizia. Le guide introduttive, unite a promemoria sul gioco responsabile e a limiti personalizzabili, rendono più facile pianificare le sessioni. È consigliabile impostare budget e obiettivi realistici, sfruttare i filtri dei giochi e consultare spesso le statistiche personali per mantenere abitudini sane.

In definitiva, vavada si concentra sull’equilibrio tra varietà, fluidità dell’esperienza e tutela dell’utente. Valutare in anticipo i termini dei bonus, provare i giochi in modalità dimostrativa quando possibile e impostare limiti chiari consente di godere di un intrattenimento di qualità. Confrontare periodicamente le proprie esigenze con le novità della piattaforma aiuta a trarre il massimo beneficio da funzionalità e promozioni disponibili.

Guida pratica per valutare piattaforme di gioco e scommesse online

Orientarsi tra piattaforme di gioco online richiede attenzione a licenze valide, trasparenza su pagamenti, limiti personalizzabili e strumenti di protezione del giocatore. Chi desidera divertirsi con responsabilità valuta anche RTP, software affidabile e tempi di risposta del supporto.

Per approfondire un operatore specifico e confrontarne i servizi con altri del mercato, puoi visitare la pagina ufficiale di Vincitu, utile punto di partenza per comprendere offerte, strumenti e qualità complessiva.

La procedura di vincitu login dovrebbe risultare rapida e sicura: verifica sempre la presenza di autenticazione a due fattori, protocolli crittografici aggiornati e una gestione chiara del recupero credenziali per prevenire accessi non autorizzati.

Nel panorama nazionale, il marchio vincitu si è distinto grazie a un approccio focalizzato sulla chiarezza delle regole promozionali, sulla protezione dei dati e su interfacce ordinate, pensate per utenti alle prime armi e giocatori esperti.

Chi predilige lo sport trova in vincitu scommesse mercati completi, copertura live e strumenti di analisi pre-match; quote aggiornate con continuità e limiti impostabili aiutano a gestire il bankroll in modo sostenibile e consapevole.

Per gli amanti dei giochi di carte e delle roulette, la sezione vincitu casino propone tavoli con regole chiare, limiti variabili e interfacce pulite, con attenzione alla qualità video e alla stabilità delle sessioni.

Gli appassionati di rulli apprezzeranno vincitu slot per catalogo diversificato, filtri veloci, informazioni su volatilità e RTP, e modalità demo dove disponibili, utili a comprendere il ritmo del gioco prima di puntare.

La mobilità conta: con vincitu app l’esperienza resta fluida su schermi differenti, grazie a notifiche configurabili, layout responsive, protezione del login e sincronizzazione dei limiti, così da mantenere controllo anche fuori casa.

Le promozioni, come vincitu bonus, vanno lette con attenzione: controlla requisito di puntata, contribuzione dei giochi, scadenze e massimali di prelievo; una gestione consapevole evita sorprese e favorisce un intrattenimento sostenibile.

Nel vivo dell’azione dal vivo, vincitu casinò valorizza croupier professionali, interfacce intuitive e tabelle informative sempre visibili; la possibilità di impostare limiti e pause resta prioritaria per un’esperienza equilibrata e serena.

  • Verifica licenza ADM e politiche di gioco responsabile.
  • Controlla RTP, volatilità e fornitore software dei titoli.
  • Esamina tempi di prelievo, commissioni e strumenti di verifica.
  • Testa usabilità, filtri, ricerca e velocità di caricamento.
  • Valuta assistenza via chat, email, telefono e tempi medi.
  • Imposta limiti, autoesclusione e promemoria di sessione.
Aspetto Dettagli
Licenza e conformità Verifica autorizzazione ADM, protocolli di sicurezza TLS e policy di protezione dati e minori.
Tipi di giochi Slot, tavoli, live, lotterie e virtuali, con filtri, preferiti e cronologia per monitorare attività.
Bonus tipici Benvenuto, cashback, free spin, missioni; sempre con T&C chiari, requisiti, contribuzioni e scadenze.
App e compatibilità Web responsivo, app iOS/Android, accessibilità, modalità risparmio dati e ottimizzazione per rete mobile.
Metodi di pagamento Carte, wallet, bonifici istantanei; tempi, limiti, KYC e totale trasparenza su eventuali commissioni.
Assistenza clienti Chat in tempo reale, email e telefono; orari, qualità delle risposte e gestione rapida delle escalation.
Strumenti responsabili Limiti di deposito, sessione e perdita, reality check, autoesclusione e collegamenti a servizi di supporto.
Quote e mercati Ampiezza dei mercati sportivi, streaming, cash out e statistiche, con aggiornamenti rapidi nelle fasi live.

Prima di iniziare, definisci un budget, stabilisci obiettivi realistici e programma pause. Leggere con calma termini e condizioni, comprendere i requisiti tecnici del dispositivo e annotare spese ricorrenti aiuta a mantenere un equilibrio sano e consapevole nel tempo.

Guida ragionata a esperienze, sicurezza e valore nel gioco online

Nel panorama italiano del gioco e delle scommesse online, la qualità di un operatore si misura da fattori concreti: trasparenza delle regole, chiarezza delle promozioni, velocità dei pagamenti, protezione dei dati personali e strumenti di controllo per il gioco responsabile. Gli utenti più attenti valutano non solo l’ampiezza del catalogo di giochi, ma anche la facilità con cui possono orientarsi tra sezioni, filtri, metodi di deposito e limiti personalizzabili. Un’esperienza moderna deve risultare coerente su desktop e su mobile, con interfacce leggere, tempi di caricamento brevi e un’assistenza pronta a risolvere dubbi o problemi.

Tra i primi aspetti che incidono sulla fruibilità c’è la gestione dell’accesso: con vincitu login la procedura di autenticazione rimane lineare, a beneficio di chi desidera entrare e iniziare rapidamente a divertirsi mantenendo alti standard di sicurezza. Per chi predilige lo sport, l’aggiornamento delle quote e la varietà dei mercati contano moltissimo: l’area dedicata a vincitu scommesse propone linee pre-match e live, statistiche sintetiche e strumenti utili a organizzare schedine con criteri di rischio e rendimento adeguati alle proprie preferenze.

La fruizione in mobilità è ormai centrale: una piattaforma che possa essere utilizzata ovunque rende la giornata più flessibile e semplifica la consultazione dei giochi preferiti. In questo senso, vincitu app offre un’interfaccia pulita, pulsanti grandi anche su schermi ridotti e sincronizzazione degli stessi servizi disponibili via browser. Allo stesso tempo, è consigliabile leggere con cura le condizioni delle promozioni: il tema del vincitu bonus richiede attenzione a rollover, scadenze e bet qualificanti, così da trarre reale vantaggio senza sorprese.

Per gli amanti dei giochi da tavolo e delle esperienze immersive, vincitu casino mette a disposizione roulette, blackjack e varianti di poker con generatori di numeri casuali certificati e limiti adatti a diversi budget. In parallelo, vincitu casinò integra sale dal vivo con croupier professionisti, tavoli in streaming e interfacce dall’aspetto elegante, creando un ambiente che unisce socialità, ritmo e affidabilità. L’insieme permette di passare con naturalezza dalle partite veloci alle sessioni più strutturate, secondo il tempo a disposizione.

Una parte significativa dell’offerta riguarda la sezione dedicata ai rulli e alle meccaniche a combinazioni: i titoli di vincitu slot spaziano tra temi classici e produzioni moderne, con volatilità differenti e funzionalità bonus come giri gratuiti, moltiplicatori e simboli espandibili. Gli utenti attenti confrontano RTP, range di puntata e presenza di funzioni come Buy Feature o modalità a cascata, privilegiando i giochi che meglio si adattano alle proprie abitudini. Filtri rapidi, demo pratiche e schede chiare agevolano scelte più consapevoli.

Al di là del catalogo, il marchio vincitu si distingue quando abbina semplicità operativa e supporto competente, soprattutto in tema di pagamenti e verifica dell’identità. Metodi di deposito diffusi, prelievi tempestivi, KYC senza intoppi e alert configurabili sugli importi spesi contribuiscono a un ecosistema sostenibile, nel quale il divertimento resta centrale ma accompagnato da strumenti concreti di tutela personale.

Per informazioni aggiornate su iniziative, regolamenti e novità di prodotto, è utile consultare le pagine ufficiali: attraverso il sito di Vincitu è possibile approfondire sezioni specifiche, verificare disponibilità regionali, conoscere i limiti minimi e massimi per transazioni e trovare riferimenti dell’assistenza in tempo reale.

Aspetto Cosa offre Beneficio
Sicurezza d’accesso 2FA, timeout di sessione, verifiche documentali Protezione dell’account e dei dati sensibili
Promozioni Benvenuto, cashback, tornei periodici Valore extra con requisiti chiari e misurabili
Offerta giochi Slot, tavoli RNG, live con croupier Varietà per stili di gioco differenti
App e mobile Notifiche, design responsive, ricerca rapida Utilizzo fluido ovunque, senza rinunce
Pagamenti Carte, wallet digitali, bonifici Depositare e prelevare con tempi certi
  • Imposta un budget e limiti di deposito coerenti con le tue possibilità.
  • Controlla RTP, volatilità e regole prima di iniziare una sessione.
  • Leggi termini e condizioni delle promozioni per evitare vincoli inattesi.
  • Verifica tempi di prelievo, eventuali commissioni e documenti richiesti.
  • Utilizza strumenti di pausa, autoesclusione e promemoria di sessione.
  • Conserva copie aggiornate dei documenti per completare il KYC senza ritardi.

Guida pratica a un portale di gioco e scommesse: qualità, sicurezza e valore

Nel panorama italiano del gioco a distanza, la scelta del portale giusto incide su qualità, sicurezza e divertimento a lungo termine. Tra i siti che uniscono interfacce moderne e un catalogo ampio, Vivabet si distingue per stabilità della piattaforma, promozioni chiare e strumenti utili per gestire il budget, elementi che contano davvero quando si desidera un’esperienza affidabile e continua, sia da desktop sia da dispositivi mobili.

Un ambiente di gioco di livello si riconosce dalla trasparenza su regole, pagamenti e limiti, dalla presenza di controlli dedicati al gioco responsabile e da un supporto clienti disponibile in più canali. Vale la pena valutare i tempi di verifica del conto, la qualità dell’assistenza durante le fasi di deposito e prelievo, e la chiarezza di termini e condizioni: più queste informazioni sono accessibili e sintetiche, più la navigazione rimane fluida e lo svago non viene interrotto da dubbi o attriti inutili.

Prima di aprire un conto, molti lettori cercano opinioni su vivabet per filtrare promesse esagerate e capire come funziona davvero la piattaforma dal punto di vista di pagamenti, limiti e assistenza, così da prevenire inconvenienti e impostare fin da subito abitudini consapevoli.

Chi preferisce giocare da smartphone apprezza la praticità della vivabet app, progettata per ridurre i consumi di dati e offrire notifiche pertinenti su quote e tornei senza risultare invasiva, con aggiornamenti periodici che migliorano prestazioni e compatibilità con i sistemi operativi più recenti.

Il capitolo dedicato alle puntate sportive, noto come vivabet scommesse, propone mercati pre-match e live su calcio, tennis, basket e altre discipline, con strumenti di cash out e statistiche integrate che aiutano a leggere il momento della gara e a prendere decisioni più informate.

Per chi ama i tavoli e i giochi con croupier, la sezione vivabet casino include roulette, blackjack e game show in diretta, con limiti flessibili, tavoli in lingua italiana e interfacce ottimizzate per schermi piccoli, così da non sacrificare la qualità visiva durante le sessioni serali.

L’accesso rapido passa da vivabet login, con opzioni di autenticazione a due fattori, promemoria per aggiornare la password e suggerimenti su PIN o biometria; buone pratiche di sicurezza digitale riducono i rischi legati a reti pubbliche e dispositivi condivisi.

Gli amanti delle macchinette troveranno nella categoria vivabet slot titoli ad alta volatilità e jackpot progressivi, con versioni demo per testare meccaniche e tabelle dei pagamenti, comprensione delle linee e delle funzioni bonus prima di passare a puntate con denaro reale.

  • Impostare limiti personali di deposito e perdita per contenere l’esposizione e giocare con serenità.
  • Verificare i requisiti di puntata dei bonus, distinguendo tra giochi che contribuiscono in misura diversa.
  • Preferire metodi di pagamento noti, tracciabili e in linea con le proprie abitudini di spesa.
  • Utilizzare le statistiche pre-gara e i match center per evitare scelte impulsive durante il live.
  • Testare le versioni demo dei giochi per valutare volatilità, ritmo e compatibilità con il proprio stile.
Funzione Cosa offre Perché conta
Controlli responsabili Limiti, autoesclusione, reality check Aiutano a mantenere equilibrio e consapevolezza
Bonus e promozioni Welcome, cashback, tornei Valorizzano il budget se ben compresi
Pagamenti Circuiti diffusi, tempi chiari Trasparenza e velocità nei prelievi
Assistenza Chat, email, FAQ aggiornate Risolve dubbi e riduce interruzioni
Catalogo giochi Sport, live, tavoli, slot Diversifica l’esperienza e i ritmi
Sicurezza Cifratura, verifiche, 2FA Tutela dati e transazioni

Prima di qualsiasi deposito, conviene completare la verifica dell’identità caricando documenti nitidi e in corso di validità, così da evitare rallentamenti nei prelievi. Un portale ben progettato indica con chiarezza i tempi medi delle procedure e segnala eventuali richieste aggiuntive, accorciando i passaggi e riducendo le attese.

Anche la qualità della connessione incide: durante le partite in diretta o i tavoli live, una rete stabile limita ritardi e disconnessioni. È utile aggiornare periodicamente browser e app, svuotare la cache e mantenere lo spazio di archiviazione libero per garantire sessioni fluide e tempi di caricamento costanti.

Infine, ricordare che il gioco è intrattenimento: fissare un budget, fare pause regolari e usare i report dell’account per monitorare la spesa sono abitudini che rendono l’esperienza più serena. Con informazioni chiare, strumenti adeguati e scelte ponderate, ogni sessione può trasformarsi in un momento piacevole, sotto controllo e coerente con le proprie aspettative.

Guida pratica per orientarsi tra giochi, bonus e strumenti di tutela dell’utente

Il panorama del gioco digitale in Italia è in continua evoluzione: nuovi studi sulla probabilità, tecnologie di pagamento istantaneo e interfacce più intuitive puntano a rendere l’esperienza fluida e consapevole. Scegliere una piattaforma significa valutare licenze, trasparenza dei termini, qualità del supporto e chiarezza dei limiti di spesa. Prima di depositare, conviene esaminare i requisiti di puntata, i tempi di prelievo e la varietà dei giochi, includendo slot, tavoli e prodotti live, per bilanciare intrattenimento, controllo del budget e tutela dei dati personali.

Per informazioni aggiornate su promozioni, strumenti di verifica dell’identità e politiche di gioco responsabile, è utile consultare le pagine ufficiali: in questo senso, un riferimento affidabile è Wazamba, che offre panoramiche dettagliate su metodi di pagamento, limiti personalizzabili e guide rapide per principianti e utenti esperti.

Il marchio wazamba è spesso citato quando si parla di ambienti di gioco dal design vivace e con cataloghi ampi, ma ciò che fa davvero la differenza è la coerenza tra promesse e condizioni effettive. Nel valutare wazamba casino, gli utenti cercano una comunicazione chiara sulle percentuali di contribuzione dei giochi, limiti di prelievo equilibrati e assistenza in lingua italiana, elementi chiave per un percorso d’iscrizione lineare e un’esperienza sostenibile nel tempo.

Un aspetto cruciale riguarda l’organizzazione dei contenuti e la navigazione su desktop e mobile: per esempio, il percorso dall’homepage ai giochi più popolari dovrebbe essere immediato e privo di frizioni. Nel contesto di wazamba online casino, molti apprezzano filtri per provider, volatilità e jackpot, oltre a banner informativi che illustrano le regole dei bonus senza ambiguità, così da decidere con cognizione quale promozione attivare e con quali obiettivi di intrattenimento.

L’esperienza da smartphone e tablet merita un capitolo a parte: menù compatti, caricamenti rapidi e notifiche essenziali riducono le distrazioni e aiutano a rimanere concentrati sul proprio budget. All’interno di wazamba app, i migliori accorgimenti includono l’accesso semplificato con autenticazione a due fattori, l’archivio dei movimenti consultabile in pochi tocchi e reminder configurabili per pause e limiti, utili a mantenere abitudini di gioco equilibrate anche fuori casa.

I passaggi di registrazione e accesso devono tutelare la privacy e impedire usi impropri dell’account. Per la procedura di wazamba login contano sia la robustezza delle password sia la verifica via email o SMS, oltre alla possibilità di impostare limiti di sessione. Un centro assistenza reattivo, via chat o ticket, è un ulteriore indicatore di serietà, soprattutto quando si tratta di verifiche documentali e aggiornamenti sull’avanzamento dei prelievi.

La qualità dei giochi si misura con criteri oggettivi: varietà dei temi, solidità del motore RNG, chiarezza delle tabelle dei pagamenti e ritorno teorico al giocatore. Nell’offerta di wazamba slot, gli utenti esperti valutano la volatilità, la frequenza delle funzioni speciali e la compatibilità mobile, mentre i nuovi giocatori apprezzano demo gratuite e guide sintetiche per capire simboli, moltiplicatori e round bonus, così da provare titoli diversi con consapevolezza.

Molti utenti desiderano integrare l’intrattenimento dei giochi da tavolo con palinsesti sportivi aggiornati e quote competitive. Nella sezione dedicata a wazamba scommesse, sono apprezzati calendari completi, mercati speciali ben organizzati e strumenti per scommesse responsabili, come limiti di puntata e cronologia esiti. Notifiche personalizzabili e statistiche pre-match contestualizzano le decisioni, evitando scelte impulsive e favorendo un approccio ponderato.

Le esperienze live con croupier e game show interattivi valorizzano l’interfaccia, la qualità video e la rapidità delle puntate. In ambito wazamba casinò, le stanze live dovrebbero garantire regole presentate con chiarezza, chat moderata e opzioni di puntata adatte a diversi profili di rischio. La presenza di tutorial rapidi e limiti regolabili direttamente dal tavolo permette di ottimizzare il tempo di gioco, mantenendolo entro confini sostenibili.

Caratteristica Dettagli utili
Bonus di benvenuto Percentuale sul primo deposito, massimali chiari e requisiti di puntata trasparenti
Tipi di gioco Slot di vari provider, tavoli classici, live dealer e jackpot progressivi
Pagamenti Carte, wallet e bonifici con tempi indicati e limiti configurabili
Sicurezza Autenticazione a due fattori, cifratura e controlli antifrode
Assistenza Chat dal vivo, email e FAQ strutturate per temi

Una buona routine prevede la preparazione di un budget, la selezione dei giochi più adatti alle proprie preferenze e la verifica preventiva dei termini promozionali. Le funzioni di promemoria e i limiti temporali aiutano a evitare eccessi; report periodici consentono invece di monitorare andamento e scelte, creando consapevolezza e autonomia decisionale.

  • Definisci un tetto di spesa e un tempo massimo prima di iniziare.
  • Consulta le regole del gioco e le tabelle dei pagamenti.
  • Verifica requisiti dei bonus e percentuali di contributo dei giochi.
  • Attiva autenticazione a due fattori e aggiorna regolarmente la password.
  • Fermati quando raggiungi i tuoi limiti o gli obiettivi prefissati.

Oltre alla selezione ragionata dei titoli, è fondamentale stabilire obiettivi realistici: l’intrattenimento deve rimanere tale, senza inseguire perdite o superare i limiti prefissati. Strumenti come l’autoesclusione, i reminder e i report settimanali forniscono una struttura concreta su cui basare decisioni prudenti, a beneficio del lungo periodo e della qualità complessiva dell’esperienza.

Panoramica di un portale di gioco e scommesse in Italia

Un portale di intrattenimento digitale di qualità in Italia deve saper coniugare trasparenza, varietà e stabilità tecnica. Gli utenti cercano innanzitutto un ambiente sicuro, con informazioni chiare su termini, regole e responsabilità. Interfacce ben progettate rendono veloce la navigazione, riducendo gli errori e migliorando l’accesso alle funzioni principali come la gestione del conto, i depositi, i prelievi e l’assistenza. Anche la disponibilità di giochi certificati, con controlli sull’equità e indicatori di volatilità e ritorno al giocatore, contribuisce a una percezione positiva del servizio. A ciò si aggiungono strumenti per fissare limiti, autoesclusione e reminder di sessione, fondamentali per promuovere abitudini di gioco consapevoli.

L’esperienza ideale si muove senza attriti tra desktop e dispositivi mobili. Le app moderne devono offrire caricamenti rapidi, modalità portrait e landscape, ricerca efficiente, demo dove consentite e tutorial chiari. Una buona piattaforma integra pagamenti riconosciuti, tempi di verifica identità rapidi, cifratura dei dati, storico delle giocate ben organizzato e un centro assistenza che copre chat, email e telefono. Le pagine informative dovrebbero spiegare chiaramente le probabilità, i criteri di assegnazione dei bonus e i requisiti di giocata, così da evitare fraintendimenti e assicurare all’utente la piena comprensione dei propri diritti e doveri.

Molti utenti salvano tra i preferiti la pagina di vincitu login per ridurre i passaggi e ritrovare rapidamente le proprie impostazioni. Altri, prima di registrarsi, cercano recensioni generali digitando vincitu per farsi un’idea della reputazione del marchio e della gamma di prodotti. Gli appassionati di sport citano spesso l’ampiezza dei mercati e delle quote legate a vincitu scommesse, valutando anche flussi live e statistiche in tempo reale. Chi predilige la mobilità apprezza la praticità di vincitu app, utile per notifiche, cash out e streaming. I nuovi iscritti, poi, chiedono dettagli su vincitu bonus, soffermandosi su condizioni, scadenze e contribuzione dei giochi. Negli scenari di carte e tavoli con croupier, la sezione vincitu casino è ricercata per ritmo, limiti e varietà di varianti. Gli amanti dei rulli, invece, descrivono il divertimento offerto dalle vincitu slot, spesso attratti da jackpot e meccaniche innovative. In alcuni casi, chi preferisce una resa linguistica con accento internazionale utilizza la forma vincitu casinò nelle ricerche, pur riferendosi alla stessa proposta ludica.

Oltre ai titoli ed eventi, contano molto la stabilità del sistema, la chiarezza delle promozioni e l’efficienza del supporto. Un buon servizio espone calendari aggiornati, filtri per trovare i giochi preferiti, sezioni dedicate alle novità, e tutorial per orientare i neofiti. Le strategie di fidelizzazione dovrebbero privilegiare una comunicazione onesta e facilmente verificabile, con meccanismi di assegnazione trasparenti e strumenti per monitorare la spesa nel tempo. Infine, la presenza di politiche di privacy solide e di un processo di verifica documentale rapido e rispettoso consolida la fiducia, elemento chiave per una relazione duratura tra operatore e giocatore.

Di seguito una sintesi di funzioni e criteri utili per valutare l’esperienza complessiva, dai pagamenti all’assistenza, passando per la qualità del catalogo e le misure di responsabilità.

Aspetto Dettagli Nota
Metodi di pagamento Carta, portafogli elettronici, bonifico, voucher Controllare eventuali commissioni e limiti
Tempi di prelievo Da poche ore a diversi giorni, in base al metodo Verifica del conto accelerata riduce i tempi
Catalogo giochi Slot, tavoli, live, lotterie, virtuali e eventi sportivi Filtri e ricerca migliorano la scoperta
Promozioni ricorrenti Bonus periodici, missioni, cashback, tornei Leggere sempre termini e contribuzioni
Sicurezza e conformità Cifratura dati, controlli KYC, normative vigenti Protezione della privacy e prevenzione frodi
Assistenza clienti Chat, email, telefono, centro assistenza Orari estesi e operatori formati fanno la differenza
Strumenti di responsabilità Autolimitazione, autoesclusione, reminder Utili per gestire tempi e budget
Esperienza su mobile Interfacce responsive, notifiche, accesso rapido Prestazioni fluide e consumi ridotti di dati

Per ottenere il massimo, è utile adottare buone pratiche fin dall’inizio: pianificare sessioni, leggere i regolamenti e confrontare l’offerta con le proprie preferenze personali, senza inseguire risultati irrealistici. La qualità dell’esperienza non dipende solo dal numero di giochi, ma dalla chiarezza delle informazioni e dall’efficienza del servizio.

  • Imposta limiti di deposito e tempo prima di iniziare a giocare.
  • Completa la verifica dell’identità per sbloccare tutte le funzioni in sicurezza.
  • Consulta le probabilità e i regolamenti dei singoli giochi.
  • Prova le versioni dimostrative quando disponibili per valutare il ritmo.
  • Usa metodi di pagamento tracciabili e sicuri.
  • Contatta l’assistenza se incontri difficoltà tecniche o dubbi sui termini.
  • Interrompi la sessione ai primi segnali di stanchezza o frustrazione.

Per approfondire aspetti come sicurezza dei dati, varietà del catalogo, strumenti di responsabilità e condizioni promozionali, puoi visitare Vincitu e valutare con calma quali servizi rispondono meglio alle tue esigenze, ricordando sempre di giocare in modo responsabile e con budget predefinito.

Guida completa alla piattaforma: funzionalità, giochi e consigli utili

Nel panorama italiano dell’intrattenimento digitale, sempre più appassionati cercano una piattaforma che unisca sicurezza, facilità d’uso e proposte di gioco variegate. Questa guida raccoglie suggerimenti pratici per orientarti tra quote, slot, tavoli dal vivo e promozioni ricorrenti, così da impostare un’esperienza sostenibile e informata. Dalla registrazione alla gestione del conto, passando per i metodi di pagamento e gli strumenti di responsabilità, troverai un quadro chiaro per valutare se l’offerta risponde alle tue aspettative quotidiane e ai tuoi obiettivi di divertimento consapevole.

Per approfondire caratteristiche, termini e disponibilità nelle diverse regioni, puoi consultare il portale ufficiale di Vstart, dove documentazione aggiornata, FAQ e contatti dell’assistenza ti aiutano a ottenere risposte rapide prima di iniziare a esplorare le funzionalità più avanzate.

Tra gli strumenti più apprezzati spicca la vstart app, pensata per chi desidera restare connesso durante la giornata senza rinunciare alla chiarezza dell’interfaccia. Le notifiche personalizzabili e i filtri rapidi facilitano la selezione di eventi, la verifica del saldo e il monitoraggio delle promozioni, mentre la sincronizzazione tra mobile e desktop riduce i tempi di attesa e limita gli errori di inserimento, specialmente quando si operano scelte in tempi ristretti.

La sezione vstart scommesse mette in evidenza mercati popolari e opzioni di nicchia, con un’attenzione particolare alle statistiche pre-partita e agli indicatori di rischio. Per chi preferisce l’azione in diretta, il modulo vstart bet live consente di reagire alle variazioni di momentum con slider intuitivi e conferme rapide, pur ricordando che la gestione del bankroll resta centrale: impostare limiti e programmare pause aiuta a mantenere il controllo e a dare priorità all’esperienza rispetto all’impulso.

Gli amanti dei giochi di carte trovano un catalogo di tavoli classici e varianti moderne, affiancati da show dal vivo che ricreano un’atmosfera immersiva. Nel vstart casinò spiccano slot con volatilità differenziata, jackpot periodici e meccaniche innovative, utili a chi cerca ritmi di gioco diversi. Per chi preferisce un approccio più tradizionale, l’area vstart casino propone roulette, blackjack e baccarat con limiti calibrati, in modo da favorire percorsi graduali e sessioni misurate.

Un capitolo a parte merita il vstart bonus, generalmente strutturato per accompagnare i primi passi e premiare l’attività continuativa con missioni, punti o cashback. Leggere con attenzione requisiti di puntata, scadenze e giochi qualificanti è essenziale per sfruttarne il valore reale, evitando di impegnare il saldo su titoli che non contribuiscono in modo efficace all’avanzamento dei traguardi collegati alla promozione.

Molti utenti scoprono vstart attraverso community e recensioni indipendenti, ma la decisione finale dovrebbe sempre passare da una verifica personale: esplora le demo gratuite, valuta la qualità dello streaming e osserva la trasparenza delle regole prima di adottare una routine.

Caratteristica Dettagli principali
Tipi di gioco Slot di vari provider, tavoli classici, live show e demo senza rischio.
Promozioni Pacchetti di benvenuto modulari, missioni periodiche, cashback e condizioni chiare.
Pagamenti Carte, e-wallet e bonifico; accrediti e prelievi con tempi indicati e limiti flessibili.
App mobile Compatibilità iOS/Android, notifiche su misura, login biometrico e modalità risparmio dati.
Assistenza Chat dal vivo, email dedicata e centro aiuto con guide rapide e tutorial.
  • Definisci un budget settimanale e rivedilo in base ai risultati reali.
  • Attiva limiti di deposito e sessione per mantenere il controllo operativo.
  • Confronta le quote e verifica la liquidità prima di confermare una giocata.
  • Leggi i requisiti di puntata e le scadenze delle promozioni prima di aderire.
  • Prova i giochi in versione demo per valutare ritmo, volatilità e interfaccia.

Prima di avviare una strategia ricorrente, dedica qualche giorno all’osservazione dei mercati, annota le abitudini personali e calibra gli obiettivi su tempistiche realistiche. Puntare sulla qualità della selezione, invece che sulla quantità, aiuta a costruire un’esperienza più serena e a trarre valore dagli strumenti disponibili, anche nelle giornate meno prevedibili.

Guida pratica all’esperienza di gioco e servizi

Nel panorama del gioco digitale, i player italiani cercano ambienti sicuri, veloci e ricchi di intrattenimento. Le piattaforme moderne puntano su interfacce intuitive, promozioni trasparenti e una varietà di titoli che vanno dai rulli ai tavoli dal vivo, senza trascurare la protezione dei dati personali e strumenti per una gestione consapevole del tempo e del budget.

Tra i nomi più discussi, wazamba ha conquistato l’attenzione grazie a grafiche originali, missioni a tema e meccaniche di progressione che premiano la costanza, elementi apprezzati da chi desidera un percorso di gioco strutturato e non soltanto una selezione di titoli.

La reputazione di qualità si riflette anche nella sigla wazamba casino, che molti associano a un’offerta orientata alla varietà, con titoli classici e novità periodiche, promozioni calendarizzate, tornei con classifiche aggiornate e regole esposte in modo chiaro per favorire decisioni informate.

Per chi preferisce giocare da browser senza installazioni, wazamba online casino mette a disposizione un’esperienza fluida, con caricamenti rapidi, filtri per categorie, demo quando consentite e percorsi guidati per i nuovi utenti che vogliono orientarsi prima di effettuare un deposito.

Per informazioni ufficiali su novità, promozioni stagionali e strumenti di tutela del giocatore, è consigliabile consultare la pagina di Wazamba, dove vengono pubblicati aggiornamenti su funzionalità, condizioni e iniziative legate al gioco responsabile.

Chi gioca in mobilità può trovare comoda wazamba app, pensata per offrire notifiche puntuali sulle promozioni attive, un’interfaccia ottimizzata per schermi ridotti e una navigazione semplificata, mantenendo elevate le prestazioni anche su reti non sempre stabili o dispositivi di fascia media.

La procedura di accesso, spesso indicata come wazamba login, è lineare: registrazione con dati essenziali, verifica dell’identità quando richiesta, possibilità di aggiungere l’autenticazione a due fattori e gestione delle preferenze di privacy direttamente dal profilo utente per un controllo puntuale.

Gli appassionati dei rulli trovano in wazamba slot un catalogo tematico molto vario, con meccaniche differenti, volatilità per ogni gusto, funzioni speciali come giri bonus e respin, oltre a panoramiche sui ritorni teorici, utili per scegliere i titoli più in linea con la propria strategia.

Per chi segue risultati sportivi e quote aggiornate, wazamba scommesse propone mercati su campionati principali e manifestazioni internazionali, con statistiche sintetiche, strumenti di calcolo potenziale e impostazioni di responsabilità che aiutano a non superare i limiti stabiliti in fase di pianificazione.

Chi predilige atmosfere con croupier dal vivo apprezzerà wazamba casinò, che include tavoli con limiti diversi, interfacce in più lingue, regole consultabili in anteprima e un’attenzione particolare alla qualità dello streaming, così da mantenere un’esperienza coinvolgente senza rinunciare alla chiarezza normativa.

Aspetto Dettagli
Bonus di benvenuto Percentuale sul primo versamento e giri su titoli selezionati, con requisiti spiegati in modo trasparente.
Tornei periodici Classifiche settimanali con premi, tabella punteggi chiara e calendari pubblici per la partecipazione.
Croupier dal vivo Tavoli gestiti da professionisti con streaming in alta definizione e limiti differenti per ogni profilo.
Programma fedeltà Progressione a livelli, missioni tematiche e punti convertibili in vantaggi esclusivi.
Pagamenti Carte, portafogli digitali e bonifico; tempistiche e limiti indicati nella sezione cassa.
Assistenza Chat in tempo reale ed email, con tempi medi di risposta comunicati agli utenti.
Gioco responsabile Limiti di deposito, reality check, autoesclusione e guide educative per uso consapevole.
  • Definisci un budget realistico e attiva i limiti personali prima di iniziare a giocare.
  • Leggi i requisiti di puntata dei bonus e verifica le scadenze per evitare sorprese.
  • Sfrutta le versioni demo, quando disponibili, per conoscere le meccaniche in tranquillità.
  • Controlla RTP e volatilità per selezionare i titoli in linea con il tuo profilo di rischio.
  • Attiva l’autenticazione a due fattori, proteggi le credenziali e verifica l’identità quando richiesto.
  • Aggiorna regolarmente dispositivo e browser per prestazioni stabili e caricamenti rapidi.
  • Consulta le regole di prelievo e prepara i documenti per velocizzare le verifiche.

Guida completa a piattaforme di gioco online: sicurezza, promozioni e strumenti

Nel panorama del gioco online italiano, scegliere un operatore affidabile significa combinare intrattenimento, sicurezza e responsabilità. I giocatori cercano slot con volatilità diversa, tavoli live con croupier professionali e una piattaforma che sappia adattarsi al loro stile. Oltre al catalogo, sono fondamentali la trasparenza delle regole, le probabilità comunicate in modo chiaro e l’assistenza rapida in lingua italiana. La qualità di un sito si misura anche dalla fluidità delle pagine, dal caricamento delle lobby e dalla stabilità durante le sessioni più intense. Per molti, wincasino è diventato un riferimento quando si parla di interfacce intuitive e di un ambiente pensato per l’utente, con percorsi semplici e guide dettagliate.

Un aspetto cruciale riguarda la registrazione e la protezione dei dati personali. Gli operatori seri applicano procedure KYC, crittografia avanzata e strumenti per monitorare accessi sospetti. Per garantire un’esperienza fluida, la fase di autenticazione deve essere rapida ma robusta, preferibilmente con sistemi a due fattori. In questo contesto, l’area riservata collegata al wincasino login consente di gestire il profilo, verificare i metodi di pagamento e impostare limiti di spesa. La chiarezza nel presentare i documenti richiesti e i tempi di verifica riduce l’attrito e permette ai nuovi utenti di iniziare a giocare in modo consapevole e senza inutili attese, concentrandosi su un divertimento responsabile.

Non meno importanti sono le promozioni, spesso determinanti nella scelta iniziale. I professionisti del settore valutano il valore reale delle offerte, andando oltre la cifra pubblicizzata e analizzando requisiti di puntata, scadenze e contributi dei giochi. È qui che la trasparenza fa la differenza: termini semplici e calcolabili aiutano a evitare sorprese. Le iniziative più apprezzate includono bonus progressivi, cashback su perdite nette e tornei con premi a leaderboard. Tra le formule più ricercate, spicca la chiarezza nell’indicare come utilizzare un wincasino bonus, con dettagli su puntate massime, giochi qualificanti e strategie per sfruttarlo senza oltrepassare i limiti di rischio fissati dal giocatore.

La mobilità è un’altra priorità: un ambiente moderno deve funzionare su smartphone e tablet con la stessa stabilità del desktop. Menù ben organizzati, filtri rapidi e notifiche non invasive migliorano la fruizione quotidiana. L’ottimizzazione delle grafiche e l’uso accorto delle animazioni evitano cali di prestazioni sui dispositivi meno recenti. Per chi viaggia spesso, la possibilità di consultare saldi, storici e promozioni in pochi tap è indispensabile. Un buon esempio è la praticità offerta dalla wincasino app, che integra funzioni di sicurezza, pagamenti veloci e sessioni live, mantenendo un consumo dati contenuto e un’interfaccia coerente con la versione web, così da non disorientare l’utente.

Chi desidera una panoramica autorevole su operatori, criteri di valutazione e tendenze del mercato può consultare la guida aggiornata su WinCasino, dove vengono messi a confronto servizi, strumenti di tutela e qualità dell’esperienza utente con un approccio concreto e privo di tecnicismi superflui.

Caratteristica Descrizione Vantaggio Principale
Sicurezza account 2FA, crittografia TLS e monitoraggio accessi Riduce il rischio di intrusioni e frodi
Promozioni Benvenuto, cashback, tornei stagionali Valore reale e requisiti trasparenti
Metodi di pagamento Carte, e-wallet, bonifico veloce Depositi e prelievi rapidi e tracciabili
Catalogo giochi Slot, tavoli live, show game Varietà per profili casual e high-roller
Assistenza Chat, email, FAQ dinamiche Soluzioni rapide e in lingua italiana
  • Controlla limiti di deposito e imposta soglie personali prima di iniziare a giocare.
  • Valuta il contributo dei giochi ai requisiti promozionali per una strategia consapevole.
  • Usa metodi di pagamento verificati per accelerare prelievi e ridurre verifiche successive.
  • Prova le versioni demo per testare volatilità, frequenza delle vincite e meccaniche bonus.

Un operatore maturo non si limita a offrire cataloghi ampi, ma guida l’utente con informazioni chiare e strumenti preventivi. Filtri per provider, categorie ben delineate e percentuali di ritorno pubblicate in modo verificabile aumentano la fiducia. Anche la sezione dedicata al gioco responsabile deve essere a portata di mano, con link diretti a risorse di aiuto e opzioni di autoesclusione. La comunicazione proattiva, che spiega le novità senza linguaggi opachi, rende l’esperienza sostenibile nel tempo e adatta a giocatori che cercano intrattenimento di qualità, tempi rapidi per le operazioni principali e un ambiente controllato, trasparente e rispettoso delle normative vigenti.

Prima di scegliere, è utile confrontare più operatori per verificare licenze, condizioni, varietà dei giochi e qualità del supporto. L’attenzione ai dettagli, dalle tempistiche di accredito dei prelievi alla precisione delle FAQ, distingue i servizi che meritano fiducia. Con un approccio informato, ogni sessione diventa più consapevole e orientata al piacere del gioco, senza rinunciare alla massima tutela del proprio profilo e del proprio budget.

Guida completa a una piattaforma di gioco moderna

Negli ultimi anni il mercato italiano dei casinò online ha visto crescere l’interesse verso brand che puntano su sicurezza, trasparenza e varietà. Tra questi, molti utenti vogliono capire come si posiziona wincasino rispetto ai concorrenti, valutando la qualità dell’esperienza, la gamma di giochi, l’efficienza dell’assistenza e le politiche di pagamento. Una guida chiara aiuta a orientarsi tra slot, tavoli dal vivo, tornei e promozioni, ma soprattutto a stabilire aspettative realistiche su limiti, requisiti di puntata e velocità delle verifiche. Di seguito trovi una sintesi pensata per chi desidera informazioni concrete prima di registrarsi o effettuare un primo deposito.

Prima di entrare nei dettagli, è utile consultare le fonti ufficiali per controllare termini aggiornati, licenza e strumenti per il gioco responsabile; a tal proposito, la piattaforma indicata qui: WinCasino consente di verificare limiti di spesa, procedure di autoesclusione e canali di supporto, così da giocare con maggiore consapevolezza. L’interfaccia pulita e i filtri per provider e volatilità facilitano la ricerca dei titoli più adatti senza perdersi tra cataloghi dispersivi.

Passando alle promozioni, l’aspetto che spesso fa la differenza è la chiarezza dei requisiti di puntata e dei criteri di contribuzione. La formula wincasino bonus mette in evidenza soglie di deposito, giochi qualificanti e scadenze, riducendo il rischio di fraintendimenti che possono compromettere l’esperienza. È utile confrontare sempre percentuale di rimborso, eventuali free spin e massimale convertibile, perché ogni promozione privilegia elementi diversi. Chi preferisce strategie prudenti può orientarsi verso offerte con requisiti più leggeri e ampia contribuzione dei giochi.

La sicurezza dell’account resta una priorità, e in questo quadro il flusso di wincasino login risulta snello ma attento, con autenticazione a più fattori opzionale, blocco dei tentativi sospetti e monitoraggio delle sessioni. È consigliabile attivare avvisi di accesso e aggiornare regolarmente la password, evitando riutilizzi su altri servizi. Le verifiche KYC, quando gestite con tempi chiari e canali cifrati, proteggono sia l’utente sia l’operatore.

Per chi gioca in mobilità, la wincasino app ottimizza navigazione, tempi di caricamento e stabilità, offrendo notifiche mirate su tornei e promozioni. Prima del download conviene controllare i permessi richiesti e l’impatto sulla batteria, oltre alla compatibilità con i principali sistemi operativi. Un buon design mobile include ricerca rapida, categorie intuitive e filtri efficaci, così da passare da slot a blackjack o roulette live con pochi tocchi.

La qualità del catalogo si misura in ampiezza e profondità: provider riconosciuti, RTP pubblici, volatilità trasparente e versioni demo sono segnali positivi. Nei giochi dal vivo contano la stabilità dello streaming e il numero di tavoli disponibili nelle fasce di punta, oltre alla presenza di limiti flessibili per accontentare sia principianti sia high roller. Sul fronte pagamenti, pluralità di metodi, commissioni esplicitate e tempi medi verificabili favoriscono un’esperienza serena, così come limiti personalizzabili, reality check e cronologia dettagliata delle transazioni.

Riassumendo, una valutazione completa tiene insieme aspetti tecnici e responsabilità personale. I punti seguenti aiutano a costruire una checklist rapida prima di aprire un conto o accettare una promozione.

  • Licenza riconosciuta e strumenti per il gioco responsabile
  • Chiarezza dei requisiti di puntata e delle scadenze
  • Varietà dei provider e trasparenza su RTP e volatilità
  • Stabilità dei tavoli dal vivo e qualità dell’esperienza mobile
  • Tempi di deposito e prelievo, con commissioni esplicitate
  • Assistenza multicanale con tempi di risposta certi
Aspetto Dettagli Cosa verificare
Bonus di benvenuto Percentuale, massimale, free spin Requisiti di puntata, scadenze, giochi qualificanti
Giochi Slot, tavoli RNG, live RTP pubblici, volatilità, provider certificati
Pagamenti Carte, e-wallet, bonifici Tempi medi, commissioni, limiti minimi/massimi
Sicurezza 2FA, crittografia, monitoraggio Procedure KYC snelle, canali cifrati
Assistenza Chat, email, FAQ Orari, qualità risposte, escalation
Mobile App e versione browser Stabilità, consumo batteria, compatibilità

Infine, ricorda che fortuna e intrattenimento vanno bilanciati con controllo e informazione: stabilisci un budget, rispetta i limiti fissati e privilegia operatori trasparenti. Solo così potrai vivere il gioco come svago consapevole, tra sessioni leggere e obiettivi realistici.

Guida pratica ai casinò online: funzionalità, sicurezza e offerte

Orientarsi nel panorama dei casinò online richiede attenzione ai dettagli: licenza valida, offerta giochi equilibrata, strumenti di gioco responsabile e pagamenti trasparenti. Per confronti aggiornati e guide indipendenti, molti utenti consultano WinCasino, una risorsa utile per capire tendenze, rischi e opportunità del settore.

Un operatore affidabile si distingue per interfaccia intuitiva, caricamenti rapidi anche su dispositivi datati, un RTP medio competitivo e un’assistenza in italiano via chat, email e telefono. La varietà conta: slot con meccaniche moderne, tavoli live con croupier professionisti, giochi di carte tradizionali e un’area live stabile. Fondamentali anche limiti di deposito flessibili, autoesclusione, strumenti di monitoraggio del tempo e informative chiare sulla protezione dei dati.

Tra i portali più discussi c’è wincasino, spesso citato per fluidità dell’esperienza e supporto rapido; tuttavia, la qualità reale si misura nel tempo, confrontando payout pubblicati, tempi medi di prelievo e trasparenza delle regole dei tornei. Valuta come vengono presentati volatilità, provider certificati e aggiornamenti delle promozioni rispetto al calendario stagionale.

Quando si parla di offerte promozionali, l’etichetta wincasino bonus compare spesso nelle ricerche. È però essenziale leggere termini e condizioni: requisiti di puntata, contributo differenziato dei giochi, massimali di vincita e scadenze. Meglio incentivi trasparenti, con equilibrio tra divertimento e valore atteso, evitando promo complesse che dilatano troppo il wagering o vincoli che limitano eccessivamente metodi e importi di prelievo.

La sicurezza dell’account parte dall’accesso: la procedura wincasino login dovrebbe prevedere password univoche, autenticazione a due fattori e avvisi per accessi anomali. Evita reti Wi‑Fi pubbliche, aggiorna regolarmente le credenziali e controlla la cronologia. In caso di tentativi sospetti, modifica subito la password, verifica i dispositivi associati e contatta l’assistenza per bloccare movimenti non autorizzati.

Per chi gioca da smartphone, la wincasino app risulta comoda grazie a notifiche puntuali, download leggeri e sincronizzazione del profilo. Verifica i permessi richiesti e la compatibilità con il sistema operativo, preferendo installazioni dagli store ufficiali. Monitora il consumo dati, imposta limiti di spesa dall’interfaccia mobile e abilita il blocco biometrico per ridurre i rischi di accessi indesiderati.

Aspetto Dettagli
Catalogo giochi Slot tematiche, tavoli live in italiano, roulette europea, blackjack multi‑mano, video poker e giochi istantanei.
Bonus e promozioni Benvenuto con requisiti espliciti, giri gratis programmati, cashback selettivi e tornei con montepremi dichiarati.
Pagamenti Depositi istantanei con carte e wallet, bonifici per prelievi, KYC snello e tracciabilità completa delle operazioni.
Sicurezza Crittografia aggiornata, fondi dei giocatori segregati, audit dell’RNG e policy robuste di tutela dei dati.
Assistenza Chat dal vivo, tempi medi di risposta sotto un’ora, FAQ dettagliate ed escalation rapida per casi complessi.

Controlla anche limiti operativi: depositi minimi e massimi, cap giornalieri e soglie che attivano verifiche aggiuntive. La trasparenza sui provider e un elenco pubblico delle licenze aiutano a riconoscere standard solidi. La modalità demo consente di testare meccaniche e volatilità, mentre i tornei con programmazione chiara favoriscono una partecipazione più consapevole e pianificata.

  • Imposta un budget settimanale e rispettalo senza eccezioni.
  • Preferisci giochi con regole chiare e volatilità coerente.
  • Non inseguire perdite; programma pause durante le sessioni.
  • Controlla requisiti di puntata prima di attivare promozioni.
  • Aggiorna dispositivi e browser per ridurre vulnerabilità.

In sintesi, un approccio informato riduce l’attrito e valorizza il divertimento. Confronta operatori, leggi le condizioni, prova i titoli in modalità dimostrativa e sfrutta gli strumenti di controllo del budget. Così farai scelte consapevoli, mantenendo l’esperienza piacevole e allineata alle tue aspettative e al tempo disponibile.

Guida pratica ai casinò online: sicurezza, giochi e promozioni

Il panorama dei giochi digitali attrae un pubblico sempre più vasto, ma per ottenere un’esperienza piacevole è essenziale combinare intrattenimento e buone pratiche. La prima regola è verificare la presenza di una licenza valida, l’uso di sistemi RNG certificati e protocolli di crittografia aggiornati. Ugualmente importante è comprendere i termini e condizioni di bonus, tornei e promozioni, così da evitare sorprese durante prelievi e riconoscimenti. Con un approccio informato, è possibile valutare il catalogo dei giochi, la qualità dell’assistenza, la trasparenza nelle politiche di pagamento e gli strumenti di gioco responsabile, inclusi limiti di spesa e l’opzione di autoesclusione. In questo modo si tutela il budget e si massimizza il divertimento.

Per un’esperienza in lingua italiana con interfaccia intuitiva e supporto continuo, molti giocatori scelgono piattaforme facili da usare: se desideri esplorarne una e valutarne i servizi, visita Winorama e confronta ogni funzionalità con le tue preferenze e il tuo stile di gioco.

Caratteristica Dettagli Perché conta
Sicurezza e licenze Regolamentazione chiara, crittografia TLS, verifica KYC Tutela dei dati e conformità normativa
Pagamenti Carte, e-wallet, bonifici; limiti e tempistiche trasparenti Depositi e prelievi affidabili e rapidi
Promozioni Benvenuto, giri gratis, cashback con requisiti espliciti Valore reale e condizioni comprensibili
Giochi Slot, tavoli e giochi istantanei con RTP indicato Scelta informata e stile di gioco coerente
Assistenza Chat live in italiano, FAQ complete, tempi di risposta brevi Supporto quando serve, senza attese
  • Controlla le condizioni dei bonus, i requisiti di puntata e le scadenze.
  • Imposta limiti realistici di deposito, perdita e sessione prima di giocare.
  • Prova le versioni demo per valutare volatilità, ritmo e meccaniche.
  • Verifica certificazioni indipendenti e protocolli di sicurezza aggiornati.
  • Preferisci metodi di pagamento tracciabili e mantieni documenti pronti per la verifica.

Tra i portali in lingua italiana dedicati all’intrattenimento digitale, winorama casino online consente di provare titoli istantanei senza download e propone tornei periodici; è sempre consigliabile leggere le regole dei giochi e confrontare limiti di puntata, volatilità e tassi di ritorno.

Quando si analizza l’offerta complessiva e l’accessibilità dell’interfaccia, winorama casino viene spesso citato per menu intuitivi e filtri utili, come categorie tematiche e livello di rischio, così da permettere a principianti ed esperti di orientarsi rapidamente tra le opzioni disponibili.

Gli appassionati di rulli trovano in winorama slot un catalogo con meccaniche rapide, funzioni speciali e jackpot locali; prima di puntare denaro reale, conviene valutare l’RTP dichiarato e l’eventuale presenza di feature come giri bonus, wild espandibili e moltiplicatori.

Per chi desidera promozioni chiare e regolari, winorama bonus può includere pacchetti di benvenuto, giri gratuiti e offerte ricorrenti; è importante leggere qual è il contributo dei giochi ai requisiti di scommessa, i massimali di vincita e la durata dell’offerta per pianificare con criterio.

La sicurezza dell’account inizia dalle credenziali: la procedura winorama login incoraggia password robuste, aggiornate e uniche, oltre all’uso dell’autenticazione a due fattori, così da ridurre i rischi di accesso non autorizzato e mantenere al sicuro fondi e dati personali.

In modo analogo, la pagina dedicata a winorama casino login offre un percorso centralizzato per entrare nell’area personale, gestire i limiti di deposito, controllare cronologia transazioni, aggiornare i dati e caricare documenti per la verifica KYC, garantendo piena trasparenza.

Per rimanere informati su nuovi titoli, aggiornamenti e modifiche ai termini, la sezione delle novità di winorama è un riferimento utile: consultarla periodicamente aiuta a pianificare il budget, sfruttare promozioni pertinenti e impostare obiettivi di gioco responsabile senza eccessi.

Guida al gioco responsabile e all’esperienza dell’utente

Nel panorama del gioco digitale, gli appassionati italiani cercano portali chiari, veloci e affidabili, capaci di unire intrattenimento e tutele concrete. Tra i siti più discussi, Winorama si distingue per un’interfaccia immediata, pagine leggere e percorsi di iscrizione lineari. Un catalogo ben organizzato, sezioni informative comprensibili e un centro assistenza presente aiutano i giocatori a orientarsi sin dal primo accesso. La trasparenza su requisiti dei bonus, tempistiche dei prelievi e norme di gioco responsabile rimane decisiva, perché permette di pianificare il budget ed evitare sorprese durante le sessioni.

Caratteristica Dettagli
Tipi di giochi Slot, gratta e vinci, giochi istantanei, titoli con jackpot e minigiochi tematici.
Bonus di benvenuto Crediti promozionali e giri gratuiti, con requisiti di puntata chiari e scadenze definite.
Metodi di pagamento Carta, portafogli elettronici e bonifico; tempi di prelievo variabili secondo il metodo scelto.
Assistenza Supporto via chat ed email, risposte in italiano e guida passo per passo.
Sicurezza Crittografia, verifica dell’età, limiti personalizzabili e opzioni di autoesclusione.

Prima di aprire un conto, molti lettori si documentano su winorama per chiarire come vengono gestiti dati personali, limiti di spesa e processi di verifica. Le pagine informative dovrebbero spiegare in modo semplice depositi, bonus e prelievi, con esempi pratici. Quando si discute di winorama casino, emergono due priorità: ampiezza del catalogo e affidabilità tecnica. Il primo aspetto riguarda temi, volatilità e meccaniche; il secondo include sicurezza delle transazioni, controlli antifrode e un servizio clienti puntuale. Un equilibrio tra divertimento e regole chiare rende l’esperienza fluida e riduce gli errori nelle fasi di convalida o pagamento.

  • Leggere i termini dei bonus e i requisiti di puntata prima di attivarli.
  • Impostare limiti di deposito e di tempo fin dall’inizio.
  • Provare le versioni demo per comprendere volatilità e meccaniche.
  • Tenere a portata di mano i documenti per la verifica dell’identità.
  • Preferire metodi di pagamento tracciabili e aggiornare spesso la password.

Per un accesso sicuro, la sezione di winorama login dovrebbe offrire autenticazione robusta, avvisi per dispositivi non riconosciuti e un percorso chiaro di recupero credenziali. È utile indicare i requisiti minimi del browser, le impostazioni consigliate per la privacy e le buone pratiche per proteggere l’account. In alternativa, la pagina di winorama casino login può fornire collegamenti rapidi alla gestione del profilo, alla verifica dell’identità e ai limiti personalizzati, così da definire fin dall’inizio un perimetro di gioco consapevole.

Le promozioni hanno senso solo se risultano comprensibili e coerenti con le abitudini di chi gioca. Il pacchetto di benvenuto e le offerte periodiche dovrebbero evidenziare i requisiti di puntata, con esempi numerici e scadenze visibili. Molti utenti valutano il valore del winorama bonus in base alla reale convertibilità in saldo prelevabile e alla coerenza con le proprie puntate medie. Sul fronte dei titoli, le winorama slot attraggono per grafica, volatilità differenziata e round speciali; indicare RTP, range di puntata e disponibilità su mobile consente scelte più informate.

Per chi preferisce giocare da casa o in mobilità, winorama casino online è comodo purché vengano rispettati principi di responsabilità e sicurezza. Connessioni protette, logout automatico, storici di sessione consultabili e strumenti di autolimitazione danno all’utente il controllo. Una piattaforma reattiva, filtri di ricerca efficaci e tutorial brevi nelle pagine di gioco aiutano i nuovi iscritti a gestire fondi, bonus e verifiche in pochi minuti, concentrandosi su divertimento consapevole e pianificazione realistica delle sessioni.

Guida completa alla piattaforma, alle funzioni e al gioco responsabile

Questa guida pratica è pensata per i lettori italiani che desiderano comprendere come orientarsi tra registrazione, sicurezza, promozioni e gestione del conto di un operatore di gioco con vincite immediate e un’ampia scelta di prodotti. Se desideri approfondire l’offerta di Winorama, qui trovi un’analisi trasparente di strumenti, funzionalità e buone pratiche per usare il servizio in modo informato, con particolare attenzione alla chiarezza delle condizioni, alla protezione dei dati e al benessere del giocatore.

Il processo di accesso è uno dei primi aspetti da valutare: la pagina di winorama login richiede credenziali create in fase di iscrizione, e uno dei segnali di qualità è la disponibilità di opzioni di verifica a due fattori o di avvisi via e‑mail/SMS quando viene effettuato un nuovo accesso. Mantieni password robuste, evita dispositivi condivisi per l’accesso e aggiorna regolarmente le informazioni di recupero per prevenire blocchi e usi non autorizzati.

Per chi preferisce un percorso dedicato al prodotto con focus sui giochi istantanei, la sezione di winorama casino login centralizza l’entrata nell’area personale con riepilogo saldo, storico transazioni, impostazioni dei limiti e collegamenti rapidi a promozioni attive. Qui è utile controllare la presenza di logout automatico dopo inattività e di sessioni tracciate, così da riconoscere rapidamente eventuali accessi insoliti.

Le promozioni possono aumentare il divertimento, ma è fondamentale valutarle in modo consapevole: la pagina informativa su winorama bonus dovrebbe mostrare con trasparenza requisiti di puntata, contribuzione dei giochi, durata e massimali. Leggere con calma termini e condizioni aiuta a capire quando un’offerta è davvero adatta alle proprie abitudini e a evitare aspettative non realistiche sul prelievo delle vincite maturate tramite incentivi.

Sul fronte dell’intrattenimento, il catalogo di giochi è un punto chiave: tra le proposte più ricercate spiccano le esperienze istantanee con meccaniche semplici e payout chiari, accompagnate da varianti con temi vivaci. In particolare, chi apprezza l’azione veloce troverà utile individuare titoli con volatilità e ritorno al giocatore ben descritti; qui si inserisce l’interesse per winorama slot, con interfacce snelle, sessioni rapide e funzioni bonus immediate.

La fruizione da browser e dispositivi mobili è ormai uno standard atteso: chi cerca un hub completo unisce spesso intrattenimento e praticità, e per questo molti confrontano i servizi di winorama casino online con l’obiettivo di ottenere caricamenti rapidi, layout reattivi, strumenti di filtraggio dei giochi e un portafoglio digitale ben integrato. L’attenzione al gioco responsabile, alle auto‑limitazioni e agli avvisi sul tempo di sessione resta un elemento fondamentale.

A livello di identità, il marchio winorama è spesso associato a prodotti immediati e a un approccio user‑friendly, mentre l’etichetta winorama casino viene utilizzata per enfatizzare la dimensione più ampia che include promozioni, assistenza e metodi di pagamento. In entrambi i casi, ciò che dovrebbe guidare la scelta è la qualità delle informazioni: schede dei giochi esaurienti, regolamenti accessibili e canali di supporto rapidi fanno la differenza nella quotidianità d’uso.

Voce Dettagli utili per l’utente
Registrazione Procedura con dati anagrafici, verifica dell’identità, impostazione dei limiti e conferma via e‑mail o SMS.
Accesso sicuro Supporto a password robuste, eventuale 2FA, disconnessione automatica e cronologia delle sessioni consultabile.
Bonus e promozioni Termini chiari su puntate richieste, giochi idonei, scadenze, massimali e restrizioni geografiche.
Varietà di giochi Instant games, gratta e vinci digitali, slot tematiche, jackpot, talvolta tavoli virtuali e mini‑giochi.
Pagamenti Circuiti principali di carte, portafogli elettronici, bonifici; limiti minimi e tempi medi di accredito.
Assistenza Chat in tempo reale, e‑mail e FAQ; nei migliori casi copertura estesa e tempi di risposta rapidi.
Mobile Interfaccia responsive, funzioni di ricerca rapide, prestazioni stabili anche su reti mobili.
Responsabilità Strumenti di auto‑esclusione, limiti di deposito e sessione, test di autovalutazione e link di supporto.
  • Definisci un budget mensile e usa i limiti di deposito per rispettarlo.
  • Programma pause regolari con promemoria sul tempo di sessione.
  • Leggi sempre le condizioni dei bonus prima di aderire a una promozione.
  • Conserva ricevute e conferme di pagamento per monitorare movimenti e prelievi.
  • Contatta il supporto se noti attività anomale o difficoltà tecniche persistenti.

Prima di iniziare, verifica i requisiti tecnici del tuo dispositivo e aggiorna il browser per garantire prestazioni ottimali, animazioni fluide e caricamenti prevedibili. Ricorda che le percentuali di ritorno al giocatore sono statistiche calcolate sul lungo periodo e non assicurano esiti individuali; per questo è utile concentrarsi sull’esperienza e sulla gestione del tempo, più che sul risultato di singole sessioni.

Infine, mantieni una prospettiva equilibrata: i giochi devono essere un passatempo piacevole, non uno strumento per risolvere problemi finanziari. Se percepisci segnali di eccesso, riduci le sessioni, rivedi i limiti e considera i canali di supporto specializzati. Un approccio informato e prudente consente di valorizzare i punti di forza delle piattaforme moderne, evitando comportamenti impulsivi e sfruttando consapevolmente strumenti e tutele disponibili.

Guida pratica a piattaforme di gioco, app e promozioni per utenti italiani

Negli ultimi anni l’esperienza di gioco a distanza si è arricchita di interfacce più veloci, cataloghi più ampi e protocolli di sicurezza più raffinati. Chi ama alternare slot, carte e tavoli live cerca una piattaforma capace di combinare facilità d’uso e trasparenza, soprattutto nella gestione dei pagamenti e dei limiti. Per chi gioca dall’Italia è diventato indispensabile confrontare i portali, esaminando licenze, strumenti di autoesclusione e chiarezza dei termini promozionali. In questo contesto, molti utenti valutano con interesse l’offerta di zetcasino online, considerandone la varietà di titoli, la qualità del supporto e la fluidità della navigazione su desktop e dispositivi mobili.

La fruizione da smartphone ha cambiato radicalmente le abitudini: notifiche mirate, caricamenti rapidi e interfacce ottimizzate favoriscono sessioni brevi ma frequenti. Per chi preferisce installare un client dedicato, la zetcasino app promette accesso istantaneo alle lobby, aggiornamenti automatici e strumenti nativi per la verifica dell’età e la limitazione dei depositi. Un’attenzione particolare è rivolta alla compatibilità con i sistemi operativi più diffusi, alla stabilità durante le sessioni live e al consumo ridotto di dati, così da garantire una giocabilità costante anche con connessioni non perfette.

Tra i criteri più considerati rientrano i pacchetti promozionali, che dovrebbero essere comprensibili e sostenibili. Il valore reale di un’offerta non si misura soltanto dall’importo nominale, bensì da fattori come i requisiti di puntata, i giochi che contribuiscono al wagering e i limiti temporali. In questa prospettiva, analizzare con calma il regolamento di un eventuale zetcasino bonus aiuta a evitare aspettative distorte: è utile verificare se i free spin hanno un tetto di vincita, se i token scadono rapidamente e quali metodi di pagamento sono esclusi.

Aspetto Dettagli utili
Licenza e conformità Controllare l’autorità di riferimento, i registri pubblici, le policy KYC/AML e la trasparenza dei termini.
Pagamenti Valutare tempi medi di prelievo, eventuali commissioni, limiti minimi/massimi, 3D Secure e metodi disponibili.
Catalogo giochi Presenza di slot, tavoli RNG e live, provider affidabili, versioni demo e filtri di ricerca efficaci.
Sicurezza Crittografia TLS aggiornata, audit indipendenti, RNG certificati e sistemi anti-frode attivi.
Gioco responsabile Autoesclusione, limiti di deposito/perdita, reality check, test di autovalutazione e risorse di supporto.
Assistenza Canali 24/7, tempi di risposta, disponibilità in italiano, FAQ chiare e tracciamento dei ticket.

Nel confronto tra operatori conviene valutare non solo i numeri ma la fruibilità complessiva: chiarezza dei termini, facilità di contatto con l’assistenza e coerenza tra promesse e risultati. Per esempio, alcuni portali presentano pagine dedicate che illustrano i passaggi per attivare promozioni e convertire i crediti; tra le risorse utili per approfondire, puoi consultare la guida collegata a questo testo su Zebet bonus, che spiega con linguaggio semplice come interpretare condizioni e requisiti delle offerte.

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Infine, nell’ecosistema competitivo del gioco a distanza, la capacità di un operatore di offrire pagamenti rapidi, limiti personalizzabili e campagne chiare determina il livello di fiducia a lungo termine. Un servizio come winspark casino online si distingue quando combina un catalogo aggiornato, sicurezza tecnica, supporto attivo e iniziative di responsabilità, incoraggiando abitudini di gioco equilibrate e un uso consapevole del proprio budget.

  1. Verifica la licenza ADM e le misure di tutela del giocatore.
  2. Controlla RTP dichiarati, certificazioni indipendenti e audit periodici.
  3. Confronta metodi di pagamento, tempi di accredito e commissioni.
  4. Leggi i termini dei bonus, i requisiti di puntata e le scadenze.
  5. Imposta limiti di deposito, sessione e perdita per giocare responsabilmente.
Caratteristica Dettagli principali
Sicurezza e licenza Crittografia aggiornata, conformità alle normative italiane, strumenti di autoesclusione e controlli dell’età.
Giochi e provider Catalogo diversificato tra slot, tavoli, live dealer e giochi istantanei, con fornitori certificati e tassi RTP pubblici.
Promozioni e requisiti Offerte con termini chiari, limiti alle puntate durante il wagering, scadenze ragionevoli e vincoli sui giochi qualificanti.
Pagamenti Metodi diffusi in Italia, tempi prevedibili per depositi e prelievi, verifiche KYC rapide e senza duplicazioni documentali.
Assistenza Supporto multicanale in orari ampi, base di conoscenza aggiornata, tracciamento dei ticket e tempi di risposta trasparenti.

Guida pratica al gioco responsabile e alle offerte per nuovi e esperti

Se desideri un riferimento chiaro per capire come valutare promozioni, sicurezza del conto e qualità dei giochi, puoi consultare Winorama per esempi concreti e suggerimenti utili su come leggere correttamente termini, requisiti e strumenti di tutela del giocatore.

Molti utenti, per accedere più rapidamente, cercano “winorama login” o “winorama casino login” pensando esclusivamente alla pagina di accesso; è una scorciatoia comoda, ma conviene sempre verificare il lucchetto del certificato SSL, salvare l’indirizzo ufficiale nei preferiti e abilitare l’autenticazione a due fattori, così da ridurre il rischio di phishing e proteggere dati e fondi.

La sicurezza dell’account non si limita alla password: usa un gestore affidabile, non riutilizzare credenziali su siti diversi, aggiorna periodicamente le informazioni e completa la verifica d’identità (KYC) prima di effettuare depositi importanti. La documentazione richiesta serve a prevenire frodi e a velocizzare eventuali prelievi, oltre a garantire che i limiti di gioco siano applicati correttamente fin dall’inizio.

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Nelle ricerche degli appassionati italiani compare spesso la query “winorama casino online”, che rimanda a pagine dedicate a licenze, cataloghi e metodi di pagamento. Prima di registrarti, valuta la trasparenza dei termini di prelievo, la velocità del supporto, i limiti configurabili di deposito e di perdita, oltre agli strumenti di autoesclusione temporanea o permanente per un’esperienza realmente responsabile.

Il sintagma “winorama casino” viene utilizzato per identificare uno specifico ecosistema di brand, ma i criteri di giudizio restano universali: misura la stabilità della piattaforma durante i picchi di traffico, leggi le recensioni che citano tempi concreti di gestione dei ticket e verifica la disponibilità di sezioni educative che spieghino probabilità, varianza e corretto bilanciamento tra divertimento e budget.

Allo stesso modo, la parola “winorama” ricorre spesso in guide e discussioni, ma non deve diventare l’unico parametro di scelta: prendi decisioni informate, definisci in anticipo una soglia di spesa sostenibile, pianifica pause regolari e considera il gioco come intrattenimento, non come una fonte di reddito. L’obiettivo è massimizzare il controllo, ridurre l’ansia e preservare il piacere dell’esperienza.

Caratteristica Cosa valutare Perché conta
Licenza e conformità Ente regolatore, numero di concessione, audit Tutela legale, trasparenza e integrità dei giochi
Bonus di benvenuto Requisiti di puntata, contributo giochi, scadenze Evita sorprese e massimizza il valore reale del promo
Pagamenti Carte, portafogli digitali, bonifici; tempi e commissioni Gestione efficiente di depositi e prelievi
Catalogo giochi Varietà di slot, tavoli, istantanei, jackpot Più scelta per stili diversi e sessioni equilibrate
Assistenza Live chat, email, orari, qualità delle risposte Risoluzione rapida di problemi tecnici e contabili
Strumenti di responsabilità Limiti, reality check, autoesclusione Controllo del tempo e del budget di gioco
  • Controlla sempre l’URL con protocollo HTTPS e il certificato valido.
  • Attiva l’autenticazione a due fattori e aggiorna regolarmente la password.
  • Leggi attentamente termini e condizioni dei bonus prima di accettarli.
  • Prova le demo per valutare volatilità, paytable e meccaniche dei giochi.
  • Stabilisci un budget settimanale e usa limiti automatici per rispettarlo.

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Chi gioca nei casinò su internet cerca una piattaforma chiara, veloce e sicura, capace di unire intrattenimento e responsabilità. Chi prova zetcasino online si aspetta un catalogo ampio con slot aggiornate, giochi da tavolo curati e tavoli live con croupier professionisti. Contano trasparenza dei termini, protezione dei dati e pagamenti affidabili. Una buona esperienza nasce da menu intuitivi, filtri efficaci e pagine leggere che si adattano al dispositivo, oltre a un supporto clienti rapido e competente in italiano.

L’accesso al conto deve essere immediato ma protetto, con autenticazione a due fattori e opzioni di recupero credenziali. La procedura di zetcasino login bilancia comodità e sicurezza, includendo verifica dell’identità e gestione dei limiti di gioco. Per i versamenti molti scelgono carte, e‑wallet e bonifici istantanei; sui prelievi pesano commissioni nulle e tempi realistici. È utile una sezione transazioni chiara con storico, ricevute e stato delle operazioni.

Le promozioni introducono e fidelizzano, ma devono restare comprensibili. Il pacchetto di benvenuto, spesso chiamato zetcasino bonus, ideale prevede requisiti di puntata equilibrati, limiti di vincita coerenti e scadenze ragionevoli. Apprezzati i giri gratuiti su slot popolari, i rimborsi periodici e le missioni a step. Un centro offerte ordinato filtra per tipologia e validità, mentre le regole includono esempi chiari, così da evitare fraintendimenti.

Il gioco in mobilità richiede ottimizzazione spinta: caricamenti rapidi, interfacce tattili precise e consumi ridotti di batteria e dati. Una buona zetcasino app offre login biometrico, notifiche personalizzabili, salvataggi sicuri e ripresa immediata della sessione. Il layout deve adattarsi a schermi piccoli senza sacrificare leggibilità, con saldo e progressi promozionali sempre visibili. Aggiornamenti regolari e test su Android e iOS denotano qualità.

Per il gioco responsabile servono strumenti pratici: autoesclusione temporanea, test di autovalutazione e link a enti di supporto. In questo ambito, zetcasino può distinguersi integrando limiti di deposito personalizzabili, promemoria di sessione e statistiche del tempo di gioco. Inoltre, spiegare RTP medi e regole dei tavoli live rafforza la fiducia.

Chi vuole confronti e aggiornamenti può trovare analisi utili anche su Zebet casino, con focus su funzionalità, promozioni e buone pratiche.

Voce Dettagli
Licenza e sicurezza Crittografia TLS, verifica del conto, strumenti di autoesclusione, audit indipendenti
Tipi di gioco Slot video, tavoli RNG, live blackjack e roulette, game show
RTP medio dichiarato Tra 95% e 97%, variabile per titolo e fornitore
Metodi di pagamento Carte, e‑wallet, bonifico istantaneo; zero commissioni lato operatore
Prelievi Verifica KYC richiesta; tempi medi 24–72 ore a seconda del metodo
Programma fedeltà Livelli progressivi, cashback periodico, missioni e premi personalizzati
Supporto e lingue Chat dal vivo ed email; assistenza in italiano e inglese

Suggerimenti pratici per giocare con serenità:

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  • Fai pause regolari e monitora la durata complessiva delle sessioni.
  • Verifica sempre termini e requisiti di puntata prima di aderire a una promozione.
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Panoramica dei casinò a accesso immediato in Italia

Nel panorama del gioco digitale italiano, le piattaforme che consentono di aprire una sessione senza installazioni sono sempre più apprezzate. Interfacce pulite, pagamenti rapidi e un catalogo di titoli in costante aggiornamento sono elementi imprescindibili per chi desidera divertirsi in pochi minuti, evitando procedure macchinose. A fare davvero la differenza sono la trasparenza delle condizioni promozionali, la qualità del supporto clienti e l’attenzione al gioco responsabile, con strumenti pratici come limiti di deposito, autoesclusione e controlli sull’età. Prima di scegliere un operatore, conviene verificare licenza, certificazioni tecniche e reputazione presso la community.

Per un orientamento chiaro e aggiornato su operatori affidabili, guide pratiche e criteri di valutazione, molti utenti consultano risorse specializzate come Instant Casino, che offrono panoramiche sintetiche, analisi dei metodi di pagamento, dettagli sui requisiti di puntata e suggerimenti per ottimizzare il proprio budget di gioco.

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Molti operatori propongono un instant casino bonus, concepito per premiare la registrazione veloce o i primi depositi con requisiti chiari, limiti di puntata ragionevoli e tempi di sblocco realistici; leggere con attenzione termini e condizioni aiuta a evitare sorprese e a massimizzare il valore effettivo dell’offerta.

Se preferisci giocare dal browser, un instant casino online consente di avviare slot, roulette e blackjack con caricamenti rapidi sia da desktop sia da mobile, riducendo al minimo gli ostacoli tecnici e garantendo un passaggio immediato dai conti di pagamento alle puntate, sempre nel rispetto delle norme.

Per le sessioni successive, l’instant casino login dovrebbe essere semplice e sicuro, magari con autenticazione a due fattori, salvataggio protetto dei dispositivi e un rapido recupero delle credenziali; così si accelera l’accesso senza rinunciare alla tutela dei dati personali e alla prevenzione delle frodi.

Chi vuole giocare in mobilità può scegliere un’instant casino app dedicata oppure una web app ottimizzata, verificando che l’interfaccia sia intuitiva, i pulsanti reagiscano con precisione e i metodi di pagamento siano completamente integrati per depositi e prelievi senza rallentamenti.

Caratteristica Dettagli utili
Tempi di registrazione Procedure semplificate con verifica rapida dell’identità e strumenti di onboarding chiari per nuovi utenti.
Metodi di pagamento Carte, portafogli elettronici e bonifici istantanei; attenzione a commissioni, limiti e tempi di accredito.
Promozioni Offerte con requisiti di puntata trasparenti, scadenze realistiche e contributi differenziati per tipologia di gioco.
Giochi disponibili Slot, tavoli live, giochi da carte e titoli con jackpot; catalogo aggiornato e filtri di ricerca utili.
RTP e certificazioni Percentuali di ritorno pubbliche e test indipendenti sul generatore di numeri casuali.
Gioco responsabile Limiti personalizzabili, autoesclusione, autovalutazioni e link a servizi di supporto.
  • Verifica la presenza di licenza valida e di audit indipendenti sui giochi.
  • Controlla termini, scadenze e requisiti delle promozioni prima di aderire.
  • Prova le versioni demo per valutare volatilità, ritmo e interfaccia dei titoli.
  • Imposta un budget, stabilisci limiti e monitora il tempo trascorso in piattaforma.
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Un elemento cruciale riguarda l’assistenza: chat in tempo reale, risposte competenti e disponibilità in orari estesi fanno la differenza quando occorre risolvere dubbi su prelievi, verifiche e limiti. Una buona piattaforma investe anche nella didattica, pubblicando guide su probabilità, volatilità e controllo dello stake, così da rendere più consapevole ogni decisione di gioco. Allo stesso modo, la chiarezza su commissioni, soglie minime di deposito e tempi di processamento dei pagamenti aiuta a pianificare con precisione il proprio percorso.

Infine, vale la pena osservare la qualità dell’esperienza su dispositivi differenti. Un design reattivo, pulsanti ben distanziati e un processo di cassa privo di attriti aumentano la soddisfazione a lungo termine. È consigliabile aggiornare regolarmente browser e sistemi operativi, mantenere antivirus e firewall attivi e utilizzare reti affidabili per transazioni e accessi. Con queste buone pratiche, l’intrattenimento resta fluido, le scelte risultano informate e il controllo del budget rimane saldo, favorendo un approccio al gioco moderno, consapevole e sostenibile.

Guida pratica a piattaforme di gioco, sicurezza e strumenti di gestione

Questa panoramica aiuta chi desidera informarsi su licenze, protezioni dell’account, promozioni e varietà di giochi. Per approfondimenti su termini, limiti personalizzabili, criteri di verifica e assistenza, consulta la pagina ufficiale di NetBet, dove sono riepilogate procedure chiare, strumenti di responsabilità e modalità di contatto operative tutti i giorni.

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Caratteristica Dettagli principali
Licenza e sicurezza Controlli KYC, crittografia TLS, limiti personalizzabili e strumenti di autoesclusione
Pagamenti Carta, portafogli digitali, bonifico; prelievi tracciabili e tempi stimati chiari
Giochi Slot, tavoli live, blackjack, roulette, game show, video poker
Promozioni Benvenuto, missioni settimanali, tornei a punti, cashback su eventi selezionati

La tutela del budget viene prima di tutto: è buona norma fissare limiti di deposito, sessione e puntata massima. Gli strumenti di monitoraggio del tempo e le statistiche delle giocate aiutano a mantenere consapevolezza. Inoltre, guide verificabili e FAQ aggiornate riducono l’incertezza su regole, varianti e payout. In caso di dubbi, l’assistenza via chat risponde rapidamente e indirizza verso la soluzione più adatta.

  • Definisci un budget settimanale e rispettalo con rigore.
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Guida pratica all’esperienza di gioco online: sicurezza, funzioni e consigli

Nel panorama italiano dei giochi a distanza, innovazione e tutela dell’utente procedono insieme. Tra i marchi storici spicca Lottomatica, apprezzata per serietà e aggiornamento costante, con un’offerta che integra promozioni, strumenti di autolimitazione e un servizio clienti ben strutturato. L’esperienza su desktop e mobile punta su interfacce chiare, pagamenti certificati e informazioni trasparenti su limiti, probabilità di vincita e termini delle promo, elementi decisivi per un divertimento consapevole.

Negli ultimi anni l’attenzione alla UX ha ridisegnato percorsi d’uso: dalla registrazione rapida alla gestione autonoma del conto gioco, tutto è pensato per ridurre attriti e dubbi. In questo contesto, l’affidabilità di lottomatica viene spesso associata a controlli puntuali, sezioni informative ordinate e guide passo passo, utili a chi muove i primi passi e a chi desidera ottimizzare promozioni e limiti personali senza rinunciare alla semplicità.

Anche l’accesso è stato semplificato: la procedura di lottomatica login prevede credenziali sicure, eventuale verifica a due fattori e promemoria per il recupero password, così da evitare blocchi evitabili. Mantenere i dati aggiornati, attivare notifiche e monitorare i movimenti del conto sono buone abitudini: permettono di riconoscere subito attività sospette e di intervenire tempestivamente, sfruttando l’assistenza e le risorse dedicate alla sicurezza.

Chi preferisce giocare in mobilità troverà nella lottomatica app un’interfaccia snella, con filtri, ricerche e funzioni rapide come depositi, prelievi e autolimitazioni. Le push personalizzate andrebbero bilanciate con impostazioni sobrie, per non eccedere nelle sessioni: un approccio pragmatico aiuta a mantenere il controllo e ad avere una visione puntuale dei costi, dei bonus attivi e dei requisiti di puntata, evitando sorprese.

Sul fronte dei contenuti, l’offerta spazia dalle slot al bingo, dai giochi numerici ai tavoli con croupier in diretta. Chi apprezza le sale tematiche troverà in lottomatica bingo estrazioni cadenzate, cartelle chiare e chat moderate. Per gli appassionati di quote e mercati, l’ecosistema di lottomatica scommesse mette in risalto lavagne live, statistiche essenziali e calendari intuitivi, con strumenti di gestione del rischio utili a pianificare budget e strategie.

Categoria Caratteristiche Bonus tipici Note di sicurezza
Bingo Sale tematiche, chat moderata, estrazioni frequenti Cartelle scontate, missioni giornaliere Limiti di spesa, cronologia acquisti
Slot RTP dichiarato, filtri per volatilità Giri gratis, cashback periodico Info su probabilità e puntate massime
Casinò live Tavoli in HD, croupier italiani Bonus dedicati con requisiti chiari Orari e limiti di puntata configurabili
Scommesse Quote live, cash out e statistiche Multipla potenziata, assicurazioni Avvisi su responsabilità e rischio
Mobile Interfaccia responsive, comandi rapidi Promo push selettive Login biometrico e 2FA
  • Verifica l’identità in tempi brevi per sbloccare prelievi.
  • Imposta limiti di deposito e sessione adatti al tuo budget.
  • Preferisci metodi di pagamento tracciabili e fee trasparenti.
  • Leggi termini e requisiti dei bonus prima di aderire.
  • Usa statistiche e cronologia per valutare le performance.
  • Fissa pause regolari e orari di gioco sostenibili.

Un elemento spesso sottovalutato è la chiarezza comunicativa: guide sintetiche, FAQ aggiornate e tutorial brevi aiutano a orientarsi tra promozioni, metodi di ricarica e tempistiche dei prelievi. La presenza di esempi realistici e di glossari rende le regole più accessibili, riducendo lo scarto tra aspettative e realtà. Anche il centro assistenza, se raggiungibile via chat, telefono ed email con orari certi, incide sulla fiducia, perché consente di risolvere dubbi su verifiche, blocchi temporanei e limiti impostati.

In definitiva, la qualità dell’esperienza dipende dall’equilibrio tra intrattenimento, controllo del rischio e trasparenza. Scegliere piattaforme autorizzate, leggere attentamente le condizioni e pianificare un budget mensile dedicato sono pratiche decisive per giocare in modo responsabile. Quando le interfacce sono intuitive e i dati sull’account sono chiari, diventa naturale concentrarsi sul divertimento, evitando abitudini impulsive. Con informazione e consapevolezza, ogni sessione può restare un passatempo piacevole e sostenibile nel lungo periodo.

Guida pratica a piattaforme di gioco e servizi

Nel panorama del gioco autorizzato in Italia, il confronto tra piattaforme digitali è diventato un tema centrale per chi desidera divertirsi responsabilmente. Tra i marchi più discussi nel settore, Leovegas è spesso citato per l’attenzione all’esperienza utente, alla varietà dei titoli e alla cura delle funzioni di sicurezza, aspetti che i giocatori moderni valutano con sempre maggiore attenzione prima di registrarsi e iniziare a esplorare cataloghi e promozioni.

Il nome leovegas è associato a un’offerta che combina usabilità, grafica ottimizzata e un’interfaccia rapida, elementi fondamentali quando si passa da slot a tavoli dal vivo. Nella sezione leovegas casino, oltre a un assortimento di giochi classici, spesso si trovano meccaniche innovative, filtri intuitivi, limiti personalizzabili e strumenti di ricerca che aiutano a individuare i titoli preferiti senza perdere tempo, migliorando la fluidità delle sessioni anche per i nuovi utenti.

Per accedere in modo sicuro, la procedura di leovegas login richiede in genere credenziali robuste e, quando disponibile, verifica a due fattori. La possibilità di reimpostare la password in modo trasparente, la tracciabilità delle attività recenti e le notifiche sul dispositivo rappresentano accorgimenti utili per mantenere il profilo protetto, soprattutto se si utilizza la stessa utenza su più dispositivi o si alternano reti domestiche e connessioni mobili.

Il tema delle promozioni è cruciale per molti giocatori: il leovegas bonus, se previsto per nuovi o già iscritti, andrebbe valutato con attenzione leggendo requisiti di puntata, scadenze e giochi qualificanti. Talvolta, in aggiunta ai crediti promozionali, sono inclusi leovegas free spins su slot selezionate; anche in questo caso è opportuno verificare limiti di vincita convertibile e contribuzione ai requisiti, così da pianificare il budget in modo equilibrato e non compromettere il divertimento.

Area Caratteristica chiave Vantaggio
Slot Volatilità e RTP indicati Scelta più informata
Live Dealer professionali, limiti flessibili Atmosfera immersiva
Promozioni Requisiti trasparenti Gestione del budget
Sicurezza Crittografia e 2FA Protezione del conto

Per chi preferisce l’intrattenimento in mobilità, la leovegas app consente di gestire conto, promozioni e giochi con un’interfaccia pensata per schermi piccoli, gesture intuitive e caricamenti rapidi. Gli aggiornamenti frequenti, le notifiche configurabili e la sincronizzazione delle preferenze tra dispositivi migliorano l’esperienza; al contempo, è buona norma verificare la compatibilità del sistema operativo, lo spazio disponibile e i permessi richiesti prima di procedere all’installazione.

Nel linguaggio comune emergono differenti espressioni per indicare la stessa proposta. Chi predilige il leovegas casino online generalmente apprezza un catalogo organizzato per categoria, con anteprime, filtri per volatilità e informazioni sul tasso di ritorno. In ambito internazionale si incontrano spesso riferimenti al leovegas online casino, un’espressione utile quando si leggono recensioni o guide in più lingue; indipendentemente dalla formula adottata, la sostanza rimane la stessa: facilità di navigazione, giochi certificati e supporto al cliente puntuale.

Non mancano gli appassionati di leovegas scommesse, attratti da palinsesti ampi, quote aggiornate e strumenti come le statistiche in tempo reale. La presenza di mercati live, la possibilità di creare combinazioni personalizzate e le funzioni di gestione del rischio, come il cash out quando disponibile, consentono di impostare strategie più consapevoli, sempre nel rispetto dei limiti stabiliti e delle regole dell’autogestione del bankroll.

  • Imposta limiti e pianifica il budget in anticipo.
  • Leggi con attenzione termini, scadenze e requisiti promozionali.
  • Verifica metodi di pagamento, costi e tempi di accredito.
  • Aggiorna regolarmente app o browser e utilizza connessioni affidabili.

Prima di iniziare, conviene consultare la sezione dedicata al gioco responsabile, impostare limiti di deposito e sessione, e utilizzare gli strumenti di autoesclusione quando necessario. Un servizio di assistenza preparato, canali di contatto chiari e un centro aiuto con guide dettagliate fanno la differenza nelle fasi di verifica, prelievo e chiarimento dei termini promozionali. Un approccio informato permette di trasformare curiosità e entusiasmo in un’esperienza sostenibile, senza rinunciare al piacere della scoperta.

Guida completa a un casinò online moderno

Nel panorama dei giochi online, gli utenti italiani cercano affidabilità, chiarezza nelle promozioni e un’interfaccia intuitiva. Molti confrontano operatori e piattaforme, leggendo opinioni indipendenti e verificando licenze, strumenti di responsabilità e tempi di prelievo. In questa analisi esploriamo criteri fondamentali per valutare un sito di gioco: qualità del catalogo, trasparenza delle condizioni promozionali, stabilità tecnica e assistenza. Chi desidera capire come un marchio si posiziona rispetto alla concorrenza spesso incrocia recensioni su pribet casino, e presta attenzione a fattori come payout verificabili, limiti personalizzabili e presenza di funzioni per il gioco responsabile.

La dimensione mobile ha un impatto decisivo sull’esperienza, perché molti preferiscono sessioni rapide in movimento, con caricamenti veloci e layout ottimizzato per schermi piccoli. In questo contesto, un’app ben progettata riduce i tempi di attesa, facilita i pagamenti e integra notifiche utili per nuove promo e tornei. Proprio per questo, alcune guide evidenziano le funzioni della pribet app in termini di stabilità, filtri per i giochi e gestione del conto. Anche la procedura di accesso incide sulla soddisfazione: flussi chiari per il pribet login, autenticazione a due fattori e recupero credenziali semplificato sono elementi da valutare con attenzione.

La sezione promozioni resta un punto nevralgico. Gli utenti non cercano solo importi elevati, ma soprattutto termini limpidi, con requisiti di puntata realistici e limiti temporali coerenti. Da questo punto di vista, guide e recensioni approfondiscono spesso la struttura del pribet casino bonus, indicando come si applicano i rollover tra slot e tavoli live. Allo stesso modo, il tema del pribet bonus riguarda non solo l’offerta di benvenuto, ma anche cashback, missioni settimanali e programmi fedeltà. In Italia si parla talvolta di pribet casinò per riferirsi alle promozioni dedicate alle slot, dove contano la contribuzione al wagering e la selezione di provider affidabili.

La reputazione di un marchio non dipende unicamente dalla quantità di titoli o dall’ammontare dei premi, ma anche dalla cura del dettaglio: pagine d’aiuto chiare, canali di assistenza reattivi e verifiche di sicurezza trasparenti. In tal senso, alcuni utenti associano il nome pribet a un set di buone pratiche che include limiti di deposito configurabili, sistemi di autoesclusione e informazioni sull’RTP fornite in modo accessibile. Contano inoltre l’integrazione con metodi di pagamento diffusi, la velocità nella convalida KYC e la presenza di audit indipendenti sui generatori di numeri casuali.

L’esperienza quotidiana si misura anche nella qualità dei tavoli live, nella varietà di slot tematiche e nella fluidità del caricamento. I filtri di ricerca, la cronologia scommesse e i preferiti migliorano l’usabilità, mentre tutorial concisi aiutano i nuovi arrivati a comprendere regole e quote. Un operatore maturo propone tornei stagionali, sfide con classifiche e jackpot con montepremi progressivi, il tutto accompagnato da guide sulla gestione del bankroll e consigli per un approccio responsabile e consapevole, così da rendere il divertimento sostenibile nel tempo.

Per confrontare condizioni, verificare promozioni attive e reperire risorse di supporto aggiornate, è possibile consultare il sito ufficiale: Pribet, dove trovare dettagli su requisiti di puntata, meccaniche dei tornei, strumenti di controllo del gioco e contatti del servizio clienti.

Sezione Dettagli principali
Giochi Slot classiche e moderne, tavoli live con croupier, game show, varianti di roulette e blackjack, titoli con jackpot progressivo.
Bonus Offerte di benvenuto con requisiti chiari, giri gratuiti su slot selezionate, cashback periodico, tornei con montepremi.
Pagamenti Carte, e-wallet e bonifici; tempi di accredito trasparenti, limiti configurabili e verifica KYC per prelievi sicuri.
Sicurezza Crittografia, protocolli anti-frode, audit su RNG, strumenti di autoesclusione e limiti personalizzati.
Assistenza Chat dal vivo, email e FAQ strutturate; tempi di risposta tracciabili e supporto in più lingue.
  • Verifica licenza e conformità normativa prima di registrarti a qualsiasi piattaforma di gioco.
  • Controlla i requisiti dei bonus e la contribuzione delle diverse categorie di giochi al wagering.
  • Usa strumenti di responsabilità: limiti di deposito, pause temporanee e autoesclusione se necessario.
  • Prediligi metodi di pagamento riconosciuti e attiva l’autenticazione a due fattori per proteggere il conto.
  • Monitora il bankroll con obiettivi misurabili, evitando inseguimenti delle perdite e sessioni troppo lunghe.

Panoramica e funzionalità principali per un’esperienza di gioco completa

Nel panorama italiano dell’intrattenimento digitale, gli utenti cercano piattaforme affidabili, intuitive e ricche di contenuti. In questo contesto, il marchio newgioco è conosciuto per la varietà di giochi, la cura dell’interfaccia e l’attenzione ai dettagli che semplificano la navigazione. Gli appassionati si aspettano tempi rapidi di caricamento, cataloghi aggiornati, strumenti per la gestione del conto e una sezione promozioni capace di valorizzare sia i nuovi iscritti sia i giocatori più assidui. La presenza di tutorial, guide e un servizio di assistenza reattivo contribuisce a costruire fiducia, rendendo più agevole l’avvio e la fruizione quotidiana dell’offerta.

Prima di accedere ai giochi, è importante verificare i requisiti minimi di sistema e preparare i documenti per la convalida del conto. La procedura di newgioco login è pensata per garantire sicurezza e semplicità, con step chiari, avvisi in caso di dati mancanti e opzioni di recupero delle credenziali. Una volta autenticati, si possono impostare limiti di deposito, controllare la cronologia delle giocate e personalizzare le preferenze, come le notifiche sugli aggiornamenti o sulle promozioni dedicate. Questo consente un controllo consapevole del tempo e del budget speso, mantenendo l’esperienza divertente e responsabile.

Tra gli strumenti più pratici spicca la newgioco app, che permette di restare connessi al proprio conto e alle novità in qualsiasi momento. L’applicazione consente di esplorare rapidamente la lobby, salvare i giochi preferiti e ricevere avvisi mirati, ad esempio sulle nuove promo o sui tornei imminenti. La sincronizzazione tra dispositivi è fluida: si può iniziare una sessione sul computer e proseguirla sul telefono, senza perdere i progressi o le impostazioni. Inoltre, gli aggiornamenti periodici migliorano prestazioni e stabilità, con particolare attenzione alla gestione dei flussi video e del live streaming, dove presente.

Per chi desidera installarla sul proprio smartphone in modo rapido, la Newgioco app offre un percorso guidato all’installazione e alla configurazione iniziale, con suggerimenti su notifiche, sicurezza e gestione dei dati.

Gli amanti del gioco tradizionale troveranno nella sezione newgioco bingo un punto di riferimento, grazie a sale virtuali con differenti fasce di prezzo, cartelle dinamiche e chat integrate. La varietà dei pattern, la velocità delle estrazioni e la presenza di premi garantiti in determinati orari rendono le partite coinvolgenti per ogni profilo di utente. La trasparenza su regole, probabilità e calendario delle partite aiuta a scegliere la stanza più adatta al proprio stile, mentre le funzioni di filtro consentono di ordinare le sale per jackpot, costo o numero di partecipanti.

Per chi preferisce i rulli e i giochi da tavolo, la libreria newgioco casino offre slot tematiche, roulette, blackjack e varianti dal vivo con croupier reali. La qualità delle sessioni streaming, la chiarezza delle interfacce e la disponibilità di statistiche in tempo reale agevolano sia i principianti sia i giocatori esperti. La suddivisione per volatilità, provider e jackpot facilita la scoperta di titoli nuovi, mentre la modalità demo, dove prevista, permette di testare meccaniche e bonus game prima di puntare denaro reale.

Gli appassionati di sport trovano nel palinsesto newgioco scommesse un’offerta ampia, con quote aggiornate di frequente e mercati speciali per eventi principali e minori. Le funzioni di cash out, le statistiche pre-match e il live tracking delle partite supportano decisioni più informate. Filtri per campionato, orario e preferiti aiutano a costruire schedine veloci, mentre i suggerimenti editoriali, laddove disponibili, propongono spunti da confrontare con la propria analisi personale.

Chi desidera massimizzare il valore delle giocate può seguire le iniziative legate al newgioco bonus, prestando attenzione a requisiti di puntata, scadenze e giochi validi per la progressione. Promozioni ricorrenti e missioni a tempo creano ulteriore coinvolgimento, ma è fondamentale gestire il bankroll con criterio, evitando di inseguire perdite e mantenendo una prospettiva equilibrata. La trasparenza dei termini e la facilità nel monitorare l’avanzamento dei requisiti sono indicatori di qualità da non sottovalutare.

  • Verificare la presenza di strumenti di gioco responsabile e impostare limiti personalizzati.
  • Controllare i metodi di pagamento supportati, i tempi di accredito e le eventuali commissioni.
  • Leggere con attenzione termini e condizioni delle promozioni prima di aderire.
  • Utilizzare le demo, quando disponibili, per conoscere meccaniche e volatilità dei titoli.
  • Affidarsi all’assistenza clienti per dubbi su documentazione, prelievi o malfunzionamenti.
Caratteristica Descrizione Vantaggi principali
App mobile Interfaccia intuitiva e sincronizzazione tra dispositivi per gestire conto e giochi. Accesso rapido, notifiche utili, aggiornamenti frequenti.
Tipi di gioco Bingo, slot, roulette, blackjack, live game e mercati sportivi. Varietà, catalogo in espansione, filtri di ricerca efficaci.
Promozioni Iniziative per nuovi iscritti e clienti abituali, con missioni e obiettivi. Maggiore valore potenziale, percorsi di progressione chiari.
Controllo del gioco Limiti, autoesclusione, storico delle giocate e strumenti informativi. Esperienza sostenibile, più consapevolezza e trasparenza.

Guida completa a giochi, quote e promozioni per un’esperienza di qualità

Per chi cerca un’esperienza moderna, sicura e ricca di varietà, rebet casino rappresenta un punto di riferimento interessante grazie a un’offerta che bilancia giochi tradizionali e innovazioni. L’attenzione alla responsabile gestione del gioco, l’interfaccia chiara e i tempi di caricamento rapidi contribuiscono a un percorso fluido anche per chi esplora per la prima volta. La navigazione tra lobby, categorie e filtri per volatilità o jackpot aiuta a individuare velocemente i titoli preferiti. Inoltre, la possibilità di testare alcune slot in modalità demo permette di comprendere il ritmo e le meccaniche prima di passare a puntate reali, migliorando la consapevolezza delle scelte e la gestione del budget.

Categoria Caratteristiche Ideale per
Casinò Live Croupier dal vivo, limiti flessibili, tavoli in italiano Chi cerca atmosfera realistica e interazione
Slot Megaways, moltiplicatori, giri gratuiti e acquisto bonus Amanti del ritmo veloce e della varietà
Scommesse Sportive Quote dinamiche, cash-out, statistiche live Tifosi e analisti di dati sportivi
Promozioni Missioni settimanali, tornei, programma fedeltà Chi punta al valore nel lungo periodo

Gli appassionati che preferiscono la dimensione sportiva troveranno in rebet scommesse un set di strumenti per analizzare eventi prima e durante il match, con mercati che spaziano dai risultati tradizionali a handicap asiatici, marcatori e statistiche di squadra. Il cash-out parziale o totale aiuta a proteggere le vincite o limitare le perdite, mentre le quote aggiornate in tempo reale rendono la fase live dinamica e strategica. Un calendario intuitivo consente di filtrare gli eventi per sport e campionato, semplificando la pianificazione del weekend o delle serate di coppe europee.

  • Strumenti per il gioco responsabile: limiti di deposito, autoesclusione, timeout.
  • Pagamenti diversificati con tempi trasparenti e nessun costo nascosto dichiarato.
  • Assistenza multicanale con FAQ approfondite e tempi di risposta rapidi.
  • App e versione mobile ottimizzata per puntate e sessioni veloci.
  • Report delle attività per monitorare spese, vincite e abitudini di gioco.

Dal punto di vista dell’esperienza d’uso quotidiana, rebet si distingue per layout pulito e percorsi semplici: i pulsanti principali sono sempre visibili, i filtri ricordano le preferenze, e le pagine informative spiegano RTP, volatilità e regole dei giochi con esempi pratici. Questo approccio aiuta i principianti a sentirsi a proprio agio senza rinunciare alla profondità che gli utenti più esperti cercano, come il confronto tra titoli, i limiti per tavolo e la cronologia puntate esportabile.

Le offerte periodiche puntano alla chiarezza, con requisiti di puntata, durata e giochi qualificanti sempre evidenziati. Chi desidera massimizzare il valore dovrebbe valutare attentamente rollover, contributi dei giochi e limiti di vincita associati alle promozioni legate a rebet bonus, così da pianificare un percorso sostenibile. Le missioni a step, i tornei a classifica e i coupon a tempo creano occasioni ricorrenti, ma il consiglio resta quello di evitare sovrapposizioni tra promozioni per non disperdere il bankroll.

Se vuoi una panoramica sintetica dei termini promozionali e delle opportunità iniziali, puoi consultare l’offerta evidenziata come Rebet24 bonus benvenuto, utile per confrontare i requisiti con il tuo stile di gioco e fissare obiettivi realistici sin dalle prime sessioni.

Per gli amanti dei rulli, la sezione dedicata alle video slot è curata e aggiornata con nuove uscite e collezioni tematiche. Le anteprime mostrano volatilità, potenziale massimo e funzioni chiave, facilitando la scelta del titolo giusto per durata e budget. Meccaniche come cluster pays, espansioni dei rulli e collezioni di simboli rendono le partite coinvolgenti. La dicitura rebet slot compare anche nelle guide interne: suggeriscono di provare vari RTP e modalità bonus per comprendere l’impatto del rischio, pianificando sessioni più brevi su volatilità alta o più estese su volatilità media, in linea con gli obiettivi personali.

In sintesi, l’ecosistema presentato valorizza trasparenza e controllo: statistiche, limiti personalizzabili e analisi delle prestazioni aiutano a prendere decisioni informate. Concentrarsi su pochi giochi o sport, utilizzare strumenti di autogestione e rivedere periodicamente la strategia è il modo più efficace per crescere in competenza senza compromettere il divertimento e il benessere.

Guida all’esperienza di gioco e scommesse online in Italia

Orientarsi nel mondo del gioco digitale richiede attenzione, metodo e la capacità di distinguere tra promozioni accattivanti e reali vantaggi per l’utente. Gli appassionati cercano piattaforme con licenza, cataloghi ampi, sistemi di pagamento trasparenti e un’assistenza clienti pronta a risolvere dubbi in tempi rapidi. A questi elementi si aggiungono funzionalità moderne come app fluide, versioni mobile ottimizzate e strumenti per il gioco responsabile, fondamentali per mantenere l’esperienza divertente e sostenibile nel lungo periodo.

Tra i marchi più discussi dai giocatori italiani, rebet viene spesso citato per la capacità di coniugare una buona profondità di palinsesto con un’interfaccia ordinata, condizioni chiare sulle promozioni e un processo di registrazione lineare. Quando si confrontano operatori, è utile verificare termini di puntata, limiti di deposito, tempi di prelievo e la qualità del supporto, poiché questi aspetti incidono concretamente sul valore percepito dal cliente.

Nel contesto di rebet casino spiccano i giochi da tavolo in più varianti, una sezione live con croupier professionali e una selezione di titoli con RTP dichiarato. La struttura dei menù facilita la ricerca per fornitore, volatilità o tema, e consente di creare preferiti per accedere rapidamente ai giochi più amati. L’integrazione di filtri e demo, dove consentito, aiuta a testare le meccaniche prima di passare a puntate con denaro reale, riducendo errori e scelte impulsive.

Chi segue quotidianamente lo sport trova in rebet scommesse un’interfaccia adatta alla consultazione rapida di quote, mercati e statistiche. La copertura pre-match e live consente di puntare su risultati, handicap, over/under e speciali, con aggiornamenti in tempo reale. L’analisi dei dati, unita a grafici di andamento, offre un supporto utile per decisioni più consapevoli, mentre le funzioni di cash out, laddove disponibili, permettono di gestire meglio l’esposizione al rischio.

Per gli appassionati di rulli, le rebet slot includono titoli classici e moderne esperienze con megaways, buy feature e round bonus multilivello. La varietà di temi, colonna sonora curata e animazioni fluide contribuiscono alla sensazione di immersione. È consigliabile valutare la volatilità in base al proprio stile di gioco: chi preferisce sessioni più lunghe può orientarsi verso volatilità bassa o media; chi cerca picchi di adrenalina può considerare varianti più estreme, accettando oscillazioni del saldo più marcate.

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Oltre ai bonus, pesano molto l’affidabilità dei pagamenti e la qualità del servizio clienti. Circuiti diffusi, carte e wallet devono essere supportati con procedure chiare per la verifica dell’identità e controlli antifrode. Nei giochi RNG è fondamentale che i titoli siano certificati, con audit periodici e logiche di estrazione testate da enti indipendenti. La presenza di limiti personalizzabili, autoesclusione e reality check è un segnale di cura per il benessere dell’utente.

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Sezione Caratteristiche Punti di forza
Casino Giochi da tavolo, live, titoli con demo e filtri avanzati Catalogo ampio, interfaccia chiara, ricerca per fornitore
Scommesse Pre-match, live, statistiche e cash out quando disponibile Quote aggiornate, mercati vari, strumenti di analisi
Slot Classiche, megaways, feature buy, volatilità variabile Temi curati, round bonus, opzioni per ogni stile di gioco
Promozioni Accoglienza, giri, missioni, programmi fedeltà Termini trasparenti, contribuzione chiara, scadenze definite
Pagamenti e Supporto Circuiti diffusi, KYC, chat ed email Tempi tracciabili, sicurezza, assistenza reattiva

In definitiva, la scelta di una piattaforma passa da un mix di fattori: solidità dell’operatore, chiarezza dei termini, qualità del palinsesto e strumenti di tutela. Un approccio paziente e informato permette di godersi l’intrattenimento senza sorprese, pianificando il tempo e le risorse in modo responsabile. Confrontare, leggere, chiedere chiarimenti e testare le funzioni gratuite dove possibile rimane il percorso più efficace per un’esperienza positiva e sostenibile nel tempo.

Guida essenziale a un portale di gioco: funzioni, sicurezza e consigli pratici

Nel panorama del gioco e delle puntate online, l’affidabilità di una piattaforma si misura dalla qualità dell’esperienza, dalla trasparenza delle regole e dalla solidità dei pagamenti. Chi cerca una guida imparziale apprezza un riepilogo chiaro su sicurezza, promozioni e varietà dei titoli. In questa panoramica valutiamo interfaccia, fluidità della navigazione e assistenza clienti, con suggerimenti per muoversi tra slot, tavoli dal vivo e mercati sportivi. L’obiettivo è offrire spunti utili alla gestione del bankroll e a comportamenti responsabili. Nel corso dell’analisi citeremo aspetti distintivi associati a librabet, per capire come si colloca rispetto ai concorrenti e quali strumenti concretamente migliorano l’esperienza di gioco, dal desktop fino al mobile.

Tra le pagine dedicate ai giochi da tavolo e alle promozioni periodiche, molti utenti cercano review equilibrate; a tal proposito, è possibile approfondire informazioni aggiornate visitando risorse come Librabet casino, con dettagli su iniziative, titoli popolari e consigli per nuovi iscritti.

Quando si valuta un portale di intrattenimento digitale come librabet casino, è importante esaminare l’architettura delle pagine, la rapidità di caricamento e la coerenza tra versioni desktop e mobile, fattori che incidono direttamente sul comfort e sull’efficacia delle sessioni.

Un capitolo che desta curiosità riguarda le promozioni: con l’etichetta librabet bonus si indicano, in genere, offerte di benvenuto, rimborsi, giri gratuiti o missioni settimanali. Ogni iniziativa va letta con attenzione, verificando requisiti di puntata, date di validità, giochi qualificanti e contributi al wagering, così da evitare sorprese nella fase di prelievo.

Per l’uso in mobilità, la presenza di una soluzione dedicata come librabet app o di una web-app reattiva consente di gestire il conto anche lontano dal PC. In ogni caso conviene configurare l’accesso sicuro con autenticazione a due fattori e credenziali robuste, proteggendo il momento del librabet login e riducendo i rischi legati a dispositivi condivisi o reti pubbliche.

Chi predilige tavoli con croupier dal vivo e selezioni di slot certificate tende a cercare cataloghi ordinati per provider, volatilità e funzioni speciali; nella sezione dedicata a librabet casinò questa suddivisione aiuta a filtrare rapidamente e concentrarsi sui giochi più coerenti con le proprie preferenze, ottimizzando tempo e budget.

Non meno rilevante è l’area sportiva: con librabet scommesse si fa riferimento a mercati pre-match e live, quote dinamiche e strumenti statistici. Gli operatori più completi propongono cash out parziale, combinazioni rapide e promozioni sul multisport, fermo restando il rispetto dei principi del gioco responsabile e l’attenzione ai limiti personali.

Caratteristica Dettagli
Selezione giochi Slot, jackpot, live, game show e carte classiche.
Promozioni Benvenuto, ricariche, tornei; requisiti espliciti e scadenze chiare.
Pagamenti Carte, e-wallet, bonifico; prelievi rapidi dopo verifica dell’identità.
Sicurezza Crittografia TLS, KYC, anti-frode e tutela dei dati personali.
Supporto Chat, e-mail, FAQ; tempi di risposta contenuti e tono professionale.
Mobile Interfaccia reattiva, gesti intuitivi e notifiche opzionali.

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  • Leggi regolamento, termini promozionali e requisiti di puntata.
  • Completa la registrazione e verifica l’identità per i prelievi.
  • Imposta limiti personali su deposito, perdita e sessione.
  • Scegli metodi di pagamento compatibili con le tue esigenze.
  • Prova le demo per valutare volatilità e ritmo dei giochi.

Per migliorare l’esperienza, suddividi il budget in sessioni, annota i risultati e non inseguire le perdite. Le quote sportive e i ritorni teorici delle slot cambiano nel tempo: confrontare le alternative aiuta a decidere con maggiore consapevolezza. Prima di confermare una giocata, ricontrolla le selezioni e valuta l’uso di strumenti di gestione del rischio; mantieni aggiornato il software e preferisci connessioni stabili. Infine, conserva le ricevute e monitora la cronologia per intervenire rapidamente in caso di anomalie.

Guida completa alla piattaforma: esperienza, sicurezza e strumenti utili per utenti italiani

Molti appassionati di gioco e scommesse cercano una piattaforma affidabile e semplice; in Italia, le discussioni ruotano spesso attorno alle funzionalità, alla trasparenza e al supporto. Le ricerche su rebet24. it e le numerose rebet24 recensioni mettono in evidenza punti di forza come la chiarezza delle promozioni e la gestione dei pagamenti, ma anche aree di miglioramento come i tempi di verifica e la personalizzazione dell’interfaccia. Chi arriva da altri ecosistemi come rebet trova familiare l’approccio all’esperienza utente, mentre chi è nuovo apprezza guide passo-passo e una community attiva. In questo contesto, rebet24 si distingue per catalogo titoli, strumenti di controllo del conto e un’assistenza orientata alla risoluzione rapida, con attenzione a normative, conformità e tutela dei minori.

Prima di iniziare, conviene salvare il collegamento di accesso ufficiale per evitare falsi mirror e pagine non aggiornate: Rebet24 login garantisce un ingresso diretto all’area personale, utile per verificare saldo, limiti, metodi di pagamento e impostazioni di sicurezza come l’autenticazione a due fattori, con percorsi chiari anche per il recupero delle credenziali.

Per chi si muove spesso, l’esperienza su smartphone è prioritaria: l’ottimizzazione dell’interfaccia rende navigazione e piazzamento rapide, con notifiche su risultati e promozioni in tempo reale. La rebet24 app consente un’esperienza coerente con la versione desktop, mantenendo menu intuitivi e tempi di caricamento contenuti; la modalità reattiva su rebet24 mobile favorisce consultazione dei mercati e gestione del conto anche con connessioni non perfette, senza rinunciare alla protezione dei dati sensibili e al controllo delle sessioni attive.

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Elemento Dettagli principali
Bonus di benvenuto La voce rebet24 bonus benvenuto prevede condizioni chiare su importi, percentuali e requisiti di puntata; verifica le esclusioni per singoli giochi e i termini di scadenza, in modo da pianificare un percorso di utilizzo coerente con il tuo stile di gioco.
Gestionale Il modulo rebet24 gestionale organizza cronologia movimenti, limiti, documenti e notifiche, permettendo di monitorare depositi, prelievi e attività con filtri avanzati e report esportabili.
Tipi di gioco Slot, tavoli live, giochi di carte e scommesse su eventi sportivi e virtuali; catalogo aggiornato con modelli di payout trasparenti e descrizioni delle meccaniche.
Sicurezza Crittografia dei dati, verifica dell’identità, monitoraggio delle sessioni, avvisi su accessi sospetti e autenticazione a due fattori per ridurre i rischi legati ad account sharing e phishing.
Pagamenti Metodi comuni in Italia, tempi di accredito indicati per ciascun canale, tracciamento delle richieste e assistenza dedicata in caso di discrepanze o ritardi.
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  • Confronta le condizioni dei giochi e le regole dei tornei prima di partecipare, soprattutto quando sono coinvolti requisiti di puntata.
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L’insieme di strumenti, politiche di sicurezza e supporto fornisce un ambiente che punta alla chiarezza e alla responsabilità. L’esperienza quotidiana beneficia di aggiornamenti regolari, percorsi di navigazione logici e pagine informative dettagliate su limiti, autoesclusione e protezione dei dati. Gli utenti esperti apprezzano la possibilità di affinare report e filtri, mentre i nuovi arrivati trovano wizard introduttivi, FAQ ben indicizzate e tutorial sintetici. Con una gestione attenta dei dati personali, canali di pagamento tracciabili e risposte puntuali dal team di assistenza, la piattaforma si propone come un ecosistema stabile per divertirsi in modo informato e consapevole lungo tutto il ciclo di utilizzo.

Guía para evaluar plataformas de juego responsables y prácticas de usuario

Explorar un operador de juegos y apuestas exige una mirada crítica sobre su transparencia, las herramientas de autocontrol y la calidad de su catálogo. Una plataforma confiable debe ofrecer límites de depósito flexibles, pruebas de realidad, autoexclusión temporal y una comunicación clara sobre probabilidades y riesgos. Además, es clave que el servicio de atención sea ágil y que la verificación de identidad se realice con procesos seguros y comprensibles para cualquier persona.

Dentro del segmento de entretenimiento digital, algunas marcas destacan por equilibrar diversión y responsabilidad. En ese contexto, resulta habitual encontrar reseñas que comparan tragaperras, ruletas, blackjack en vivo y otros títulos, además de evaluar la experiencia móvil y las formas de pago. Para quienes valoran decisiones bien informadas, conviene observar indicadores de juego limpio, auditorías independientes y políticas contra el fraude o el lavado de dinero, elementos que construyen confianza de largo plazo.

Al considerar la reputación de un operador, también influyen los testimonios de la comunidad y la constancia en pagos rápidos. Cuando la página ofrece guías educativas sobre probabilidades, glosarios y simuladores, el usuario entiende mejor los riesgos y evita expectativas irreales. La educación en juego responsable, unida a mecánicas de bonificación transparentes, permite disfrutar del ocio con mayor criterio y con menos sorpresas.

La conversación sobre experiencias seguras suele incluir comparativas específicas, y en ese marco algunos analistas citan a paf casino como un referente para hablar de integridad, herramientas de control y una propuesta que no se limita a sumar títulos, sino a construir un entorno confiable y claro.

Si deseas conocer la propuesta completa y los valores de responsabilidad que la distinguen, visita Paf para obtener información oficial y actualizada, términos vigentes, compromisos sociales y detalles sobre cómo se integran las políticas de protección del jugador en su día a día.

En el ecosistema de entretenimiento digital, las reseñas sobre paf casino online suelen valorar la usabilidad, la carga rápida de juegos, la estabilidad del streaming en vivo y la facilidad para encontrar límites personalizados en pocos clics. Una navegación clara reduce fricciones y ayuda a tomar decisiones conscientes durante sesiones breves y planificadas.

Al evaluar promociones, conviene fijarse en requisitos de apuesta, contribuciones por tipo de juego y plazos. Por eso, cuando un análisis menciona paf casino bonus, normalmente se detiene en la claridad de sus condiciones y en la forma en que comunica reglas para evitar malentendidos, algo esencial para principiantes y usuarios experimentados.

Quienes disfrutan de pronósticos deportivos y mercados en directo suelen prestar atención a cuotas, coberturas y límites de stake. En reportes especializados, el apartado de paf apuestas se analiza por la variedad de deportes, la profundidad de mercados y las herramientas de control del gasto, con notificaciones útiles para gestionar el tiempo conectado.

La solidez de una marca también se nota en cómo integra su casino tradicional con experiencias en vivo, desde crupieres profesionales hasta estudios con buena iluminación y audio nítido. En revisiones comparativas, la expresión casino paf aparece ligada a la coherencia del catálogo, la estabilidad de la plataforma y la consistencia de sus estándares de seguridad.

El acceso desde el móvil es clave para sesiones cortas y responsables. Por ello, muchas guías destacan la calidad de la paf app cuando describen características como autenticación segura, recordatorios de pausas, límites configurables y una interfaz que prioriza información esencial sin distracciones, todo orientado a decidir mejor en pantallas pequeñas.

Además de las funciones y el catálogo, la identidad corporativa y el propósito social importan. En algunos análisis, se subraya que paf como nombre se asocia a iniciativas de responsabilidad que buscan equilibrar el entretenimiento con una perspectiva preventiva y educativa, destacando la importancia de jugar por diversión y no como una vía de ingresos.

Característica Detalle Beneficio para el usuario
Límites personales Depósito, pérdidas, tiempo y sesión Control del gasto y sesiones planificadas
Juegos en vivo Ruleta, blackjack, shows con presentadores Interacción real y experiencias inmersivas
Transparencia Condiciones claras y RTP visibles Decisiones informadas y menos confusiones
Atención al cliente Chat, correo y centro de ayuda Resolución rápida de dudas y trámites
Pagos Métodos verificados y retiros fiables Gestión segura de fondos

Antes de registrarte, revisa siempre la licencia, verifica los límites, lee términos de bonos y considera fijar un presupuesto semanal. Un enfoque prudente reduce riesgos y mejora la experiencia, porque te permite jugar por entretenimiento, respetando tus objetivos personales y tu tiempo.

  • Define un presupuesto y un tiempo máximo por sesión.
  • Lee con calma los requisitos de apuesta y los plazos.
  • Activa recordatorios y límites desde el primer día.
  • Prioriza juegos que conozcas y consulta su RTP.
  • Detente si pierdes el control o si jugar deja de ser divertido.

Guía práctica para evaluar plataformas de juego y apuestas en línea

El mercado español de entretenimiento digital ha evolucionado con rapidez, y hoy los jugadores valoran especialmente la claridad de los términos promocionales, la seguridad de los pagos y la diversidad de juegos. Antes de registrarse, conviene observar la calidad del soporte, la transparencia de los límites y herramientas de juego responsable, así como la estabilidad del sitio en horas de máxima afluencia. Entre las comparativas más citadas por los aficionados se menciona casumo online casino como referencia para analizar catálogos, experiencias de usuario y tiempos de verificación, siempre contrastando fuentes independientes y criterios objetivos.

La facilidad de acceso es un factor clave: muchos usuarios teclean casumo login para confirmar cómo funciona el ingreso a la cuenta, cuáles son los pasos de recuperación de contraseñas y qué medidas de autenticación adicional se ofrecen. Quienes prefieren jugar desde el móvil, por su parte, suelen evaluar la eficiencia de casumo app en términos de estabilidad, consumo de datos, compatibilidad con distintas versiones de sistemas operativos y la fluidez de las notificaciones, especialmente aquellas relacionadas con límites de depósito, verificación de identidad, promociones activas y actualizaciones de los métodos de pago más habituales en España.

Característica Detalle a evaluar
Juegos Tragamonedas, ruleta, blackjack, juegos en vivo, proveedores certificados
Métodos de pago Tarjeta, monederos electrónicos, transferencias, tiempos de retiro
Seguridad Cifrado, políticas de privacidad, auditorías y licencias
Juego responsable Límites, autoexclusión, pruebas de autoevaluación, recursos de ayuda
Atención al cliente Chat, correo, disponibilidad 24/7, tiempo de respuesta
Promociones Condiciones claras, requisitos de apuesta, caducidad, transparencia

Otro punto imprescindible es comprender la letra pequeña de cualquier incentivo. Muchas veces se citan nombres comerciales para hablar de bonificaciones; así, casumo bonus aparece en discusiones sobre si los requisitos de apuesta resultan razonables, cómo se contribuye con cada tipo de juego y qué plazos existen para liberar fondos. A su vez, algunos aficionados combinan casino con deporte y revisan casumo apuestas para entender cuotas, mercados disponibles, estadísticas previas y herramientas útiles para gestionar el bankroll con disciplina en eventos en vivo o prepartido.

  • Verifica licencias válidas y auditorías externas de las plataformas que compares.
  • Revisa los tiempos de retiro y posibles comisiones antes de depositar.
  • Lee con atención requisitos de apuesta y límites por juego y promoción.
  • Prueba la versión móvil y la calidad del soporte antes de jugar en serio.
  • Define límites personales y utiliza herramientas de control del tiempo.

En reseñas y foros, algunos lectores escriben casumo casino para buscar opiniones de usuarios, mientras otros prefieren la variante casino casumo; la diferencia práctica es nula, pero conviene contrastar datos en varias fuentes y no quedarse solo con testimonios aislados. Más allá de la etiqueta, la consulta casumo online suele conducir a análisis sobre estabilidad del sitio, compatibilidad con navegadores y calidad visual. La marca casumo se menciona a menudo para ilustrar criterios comparativos, aunque lo fundamental es aplicar estándares verificables y medir con rigor.

Quien desea una visión completa sobre registro, verificación de identidad, límites y métodos de pago puede revisar informes especializados que incluyen casumo casino online como referencia entre muchas otras marcas. Para una síntesis práctica con contexto normativo y enlaces de utilidad, te recomendamos consultar reseñas consolidadas; si buscas una panorámica clara y actualizada, visita Casumo y compara sus datos con otras guías independientes antes de decidir dónde jugar de forma responsable.

Guía práctica para elegir tu casino en línea en España

El panorama de los juegos de azar en España evoluciona con rapidez, y los usuarios valoran plataformas que sean claras con licencias, pagos y protección de datos. Entre las opciones más comentadas por los aficionados, hay quienes comparan reseñas de one casino online para entender cómo se comporta frente a competidores en aspectos como catálogo, usabilidad desde móvil y calidad del soporte. Antes de registrarte en cualquier página, conviene revisar la política de juego responsable y los avisos legales que exige la DGOJ.

Más allá del primer vistazo, evaluar un operador requiere método: analizar términos, límites de retiro, verificación de identidad y tiempos de respuesta. Si quieres profundizar en un operador con enfoque sencillo y promociones transparentes, visita el sitio oficial de OneCasino y contrasta su propuesta con tus prioridades personales, ya sea jugar slots, mesas en vivo o aprovechar promociones recurrentes. Fíjate siempre en la letra pequeña antes de activar cualquier oferta.

El acceso a la cuenta es un punto crítico: el proceso de one casino login debe contar con cifrado, recuperación segura de credenciales y, preferiblemente, autenticación en dos pasos. Guarda tus datos en un gestor fiable y evita redes Wi‑Fi públicas. Tras verificar tu identidad, podrás ajustar límites de depósito, vigilar movimientos y configurar alertas.

Sobre las promociones, recuerda que el valor real no está en la cifra, sino en sus condiciones. Antes de aceptar one casino bonus, revisa requisitos de apuesta, juegos que contribuyen, ventana de validez y topes de ganancias. Un bono sano permite avanzar con apuestas moderadas, no condiciona a títulos limitados y se acompaña de términos claros en español.

El juego desde el móvil es clave; si existe one casino app para tu sistema, comprueba permisos, consumo de datos y estabilidad. En su ausencia, una web responsive debe cargar rápido, mantener filtros accesibles y ofrecer búsqueda efectiva. Activa notificaciones solo si aportan valor real, como alertas de verificación, estado de retiros o límites personales.

Practicar con equilibrio es esencial. Define un presupuesto semanal, usa recordatorios de sesión y activa autoexclusión si detectas pérdida de control. Los operadores regulados deben ofrecer herramientas de pausa, pruebas de autoevaluación y enlaces a ayuda externa. La verificación de edad, las restricciones publicitarias y los mensajes de riesgo son señales de compromiso real.

En pagos, prioriza métodos a tu nombre: tarjetas principales, monederos electrónicos o transferencia bancaria. Los depósitos deben acreditarse al instante y las retiradas moverse con plazos publicados y razonables. Evita múltiples solicitudes simultáneas, conserva comprobantes y confirma comisiones antes de operar. Un historial claro facilita conciliaciones y evita malentendidos.

El catálogo ideal mezcla slots de proveedores reconocidos, ruletas y cartas con crupier en vivo, y juegos con mecánicas modernas. Valora RTP teórico, límites por mesa y funciones de demostración. Un lobby bien ordenado, con colecciones temáticas y filtros por volatilidad, hace más fácil encontrar experiencias acordes a tu estilo.

En imagen y propuesta, one casino ha ganado terreno por su interfaz limpia y enfoque en comodidad del usuario. Aun así, cada perfil es distinto: prueba la plataforma con depósitos modestos, mide tiempos de respuesta y decide en base a tu tolerancia al riesgo y tus objetivos de ocio.

Aspecto Qué revisar Señal positiva
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Promociones Requisitos de apuesta, contribución, caducidad Rollover razonable y términos visibles
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Aspecto Detalle relevante
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Slots Selección con RTP competitivo, volatilidad variada y rondas de bonificación con compras opcionales.
Promociones Misiones, cofres y retos con requisitos transparentes; conviene revisar términos antes de aceptar.
Métodos de pago Tarjetas, monederos y transferencias; depósitos instantáneos y retiradas sujetas a verificación.
Seguridad Cifrado avanzado, controles de sesión, verificación en dos pasos y auditorías independientes.
Atención al cliente Chat, correo y base de conocimiento con guías, preguntas frecuentes y tutoriales paso a paso.
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Onderdeel Wat te verwachten Snelle tip
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Bonussen Welkomstdeal, herlaadacties, free spins Check rondspeelvoorwaarden per speltype
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Team

We are a multidisciplinary team of biotech entrepreneurs and scientists united by our commitment to deliver next-generation therapies to transform the treatment of severe autoimmune diseases.

  • Leadership
  • Board Of Directors
  • Investors
Dianthus is supported by a strong syndicate of experienced life science investors, including 5AM Ventures, Avidity Partners, Fairmount, Fidelity Management & Research Company, Tellus BioVentures, Venrock, Wedbush Healthcare Partners, and others.
Photo of speaker talking to engaged and smiling people in business casual attire sitting down at round tables in an event space.

Join us

Dianthus is currently looking to strengthen our team with visionary, entrepreneurial and passionate individuals to make a lasting impact in the lives of patients through novel complement therapeutics. Headquartered in New York City with offices in Waltham, MA, we offer flexible hybrid, and fully remote opportunities.

A close-up photo of a person’s hands holding and scrolling on a smartphone.

News

  • Jan 05 2026 | Dianthus Therapeutics To Participate in the 44th Annual J.P. Morgan Healthcare Conference
    X
    News
    Jan 05 2026 | Dianthus Therapeutics To Participate in the 44th Annual J.P. Morgan Healthcare Conference

    NEW YORK and WALTHAM, Mass., Jan. 05, 2026 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to developing next-generation therapies to transform the treatment of severe autoimmune diseases, today announced the Company’s participation in the 44th Annual J.P. Morgan Healthcare conference in San Francisco. Marino Garcia, CEO of Dianthus Therapeutics, will present a corporate overview on Monday, January 12, 2026 at 3:00 pm PST / 6:00 p.m. EST and will host one-on-one meetings with investors.

    A webcast of this presentation may be accessed under “News and Events” in the Investors section of the Dianthus Therapeutics website.

    About Dianthus Therapeutics
    Dianthus Therapeutics, Inc. is a clinical-stage biotechnology company dedicated to developing next-generation therapies to transform the treatment of severe autoimmune diseases. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who aim to deliver transformative medicines for people living with severe autoimmune and inflammatory diseases.

    To learn more, please visit www.dianthustx.com and follow us on LinkedIn

    Contact
    Jennifer Davis Ruff
    Dianthus Therapeutics
    jdavisruff@dianthustx.com

  • Dec 23 2025 | Leads Biolabs And Dianthus Therapeutics Announce Initiation of Phase 1 Trial Of LBL-047 (DNTH212) In Healthy Volunteers and Patients With Systemic Lupus Erythematosus (SLE)
    X
    News
    Dec 23 2025 | Leads Biolabs And Dianthus Therapeutics Announce Initiation of Phase 1 Trial Of LBL-047 (DNTH212) In Healthy Volunteers and Patients With Systemic Lupus Erythematosus (SLE)

    LBL-047 (DNTH212) is a bifunctional fusion protein targeting plasmacytoid dendritic cell (pDC) BDCA2 to reduce Type 1 interferon production, while simultaneously inhibiting BAFF/APRIL to suppress B cell function 

    Top-line results in healthy volunteers anticipated in 2H’26

    Dianthus to provide update on indication prioritization in 1H’26

    LBL-047 (DNTH212) has the potential to be a first-line biologic in multiple autoimmune disorders with patient-friendly S.C. self-administration and Q4W or less frequent dosing

    NANJING, China and NEW YORK and WALTHAM, Mass., Dec. 23, 2025 (GLOBE NEWSWIRE) — Nanjing Leads Biolabs Co., Ltd. (“Leads Biolabs”) (9887.HK), a clinical-stage biotechnology company focused on developing innovative therapies in oncology, autoimmune, and other severe diseases, and Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to developing next-generation therapies to transform the treatment of severe autoimmune diseases, today announced the first subject has been successfully dosed in the Phase 1 clinical trial of LBL-047 (DNTH212), a potential first- and best-in-class anti-BDCA2/TACI bifunctional fusion protein developed by Leads Biolabs.

    This two-part, double-blind, randomized, placebo-controlled, dose-escalation (single ascending dose) Phase 1 trial is designed to evaluate the safety, tolerability and PK/PD of LBL-047 (DNTH212) in healthy volunteers (Part A) and patients with systemic lupus erythematosus (Part B). The healthy volunteer part of the study is led by Professor Meng Xianmin at Shanghai Public Health Clinical Center, while the SLE part is led by Professors Ye Shuang and Chen Sheng at Renji Hospital, Shanghai Jiaotong University School of Medicine.

    By targeting both the innate and adaptive immune systems via two clinically validated pathways that are known drivers of autoimmune disease, this complementary and differentiated approach has the potential to address multiple autoimmune indications with improved outcomes. LBL-047 (DNTH212) has the potential to be a first-line biologic with patient-friendly, S.C. self-administration and Q4W or less frequent dosing.

    On October 16, 2025, Leads Biolabs entered into an exclusive global partnership with Dianthus, with the total potential deal value reaching up to $1 billion. Under the agreement, Dianthus licensed exclusive global rights from Leads Biolabs to research, develop, manufacture and commercialize LBL-047 outside Greater China, where it is known as DNTH212, jointly advancing its global development to maximize clinical and commercial potential. Dianthus expects to provide an update on prioritized indications for DNTH212 in the first half of 2026.

    “We are pleased to announce the successful dosing of the first subject in our Phase 1 trial of LBL-047. By simultaneously targeting multiple pathways, LBL-047 is designed to address the limitations of single-target therapies. We look forward to advancing this program in collaboration with Dianthus Therapeutics to deliver potentially transformative options for patients worldwide,” said Dr. Charles Cai, Chief Medical Officer of Leads Biolabs.

    “Initiating this Phase 1 study is the first step to realizing the much anticipated by physicians outcome of targeting multiple pertinent dysfunctional pathways in several autoimmune indications,” said Dr. Simrat Randhawa, Head of Research & Development at Dianthus Therapeutics.

    About LBL-047 (DNTH212)
    LBL-047 (DNTH212) is an investigational bifunctional fusion protein composed of a humanized anti-blood dendritic cell antigen 2 (BDCA2) antibody and an engineered transmembrane activator and CAML interactor (TACI) ectodomain. It is designed to selectively deplete pDCs to reduce type 1 interferon production, while simultaneously inhibiting B-cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL) signaling pathways to suppress B-cell activation, differentiation, and antibody production. By targeting two key drivers of autoimmune disease pathogenesis, this differentiated approach has the potential to address multiple autoimmune indications. Additionally, LBL-047 (DNTH212) has also been optimized with Fc engineering to extend its half-life, offering the potential for a patient-friendly subcutaneous self-administration regimen with a dosing frequency of Q4W or less, supporting its potential as a first-line biologic therapy.

    About Dianthus Therapeutics
    Dianthus Therapeutics, Inc. is a clinical-stage biotechnology company dedicated to developing next-generation therapies to transform the treatment of severe autoimmune diseases. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who aim to deliver transformative medicines for people living with severe autoimmune and inflammatory diseases.

    To learn more, please visit www.dianthustx.com and follow us on LinkedIn

    About Leads Biolabs
    Founded in 2012, Leads Biolabs is a clinical-stage biotechnology company dedicated to the discovery, development, and commercialization of innovative therapies to address unmet medical needs in oncology, autoimmune, and other severe diseases both in China and globally. As a front-runner in next-generation immuno-oncology treatments, the company has a differentiated pipeline of 14 innovative drug candidates, including six clinical-stage drug candidates, of which four lead products are among the top-tier clinically advanced candidates globally.

    Leads Biolabs adopts a science-driven R&D approach and has successfully established comprehensive R&D capabilities spanning antibody discovery and engineering, in vivo and in vitro efficacy evaluation, as well as druggability assessment. The company has also developed multiple proprietary technology platforms, including LeadsBody platform (a CD3 T-cell engager platform), X-body platform (a 4-1BB engager platform), TOPiKinectics (ADC platform), which serve as the cornerstone for continued innovation and have been validated by the clinical outcomes of bispecific antibody portfolios.

    Leads Biolabs has established integrated capabilities across early discovery, translational medicine, clinical development, CMC and business development. The innovative nature and competitive strengths of drug candidates, coupled with global perspectives, proactive strategy, and efficient clinical validation, have made the company an attractive partner for leading industry players and investment institutions. For more information, please visit https://en.leadsbiolabs.com/

    Dianthus Cautionary Statement Regarding Forward-Looking Statements
    Certain statements in this press release, other than purely historical information, may constitute “forward-looking statements” within the meaning of the federal securities laws, including for purposes of the safe harbor provisions under the United States Private Securities Litigation Reform Act of 1995, express or implied statements regarding future plans and prospects, including statements regarding the expectations or plans for discovery, preclinical studies, clinical trials and research and development programs, in particular with respect to DNTH212, and any developments or results in connection therewith, including the target product profile and administration of DNTH212; the anticipated timing of the initiation and results from those studies and trials; expectations regarding the clinical trial designs or indications; expectations regarding the time period over which the Company’s capital resources are expected to be sufficient to fund its anticipated operations; and expectations regarding market size, patient population size, and potential opportunities for complement therapies, in particular with respect to DNTH212. DNTH212 is an investigational agent that is not approved as a therapy in any indication in any jurisdiction worldwide. The words “opportunity,” “potential,” “milestones,” “runway,” “will,” “anticipate,” “achieve,” “near-term,” “catalysts,” “pursue,” “pipeline,” “believe,” “continue,” “could,” “estimate,” “expect,” “intend,” “may,” “might,” “plan,” “possible,” “predict,” “project,” “should,” “strive,” “would,” “aim,” “target,” “commit,” and similar expressions (including the negatives of these terms or variations of them) generally identify forward-looking statements, but the absence of these words does not mean that statement is not forward looking.

    Actual results could differ materially from those included in the forward-looking statements due to various factors, risks and uncertainties, including, but not limited to, that preclinical testing of DNTH212 and data from clinical trials may not be predictive of the results or success of ongoing or later clinical trials, that the development of DNTH212 may take longer and/or cost more than planned, that the Company or its partner may be unable to successfully complete the clinical development of the Company’s compounds, that the Company or its partner may be delayed in initiating, enrolling or completing its planned clinical trials, and that the Company’s compounds may not receive regulatory approval or become commercially successful products. These and other risks and uncertainties are identified under the heading “Risk Factors” included in the Company’s Annual Report on Form 10-K for the period ended December 31, 2024, and other filings that the Company has made and may make with the SEC in the future. Nothing in this press release should be regarded as a representation by any person that the forward-looking statements set forth herein will be achieved or that any of the contemplated results of such forward-looking statements will be achieved.

    The forward-looking statements in this press release speak only as of the date they are made and are qualified in their entirety by reference to the cautionary statements herein. Dianthus undertakes no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future events or otherwise, except as required by law.

    Dianthus Therapeutics Contact
    Jennifer Davis Ruff
    Dianthus Therapeutics
    jdavisruff@dianthustx.com

    Leads Biolabs Contact
    pr@leadsbiolabs.com

  • Nov 24 2025 | Dianthus Therapeutics To Participate in the 8th Annual Evercore Healthcare Conference
    X
    News
    Nov 24 2025 | Dianthus Therapeutics To Participate in the 8th Annual Evercore Healthcare Conference

    NEW YORK and WALTHAM, Mass., Nov. 24, 2025 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to developing next-generation therapies to transform the treatment of severe autoimmune diseases, today announced the Company’s participation in the 8th Annual Evercore Healthcare Conference in Coral Gables, Florida. Marino Garcia, CEO of Dianthus Therapeutics, will participate in a fireside chat on Tuesday, December 2, 2025 at 2:35 p.m. ET and will host one-on-one meetings with investors.

    A webcast of this presentation may be accessed under “News and Events” in the Investors section of the Dianthus Therapeutics website.

    About Dianthus Therapeutics
    Dianthus Therapeutics, Inc. is a clinical-stage biotechnology company dedicated to developing next-generation therapies to transform the treatment of severe autoimmune diseases. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who aim to deliver transformative medicines for people living with severe autoimmune and inflammatory diseases.

    To learn more, please visit www.dianthustx.com and follow us on LinkedIn

    Contact
    Jennifer Davis Ruff
    Dianthus Therapeutics
    jdavisruff@dianthustx.com

X
News
Jan 05 2026 | Dianthus Therapeutics To Participate in the 44th Annual J.P. Morgan Healthcare Conference
NEW YORK and WALTHAM, Mass., Jan. 05, 2026 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to developing next-generation therapies… READ MORE
News
Jan 05 2026 | Dianthus Therapeutics To Participate in the 44th Annual J.P. Morgan Healthcare Conference

NEW YORK and WALTHAM, Mass., Jan. 05, 2026 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to developing next-generation therapies to transform the treatment of severe autoimmune diseases, today announced the Company’s participation in the 44th Annual J.P. Morgan Healthcare conference in San Francisco. Marino Garcia, CEO of Dianthus Therapeutics, will present a corporate overview on Monday, January 12, 2026 at 3:00 pm PST / 6:00 p.m. EST and will host one-on-one meetings with investors.

A webcast of this presentation may be accessed under “News and Events” in the Investors section of the Dianthus Therapeutics website.

About Dianthus Therapeutics
Dianthus Therapeutics, Inc. is a clinical-stage biotechnology company dedicated to developing next-generation therapies to transform the treatment of severe autoimmune diseases. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who aim to deliver transformative medicines for people living with severe autoimmune and inflammatory diseases.

To learn more, please visit www.dianthustx.com and follow us on LinkedIn

Contact
Jennifer Davis Ruff
Dianthus Therapeutics
jdavisruff@dianthustx.com

Dec 23 2025 | Leads Biolabs And Dianthus Therapeutics Announce Initiation of Phase 1 Trial Of LBL-047 (DNTH212) In Healthy Volunteers and Patients With Systemic Lupus Erythematosus (SLE)
LBL-047 (DNTH212) is a bifunctional fusion protein targeting plasmacytoid dendritic cell (pDC) BDCA2 to reduce Type 1 interferon production, while simultaneously inhibiting BAFF/APRIL to suppress… READ MORE
News
Dec 23 2025 | Leads Biolabs And Dianthus Therapeutics Announce Initiation of Phase 1 Trial Of LBL-047 (DNTH212) In Healthy Volunteers and Patients With Systemic Lupus Erythematosus (SLE)

LBL-047 (DNTH212) is a bifunctional fusion protein targeting plasmacytoid dendritic cell (pDC) BDCA2 to reduce Type 1 interferon production, while simultaneously inhibiting BAFF/APRIL to suppress B cell function 

Top-line results in healthy volunteers anticipated in 2H’26

Dianthus to provide update on indication prioritization in 1H’26

LBL-047 (DNTH212) has the potential to be a first-line biologic in multiple autoimmune disorders with patient-friendly S.C. self-administration and Q4W or less frequent dosing

NANJING, China and NEW YORK and WALTHAM, Mass., Dec. 23, 2025 (GLOBE NEWSWIRE) — Nanjing Leads Biolabs Co., Ltd. (“Leads Biolabs”) (9887.HK), a clinical-stage biotechnology company focused on developing innovative therapies in oncology, autoimmune, and other severe diseases, and Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to developing next-generation therapies to transform the treatment of severe autoimmune diseases, today announced the first subject has been successfully dosed in the Phase 1 clinical trial of LBL-047 (DNTH212), a potential first- and best-in-class anti-BDCA2/TACI bifunctional fusion protein developed by Leads Biolabs.

This two-part, double-blind, randomized, placebo-controlled, dose-escalation (single ascending dose) Phase 1 trial is designed to evaluate the safety, tolerability and PK/PD of LBL-047 (DNTH212) in healthy volunteers (Part A) and patients with systemic lupus erythematosus (Part B). The healthy volunteer part of the study is led by Professor Meng Xianmin at Shanghai Public Health Clinical Center, while the SLE part is led by Professors Ye Shuang and Chen Sheng at Renji Hospital, Shanghai Jiaotong University School of Medicine.

By targeting both the innate and adaptive immune systems via two clinically validated pathways that are known drivers of autoimmune disease, this complementary and differentiated approach has the potential to address multiple autoimmune indications with improved outcomes. LBL-047 (DNTH212) has the potential to be a first-line biologic with patient-friendly, S.C. self-administration and Q4W or less frequent dosing.

On October 16, 2025, Leads Biolabs entered into an exclusive global partnership with Dianthus, with the total potential deal value reaching up to $1 billion. Under the agreement, Dianthus licensed exclusive global rights from Leads Biolabs to research, develop, manufacture and commercialize LBL-047 outside Greater China, where it is known as DNTH212, jointly advancing its global development to maximize clinical and commercial potential. Dianthus expects to provide an update on prioritized indications for DNTH212 in the first half of 2026.

“We are pleased to announce the successful dosing of the first subject in our Phase 1 trial of LBL-047. By simultaneously targeting multiple pathways, LBL-047 is designed to address the limitations of single-target therapies. We look forward to advancing this program in collaboration with Dianthus Therapeutics to deliver potentially transformative options for patients worldwide,” said Dr. Charles Cai, Chief Medical Officer of Leads Biolabs.

“Initiating this Phase 1 study is the first step to realizing the much anticipated by physicians outcome of targeting multiple pertinent dysfunctional pathways in several autoimmune indications,” said Dr. Simrat Randhawa, Head of Research & Development at Dianthus Therapeutics.

About LBL-047 (DNTH212)
LBL-047 (DNTH212) is an investigational bifunctional fusion protein composed of a humanized anti-blood dendritic cell antigen 2 (BDCA2) antibody and an engineered transmembrane activator and CAML interactor (TACI) ectodomain. It is designed to selectively deplete pDCs to reduce type 1 interferon production, while simultaneously inhibiting B-cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL) signaling pathways to suppress B-cell activation, differentiation, and antibody production. By targeting two key drivers of autoimmune disease pathogenesis, this differentiated approach has the potential to address multiple autoimmune indications. Additionally, LBL-047 (DNTH212) has also been optimized with Fc engineering to extend its half-life, offering the potential for a patient-friendly subcutaneous self-administration regimen with a dosing frequency of Q4W or less, supporting its potential as a first-line biologic therapy.

About Dianthus Therapeutics
Dianthus Therapeutics, Inc. is a clinical-stage biotechnology company dedicated to developing next-generation therapies to transform the treatment of severe autoimmune diseases. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who aim to deliver transformative medicines for people living with severe autoimmune and inflammatory diseases.

To learn more, please visit www.dianthustx.com and follow us on LinkedIn

About Leads Biolabs
Founded in 2012, Leads Biolabs is a clinical-stage biotechnology company dedicated to the discovery, development, and commercialization of innovative therapies to address unmet medical needs in oncology, autoimmune, and other severe diseases both in China and globally. As a front-runner in next-generation immuno-oncology treatments, the company has a differentiated pipeline of 14 innovative drug candidates, including six clinical-stage drug candidates, of which four lead products are among the top-tier clinically advanced candidates globally.

Leads Biolabs adopts a science-driven R&D approach and has successfully established comprehensive R&D capabilities spanning antibody discovery and engineering, in vivo and in vitro efficacy evaluation, as well as druggability assessment. The company has also developed multiple proprietary technology platforms, including LeadsBody platform (a CD3 T-cell engager platform), X-body platform (a 4-1BB engager platform), TOPiKinectics (ADC platform), which serve as the cornerstone for continued innovation and have been validated by the clinical outcomes of bispecific antibody portfolios.

Leads Biolabs has established integrated capabilities across early discovery, translational medicine, clinical development, CMC and business development. The innovative nature and competitive strengths of drug candidates, coupled with global perspectives, proactive strategy, and efficient clinical validation, have made the company an attractive partner for leading industry players and investment institutions. For more information, please visit https://en.leadsbiolabs.com/

Dianthus Cautionary Statement Regarding Forward-Looking Statements
Certain statements in this press release, other than purely historical information, may constitute “forward-looking statements” within the meaning of the federal securities laws, including for purposes of the safe harbor provisions under the United States Private Securities Litigation Reform Act of 1995, express or implied statements regarding future plans and prospects, including statements regarding the expectations or plans for discovery, preclinical studies, clinical trials and research and development programs, in particular with respect to DNTH212, and any developments or results in connection therewith, including the target product profile and administration of DNTH212; the anticipated timing of the initiation and results from those studies and trials; expectations regarding the clinical trial designs or indications; expectations regarding the time period over which the Company’s capital resources are expected to be sufficient to fund its anticipated operations; and expectations regarding market size, patient population size, and potential opportunities for complement therapies, in particular with respect to DNTH212. DNTH212 is an investigational agent that is not approved as a therapy in any indication in any jurisdiction worldwide. The words “opportunity,” “potential,” “milestones,” “runway,” “will,” “anticipate,” “achieve,” “near-term,” “catalysts,” “pursue,” “pipeline,” “believe,” “continue,” “could,” “estimate,” “expect,” “intend,” “may,” “might,” “plan,” “possible,” “predict,” “project,” “should,” “strive,” “would,” “aim,” “target,” “commit,” and similar expressions (including the negatives of these terms or variations of them) generally identify forward-looking statements, but the absence of these words does not mean that statement is not forward looking.

Actual results could differ materially from those included in the forward-looking statements due to various factors, risks and uncertainties, including, but not limited to, that preclinical testing of DNTH212 and data from clinical trials may not be predictive of the results or success of ongoing or later clinical trials, that the development of DNTH212 may take longer and/or cost more than planned, that the Company or its partner may be unable to successfully complete the clinical development of the Company’s compounds, that the Company or its partner may be delayed in initiating, enrolling or completing its planned clinical trials, and that the Company’s compounds may not receive regulatory approval or become commercially successful products. These and other risks and uncertainties are identified under the heading “Risk Factors” included in the Company’s Annual Report on Form 10-K for the period ended December 31, 2024, and other filings that the Company has made and may make with the SEC in the future. Nothing in this press release should be regarded as a representation by any person that the forward-looking statements set forth herein will be achieved or that any of the contemplated results of such forward-looking statements will be achieved.

The forward-looking statements in this press release speak only as of the date they are made and are qualified in their entirety by reference to the cautionary statements herein. Dianthus undertakes no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future events or otherwise, except as required by law.

Dianthus Therapeutics Contact
Jennifer Davis Ruff
Dianthus Therapeutics
jdavisruff@dianthustx.com

Leads Biolabs Contact
pr@leadsbiolabs.com

Nov 24 2025 | Dianthus Therapeutics To Participate in the 8th Annual Evercore Healthcare Conference
NEW YORK and WALTHAM, Mass., Nov. 24, 2025 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to developing next-generation therapies… READ MORE
News
Nov 24 2025 | Dianthus Therapeutics To Participate in the 8th Annual Evercore Healthcare Conference

NEW YORK and WALTHAM, Mass., Nov. 24, 2025 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to developing next-generation therapies to transform the treatment of severe autoimmune diseases, today announced the Company’s participation in the 8th Annual Evercore Healthcare Conference in Coral Gables, Florida. Marino Garcia, CEO of Dianthus Therapeutics, will participate in a fireside chat on Tuesday, December 2, 2025 at 2:35 p.m. ET and will host one-on-one meetings with investors.

A webcast of this presentation may be accessed under “News and Events” in the Investors section of the Dianthus Therapeutics website.

About Dianthus Therapeutics
Dianthus Therapeutics, Inc. is a clinical-stage biotechnology company dedicated to developing next-generation therapies to transform the treatment of severe autoimmune diseases. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who aim to deliver transformative medicines for people living with severe autoimmune and inflammatory diseases.

To learn more, please visit www.dianthustx.com and follow us on LinkedIn

Contact
Jennifer Davis Ruff
Dianthus Therapeutics
jdavisruff@dianthustx.com

Nov 05 2025 | Dianthus Therapeutics Highlights Recent Business Achievements and Reports Q3 Financial Results
Claseprubart achieved statistically significant and clinically meaningful improvements in Myasthenia Gravis Activities of Daily Living (MG-ADL), Quantitative Myasthenia Gravis (QMG), and other efficacy measures at… READ MORE
News
Nov 05 2025 | Dianthus Therapeutics Highlights Recent Business Achievements and Reports Q3 Financial Results

Claseprubart achieved statistically significant and clinically meaningful improvements in Myasthenia Gravis Activities of Daily Living (MG-ADL), Quantitative Myasthenia Gravis (QMG), and other efficacy measures at Week 13 in Phase 2 MaGic trial in gMG

New claseprubart data from the MaGic open-label extension supporting potential for 300mg/2mL Q4W dosing and new in vitro data highlighting potential efficacy benefits of upstream (aC1s, claseprubart) vs. downstream (C5, ravulizumab) complement inhibition were presented during the AANEM Annual Meeting in October 2025

Phase 3 gMG trial including two claseprubart treatment arms, 300mg/2mL Q2W and 300mg/2mL Q4W, vs. placebo anticipated to initiate in 2026

Accelerated timing for interim responder analysis for Phase 3 CAPTIVATE trial of claseprubart in Chronic Inflammatory Demyelinating Polyneuropathy (CIDP); now anticipated in Q2’26 (formerly 2H’26) due to faster than expected enrollment

Phase 2 MoMeNtum trial of claseprubart in Multifocal Motor Neuropathy (MMN) ongoing; top-line results anticipated in 2H’26

Announced exclusive license agreement for DNTH212, a bifunctional BDCA2 and BAFF/APRIL inhibitor; Phase 1 healthy volunteer data anticipated in 2H’26

Estimated ~$525 million of cash after DNTH212 upfront and near-term milestone payments provides runway into 2028

NEW YORK and WALTHAM, Mass., Nov. 05, 2025 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to developing next-generation therapies to transform the treatment of severe autoimmune diseases, today reported financial results for the third quarter ending September 30, 2025, and provided an update on recent business achievements.

“I’m extremely proud of our team’s outstanding track record of execution against our vision to become a leading biotech company in the I&I field. Just in the past 2 months, we delivered impressive results from the gMG MaGic trial, accelerated the timing of the interim responder analysis from our CIDP CAPTIVATE trial from 2H’26 to Q2’26, and in-licensed DNTH212, a new and exciting clinical-stage bifunctional fusion protein. Both claseprubart and DNTH212 have validated mechanisms of action with pipeline-in-a-product potential, and aim to deliver best-in-class efficacy, safety, and convenience with infrequent, subcutaneous self-administration,” said Marino Garcia, Chief Executive Officer of Dianthus Therapeutics. “The claseprubart efficacy and safety data from the MaGic trial, including the recently presented data for placebo patients transitioning to claseprubart in the OLE and the post-hoc analyses highlighting the impact of QMG screening criteria on MG-ADL results, strongly support our Phase 3 plans to advance both 300mg/2mL Q2W and 300mg/2mL Q4W as a potential best-in-class treatment option in gMG. We remain focused on execution as we aim to deliver first-line biologic therapies that can meaningfully improve the lives of patients with severe autoimmune diseases.”

Claseprubart (DNTH103) Clinical Development

Claseprubart is an investigational, clinical-stage, potent monoclonal antibody engineered to selectively target the classical pathway by inhibiting only the active form of the C1s protein, a clinically validated complement target. Claseprubart is designed to enable a more convenient, subcutaneous, self-administered injection dosed as infrequently as once every two or four weeks. Claseprubart has the potential to be a best-in-class pipeline-in-a-product across a range of autoimmune disorders with high unmet need.

Generalized Myasthenia Gravis (gMG)

  • Positive Phase 2 data reported in September and presented at AANEM: Results from the MaGic trial, a global, randomized, double-blind, placebo-controlled Phase 2 trial in patients with gMG who are acetylcholine receptor (AChR) antibody positive, were reported in September and presented at the American Association of Neuromuscular and Electromagnetic Medicine (AANEM) Annual Meeting. Claseprubart 300mg/2mL and 600mg/4mL Q2W demonstrated rapid, statistically significant and clinically meaningful improvements over placebo as measured by both MG-ADL and QMG, including at Week 1 and at Week 13. The claseprubart 300mg/2mL Q2W dose was also statistically significant and clinically meaningful across other key efficacy endpoints, including Minimal Symptom Expression (MSE), Myasthenia Gravis Composite (MGC) Score and the Myasthenia Gravis Quality of Life Scale (MG-QoL-15r). Claseprubart was generally well tolerated with no drug-related Serious Adverse Events (SAEs) or discontinuations due to any related adverse event.
  • New MaGic data presented during AANEM: New claseprubart data were presented during AANEM and in a Virtual Industry Forum titled Upstream Targeting: Rethinking MG Treatment Through Active C1s Inhibition, which included:
    • A robust MG-ADL decline at week 4 in the open-label extension (OLE) of -2.5 points and QMG score reduction of -3.2 points for patients on placebo during the RCT who received only two doses of claseprubart 600mg/4mL Q2W without a loading dose and achieved a PK level far below the steady state of 300mg/2mL Q2W, supporting potential for Q4W dosing of 300mg/2mL
    • A subgroup analysis of patients enrolled in the MaGic trial with a QMG score ≥10 at baseline which demonstrated a 3-point difference from placebo in MG-ADL treatment effect for 300mg/2mL Q2W
    • In vitro data demonstrating the benefits of upstream (active C1s with claseprubart) vs. downstream (C5 with ravulizumab) inhibition in the prevention of pro-inflammatory split products C3a and C3b
  • Phase 3 trial expected to begin in 2026: An end-of-Phase 2 meeting is planned with the FDA to align on the proposed design of a Phase 3 trial for claseprubart in gMG that investigates both 300mg/2mL Q2W and 300mg/2mL Q4W doses vs. placebo and includes QMG ≥10 screening criteria.

Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

  • Phase 3 CAPTIVATE CIDP trial interim responder analysis now expected in Q2’26: The CAPTIVATE trial is a single, global, two-part, randomized withdrawal Phase 3 trial in patients with CIDP, and an interim responder analysis (n=40) from Part A of this trial is now expected in Q2’26, accelerated from previous guidance of 2H’26 due to faster than expected enrollment. The Company believes this single pivotal trial will support a BLA filing in adult patients with CIDP.

Multifocal Motor Neuropathy (MMN)

  • Phase 2 MoMeNtum MMN trial remains on track for top-line results in 2H’26: The MoMeNtum trial is an ongoing global, randomized, double-blind, placebo-controlled Phase 2 trial in patients with MMN.

DNTH212 Clinical Development

DNTH212 is an investigational, extended half-life bifunctional fusion protein targeting plasmacytoid dendritic cell (pDC) BDCA2 to reduce Type 1 interferon production, while simultaneously inhibiting BAFF/APRIL to suppress B cell function. By targeting both the innate and adaptive immune systems via two clinically validated pathways that are known drivers of autoimmune disease pathogenesis, this complementary and differentiated approach has the potential to address multiple autoimmune indications with improved outcomes.

  • Phase 1 data anticipated in 2H’26: A two-part Phase 1 study in China in healthy volunteers (Part A) and patients with systemic lupus erythematosus (Part B) is expected to initiate by year-end 2025, with top-line results in healthy volunteers expected in the second half of 2026. An update on indication prioritization for DNTH212 is planned for 2026.

Corporate Updates

  • On September 11, Dianthus announced the closing of an upsized underwritten public offering of common stock, with aggregate gross proceeds of approximately $288 million.
  • On October 16, Dianthus entered into an exclusive licensing agreement with Nanjing Leads Biolabs Co., Ltd. (“Leads” (9887.HK)) for DNTH212 (being developed in China by Leads Biolabs as LBL-047), a first and potentially best-in-class bifunctional BDCA2 and BAFF/APRIL inhibitor.

Third-Quarter 2025 Financial Results

  • Cash Position – An estimated $525 million of adjusted cash, cash equivalents and investments as of September 30, 2025 is projected to provide runway into 2028. This $525 million estimate includes cash, cash equivalents and investments as of September 30, 2025 of approximately $555.5 million, less $30 million of upfront and near-term milestone payments payable to Leads Biolabs.
  • R&D Expenses – Research and development (R&D) expenses for the quarter ended September 30, 2025 were $32.5 million, inclusive of $2.5 million of stock-based compensation, compared to $25.5 million for the quarter ended September 30, 2024, which included $1.7 million of stock-based compensation. This increase in R&D expenses was primarily driven by higher clinical costs, milestone costs, and increased headcount to support claseprubart Phase 2 and Phase 3 development.
  • G&A Expenses – General and administrative (G&A) expenses for the quarter ended September 30, 2025 totaled $8.2 million, inclusive of stock-based compensation of $3.3 million, compared to $6.5 million for the quarter ended September 30, 2024, which included $2.2 million of stock-based compensation. This increase in G&A expenses was primarily due to increased headcount.
  • Net Loss – Net loss for the quarter ended September 30, 2025 was $36.8 million or $0.97 per share (basic and diluted) compared to $25.2 million or $0.74 per share (basic and diluted) for the quarter ended September 30, 2024.
  • Additional Information – For additional information on the Company’s financial results for the quarter ended September 30, 2025, please refer to the Form 10-Q filed with the SEC.

About Claseprubart (DNTH103)
Claseprubart is an investigational, clinical-stage, potent monoclonal antibody engineered to selectively target the classical pathway by inhibiting only the active form of the C1s protein, a clinically validated complement target. Claseprubart is enhanced with YTE half-life extension technology designed to enable a more convenient subcutaneous, infrequently dosed, self-administered injection. Additionally, selective inhibition of the classical complement pathway may lower patient risk of infection from encapsulated bacteria by preserving immune activity of the lectin and alternative pathways. As the classical pathway plays a significant role in disease pathology, claseprubart has the potential to be a best-in-class pipeline-in-a-product across a range of autoimmune disorders with high unmet need. Dianthus is building a neuromuscular franchise with claseprubart and expects to initiate a Phase 3 trial in gMG in 2026, the interim responder analysis of the Phase 3 CAPTIVATE trial in Chronic Inflammatory Demyelinating Polyneuropathy in Q2’26, and top-line data from the Phase 2 MoMeNtum trial in Multifocal Motor Neuropathy in 2H’26.

Claseprubart is an investigational agent that is not approved as a therapy in any indication in any jurisdiction worldwide.

About DNTH212
DNTH212 is an investigational, extended half-life bifunctional fusion protein targeting plasmacytoid dendritic cell (pDC) BDCA2 to reduce Type 1 interferon production, while simultaneously inhibiting BAFF/APRIL to suppress B cell function. By targeting both the innate and adaptive immune systems via two clinically validated pathways that are known drivers of autoimmune disease pathogenesis, this complementary and differentiated approach has the potential to address multiple autoimmune indications with improved outcomes. A two-part Phase 1 study in China in healthy volunteers (Part A) and patients with systemic lupus erythematosus (Part B) is expected to initiate by year-end 2025, with top-line results in healthy volunteers expected in the second half of 2026.

DNTH212 is an investigational agent that is not approved as a therapy in any indication in any jurisdiction worldwide.

About Dianthus Therapeutics
Dianthus Therapeutics, Inc. is a clinical-stage biotechnology company dedicated to developing next-generation therapies to transform the treatment of severe autoimmune diseases. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who aim to deliver transformative medicines for people living with severe autoimmune and inflammatory diseases.

To learn more, please visit www.dianthustx.com and follow us on LinkedIn

Cautionary Statement Regarding Forward-Looking Statements
Certain statements in this press release, other than purely historical information, may constitute “forward-looking statements” within the meaning of the federal securities laws, including for purposes of the safe harbor provisions under the United States Private Securities Litigation Reform Act of 1995, express or implied statements regarding future plans and prospects, including statements regarding the expectations or plans for discovery, preclinical studies, clinical trials and research and development programs, in particular with respect to claseprubart and DNTH212, and any developments or results in connection therewith, including the target product profile and administration of claseprubart and DNTH212; the anticipated timing of the initiation and results from those studies and trials; expectations regarding the clinical trial designs or indications; expectations regarding the time period over which the Company’s capital resources are expected to be sufficient to fund its anticipated operations; and expectations regarding market size, patient population size, and potential opportunities for complement therapies, in particular with respect to claseprubart and DNTH212. Claseprubart and DNTH212 are investigational agents that are not approved as therapies in any indication in any jurisdiction worldwide. The words “opportunity,” “potential,” “milestones,” “runway,” “will,” “anticipate,” “achieve,” “near-term,” “catalysts,” “pursue,” “pipeline,” “believe,” “continue,” “could,” “estimate,” “expect,” “intend,” “may,” “might,” “plan,” “possible,” “predict,” “project,” “should,” “strive,” “would,” “aim,” “target,” “commit,” and similar expressions (including the negatives of these terms or variations of them) generally identify forward-looking statements, but the absence of these words does not mean that statement is not forward looking.

Actual results could differ materially from those included in the forward-looking statements due to various factors, risks and uncertainties, including, but not limited to, that preclinical testing of claseprubart and DNTH212 and data from clinical trials may not be predictive of the results or success of ongoing or later clinical trials, that the development of claseprubart or DNTH212 may take longer and/or cost more than planned, that the Company or its partner may be unable to successfully complete the clinical development of the Company’s compounds, that the Company or its partner may be delayed in initiating, enrolling or completing its planned clinical trials, and that the Company’s compounds may not receive regulatory approval or become commercially successful products. These and other risks and uncertainties are identified under the heading “Risk Factors” included in the Company’s Annual Report on Form 10-K for the period ended December 31, 2024, and other filings that the Company has made and may make with the SEC in the future. Nothing in this press release should be regarded as a representation by any person that the forward-looking statements set forth herein will be achieved or that any of the contemplated results of such forward-looking statements will be achieved.

The forward-looking statements in this press release speak only as of the date they are made and are qualified in their entirety by reference to the cautionary statements herein. Dianthus undertakes no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future events or otherwise, except as required by law.

Contact
Jennifer Davis Ruff
Dianthus Therapeutics
jdavisruff@dianthustx.com

DIANTHUS THERAPEUTICS, INC.
Condensed Consolidated Balance Sheets
(in thousands, except share and per share data)
(unaudited)
 
  September 30,
2025
    December 31,
2024
 
Assets          
Current assets:          
Cash and cash equivalents $ 55,984     $ 22,792  
Short-term investments   346,629       252,449  
Receivable from former related party         807  
Accounts receivable, net   5,000        
Prepaid expenses and other current assets   6,212       4,856  
Total current assets   413,825       280,904  
Long-term investments   152,874       81,728  
Property and equipment, net   185       194  
Right-of-use operating lease assets   1,306       1,553  
Other assets and restricted cash   9,255       9,629  
Total assets $ 577,445     $ 374,008  
Liabilities and Stockholders’ Equity          
Current liabilities:          
Accounts payable $ 6,705     $ 4,579  
Accrued expenses   15,979       13,074  
Current portion of deferred revenue   954       479  
Current portion of operating lease liabilities   217       320  
Total current liabilities   23,855       18,452  
Deferred revenue   6,068       1,908  
Long-term operating lease liabilities   1,068       1,171  
Total liabilities   30,991       21,531  
Commitments and contingencies          
Stockholders’ equity:          
Preferred stock          
Common stock   43       31  
Additional paid-in capital   818,545       526,732  
Accumulated deficit   (272,297 )     (174,392 )
Accumulated other comprehensive income   163       106  
Total stockholders’ equity   546,454       352,477  
Total liabilities and stockholders’ equity $ 577,445     $ 374,008  

DIANTHUS THERAPEUTICS, INC.
Condensed Consolidated Statements of Operations and Comprehensive Loss
(in thousands, except share and per share data)
(unaudited)
 
  Three Months Ended
September 30,
    Nine Months Ended
September 30,
 
  2025     2024     2025     2024  
Revenues:                      
License revenue – former related party $     $ 2,172     $     $ 4,909  
License revenue   396             1,752        
Total revenues   396       2,172       1,752       4,909  
Operating expenses:                      
Research and development   32,489       25,544       85,743       56,692  
General and administrative   8,195       6,528       24,401       18,165  
Total operating expenses   40,684       32,072       110,144       74,857  
Loss from operations   (40,288 )     (29,900 )     (108,392 )     (69,948 )
Other income/(expense):                      
Interest and investment income   3,658       4,445       10,852       13,375  
Gain on investment in former related party   227       307       254       307  
Loss on currency exchange, net   (2 )     (48 )     (54 )     (91 )
Other (expense)/income   (360 )     22       (565 )     (172 )
Total other income   3,523       4,726       10,487       13,419  
Net loss $ (36,765 )   $ (25,174 )   $ (97,905 )   $ (56,529 )
Net loss per share attributable to common stockholders,
basic and diluted
$ (0.97 )   $ (0.74 )   $ (2.68 )   $ (1.73 )
Weighted-average number of shares of common stock
outstanding including shares issuable under equity classified pre-funded warrants, used in computing net loss per share of common stock, basic and diluted
  37,794,088       34,236,728       36,476,370       32,614,771  
Comprehensive loss:                      
Net loss $ (36,765 )   $ (25,174 )   $ (97,905 )   $ (56,529 )
Other comprehensive income:                      
Unrealized gain on marketable securities   65       718       57       634  
Total other comprehensive income   65       718       57       634  
Total comprehensive loss $ (36,700 )   $ (24,456 )   $ (97,848 )   $ (55,895 )

Nov 04 2025 | Dianthus Therapeutics to Participate in Four Investor Conferences During November
NEW YORK and WALTHAM, Mass., Nov. 04, 2025 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to developing next-generation therapies… READ MORE
News
Nov 04 2025 | Dianthus Therapeutics to Participate in Four Investor Conferences During November

NEW YORK and WALTHAM, Mass., Nov. 04, 2025 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to developing next-generation therapies to transform the treatment of severe autoimmune diseases, today announced the company’s participation in four upcoming investor conferences.

Marino Garcia, CEO of Dianthus Therapeutics, will participate in fireside chats and host one-on-one investor meetings at the following conferences:

  • Guggenheim 2nd Annual Healthcare Innovation Conference (Boston) – Fireside chat on Tuesday, November 11, 2025 at 3:30 p.m. ET
  • TD Cowen Immunology & Inflammation Summit (Virtual) – Fireside chat on Wednesday, November 12, 2025 at 9:30 a.m. ET
  • Stifel 2025 Healthcare Conference (New York) – Fireside chat on Thursday, November 13, 2025 at 2:00 p.m. ET
  • Jefferies Global Healthcare Conference (London) – Corporate overview presentation on Monday, November 17, 2025 at 1.30 p.m. GMT

Webcasts of these presentations may be accessed under “News and Events” in the Investors section of the Dianthus Therapeutics website.

About Dianthus Therapeutics
Dianthus Therapeutics, Inc. is a clinical-stage biotechnology company dedicated to developing next-generation therapies to transform the treatment of severe autoimmune diseases. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who aim to deliver transformative medicines for people living with severe autoimmune and inflammatory diseases.

To learn more, please visit www.dianthustx.com and follow us on LinkedIn

Contact
Jennifer Davis Ruff
Dianthus Therapeutics
jdavisruff@dianthustx.com

Oct 29 2025 | Dianthus Therapeutics Highlights New Claseprubart Data Presented During 2025 AANEM Annual Meeting
Positive data from Phase 2 MaGic trial presented for claseprubart in generalized Myasthenia Gravis, including new open-label extension data further supporting potential for 300mg/2mL Q4W… READ MORE
News
Oct 29 2025 | Dianthus Therapeutics Highlights New Claseprubart Data Presented During 2025 AANEM Annual Meeting

Positive data from Phase 2 MaGic trial presented for claseprubart in generalized Myasthenia Gravis, including new open-label extension data further supporting potential for 300mg/2mL Q4W dosing

Phase 3 gMG trial planned to include QMG 10 screening criteria and two claseprubart treatment arms, 300mg/2mL Q2W and 300mg/2mL Q4W, vs. placebo anticipated to initiate in 2026

Additionally, new preclinical data highlight potential efficacy benefits of upstream (aC1s) vs. downstream (C5) complement inhibition

Virtual industry forum replay available

NEW YORK and WALTHAM, Mass., Oct. 29, 2025 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to developing next-generation therapies to transform the treatment of severe autoimmune diseases, today reviewed new data from the Phase 2 MaGic trial of claseprubart in generalized Myasthenia Gravis (gMG) presented during the Myasthenia Gravis Foundation of America (MGFA) Scientific Session of the American Association of Neuromuscular and Electromagnetic Medicine (AANEM) Annual Meeting.

During AANEM, Dr. Pushpa Narayanaswami, MD from Harvard Medical School presented the successful Phase 2 MaGic trial data for the first time at a medical conference. In addition, during a Virtual Industry Forum titled Upstream Targeting: Rethinking MG Treatment Through Active C1s Inhibition, new data were released, which included:

  • A robust MG-ADL decline at week 4 in the open-label extension (OLE) of -2.5 points and QMG score reduction of -3.2 points for patients on placebo during the RCT who received only two doses of claseprubart 600mg/4mL Q2W without a loading dose and achieved a PK level far below the steady state of 300mg/2mL Q2W, supporting potential for Q4W dosing of 300mg/2mL
  • A subgroup analysis of patients enrolled in the MaGic trial with a QMG score ≥10 at baseline which demonstrated an increase in MG-ADL treatment effect for 300mg/2mL Q2W to a 3-point difference from placebo
  • In vitro data demonstrating the benefits of upstream (active C1s with claseprubart) vs. downstream (C5 with ravulizumab) inhibition in the prevention of pro-inflammatory split products C3a and C3b

“This post hoc analysis is driving our decision to add a QMG inclusion criteria and a 300mg/2mL S.C. Q4W arm, in addition to a Q2W arm, in our Phase 3 MG study,” said Simrat Randhawa, MD, MBA, Executive Vice President and Head of R&D of Dianthus Therapeutics. “Given the impressive Phase 2 data combined with the very encouraging post hoc data presented today, we are further motivated to rapidly proceed to Phase 3.”

The claseprubart data presented at AANEM and an archived webcast of the virtual industry forum titled Upstream Targeting: Rethinking MG Treatment Through Active C1s Inhibition, featuring an expert panel including Pushpa Narayanaswami, MD, Tuan Vu, MD, Stojan Peric, MD, PhD, Shahar Shelly, MD, are now available on the Dianthus Therapeutics website.

Agenda: Upstream Targeting: Rethinking MG Treatment Through Active C1s Inhibition

  • Opening Remarks – Introduction to Dianthus Therapeutics and Claseprubart: Simrat Randhawa, MD, EVP and Head of R&D of Dianthus Therapeutics
  • Clinical & Treatment Gaps: Tuan Vu, MD
  • Panel Discussion Part 1: Clinical and Treatment Gaps
  • C1s Inhibition Mechanism of Action (MoA) Animation 
  • Upstream Inhibition of Classical Pathway: Shahar Shelly, MD
  • MaGic Phase 2 Data: Pushpa Narayanaswami, MD
  • Panel Discussion Part 2: Feedback on MaGic Results and Potential of C1s Inhibition
  • Closing Remarks – Phase 3 and Future Outlook: Simrat Randhawa, MD, EVP and Head of R&D of Dianthus Therapeutics

About Claseprubart (DNTH103)
Claseprubart is an investigational, clinical-stage, potent monoclonal antibody engineered to selectively target the classical pathway by inhibiting only the active form of the C1s protein, a clinically validated complement target. Claseprubart is enhanced with YTE half-life extension technology designed to enable a more convenient subcutaneous, infrequently dosed, self-administered injection. Additionally, selective inhibition of the classical complement pathway may lower patient risk of infection from encapsulated bacteria by preserving immune activity of the lectin and alternative pathways. As the classical pathway plays a significant role in disease pathology, claseprubart has the potential to be a best-in-class pipeline-in-a-product across a range of autoimmune disorders with high unmet need. Dianthus is building a neuromuscular franchise with claseprubart and expects to initiate a Phase 3 trial in gMG in 2026, the interim responder analysis of the Phase 3 CAPTIVATE trial in Chronic Inflammatory Demyelinating Polyneuropathy in 2H’26, and top-line data from the Phase 2 MoMeNtum trial in Multifocal Motor Neuropathy in 2H’26.

Claseprubart is an investigational agent that is not approved as a therapy in any indication in any jurisdiction worldwide.

About Dianthus Therapeutics
Dianthus Therapeutics, Inc. is a clinical-stage biotechnology company dedicated to developing next-generation therapies to transform the treatment of severe autoimmune diseases. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who aim to deliver transformative medicines for people living with severe autoimmune and inflammatory diseases.

To learn more, please visit www.dianthustx.com and follow us on LinkedIn

Cautionary Statement Regarding Forward-Looking Statements
Certain statements in this press release, other than purely historical information, may constitute “forward-looking statements” within the meaning of the federal securities laws, including for purposes of the safe harbor provisions under the United States Private Securities Litigation Reform Act of 1995, express or implied statements regarding future plans and prospects, including statements regarding the expectations or plans for discovery, preclinical studies, clinical trials and research and development programs, in particular with respect to claseprubart, and any developments or results in connection therewith, including the target product profile and administration of claseprubart; the anticipated timing of the initiation and results from those studies and trials; expectations regarding the clinical trial design for the Phase 3 trial for claseprubart in gMG; expectations regarding the time period over which the Company’s capital resources are expected to be sufficient to fund its anticipated operations; and expectations regarding market size, patient population size, and potential opportunities for complement therapies, in particular with respect to claseprubart. Claseprubart is an investigational agent that is not approved as a therapy in any indication in any jurisdiction worldwide. The words “opportunity,” “potential,” “milestones,” “runway,” “will,” “anticipate,” “achieve,” “near-term,” “catalysts,” “pursue,” “pipeline,” “believe,” “continue,” “could,” “estimate,” “expect,” “intend,” “may,” “might,” “plan,” “possible,” “predict,” “project,” “should,” “strive,” “would,” “aim,” “target,” “commit,” and similar expressions (including the negatives of these terms or variations of them) generally identify forward-looking statements, but the absence of these words does not mean that statement is not forward looking.

Actual results could differ materially from those included in the forward-looking statements due to various factors, risks and uncertainties, including, but not limited to, that preclinical testing of claseprubart and data from clinical trials may not be predictive of the results or success of ongoing or later clinical trials, that the development of claseprubart or the Company’s other compounds may take longer and/or cost more than planned, that the Company may be unable to successfully complete the clinical development of the Company’s compounds, that the Company may be delayed in initiating, enrolling or completing its planned clinical trials, and that the Company’s compounds may not receive regulatory approval or become commercially successful products. These and other risks and uncertainties are identified under the heading “Risk Factors” included in the Company’s Annual Report on Form 10-K for the period ended December 31, 2024, and other filings that the Company has made and may make with the SEC in the future. Nothing in this press release should be regarded as a representation by any person that the forward-looking statements set forth herein will be achieved or that any of the contemplated results of such forward-looking statements will be achieved.

The forward-looking statements in this press release speak only as of the date they are made and are qualified in their entirety by reference to the cautionary statements herein. Dianthus undertakes no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future events or otherwise, except as required by law.

Contact
Jennifer Davis Ruff
Dianthus Therapeutics
jdavisruff@dianthustx.com

Oct 16 2025 | Dianthus Therapeutics Announces Exclusive License Agreement with Leads Biolabs for DNTH212, a First and Potentially Best-In-Class, Phase 1 Ready Bifunctional BDCA2 & BAFF/APRIL Inhibitor for Severe Autoimmune Diseases
DNTH212 is a bifunctional fusion protein targeting plasmacytoid dendritic cell (pDC) BDCA2 to reduce Type 1 interferon production, while simultaneously inhibiting BAFF/APRIL to suppress B… READ MORE
News
Oct 16 2025 | Dianthus Therapeutics Announces Exclusive License Agreement with Leads Biolabs for DNTH212, a First and Potentially Best-In-Class, Phase 1 Ready Bifunctional BDCA2 & BAFF/APRIL Inhibitor for Severe Autoimmune Diseases

DNTH212 is a bifunctional fusion protein targeting plasmacytoid dendritic cell (pDC) BDCA2 to reduce Type 1 interferon production, while simultaneously inhibiting BAFF/APRIL to suppress B cell function 

Demonstrated superior inhibition of pDCs vs. litifilimab in vitro and superior Ig reductions vs. povetacicept in NHPs highlight the potential for improved clinical benefit in severe autoimmune diseases

DNTH212 has the potential to be a first line biologic in multiple autoimmune disorders with patient-friendly S.C. self-administration and Q4W or less frequent dosing

IND cleared by FDA in September 2025 and expected to clear in China in Q4’25. Phase 1 study of DNTH212 expected to initiate in Q4’25 with top-line results in healthy volunteers in 2H’26

Pro forma estimated cash of ~$525 million; reaffirms runway into 2028

Investor conference call and webcast to be held today at 8:00 a.m. ET

NEW YORK and WALTHAM, Mass., Oct. 16, 2025 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to developing next-generation therapies to transform the treatment of severe autoimmune diseases, today announced it has entered into an exclusive licensing agreement with Nanjing Leads Biolabs Co., Ltd. (“Leads” (9887.HK) for DNTH212 (being developed in China by Leads Biolabs as LBL-047), a first and potentially best-in-class bifunctional BDCA2 and BAFF/APRIL inhibitor.

DNTH212 is an investigational, extended half-life bifunctional fusion protein targeting plasmacytoid dendritic cell (pDC) BDCA2 to reduce Type 1 interferon production, while simultaneously inhibiting BAFF/APRIL to suppress B cell function. By targeting both the innate and adaptive immune systems via two clinically validated pathways that are known drivers of autoimmune disease pathogenesis, this complementary and differentiated approach has the potential to address multiple autoimmune indications with improved outcomes.

“We are excited to partner with Leads Biolabs and build upon our vision of becoming a leading autoimmune-focused biopharmaceutical company with the addition of DNTH212 to our pipeline,” said Marino Garcia, Chief Executive Officer of Dianthus Therapeutics. “Both claseprubart and DNTH212, with their validated mechanisms of action and patient friendly convenience of infrequent S.C. self-administration, have the potential to significantly improve the lives of patients suffering from a range of severe autoimmune disorders. We look forward to leveraging the pipeline-in-a-product potential of DNTH212.”

pDCs are specialized immune cells that produce large amounts of Type 1 interferons (IFN- and IFN-). High levels of Type 1 interferon drive chronic inflammation and tissue damage, making Type 1 interferon inhibition a promising therapeutic strategy in multiple autoimmune diseases. DNTH212 demonstrated comparable IFNα inhibition and superior pDC depletion in-vitro compared to litifilimab, a late-stage clinically validated BDCA2 monoclonal antibody.

BAFF/APRIL activation of B cells generate autoantibodies against tissues that trigger inflammation and tissue damage. Inhibiting BAFF/APRIL has been shown to be a clinically validated therapeutic strategy in numerous autoimmune diseases. DNTH212 demonstrated superior inhibition of immunoglobulins (i.e. IgM, IgA, and IgG) in non-human primates compared to povetacicept, a late-stage clinically validated BAFF/APRIL inhibitor.

“The medical team is ready to exploit the full potential of this unique asset targeting both the innate and adaptive immune systems,” said Dr. Simrat Randhawa, Head of Research & Development of Dianthus Therapeutics. “Autoimmune experts have been asking for combination biologic approaches for years so we expect an enthusiastic reception from them as we roll out our target indications.”

A two-part Phase 1 study in China in healthy volunteers (Part A) and patients with systemic lupus erythematosus (Part B) is expected to initiate by year end 2025, with top-line results in healthy volunteers expected in the second half of 2026.

“We are pleased to partner with Dianthus, a leading biotechnology company with a proven track record of executing complex global clinical trials and delivering meaningful results for patients,” said Dr. Xiaoqiang Kang, Founder, Chairman and CEO of Leads Biolabs. “This collaboration reinforces our commitment to advancing highly innovative drug candidates into the clinic to address serious autoimmune conditions, while further diversifying our pipeline and positioning Leads Biolabs for long-term growth. Dianthus’ deep experience and expertise in this space will be invaluable as we work to bring LBL-047 to patients worldwide.”

License Overview:

Under the terms of the agreement, Dianthus will pay Leads Biolabs up to $38 million, comprised of $30 million in upfront and near-term milestone payments plus an additional $8 million milestone upon the initiation of a Dianthus-led Phase 1 study, for exclusive rights to develop and commercialize DNTH212 globally outside of Greater China. Leads Biolabs will also be eligible to receive up to an additional $962 million in total development and regulatory approval milestones and sales-based milestones across multiple indications, as well as tiered royalties from mid-single digits up to a low double-digit on ex-Greater China net sales.

Dianthus will have an estimated pro forma cash balance of approximately $525 million following the in-licensing of DNTH212. Estimated pro forma cash includes preliminary and unaudited cash, cash equivalents and investments as of September 30, 2025 of approximately $555 million less $30 million of upfront and near-term milestone payments made to Leads Biolabs as part of the in-licensing.

Dianthus is reaffirming its guidance of cash runway into 2028, including the planned development of DNTH212.

Investor Conference Call & Webcast to be Held at 8:00 a.m. ET Today
Dianthus Therapeutics will host an investor call and webcast to discuss the licensing agreement today, October 16, 2025 at 8:00 a.m. ET. Please click here to register for this event.

The live webcast may be accessed via the Investors section of the Dianthus Therapeutics website at https://investor.dianthustx.com/. A replay of the webcast will be available following the call.

About Dianthus Therapeutics
Dianthus Therapeutics, Inc. is a clinical-stage biotechnology company dedicated to developing next-generation therapies to transform the treatment of severe autoimmune diseases. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who aim to deliver transformative medicines for people living with severe autoimmune and inflammatory diseases.

To learn more, please visit www.dianthustx.com and follow us on LinkedIn

About Leads Biolabs
Founded in 2012, Leads Biolabs is a clinical-stage biotechnology company developing innovative therapies for underserved medical needs in oncology, autoimmune, and other severe diseases in China and globally. A front-runner in next-generation immuno-oncology, the company has a pipeline of 14 drug candidates, including six clinical-stage programs, four of which are among the most advanced in their class. Leads Biolabs leverages proprietary platforms, including LeadsBody™ (CD3 T-cell engager) and X-body™ (4-1BB engager), along with integrated capabilities across discovery, translational medicine, clinical development, CMC, and business development. The innovative nature and competitive strengths of its drug candidates, combined with a proactive strategy, efficient clinical validation, and global perspective, position Leads Biolabs as a preferred partner for leading biopharmaceutical companies and venture capital investors.

For more information, please visit https://en.leadsbiolabs.com/.

Cautionary Statement Regarding Forward-Looking Statements
Certain statements in this press release, other than purely historical information, may constitute “forward-looking statements” within the meaning of the federal securities laws, including for purposes of the safe harbor provisions under the United States Private Securities Litigation Reform Act of 1995, express or implied statements regarding future plans and prospects, including statements regarding the expectations or plans for discovery, preclinical studies, clinical trials and research and development programs, in particular with respect to claseprubart and DNTH212, and any developments or results in connection therewith, including the target product profile and administration of claseprubart and DNTH212; the anticipated timing of the initiation and results from those studies and trials; expectations regarding the clinical trial designs or indications; expectations regarding the time period over which the Company’s capital resources are expected to be sufficient to fund its anticipated operations; and expectations regarding market size, patient population size, and potential opportunities for complement therapies, in particular with respect to claseprubart and DNTH212. Claseprubart and DNTH212 are investigational agents that are not approved as therapies in any indication in any jurisdiction worldwide. The words “opportunity,” “potential,” “milestones,” “runway,” “will,” “anticipate,” “achieve,” “near-term,” “catalysts,” “pursue,” “pipeline,” “believe,” “continue,” “could,” “estimate,” “expect,” “intend,” “may,” “might,” “plan,” “possible,” “predict,” “project,” “should,” “strive,” “would,” “aim,” “target,” “commit,” and similar expressions (including the negatives of these terms or variations of them) generally identify forward-looking statements, but the absence of these words does not mean that statement is not forward looking.

Actual results could differ materially from those included in the forward-looking statements due to various factors, risks and uncertainties, including, but not limited to, that preclinical testing of claseprubart and DNTH212 and data from clinical trials may not be predictive of the results or success of ongoing or later clinical trials, that the development of claseprubart or DNTH212 may take longer and/or cost more than planned, that the Company or its partner may be unable to successfully complete the clinical development of the Company’s compounds, that the Company or its partner may be delayed in initiating, enrolling or completing its planned clinical trials, and that the Company’s compounds may not receive regulatory approval or become commercially successful products. These and other risks and uncertainties are identified under the heading “Risk Factors” included in the Company’s Annual Report on Form 10-K for the period ended December 31, 2024, and other filings that the Company has made and may make with the SEC in the future. Nothing in this press release should be regarded as a representation by any person that the forward-looking statements set forth herein will be achieved or that any of the contemplated results of such forward-looking statements will be achieved.

The forward-looking statements in this press release speak only as of the date they are made and are qualified in their entirety by reference to the cautionary statements herein. Dianthus undertakes no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future events or otherwise, except as required by law.

Contact
Jennifer Davis Ruff
Dianthus Therapeutics
jdavisruff@dianthustx.com

Oct 02 2025 | Dianthus Therapeutics Highlights Claseprubart Data Presentations Planned for 2025 AANEM Annual Meeting
Positive results from Phase 2 MaGic trial including additional analyses, and new preclinical data highlighting potential benefits of upstream inhibition, to be presented for claseprubart in… READ MORE
News
Oct 02 2025 | Dianthus Therapeutics Highlights Claseprubart Data Presentations Planned for 2025 AANEM Annual Meeting

Positive results from Phase 2 MaGic trial including additional analyses, and new preclinical data highlighting potential benefits of upstream inhibition, to be presented for claseprubart in generalized Myasthenia Gravis

NEW YORK and WALTHAM, Mass., Oct. 02, 2025 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to advancing the next generation of antibody complement therapeutics to treat severe autoimmune diseases, today announced that the results of the Phase 2 MaGic trial of claseprubart in generalized Myasthenia Gravis (gMG) will be presented in an oral presentation at the American Association of Neuromuscular and Electromagnetic Medicine (AANEM) Annual Meeting, taking place October 29 to November 1, 2025 in San Francisco, California. In addition, the Company will host a virtual industry forum on October 29 titled Upstream Targeting: Rethinking MG Treatment Through Active C1s Inhibition.

Oral Presentation
October 29, 2025, 11:20-11:29am PST
MGFA Scientific Session
Topline Results from MaGic, a Phase 2 Trial of Claseprubart (DNTH103), an Active C1s Inhibitor, in Generalized Myasthenia Gravis
Presented by Pushpa Narayanaswami, MD

Virtual Industry Forum
October 29, 2025, 11:30am-12:30pm PST
Upstream Targeting: Rethinking MG Treatment Through Active C1s Inhibition
Featuring an expert panel including Pushpa Narayanaswami, MD, Tuan Vu, MD, Stojan Peric, MD, PhD, and Shahar Shelly, MD

Click here to view the Virtual Industry Forum presentation live on October 29, 2025 or watch the archived event upon completion.

About Claseprubart (DNTH103)
Claseprubart is an investigational, clinical-stage, potent monoclonal antibody engineered to selectively target the classical pathway by inhibiting only the active form of the C1s protein, a clinically validated complement target. Claseprubart is enhanced with YTE half-life extension technology designed to enable a more convenient subcutaneous, infrequently dosed, self-administered injection. Additionally, selective inhibition of the classical complement pathway may lower patient risk of infection from encapsulated bacteria by preserving immune activity of the lectin and alternative pathways. As the classical pathway plays a significant role in disease pathology, claseprubart has the potential to be a best-in-class pipeline-in-a-product across a range of autoimmune disorders with high unmet need. Dianthus is building a neuromuscular franchise with claseprubart and expects to initiate a Phase 3 trial in gMG in 2026, the interim responder analysis of the Phase 3 CAPTIVATE trial in Chronic Inflammatory Demyelinating Polyneuropathy in 2H’26, and top-line data from the Phase 2 MoMeNtum trial in Multifocal Motor Neuropathy in 2H’26.

Claseprubart is an investigational agent that is not approved as a therapy in any indication in any jurisdiction worldwide.

About Dianthus Therapeutics
Dianthus Therapeutics is a clinical-stage biotechnology company dedicated to designing and delivering novel, best-in-class monoclonal antibodies with improved selectivity and potency. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who are leading the development of next-generation antibody complement therapeutics, aiming to deliver transformative medicines for people living with severe autoimmune and inflammatory diseases.

To learn more, please visit www.dianthustx.com and follow us on LinkedIn

Cautionary Statement Regarding Forward-Looking Statements
Certain statements in this press release, other than purely historical information, may constitute “forward-looking statements” within the meaning of the federal securities laws, including for purposes of the safe harbor provisions under the United States Private Securities Litigation Reform Act of 1995, express or implied statements regarding future plans and prospects, including statements regarding the expectations or plans for discovery, preclinical studies, clinical trials and research and development programs, in particular with respect to claseprubart, and any developments or results in connection therewith, including the target product profile and administration of claseprubart; the anticipated timing of the initiation and results from those studies and trials; expectations regarding the clinical trial design for the Phase 3 trial for claseprubart in gMG; expectations regarding the time period over which the Company’s capital resources are expected to be sufficient to fund its anticipated operations; and expectations regarding market size, patient population size, and potential opportunities for complement therapies, in particular with respect to claseprubart. Claseprubart is an investigational agent that is not approved as a therapy in any indication in any jurisdiction worldwide. The words “opportunity,” “potential,” “milestones,” “runway,” “will,” “anticipate,” “achieve,” “near-term,” “catalysts,” “pursue,” “pipeline,” “believe,” “continue,” “could,” “estimate,” “expect,” “intend,” “may,” “might,” “plan,” “possible,” “predict,” “project,” “should,” “strive,” “would,” “aim,” “target,” “commit,” and similar expressions (including the negatives of these terms or variations of them) generally identify forward-looking statements, but the absence of these words does not mean that statement is not forward looking.

Actual results could differ materially from those included in the forward-looking statements due to various factors, risks and uncertainties, including, but not limited to, that preclinical testing of claseprubart and data from clinical trials may not be predictive of the results or success of ongoing or later clinical trials, that the development of claseprubart or the Company’s other compounds may take longer and/or cost more than planned, that the Company may be unable to successfully complete the clinical development of the Company’s compounds, that the Company may be delayed in initiating, enrolling or completing its planned clinical trials, and that the Company’s compounds may not receive regulatory approval or become commercially successful products. These and other risks and uncertainties are identified under the heading “Risk Factors” included in the Company’s Annual Report on Form 10-K for the period ended December 31, 2024, and other filings that the Company has made and may make with the SEC in the future. Nothing in this press release should be regarded as a representation by any person that the forward-looking statements set forth herein will be achieved or that any of the contemplated results of such forward-looking statements will be achieved.

The forward-looking statements in this press release speak only as of the date they are made and are qualified in their entirety by reference to the cautionary statements herein. Dianthus undertakes no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future events or otherwise, except as required by law.

Contact
Jennifer Davis Ruff
Dianthus Therapeutics
jdavisruff@dianthustx.com

Sep 11 2025 | Dianthus Therapeutics, Inc. Announces Closing of its Upsized $288 Million Underwritten Public Offering Including Full Exercise of Underwriters’ Option to Purchase Additional Shares
NEW YORK and WALTHAM, Mass., Sept. 11, 2025 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to advancing the next… READ MORE
News
Sep 11 2025 | Dianthus Therapeutics, Inc. Announces Closing of its Upsized $288 Million Underwritten Public Offering Including Full Exercise of Underwriters’ Option to Purchase Additional Shares

NEW YORK and WALTHAM, Mass., Sept. 11, 2025 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to advancing the next generation of antibody complement therapeutics to treat severe autoimmune diseases (“Dianthus” or the “Company”), today announced that it closed its previously announced underwritten public offering of 7,627,879 shares of its common stock, including the full exercise by the underwriters of their option to purchase an additional 1,140,000 shares, at a public offering price of $33.00 per share, and, in lieu of common stock to certain investors, pre-funded warrants to purchase up to 1,112,121 shares of its common stock at a public offering price of $32.999 per pre-funded warrant. The pre-funded warrants have an exercise price of $0.001 per share and are exercisable immediately. The aggregate gross proceeds to Dianthus from the offering were approximately $288 million before deducting underwriting discounts and commissions and other offering expenses payable by Dianthus. All of the securities were offered by Dianthus.

Dianthus intends to use the net proceeds from this offering to advance the Company’s preclinical and clinical development activities, as well as for working capital and general corporate purposes.

Jefferies, TD Cowen, Evercore ISI and Stifel acted as joint book-running managers for the offering. LifeSci Capital also acted as lead manager for the offering.

A shelf registration statement relating to these securities was filed with the Securities and Exchange Commission (“SEC”) and became effective on October 9, 2024. This offering was made only by means of a written prospectus, including a prospectus supplement, forming a part of an effective registration statement. A final prospectus supplement and accompanying prospectus relating to the offering have been filed with the SEC and are available on the SEC’s website, located at www.sec.gov., and may also be obtained from: Jefferies LLC, Attention: Equity Syndicate Prospectus Department, 520 Madison Avenue, New York, NY 10022, by telephone at (877) 821-7388, or by email at Prospectus_Department@Jefferies.com; TD Securities (USA) LLC, 1 Vanderbilt Avenue, New York, NY 10017, by telephone at (855) 495-9846, or by email at TD.ECM_Prospectus@tdsecurities.com; Evercore Group L.L.C., Attention: Equity Capital Markets, 55 East 52nd Street, 35th Floor, New York, NY 10055, by telephone at (888) 474-0200, or by email at ecm.prospectus@evercore.com; or Stifel, Nicolaus & Company, Incorporated, Attention: Syndicate, One Montgomery Street, Suite 3700, San Francisco, CA 94104, by telephone at (415) 364-2720, or by email at syndprospectus@stifel.com.

This press release shall not constitute an offer to sell, or the solicitation of an offer to buy, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation, or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.

About Dianthus Therapeutics

Dianthus Therapeutics is a clinical-stage biotechnology company dedicated to designing and delivering novel, best-in-class monoclonal antibodies with improved selectivity and potency. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who are leading the development of next-generation antibody complement therapeutics, aiming to deliver transformative medicines for people living with severe autoimmune and inflammatory diseases.

Cautionary Statement Regarding Forward-Looking Statements

Certain statements in this press release, other than purely historical information, may constitute “forward-looking statements” within the meaning of the federal securities laws, including for purposes of the safe harbor provisions under the United States Private Securities Litigation Reform Act of 1995, express or implied statements regarding Dianthus’ expectations regarding the use of proceeds from the public offering and the potential value and clinical benefit of the Company’s product candidates. The words “opportunity,” “potential,” “milestones,” “runway,” “will,” “anticipate,” “achieve,” “near-term,” “catalysts,” “pursue,” “pipeline,” “believe,” “continue,” “could,” “estimate,” “expect,” “intend,” “may,” “might,” “plan,” “possible,” “predict,” “project,” “should,” “strive,” “would,” “aim,” “target,” “commit,” and similar expressions (including the negatives of these terms or variations of them) generally identify forward-looking statements, but the absence of these words does not mean that statement is not forward looking.

Actual results could differ materially from those included in the forward-looking statements due to various factors, risks and uncertainties, including, but not limited to, that preclinical testing of claseprubart and data from clinical trials may not be predictive of the results or success of ongoing or later clinical trials, that the development of claseprubart or the Company’s other compounds may take longer and/or cost more than planned, that the Company may be unable to successfully complete the clinical development of the Company’s compounds, that the Company may be delayed in initiating, enrolling or completing its planned clinical trials, and that the Company’s compounds may not receive regulatory approval or become commercially successful products. These and other risks and uncertainties are identified under the heading “Risk Factors” included in the Company’s Annual Report on Form 10-K for the period ended December 31, 2024, and other filings that the Company has made and may make with the SEC in the future. Nothing in this press release should be regarded as a representation by any person that the forward-looking statements set forth herein will be achieved or that any of the contemplated results of such forward-looking statements will be achieved.

The forward-looking statements in this press release speak only as of the date they are made and are qualified in their entirety by reference to the cautionary statements herein. Dianthus undertakes no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future events or otherwise, except as required by law.

Contact
Jennifer Davis Ruff
Dianthus Therapeutics
jdavisruff@dianthustx.com

Sep 09 2025 | Dianthus Therapeutics, Inc. Announces Pricing of Upsized $251 Million Underwritten Public Offering
NEW YORK and WALTHAM, Mass., Sept. 09, 2025 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to advancing the next… READ MORE
News
Sep 09 2025 | Dianthus Therapeutics, Inc. Announces Pricing of Upsized $251 Million Underwritten Public Offering

NEW YORK and WALTHAM, Mass., Sept. 09, 2025 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to advancing the next generation of antibody complement therapeutics to treat severe autoimmune diseases (“Dianthus” or the “Company”), today announced the pricing of its previously announced upsized underwritten public offering of 6,487,879 shares of its common stock at a public offering price per share of $33.00 and, in lieu of common stock to certain investors, pre-funded warrants to purchase up to 1,112,121 shares of its common stock at a public offering price of $32.999 per pre-funded warrant. The pre-funded warrants have an exercise price of $0.001 per share and are exercisable immediately. The aggregate gross proceeds to Dianthus from the offering are expected to be approximately $251 million before deducting underwriting discounts and commissions and other offering expenses payable by Dianthus, excluding any exercise of the underwriters’ option to purchase additional shares. The offering is expected to close on September 11, 2025, subject to the satisfaction of customary closing conditions. In addition, Dianthus has granted the underwriters a 30-day option to purchase up to an additional 1,140,000 shares of its common stock at the public offering price, less underwriting discounts and commissions. All of the securities are being offered by Dianthus.

Dianthus intends to use the net proceeds from this offering to advance the Company’s preclinical and clinical development activities, as well as for working capital and general corporate purposes.

Jefferies, TD Cowen, Evercore ISI and Stifel are acting as joint book-running managers for the offering. LifeSci Capital is also acting as lead manager for the offering.

A shelf registration statement relating to these securities was filed with the Securities and Exchange Commission (“SEC”) and became effective on October 9, 2024. This offering is being made only by means of a written prospectus, including a prospectus supplement, forming a part of an effective registration statement. A preliminary prospectus supplement and accompanying prospectus relating to the offering have been filed with the SEC and are available on the SEC’s website, located at www.sec.gov. A copy of the final prospectus supplement and the accompanying prospectus relating to the offering will be filed with the SEC and will be available on the SEC’s website, located at www.sec.gov, and, when available, may be obtained from: Jefferies LLC, Attention: Equity Syndicate Prospectus Department, 520 Madison Avenue, New York, NY 10022, by telephone at (877) 821-7388, or by email at Prospectus_Department@Jefferies.com; TD Securities (USA) LLC, 1 Vanderbilt Avenue, New York, NY 10017, by telephone at (855) 495-9846, or by email at TD.ECM_Prospectus@tdsecurities.com; Evercore Group L.L.C., Attention: Equity Capital Markets, 55 East 52nd Street, 35th Floor, New York, NY 10055, by telephone at (888) 474-0200, or by email at ecm.prospectus@evercore.com; or Stifel, Nicolaus & Company, Incorporated, Attention: Syndicate, One Montgomery Street, Suite 3700, San Francisco, CA 94104, by telephone at (415) 364-2720, or by email at syndprospectus@stifel.com.

This press release shall not constitute an offer to sell, or the solicitation of an offer to buy, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation, or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.

About Dianthus Therapeutics

Dianthus Therapeutics is a clinical-stage biotechnology company dedicated to designing and delivering novel, best-in-class monoclonal antibodies with improved selectivity and potency. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who are leading the development of next-generation antibody complement therapeutics, aiming to deliver transformative medicines for people living with severe autoimmune and inflammatory diseases.

Cautionary Statement Regarding Forward-Looking Statements

Certain statements in this press release, other than purely historical information, may constitute “forward-looking statements” within the meaning of the federal securities laws, including for purposes of the safe harbor provisions under the United States Private Securities Litigation Reform Act of 1995, express or implied statements regarding Dianthus’ expectations regarding the consummation of the offering, the satisfaction of customary closing conditions with respect to the offering and the potential value and clinical benefit of the Company’s product candidates. The words “opportunity,” “potential,” “milestones,” “runway,” “will,” “anticipate,” “achieve,” “near-term,” “catalysts,” “pursue,” “pipeline,” “believe,” “continue,” “could,” “estimate,” “expect,” “intend,” “may,” “might,” “plan,” “possible,” “predict,” “project,” “should,” “strive,” “would,” “aim,” “target,” “commit,” and similar expressions (including the negatives of these terms or variations of them) generally identify forward-looking statements, but the absence of these words does not mean that statement is not forward looking.

Actual results could differ materially from those included in the forward-looking statements due to various factors, risks and uncertainties, including, but not limited to, that preclinical testing of claseprubart and data from clinical trials may not be predictive of the results or success of ongoing or later clinical trials, that the development of claseprubart or the Company’s other compounds may take longer and/or cost more than planned, that the Company may be unable to successfully complete the clinical development of the Company’s compounds, that the Company may be delayed in initiating, enrolling or completing its planned clinical trials, and that the Company’s compounds may not receive regulatory approval or become commercially successful products. These and other risks and uncertainties are identified under the heading “Risk Factors” included in the Company’s Annual Report on Form 10-K for the period ended December 31, 2024, and other filings that the Company has made and may make with the SEC in the future. Nothing in this press release should be regarded as a representation by any person that the forward-looking statements set forth herein will be achieved or that any of the contemplated results of such forward-looking statements will be achieved.

The forward-looking statements in this press release speak only as of the date they are made and are qualified in their entirety by reference to the cautionary statements herein. Dianthus undertakes no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future events or otherwise, except as required by law.

Contact
Jennifer Davis Ruff
Dianthus Therapeutics
jdavisruff@dianthustx.com

Sep 08 2025 | Dianthus Therapeutics, Inc. Announces Proposed $150 Million Underwritten Public Offering
NEW YORK and WALTHAM, Mass., Sept. 08, 2025 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to advancing the next… READ MORE
News
Sep 08 2025 | Dianthus Therapeutics, Inc. Announces Proposed $150 Million Underwritten Public Offering

NEW YORK and WALTHAM, Mass., Sept. 08, 2025 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to advancing the next generation of antibody complement therapeutics to treat severe autoimmune diseases (“Dianthus” or the “Company”), today announced that it has commenced an underwritten public offering of $150 million of its shares of its common stock or, in lieu of common stock to certain investors that so choose, pre-funded warrants to purchase shares of its common stock. In addition, Dianthus expects to grant the underwriters a 30-day option to purchase up to an additional $22.5 million of its shares of common stock at the public offering price, less underwriting discounts and commissions. The proposed public offering is subject to market and other conditions, and there can be no assurance as to whether or when the offering may be completed or as to the actual size or terms of the offering. All of the securities are being offered by Dianthus.

Dianthus intends to use the net proceeds from this offering to advance the Company’s preclinical and clinical development activities, as well as for working capital and general corporate purposes.

Jefferies, TD Cowen, Evercore ISI and Stifel are acting as joint book-running managers for the proposed offering.

A shelf registration statement relating to these securities was filed with the Securities and Exchange Commission (“SEC”) and became effective on October 9, 2024. This offering will be made only by means of a written prospectus, including a prospectus supplement, forming a part of an effective registration statement. A copy of the preliminary prospectus supplement and the accompanying prospectus relating to the offering may be obtained, when available, from: Jefferies LLC, Attention: Equity Syndicate Prospectus Department, 520 Madison Avenue, New York, NY 10022, by telephone at (877) 821-7388, or by email at Prospectus_Department@Jefferies.com; TD Securities (USA) LLC, 1 Vanderbilt Avenue, New York, NY 10017, by telephone at (855) 495-9846, or by email at TD.ECM_Prospectus@tdsecurities.com; Evercore Group L.L.C., Attention: Equity Capital Markets, 55 East 52nd Street, 35th Floor, New York, NY 10055, by telephone at (888) 474-0200, or by email at ecm.prospectus@evercore.com; or Stifel, Nicolaus & Company, Incorporated, Attention: Syndicate, One Montgomery Street, Suite 3700, San Francisco, CA 94104, by telephone at (415) 364-2720, or by email at syndprospectus@stifel.com.

This press release shall not constitute an offer to sell, or the solicitation of an offer to buy, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation, or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.

About Dianthus Therapeutics

Dianthus Therapeutics is a clinical-stage biotechnology company dedicated to designing and delivering novel, best-in-class monoclonal antibodies with improved selectivity and potency. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who are leading the development of next-generation antibody complement therapeutics, aiming to deliver transformative medicines for people living with severe autoimmune and inflammatory diseases.

Cautionary Statement Regarding Forward-Looking Statements

Certain statements in this press release, other than purely historical information, may constitute “forward-looking statements” within the meaning of the federal securities laws, including for purposes of the safe harbor provisions under the United States Private Securities Litigation Reform Act of 1995, express or implied statements regarding Dianthus’ expectations regarding the proposed offering, including the timing, size, structure and completion of the proposed offering on the anticipated terms, the anticipated use of the net proceeds from the offering, the grant to the underwriters of the option to purchase additional shares and the potential value and clinical benefit of the Company’s product candidates. The words “opportunity,” “potential,” “milestones,” “runway,” “will,” “anticipate,” “achieve,” “near-term,” “catalysts,” “pursue,” “pipeline,” “believe,” “continue,” “could,” “estimate,” “expect,” “intend,” “may,” “might,” “plan,” “possible,” “predict,” “project,” “should,” “strive,” “would,” “aim,” “target,” “commit,” and similar expressions (including the negatives of these terms or variations of them) generally identify forward-looking statements, but the absence of these words does not mean that statement is not forward looking.

Actual results could differ materially from those included in the forward-looking statements due to various factors, risks and uncertainties, including, but not limited to, that preclinical testing of claseprubart and data from clinical trials may not be predictive of the results or success of ongoing or later clinical trials, that the development of claseprubart or the Company’s other compounds may take longer and/or cost more than planned, that the Company may be unable to successfully complete the clinical development of the Company’s compounds, that the Company may be delayed in initiating, enrolling or completing its planned clinical trials, and that the Company’s compounds may not receive regulatory approval or become commercially successful products. These and other risks and uncertainties are identified under the heading “Risk Factors” included in the Company’s Annual Report on Form 10-K for the period ended December 31, 2024, and other filings that the Company has made and may make with the SEC in the future. Nothing in this press release should be regarded as a representation by any person that the forward-looking statements set forth herein will be achieved or that any of the contemplated results of such forward-looking statements will be achieved.

The forward-looking statements in this press release speak only as of the date they are made and are qualified in their entirety by reference to the cautionary statements herein. Dianthus undertakes no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future events or otherwise, except as required by law.

Contact
Jennifer Davis Ruff
Dianthus Therapeutics
jdavisruff@dianthustx.com

Sep 08 2025 | Dianthus Therapeutics Announces Positive Data for Claseprubart (DNTH103) from the Phase 2 MaGic Trial in Generalized Myasthenia Gravis, Supporting Its Potential Best-In-Class Profile
Claseprubart 300mg and 600mg Q2W doses both achieved statistically significant and clinically meaningful improvements in Myasthenia Gravis Activities of Daily Living (MG-ADL) and Quantitative Myasthenia… READ MORE
News
Sep 08 2025 | Dianthus Therapeutics Announces Positive Data for Claseprubart (DNTH103) from the Phase 2 MaGic Trial in Generalized Myasthenia Gravis, Supporting Its Potential Best-In-Class Profile

Claseprubart 300mg and 600mg Q2W doses both achieved statistically significant and clinically meaningful improvements in Myasthenia Gravis Activities of Daily Living (MG-ADL) and Quantitative Myasthenia Gravis (QMG) scores at Week 13

Claseprubart demonstrated a rapid and sustained onset of action, with both doses achieving statistically significant improvements in MG-ADL and QMG scores at Week 1

Claseprubart 300mg Q2W dose was also statistically significant and clinically meaningful across other key efficacy endpoints, including Minimal Symptom Expression (MSE), Myasthenia Gravis Composite (MGC) Score and the Myasthenia Gravis Quality of Life Scale (MG-QoL-15r)

Both 300mg and 600mg doses of claseprubart were comparable across key efficacy endpoints, supporting its target product profile of a single, convenient 300mg/2mL self-administered, subcutaneous autoinjector dosed once every two weeks

Claseprubart had a favorable safety profile with no related serious infections, clinical symptoms of emergent autoimmune disease, or drug-related serious adverse events or discontinuations, supporting its target product profile of no Boxed Warning or REMS for meningococcal infections

Phase 3 gMG trial evaluating 300mg/2mL Q2W and Q4W vs. placebo anticipated to initiate in 2026

Investor conference call and webcast to be held today, September 8, 2025 at 8:00 a.m. ET 

NEW YORK and WALTHAM, Mass., Sept. 08, 2025 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to advancing the next generation of antibody complement therapeutics to treat severe autoimmune diseases, today announced positive top-line data from the Phase 2 MaGic trial evaluating the safety and efficacy of claseprubart (DNTH103) in adults with acetylcholine receptor antibody positive (AChR+) generalized Myasthenia Gravis (gMG).

“The results from MaGic mark a significant milestone for Dianthus and are an important step forward for people living with gMG. These results are also a reflection of the commitment and talent of the entire Dianthus team, and I want to thank them for their outstanding execution of this clinical trial,” said Marino Garcia, President and Chief Executive Officer of Dianthus Therapeutics. “The concordance of the efficacy and safety data from the MaGic trial strongly support our best-in-class target product profile for claseprubart 300mg/2mL Q2W in gMG and bolsters our confidence in our execution of the CIDP and MMN clinical programs.”

About the Phase 2 MaGic Trial
The MaGic trial is a global, randomized, double-blind, placebo-controlled Phase 2 trial that enrolled 65 AChR+ participants with gMG. Following an initial loading dose, claseprubart was administered every two weeks (Q2W) via subcutaneous (S.C.) injection at a dose of 300mg/2mL or 600mg/4mL. The initial randomized treatment duration was 13 weeks, followed by a 52-week open-label extension. The primary endpoint of the study was safety and tolerability. Secondary and exploratory efficacy endpoints included Myasthenia Gravis Activities of Daily Living Scale (MG-ADL) and Quantitative Myasthenia Gravis (QMG) score assessments, as well as Minimal Symptom Expression (MSE), Myasthenia Gravis Composite (MGC) score and the Myasthenia Gravis Quality of Life Scale (MG-QOL-15r). 

Summary Results from the Phase 2 MaGic Trial
Claseprubart 300mg and 600mg demonstrated rapid, statistically significant and clinically meaningful improvements over placebo as measured by both MG-ADL and QMG, including at Week 1 and at Week 13. The claseprubart 300mg Q2W dose was also statistically significant and clinically meaningful across other key efficacy endpoints, including Minimal Symptom Expression (MSE), Myasthenia Gravis Composite (MGC) Score and the Myasthenia Gravis Quality of Life Scale (MG-QoL-15r).

Claseprubart was generally well tolerated with no drug-related Serious Adverse Events (SAEs) or discontinuations due to any related adverse event. Claseprubart had a favorable clinical safety profile comparable to placebo with no treatment-related serious bacterial infections and no clinical symptoms of emergent autoimmune disorders observed.

“I would like to thank the MaGic investigators and site staff who made the seamless execution of this study possible,” said Simrat Randhawa, MD, Chief Medical Officer of Dianthus Therapeutics. “The consistent and meaningful treatment effect seen in both treatment arms across multiple standard MG efficacy metrics in this Phase 2 trial gives me and my team great confidence in our ability to execute a successful Phase 3 trial.”

“gMG is a chronic condition that can be treated with complement and FcRn inhibitors. The ideal drug should provide continuous symptom control and have low infection risks, infrequent side effects, convenient dosing schedule, and minimal administration burden,” said Dr. Tuan Vu, a Professor of Neurology at the University of South Florida Morsani College of Medicine. “If these impressive results were replicated in a Phase 3 trial, claseprubart may be a differentiated treatment option for patients with gMG.”

Efficacy Results

MG-ADL

  • Claseprubart dosed at 300mg S.C. Q2W achieved a statistically significant and clinically meaningful mean improvement from baseline of 4.6 points in MG-ADL score at Week 13 (placebo-adjusted improvement: 1.8 points; P=0.0113). A statistically significant improvement in the MG-ADL was also seen as early as Week 1 with 300mg.
  • Claseprubart dosed at 600mg S.C. Q2W achieved a statistically significant and clinically meaningful mean improvement from baseline of 5.4 points in MG-ADL score at Week 13 (placebo-adjusted improvement: 2.6 points; P=0.0006). A statistically significant improvement in the MG-ADL was also seen as early as Week 1 with 600mg.
  • As expected, there was no statistically significant difference between the claseprubart 300mg and 600mg arms in MG-ADL score at any time point.

QMG

  • Claseprubart dosed at 300mg S.C. Q2W achieved a statistically significant and clinically meaningful mean improvement from baseline of 4.4 points in QMG score at Week 13 (placebo-adjusted improvement: 2.4; P=0.0144). A statistically significant improvement in QMG was also seen as early as Week 1 with 300mg.
  • Claseprubart dosed at 600mg S.C. Q2W achieved a statistically significant and clinically meaningful mean improvement from baseline of 4.5 points in QMG score at Week 13 (placebo-adjusted improvement: 2.5; P=0.0111). A statistically significant improvement in QMG was also seen as early as Week 1 with 600mg.
  • As expected, there was no statistically significant difference between the claseprubart 300mg and 600mg arms in QMG score at any time point.

Efficacy Summary at Week 13

  Placebo
N=22
Claseprubart 300mg Q2W
N=21
Claseprubart 600mg Q2W
N=22
    Absolute Placebo-Adjusted Absolute Placebo-Adjusted
MG-ADL mean change from baseline -2.8   -4.6   -1.8
(P=0.0113)*
-5.4   -2.6
(P=0.0006)*
QMG mean change from baseline -2.0   -4.4   -2.4
(P=0.0144)*
-4.5   -2.5
(P=0.0111)*
MSE 14%   37%   23%
(P=0.0550)*
27%   13%
(P=0.1031)
MGC mean change from baseline -3.1   -8.7   -5.6
(P=0.0008)*
-8.6   -5.5
(P=0.0008)*
MG-QoL-15r mean change from baseline -3.9   -6.1   -2.2
(P=0.0414)*
-5.4   -1.5
(P=0.1122)

*One-sided p-values are presented for comparisons of claseprubart vs placebo, with any p-value below 0.1 considered nominally statistically significant.

Safety and Tolerability Results

  • Claseprubart was generally well tolerated and demonstrated a clinical safety profile in both treatment arms comparable to placebo.
  • No infection signal was observed, including no related serious bacterial infections in the treatment arms; the only related serious adverse event (SAE) of infection occurred in the placebo arm.
  • There were no symptoms indicative of autoimmune activation.
  • Injection site reactions (ISRs) were infrequent and generally mild, and there were no claseprubart discontinuations from RCT due to related AEs.

Next Steps
“Based on the comparable efficacy data demonstrated in MaGic by the 300mg and 600mg Q2W doses, as well as encouraging early data from the open-label extension, we are planning for an end-of-Phase 2 meeting with the FDA to align on the proposed design of a Phase 3 trial for claseprubart in Myasthenia Gravis that investigates both 300mg Q2W and 300mg Q4W doses vs. placebo,” said Marino Garcia, President and Chief Executive Officer of Dianthus Therapeutics. “2026 will be a catalyst-rich year, with the initiation of the Phase 3 gMG trial followed by results from the interim responder analysis of the Phase 3 CAPTIVATE trial in Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) and top-line results from the Phase 2 MoMeNtum trial in Multifocal Motor Neuropathy (MMN), both in 2H’26.”

Investor Conference Call & Webcast to be Held at 8:00 a.m. ET Today
Dianthus Therapeutics will host an investor call and webcast to discuss the Phase 2 MaGic results today, September 8, 2025 at 8:00 a.m. ET. Please click here to register for this event.

The live webcast may be accessed via the Investors section of the Dianthus Therapeutics website at https://investor.dianthustx.com/. A replay of the webcast will be available following the call.

About Claseprubart (DNTH103)
Claseprubart is an investigational, clinical-stage, potent monoclonal antibody engineered to selectively target the classical pathway by inhibiting only the active form of the C1s protein, a clinically validated complement target. Claseprubart is enhanced with YTE half-life extension technology designed to enable a more convenient subcutaneous, infrequently dosed, self-administered injection. Additionally, selective inhibition of the classical complement pathway may lower patient risk of infection from encapsulated bacteria by preserving immune activity of the lectin and alternative pathways. As the classical pathway plays a significant role in disease pathology, claseprubart has the potential to be a best-in-class pipeline-in-a-product across a range of autoimmune disorders with high unmet need. Dianthus is building a neuromuscular franchise with claseprubart and expects to initiate a Phase 3 trial in gMG in 2026, the interim responder analysis of the Phase 3 CAPTIVATE trial in Chronic Inflammatory Demyelinating Polyneuropathy in 2H’26, and top-line data from the Phase 2 MoMeNtum trial in Multifocal Motor Neuropathy in 2H’26.

Claseprubart is an investigational agent that is not approved as a therapy in any indication in any jurisdiction worldwide.

About Generalized Myasthenia Gravis
Generalized Myasthenia Gravis (gMG) is a chronic autoimmune disorder driven by the classical pathway that causes progressive muscle weakness. Over 100,000 people in the U.S. are living with gMG and approximately 85% have AChR autoantibody-driven disease. Despite availability of current treatment options, a significant number of patients remain uncontrolled and are seeking better treatment options which may offer sustained efficacy, lower potential risk for infections, and convenient dosing and administration.

About Dianthus Therapeutics
Dianthus Therapeutics is a clinical-stage biotechnology company dedicated to designing and delivering novel, best-in-class monoclonal antibodies with improved selectivity and potency. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who are leading the development of next-generation antibody complement therapeutics, aiming to deliver transformative medicines for people living with severe autoimmune and inflammatory diseases.

To learn more, please visit www.dianthustx.com and follow us on LinkedIn

Cautionary Statement Regarding Forward-Looking Statements
Certain statements in this press release, other than purely historical information, may constitute “forward-looking statements” within the meaning of the federal securities laws, including for purposes of the safe harbor provisions under the United States Private Securities Litigation Reform Act of 1995, express or implied statements regarding future plans and prospects, including statements regarding the expectations or plans for discovery, preclinical studies, clinical trials and research and development programs, in particular with respect to claseprubart, and any developments or results in connection therewith, including the target product profile and administration of claseprubart; the anticipated timing of the initiation and results from those studies and trials; expectations regarding the clinical trial design for the Phase 3 trial for claseprubart in gMG; expectations regarding the time period over which the Company’s capital resources are expected to be sufficient to fund its anticipated operations; and expectations regarding market size, patient population size, and potential opportunities for complement therapies, in particular with respect to claseprubart. Claseprubart is an investigational agent that is not approved as a therapy in any indication in any jurisdiction worldwide. The words “opportunity,” “potential,” “milestones,” “runway,” “will,” “anticipate,” “achieve,” “near-term,” “catalysts,” “pursue,” “pipeline,” “believe,” “continue,” “could,” “estimate,” “expect,” “intend,” “may,” “might,” “plan,” “possible,” “predict,” “project,” “should,” “strive,” “would,” “aim,” “target,” “commit,” and similar expressions (including the negatives of these terms or variations of them) generally identify forward-looking statements, but the absence of these words does not mean that statement is not forward looking.

Actual results could differ materially from those included in the forward-looking statements due to various factors, risks and uncertainties, including, but not limited to, that preclinical testing of claseprubart and data from clinical trials may not be predictive of the results or success of ongoing or later clinical trials, that the development of claseprubart or the Company’s other compounds may take longer and/or cost more than planned, that the Company may be unable to successfully complete the clinical development of the Company’s compounds, that the Company may be delayed in initiating, enrolling or completing its planned clinical trials, and that the Company’s compounds may not receive regulatory approval or become commercially successful products. These and other risks and uncertainties are identified under the heading “Risk Factors” included in the Company’s Annual Report on Form 10-K for the period ended December 31, 2024, and other filings that the Company has made and may make with the SEC in the future. Nothing in this press release should be regarded as a representation by any person that the forward-looking statements set forth herein will be achieved or that any of the contemplated results of such forward-looking statements will be achieved.

The forward-looking statements in this press release speak only as of the date they are made and are qualified in their entirety by reference to the cautionary statements herein. Dianthus undertakes no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future events or otherwise, except as required by law.

Contact
Jennifer Davis Ruff
Dianthus Therapeutics
jdavisruff@dianthustx.com

Sep 07 2025 | Dianthus Therapeutics to Host Conference Call and Webcast to Discuss Results from Phase 2 MaGic Trial of Claseprubart (DNTH103) in Generalized Myasthenia Gravis
NEW YORK and WALTHAM, Mass., Sept. 07, 2025 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to advancing the next… READ MORE
News
Sep 07 2025 | Dianthus Therapeutics to Host Conference Call and Webcast to Discuss Results from Phase 2 MaGic Trial of Claseprubart (DNTH103) in Generalized Myasthenia Gravis

NEW YORK and WALTHAM, Mass., Sept. 07, 2025 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to advancing the next generation of antibody complement therapeutics to treat severe autoimmune diseases, today announced a conference call and webcast to discuss results from the Phase 2 MaGic trial of claseprubart (DNTH103) in generalized Myasthenia Gravis (gMG) scheduled for tomorrow, Monday, September 8, 2025 at 8:00 a.m. EDT.

Investor Webcast & Conference Call Information
To access the live conference call by phone, please register here. Conference call participants in the question and answer session should pre-register to receive the dial-in number and personal PIN. 

A live webcast may be accessed through the Investors and Media section of the Company’s website, www.dianthustx.com. Following the call, a replay will be available at the same location.

About Dianthus Therapeutics
Dianthus Therapeutics is a clinical-stage biotechnology company dedicated to designing and delivering novel, best-in-class monoclonal antibodies with improved selectivity and potency. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who are leading the development of next-generation antibody complement therapeutics, aiming to deliver transformative medicines for people living with severe autoimmune and inflammatory diseases.

To learn more, please visit www.dianthustx.com and follow us on LinkedIn

Contact
Jennifer Davis Ruff
Dianthus Therapeutics
jdavisruff@dianthustx.com

Aug 07 2025 | Dianthus Therapeutics Highlights Recent Business Achievements and Reports Q2 Financial Results
Phase 2 MaGic trial of claseprubart (DNTH103) in generalized Myasthenia Gravis (gMG) top-line results anticipated in September 2025; the first of three catalysts for the… READ MORE
News
Aug 07 2025 | Dianthus Therapeutics Highlights Recent Business Achievements and Reports Q2 Financial Results

Phase 2 MaGic trial of claseprubart (DNTH103) in generalized Myasthenia Gravis (gMG) top-line results anticipated in September 2025; the first of three catalysts for the claseprubart neuromuscular franchise by YE’26

Phase 3 CAPTIVATE trial of claseprubart in Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) ongoing; interim responder analysis anticipated in 2H’26

Phase 2 MoMeNtum trial of claseprubart in Multifocal Motor Neuropathy (MMN) ongoing;
top-line results anticipated in 2H’26

$309.1 million of cash provides runway into 2H’27

NEW YORK and WALTHAM, Mass., Aug. 07, 2025 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to advancing the next generation of antibody complement therapeutics to treat severe autoimmune diseases, today reported financial results for the second quarter ending June 30, 2025, and provided an update on recent business achievements.

“We look forward to reporting top-line Phase 2 results from our MaGic trial with claseprubart in gMG in September. We believe the multibillion-dollar gMG market has significant potential to expand, as only approximately 10% of AChR+ patients in the U.S. are currently on FcRn or complement therapies today,” said Marino Garcia, Chief Executive Officer of Dianthus Therapeutics. “Our recently completed quantitative market research with gMG treating neurologists in the U.S. clearly highlights their desire for new, improved therapies, specifically those with greater durability of symptom control, a differentiated safety profile by eliminating the boxed warning and REMS of C5 inhibitors, and a more convenient, patient-friendly delivery like an infrequent, self-administered autoinjector. We believe claseprubart has the potential to effectively address these unmet needs and help expand the use of biologics earlier in the treatment paradigm with patients that would otherwise delay the use of more burdensome biologics.”

Claseprubart (DNTH103) Clinical Development

Claseprubart is an investigational, clinical-stage, potent monoclonal antibody engineered to selectively target the classical pathway by inhibiting only the active form of the C1s protein, a clinically validated complement target. Claseprubart is designed to enable a more convenient, subcutaneous, self-administered injection dosed as infrequently as once every two weeks. Claseprubart has the potential to be a best-in-class pipeline-in-a-product across a range of autoimmune disorders with high unmet need.

Generalized Myasthenia Gravis (gMG)

  • Top-line Phase 2 MaGic gMG trial results anticipated in September: The MaGic trial is a global, randomized, double-blind, placebo-controlled Phase 2 trial in patients with gMG who are acetylcholine receptor (AChR) antibody positive. As previously announced in May, enrollment in this trial was completed with 65 patients, exceeding the target of 60.

Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

  • Phase 3 CAPTIVATE CIDP trial ongoing: The CAPTIVATE trial is a single, global, two-part, randomized withdrawal Phase 3 trial in patients with CIDP, and it remains on track for an interim responder analysis in 2H’26. The Company believes this single pivotal trial will support a BLA filing in adult patients with CIDP.

Multifocal Motor Neuropathy (MMN)

  • Phase 2 MoMeNtum MMN trial ongoing: The MoMeNtum trial is a global, randomized, double-blind, placebo-controlled Phase 2 trial in patients with MMN, and it remains on track to report top-line results in 2H’26.

Corporate Updates

  • The International Nonproprietary Name (INN) has been finalized and DNTH103, a potentially best-in-class investigational classical pathway inhibitor, is now called claseprubart.
  • On May 22, 2025, Simon Read, Ph.D., joined the Company’s Board of Directors. Dr. Read is a serial entrepreneur with more than 30 years of biopharmaceutical experience. He served as CEO and Founder of Mariana Oncology until its acquisition by Novartis in 2024 and CSO of Ra Pharma until its acquisition by UCB in 2020.

Second-Quarter 2025 Financial Results

  • Cash Position – $309.1 million of cash, cash equivalents and investments as of June 30, 2025 is projected to provide runway into the second half of 2027.
  • R&D Expenses – Research and development (R&D) expenses for the quarter ended June 30, 2025 were $26.3 million, inclusive of $2.5 million of stock-based compensation, compared to $18.1 million for the quarter ended June 30, 2024, which included $1.4 million of stock-based compensation. This increase in R&D expenses was primarily driven by higher clinical costs, chemistry, manufacturing and controls (CMC) costs, and increased headcount to support claseprubart Phase 2 and Phase 3 development.
  • G&A Expenses – General and administrative (G&A) expenses for the quarter ended June 30, 2025 totaled $8.9 million, inclusive of stock-based compensation of $3.2 million, compared to $6.0 million for the quarter ended June 30, 2024, which included $1.8 million of stock-based compensation. This increase in G&A expenses was primarily due to increased headcount.
  • Net Loss – Net loss for the quarter ended June 30, 2025 was $31.6 million or $0.88 per share (basic and diluted) compared to $17.6 million or $0.51 per share (basic and diluted) for the quarter ended June 30, 2024.
  • Additional Information – For additional information on the Company’s financial results for the quarter ended June 30, 2025, please refer to the Form 10-Q filed with the SEC.

About Claseprubart
Claseprubart is an investigational, clinical-stage, potent monoclonal antibody engineered to selectively target the classical pathway by inhibiting only the active form of the C1s protein, a clinically validated complement target. Claseprubart is enhanced with YTE half-life extension technology designed to enable a more convenient subcutaneous, self-administered injection dosed as infrequently as once every two weeks. Additionally, selective inhibition of the classical complement pathway may lower patient risk of infection from encapsulated bacteria by preserving immune activity of the lectin and alternative pathways. As the classical pathway plays a significant role in disease pathology, claseprubart has the potential to be a best-in-class pipeline-in-a-product across a range of autoimmune disorders with high unmet need. Dianthus is building a neuromuscular franchise with claseprubart and anticipates reporting top-line data from the Phase 2 MaGic trial in generalized Myasthenia Gravis in September 2025, the interim responder analysis of the Phase 3 CAPTIVATE trial in Chronic Inflammatory Demyelinating Polyneuropathy in 2H’26, and top-line data from the Phase 2 MoMeNtum trial in Multifocal Motor Neuropathy in 2H’26.

Claseprubart is an investigational agent that is not approved as a therapy in any indication in any jurisdiction worldwide.

About Dianthus Therapeutics
Dianthus Therapeutics is a clinical-stage biotechnology company dedicated to designing and delivering novel, best-in-class monoclonal antibodies with improved selectivity and potency. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who are leading the development of next-generation antibody complement therapeutics, aiming to deliver transformative medicines for people living with severe autoimmune and inflammatory diseases.

To learn more, please visit www.dianthustx.com and follow us on LinkedIn

Cautionary Statement Regarding Forward-Looking Statements
Certain statements in this press release, other than purely historical information, may constitute “forward-looking statements” within the meaning of the federal securities laws, including for purposes of the safe harbor provisions under the United States Private Securities Litigation Reform Act of 1995, express or implied statements regarding future plans and prospects, including statements regarding the expectations or plans for discovery, preclinical studies, clinical trials and research and development programs, in particular with respect to claseprubart, and any developments or results in connection therewith, including the target product profile and administration of claseprubart; the anticipated timing of the initiation and results from those studies and trials; expectations regarding the time period over which the Company’s capital resources are expected to be sufficient to fund its anticipated operations; and expectations regarding the market and potential opportunities for complement therapies, in particular with respect to claseprubart. Claseprubart is an investigational agent that is not approved as a therapy in any indication in any jurisdiction worldwide. The words “opportunity,” “potential,” “milestones,” “runway,” “will,” “anticipate,” “achieve,” “near-term,” “catalysts,” “pursue,” “pipeline,” “believe,” “continue,” “could,” “estimate,” “expect,” “intend,” “may,” “might,” “plan,” “possible,” “predict,” “project,” “should,” “strive,” “would,” “aim,” “target,” “commit,” and similar expressions (including the negatives of these terms or variations of them) generally identify forward-looking statements, but the absence of these words does not mean that statement is not forward looking.

Actual results could differ materially from those included in the forward-looking statements due to various factors, risks and uncertainties, including, but not limited to, that preclinical testing of claseprubart and data from clinical trials may not be predictive of the results or success of ongoing or later clinical trials, that the development of claseprubart or the Company’s other compounds may take longer and/or cost more than planned, that the Company may be unable to successfully complete the clinical development of the Company’s compounds, that the Company may be delayed in initiating, enrolling or completing its planned clinical trials, and that the Company’s compounds may not receive regulatory approval or become commercially successful products. These and other risks and uncertainties are identified under the heading “Risk Factors” included in the Company’s Annual Report on Form 10-K for the period ended December 31, 2024, and other filings that the Company has made and may make with the SEC in the future. Nothing in this press release should be regarded as a representation by any person that the forward-looking statements set forth herein will be achieved or that any of the contemplated results of such forward-looking statements will be achieved.

The forward-looking statements in this press release speak only as of the date they are made and are qualified in their entirety by reference to the cautionary statements herein. Dianthus undertakes no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future events or otherwise, except as required by law.

Contact
Jennifer Davis Ruff
Dianthus Therapeutics
jdavisruff@dianthustx.com

DIANTHUS THERAPEUTICS, INC.

Condensed Consolidated Balance Sheets
(in thousands, except share and per share data)
(unaudited)

 
  June 30,
2025
    December 31,
2024
 
Assets          
Current assets:          
Cash and cash equivalents $ 13,237     $ 22,792  
Short-term investments   244,152       252,449  
Receivable from former related party         807  
Accounts receivable, net   39        
Prepaid expenses and other current assets   6,177       4,856  
Total current assets   263,605       280,904  
Long-term investments   51,705       81,728  
Property and equipment, net   207       194  
Right-of-use operating lease assets   1,378       1,553  
Other assets and restricted cash   9,181       9,629  
Total assets $ 326,076     $ 374,008  
Liabilities and Stockholders’ Equity          
Current liabilities:          
Accounts payable $ 5,404     $ 4,579  
Accrued expenses   13,999       13,074  
Current portion of deferred revenue   479       479  
Current portion of operating lease liabilities   211       320  
Total current liabilities   20,093       18,452  
Deferred revenue   1,785       1,908  
Long-term operating lease liabilities   1,119       1,171  
Total liabilities   22,997       21,531  
Commitments and contingencies          
Stockholders’ equity:          
Preferred stock          
Common stock   32       31  
Additional paid-in capital   538,481       526,732  
Accumulated deficit   (235,532 )     (174,392 )
Accumulated other comprehensive income   98       106  
Total stockholders’ equity   303,079       352,477  
Total liabilities and stockholders’ equity $ 326,076     $ 374,008  

DIANTHUS THERAPEUTICS, INC.

Condensed Consolidated Statements of Operations and Comprehensive Loss
(in thousands, except share and per share data)
(unaudited)

 
  Three Months Ended
June 30,
    Six Months Ended
June 30,
 
  2025     2024     2025     2024  
Revenues:                      
License revenue – former related party $     $ 1,863     $     $ 2,737  
License revenue   193             1,356        
Total revenues   193       1,863       1,356       2,737  
Operating expenses:                      
Research and development   26,251       18,070       53,254       31,148  
General and administrative   8,869       5,997       16,206       11,637  
Total operating expenses   35,120       24,067       69,460       42,785  
Loss from operations   (34,927 )     (22,204 )     (68,104 )     (40,048 )
Other income/(expense):                      
Interest and investment income   3,403       4,708       7,194       8,930  
Gain on investment in former related party   32             27        
Loss on currency exchange, net   (30 )     (31 )     (52 )     (43 )
Other expense   (107 )     (80 )     (205 )     (194 )
Total other income   3,298       4,597       6,964       8,693  
Net loss $ (31,629 )   $ (17,607 )   $ (61,140 )   $ (31,355 )
Net loss per share attributable to common stockholders,
basic and diluted
$ (0.88 )   $ (0.51 )   $ (1.71 )   $ (0.99 )
Weighted-average number of shares of common stock
outstanding including shares issuable under equity
classified pre-funded warrants, used in computing
net loss per share of common stock, basic and diluted
  35,822,308       34,227,038       35,806,591       31,794,881  
Comprehensive loss:                      
Net loss $ (31,629 )   $ (17,607 )   $ (61,140 )   $ (31,355 )
Other comprehensive loss:                      
Unrealized loss on marketable securities   (172 )     (10 )     (8 )     (84 )
Total other comprehensive loss   (172 )     (10 )     (8 )     (84 )
Total comprehensive loss $ (31,801 )   $ (17,617 )   $ (61,148 )   $ (31,439 )

May 29 2025 | Dianthus Therapeutics to Webcast Presentation at the Jefferies Global Healthcare Conference
NEW YORK and WALTHAM, Mass., May 29, 2025 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to advancing the next… READ MORE
News
May 29 2025 | Dianthus Therapeutics to Webcast Presentation at the Jefferies Global Healthcare Conference

NEW YORK and WALTHAM, Mass., May 29, 2025 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to advancing the next generation of antibody complement therapeutics to treat severe autoimmune diseases, today announced the Company’s participation in the Jefferies Global Healthcare Conference. Marino Garcia, Chief Executive Officer, will participate in a fireside chat on Thursday, June 5, 2025 at 9:55 a.m. EDT in New York City and will host one-on-one meetings with investors.

A live webcast of the Company’s presentation may be accessed under “News and Events” in the Investors section of the Dianthus Therapeutics website.

About Dianthus Therapeutics
Dianthus Therapeutics is a clinical-stage biotechnology company dedicated to designing and delivering novel, best-in-class monoclonal antibodies with improved selectivity and potency. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who are leading the development of next-generation antibody complement therapeutics, aiming to deliver transformative medicines for people living with severe autoimmune and inflammatory diseases.

To learn more, please visit www.dianthustx.com and follow us on LinkedIn

Contact
Jennifer Davis Ruff
Dianthus Therapeutics
jdavisruff@dianthustx.com

May 22 2025 | Dianthus Therapeutics Appoints Simon Read, Ph.D., to Board of Directors
Dr. Read brings >30 years of leadership and scientific expertise in the biopharmaceutical industry Previously served as CEO and Founder of Mariana Oncology until its… READ MORE
News
May 22 2025 | Dianthus Therapeutics Appoints Simon Read, Ph.D., to Board of Directors

Dr. Read brings >30 years of leadership and scientific expertise in the biopharmaceutical industry

Previously served as CEO and Founder of Mariana Oncology until its acquisition by Novartis in 2024 and CSO of Ra Pharma until its acquisition by UCB in 2020

NEW YORK and WALTHAM, Mass., May 22, 2025 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to advancing the next generation of antibody complement therapeutics to treat severe autoimmune diseases, today announced the appointment of Simon Read, Ph.D., to the Company’s Board of Directors. Dr. Read is a serial entrepreneur with more than 30 years of biopharmaceutical experience. Dianthus also announced that Lonnie Moulder will transition from the Board of Directors.

“I am pleased to welcome Simon to the Dianthus Board of Directors. His wealth of experience leading biopharmaceutical companies and R&D organizations will be invaluable as Dianthus continues to advance its mid- and late-stage clinical programs,” said Alison Lawton, Chair of the Dianthus Therapeutics Board of Directors. “I would also like to thank Lonnie for his dedicated service to the Board. His perspective and support were instrumental during a period when Dianthus quickly grew from a private, preclinical stage company to a publicly traded company now with three ongoing clinical trials.”

“I have been extremely impressed with the Dianthus team’s ability to advance a potential best-in-class complement inhibitor with significant potential since our initial seed investment in 2019,” said Lonnie Moulder, Managing Member, Tellus BioVentures LLC and Founder, Chairman and CEO, Zenas BioPharma. “I wish continued success to Dianthus as I transition from the Board and remain confident in the team’s ability to transform the lives of patients living with severe autoimmune diseases.”

Dr. Read most recently served as CEO and founder of Mariana Oncology until its acquisition by Novartis and was Chief Scientific Officer at Ra Pharma until its acquisition by UCB Pharma. Prior to this, he held R&D leadership roles at GlaxoSmithKline, AstraZeneca and Roche/Genentech and worked on the clinical development of some of the most well-known drugs in the immunology area, including Rituxan® and Actemra®. Dr. Read is a Fellow of the Royal Society of Medicine (UK) and Chairman of the Board of Ethyreal Bio. He previously served on the Board of Triana Biomedicines and Oxstem Ltd (UK). He obtained his Ph.D. from University of Hertfordshire, studied Physiology at the University of Manchester in the UK, and has authored over 50 articles in peer reviewed journals.

“The Dianthus team has done an excellent job executing rapidly on its three clinical programs with DNTH103,” said Dr. Read. “This is an exciting time for the Company with Phase 2 MaGic results anticipated in September. I look forward to partnering with this exceptional team and Board of Directors as I see tremendous potential for DNTH103 as a best-in-class, differentiated therapy option for patients with severe neuromuscular conditions.”

About Dianthus Therapeutics
Dianthus Therapeutics is a clinical-stage biotechnology company dedicated to designing and delivering novel, best-in-class monoclonal antibodies with improved selectivity and potency. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who are leading the development of next-generation antibody complement therapeutics, aiming to deliver transformative medicines for people living with severe autoimmune and inflammatory diseases.

To learn more, please visit www.dianthustx.com and follow us on LinkedIn

Cautionary Statement Regarding Forward-Looking Statements
Certain statements in this press release, other than purely historical information, may constitute “forward-looking statements” within the meaning of the federal securities laws, including for purposes of the safe harbor provisions under the United States Private Securities Litigation Reform Act of 1995, express or implied statements regarding future plans and prospects, including statements regarding the expectations or plans for discovery, preclinical studies, clinical trials and research and development programs, in particular with respect to DNTH103, and any developments or results in connection therewith, including the target product profile and administration of DNTH103; the anticipated timing of the initiation and results from those studies and trials; expectations regarding the time period over which the Company’s capital resources are expected to be sufficient to fund its anticipated operations; and expectations regarding the market and potential opportunities for complement therapies, in particular with respect to DNTH103. The words “opportunity,” “potential,” “milestones,” “runway,” “will,” “anticipate,” “achieve,” “near-term,” “catalysts,” “pursue,” “pipeline,” “believe,” “continue,” “could,” “estimate,” “expect,” “intend,” “may,” “might,” “plan,” “possible,” “predict,” “project,” “should,” “strive,” “would,” “aim,” “target,” “commit,” and similar expressions (including the negatives of these terms or variations of them) generally identify forward-looking statements, but the absence of these words does not mean that statement is not forward looking.

Actual results could differ materially from those included in the forward-looking statements due to various factors, risks and uncertainties, including, but not limited to, that preclinical testing of DNTH103 and data from clinical trials may not be predictive of the results or success of ongoing or later clinical trials, that the development of DNTH103 or the Company’s other compounds may take longer and/or cost more than planned, that the Company may be unable to successfully complete the clinical development of the Company’s compounds, that the Company may be delayed in initiating, enrolling or completing its planned clinical trials, and that the Company’s compounds may not receive regulatory approval or become commercially successful products. These and other risks and uncertainties are identified under the heading “Risk Factors” included in the Company’s Annual Report on Form 10-K for the period ended December 31, 2024, and other filings that the Company has made and may make with the SEC in the future. Nothing in this press release should be regarded as a representation by any person that the forward-looking statements set forth herein will be achieved or that any of the contemplated results of such forward-looking statements will be achieved.

The forward-looking statements in this press release speak only as of the date they are made and are qualified in their entirety by reference to the cautionary statements herein. Dianthus undertakes no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future events or otherwise, except as required by law.

Contact
Jennifer Davis Ruff
Dianthus Therapeutics
jdavisruff@dianthustx.com

May 12 2025 | Dianthus Therapeutics Highlights Recent Business Achievements and Reports Q1 Financial Results
Completed enrollment in Phase 2 MaGic trial of DNTH103 in generalized Myasthenia Gravis (gMG) Top-line MaGic results anticipated in September 2025 to be the first… READ MORE
News
May 12 2025 | Dianthus Therapeutics Highlights Recent Business Achievements and Reports Q1 Financial Results

Completed enrollment in Phase 2 MaGic trial of DNTH103 in generalized Myasthenia Gravis (gMG)

Top-line MaGic results anticipated in September 2025 to be the first of three catalysts for the DNTH103 neuromuscular franchise by YE’26

Phase 3 CAPTIVATE trial of DNTH103 in Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) ongoing; interim responder analysis anticipated in 2H’26

Phase 2 MoMeNtum trial of DNTH103 in Multifocal Motor Neuropathy (MMN) ongoing;
top-line results anticipated in 2H’26

$331.5 million of cash provides runway into 2H’27

NEW YORK and WALTHAM, Mass., May 12, 2025 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to advancing the next generation of antibody complement therapeutics to treat severe autoimmune diseases, today reported financial results for the first quarter ending March 31, 2025, and provided an update on recent business achievements.

“The first few months of 2025 represent continued excellence in execution by the Dianthus team, including the timely completion of enrollment in our Phase 2 MaGic trial of DNTH103 in gMG, and we look forward to reporting top-line results in September,” said Marino Garcia, Chief Executive Officer of Dianthus Therapeutics. “Despite currently approved biologics in the gMG market, significant opportunities remain for improved first-line treatment options. We believe that achieving DNTH103’s target profile of effective, consistent symptom control, differentiated safety, and convenient dosing and administration could position it as a preferred first-line biologic therapy across the three neuromuscular indications of gMG, CIDP and MMN.”

DNTH103 Clinical Development

DNTH103 is an investigational, clinical-stage, potent monoclonal antibody engineered to selectively target the classical pathway by inhibiting only the active form of the C1s protein, a clinically validated complement target. DNTH103 is designed to enable a more convenient subcutaneous, self-administered injection dosed as infrequently as once every two weeks. DNTH103 has the potential to be a best-in-class pipeline-in-a-product across a range of autoimmune disorders with high unmet need.

Generalized Myasthenia Gravis (gMG)

  • Enrollment complete in Phase 2 MaGic gMG trial: The MaGic trial is a global, randomized, double-blind, placebo-controlled Phase 2 trial in patients with gMG who are acetylcholine receptor (AChR) antibody positive. Enrollment in this trial is now complete with 65 patients, exceeding the target of 60, and top-line results are anticipated in September 2025.

Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

  • Phase 3 CAPTIVATE CIDP trial ongoing: The CAPTIVATE trial is a single, global, two-part, randomized withdrawal Phase 3 trial in patients with CIDP, and it remains on track for an interim responder analysis in 2H’26. The Company believes this single pivotal trial will support a BLA filing in adult patients with CIDP.

Multifocal Motor Neuropathy (MMN)

  • Phase 2 MoMeNtum MMN trial ongoing: The MoMeNtum trial is a global, randomized, double-blind, placebo-controlled Phase 2 trial in patients with MMN, and it remains on track to report top-line results in 2H’26.

Corporate Updates

First-Quarter 2025 Financial Results

  • Cash Position – $331.5 million of cash, cash equivalents and investments as of March 31, 2025 is projected to provide runway into the second half of 2027.
  • R&D Expenses – Research and development (R&D) expenses for the quarter ended March 31, 2025 were $27.0 million, inclusive of $2.5 million of stock-based compensation, compared to $13.1 million for the quarter ended March 31, 2024, which included $0.8 million of stock-based compensation. This increase in R&D expenses was primarily driven by higher clinical costs, chemistry, manufacturing and controls (CMC) costs, and increased headcount to support DNTH103 Phase 2 and Phase 3 development.
  • G&A Expenses – General and administrative (G&A) expenses for the quarter ended March 31, 2025 totaled $7.3 million, inclusive of stock-based compensation of $2.8 million, compared to $5.6 million for the quarter ended March 31, 2024, which included $1.2 million of stock-based compensation. This increase in G&A expenses was primarily due to increased headcount.
  • Net Loss – Net loss for the quarter ended March 31, 2025 was $29.5 million or $0.82 per share (basic and diluted) compared to $13.7 million or $0.54 per share (basic and diluted) for the quarter ended March 31, 2024.
  • Additional Information – For additional information on the Company’s financial results for the quarter ended March 31, 2025, please refer to the Form 10-Q filed with the SEC.

About DNTH103
DNTH103 is an investigational, clinical-stage, potent monoclonal antibody engineered to selectively target the classical pathway by inhibiting only the active form of the C1s protein, a clinically validated complement target. DNTH103 is enhanced with YTE half-life extension technology designed to enable a more convenient subcutaneous, self-administered injection dosed as infrequently as once every two weeks. Additionally, selective inhibition of the classical complement pathway may lower patient risk of infection from encapsulated bacteria by preserving immune activity of the lectin and alternative pathways. As the classical pathway plays a significant role in disease pathology, DNTH103 has the potential to be a best-in-class pipeline-in-a-product across a range of autoimmune disorders with high unmet need. Dianthus is building a neuromuscular franchise with DNTH103 and anticipates reporting top-line data from the Phase 2 MaGic trial in generalized Myasthenia Gravis in September 2025, the interim responder analysis of the Phase 3 CAPTIVATE trial in Chronic Inflammatory Demyelinating Polyneuropathy in 2H’26, and top-line data from the Phase 2 MoMeNtum trial in Multifocal Motor Neuropathy in 2H’26.

DNTH103 is an investigational agent that is not approved as a therapy in any indication in any jurisdiction worldwide.

About Dianthus Therapeutics
Dianthus Therapeutics is a clinical-stage biotechnology company dedicated to designing and delivering novel, best-in-class monoclonal antibodies with improved selectivity and potency. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who are leading the development of next-generation antibody complement therapeutics, aiming to deliver transformative medicines for people living with severe autoimmune and inflammatory diseases.

To learn more, please visit www.dianthustx.com and follow us on LinkedIn

Cautionary Statement Regarding Forward-Looking Statements
Certain statements in this press release, other than purely historical information, may constitute “forward-looking statements” within the meaning of the federal securities laws, including for purposes of the safe harbor provisions under the United States Private Securities Litigation Reform Act of 1995, express or implied statements regarding future plans and prospects, including statements regarding the expectations or plans for discovery, preclinical studies, clinical trials and research and development programs, in particular with respect to DNTH103, and any developments or results in connection therewith, including the target product profile and administration of DNTH103; the anticipated timing of the initiation and results from those studies and trials; expectations regarding the time period over which the Company’s capital resources are expected to be sufficient to fund its anticipated operations; and expectations regarding the market and potential opportunities for complement therapies, in particular with respect to DNTH103. The words “opportunity,” “potential,” “milestones,” “runway,” “will,” “anticipate,” “achieve,” “near-term,” “catalysts,” “pursue,” “pipeline,” “believe,” “continue,” “could,” “estimate,” “expect,” “intend,” “may,” “might,” “plan,” “possible,” “predict,” “project,” “should,” “strive,” “would,” “aim,” “target,” “commit,” and similar expressions (including the negatives of these terms or variations of them) generally identify forward-looking statements, but the absence of these words does not mean that statement is not forward looking.

Actual results could differ materially from those included in the forward-looking statements due to various factors, risks and uncertainties, including, but not limited to, that preclinical testing of DNTH103 and data from clinical trials may not be predictive of the results or success of ongoing or later clinical trials, that the development of DNTH103 or the Company’s other compounds may take longer and/or cost more than planned, that the Company may be unable to successfully complete the clinical development of the Company’s compounds, that the Company may be delayed in initiating, enrolling or completing its planned clinical trials, and that the Company’s compounds may not receive regulatory approval or become commercially successful products. These and other risks and uncertainties are identified under the heading “Risk Factors” included in the Company’s Annual Report on Form 10-K for the period ended December 31, 2024, and other filings that the Company has made and may make with the SEC in the future. Nothing in this press release should be regarded as a representation by any person that the forward-looking statements set forth herein will be achieved or that any of the contemplated results of such forward-looking statements will be achieved.

The forward-looking statements in this press release speak only as of the date they are made and are qualified in their entirety by reference to the cautionary statements herein. Dianthus undertakes no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future events or otherwise, except as required by law.

Contact
Jennifer Davis Ruff
Dianthus Therapeutics
jdavisruff@dianthustx.com

DIANTHUS THERAPEUTICS, INC.

Condensed Consolidated Balance Sheets
(in thousands, except share and per share data)
(unaudited)

 
  March 31,
2025
    December 31,
2024
 
Assets          
Current assets:          
Cash and cash equivalents $ 10,116     $ 22,792  
Short-term investments   253,114       252,449  
Receivable from related party         807  
Accounts receivable, net   1,000        
Prepaid expenses and other current assets   6,769       4,856  
Total current assets   270,999       280,904  
Long-term investments   68,308       81,728  
Property and equipment, net   191       194  
Right-of-use operating lease assets   1,447       1,553  
Other assets and restricted cash   7,635       9,629  
Total assets $ 348,580     $ 374,008  
Liabilities and Stockholders’ Equity          
Current liabilities:          
Accounts payable $ 8,269     $ 4,579  
Accrued expenses   7,979       13,074  
Current portion of deferred revenue   479       479  
Current portion of operating lease liabilities   226       320  
Total current liabilities   16,953       18,452  
Deferred revenue   1,851       1,908  
Long-term operating lease liabilities   1,170       1,171  
Total liabilities   19,974       21,531  
Commitments and contingencies          
Stockholders’ equity:          
Preferred stock          
Common stock   32       31  
Additional paid-in capital   532,207       526,732  
Accumulated deficit   (203,903 )     (174,392 )
Accumulated other comprehensive income   270       106  
Total stockholders’ equity   328,606       352,477  
Total liabilities and stockholders’ equity $ 348,580     $ 374,008  
               

DIANTHUS THERAPEUTICS, INC.

Condensed Consolidated Statements of Operations and Comprehensive Loss
(in thousands, except share and per share data)
(unaudited)

 
  Three Months Ended
March 31,
 
  2025     2024  
Revenues:          
License revenue – related party $     $ 874  
License revenue   1,163        
Total revenues   1,163       874  
Operating expenses:          
Research and development   27,003       13,078  
General and administrative   7,337       5,640  
Total operating expenses   34,340       18,718  
Loss from operations   (33,177 )     (17,844 )
Other income/(expense):          
Interest and investment income   3,791       4,222  
Loss on investment in related party   (5 )      
Loss on currency exchange, net   (22 )     (12 )
Other expense   (98 )     (114 )
Total other income   3,666       4,096  
Net loss $ (29,511 )   $ (13,748 )
Net loss per share attributable to common stockholders, basic and diluted $ (0.82 )   $ (0.54 )
Weighted-average number of shares of common stock outstanding including shares issuable under equity-classified pre-funded warrants, used in computing net loss per share of common stock, basic and diluted   35,790,700       25,665,475  
Comprehensive loss:          
Net loss $ (29,511 )   $ (13,748 )
Other comprehensive income/(loss):          
Unrealized gain/(loss) on marketable securities   164       (74 )
Total other comprehensive income/(loss)   164       (74 )
Total comprehensive loss $ (29,347 )   $ (13,822 )
               

May 05 2025 | Dianthus Therapeutics Completes Enrollment of Phase 2 MaGic Trial of DNTH103 in Generalized Myasthenia Gravis With Top-Line Results Expected in September
MaGic trial exceeded enrollment target of 60 patients Top-line results anticipated this September will be the first of three DNTH103 catalysts by YE’26 Building a… READ MORE
News
May 05 2025 | Dianthus Therapeutics Completes Enrollment of Phase 2 MaGic Trial of DNTH103 in Generalized Myasthenia Gravis With Top-Line Results Expected in September

MaGic trial exceeded enrollment target of 60 patients

Top-line results anticipated this September will be the first of three DNTH103 catalysts by YE’26

Building a neuromuscular franchise with DNTH103 in gMG, CIDP and MMN with a potential best-in-class, potent classical pathway inhibitor intended as a self-administered autoinjector dosed once every two weeks

NEW YORK and WALTHAM, Mass., May 05, 2025 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to advancing the next generation of antibody complement therapeutics to treat severe autoimmune diseases, today announced completion of enrollment in the Phase 2 MaGic trial of DNTH103 in patients with generalized Myasthenia Gravis (gMG). DNTH103 is an investigational, clinical-stage, potent monoclonal antibody engineered to selectively target the classical pathway by inhibiting only the active form of the C1s protein. Initial top-line results from the MaGic trial are anticipated in September 2025.

MaGic is a global, randomized, double-blind, placebo-controlled Phase 2 trial that enrolled 65 patients with acetylcholine receptor (AChR) antibody positive gMG, exceeding the enrollment target of 60 patients. The primary endpoint of the trial is safety and tolerability, and key secondary endpoints include Myasthenia Gravis Activities of Daily Living Scale (MG-ADL) and Quantitative Myasthenia Gravis (QMG) score assessments.

“We are pleased to have reached this important milestone in the development of DNTH103 for gMG, which is well understood to be a classical pathway-driven disease,” said Marino Garcia, Chief Executive Officer of Dianthus Therapeutics. “Latest estimates indicate that the gMG market in the U.S. exceeds 100,000 patients, approximately 85% of whom have AChR autoantibody-driven disease, with growing first-line biologic use. Despite currently approved treatment options, a significant unmet need exists for patients seeking continuous symptom control, lower risk for infections, and more convenient dosing and administration, which we believe DNTH103 has the potential to address as a first-line therapy.”

DNTH103 is an investigational, clinical-stage, potent monoclonal antibody engineered to selectively target the classical pathway by inhibiting only the active form of the C1s protein, a clinically validated complement target. DNTH103 is designed to enable a more convenient subcutaneous, self-administered injection dosed as infrequently as once every two weeks. DNTH103 has the potential to be a best-in-class pipeline-in-a-product across a range of autoimmune disorders with high unmet need and is also being evaluated in the ongoing Phase 3 CAPTIVATE trial in Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) and the ongoing Phase 2 MoMeNtum trial in Multifocal Motor Neuropathy (MMN). The Company is on track for the interim responder analysis of the Phase 3 CAPTIVATE trial in CIDP and top-line data from the Phase 2 MoMeNtum trial in MMN in 2H’26.

About the Phase 2 MaGic Trial
The MaGic trial is a global, randomized, double-blind, placebo-controlled Phase 2 study in patients with generalized Myasthenia Gravis who are acetylcholine receptor (AChR) antibody positive. Following an initial loading dose, DNTH103 will be administered every two weeks (Q2W) via subcutaneous (S.C.) injection. The S.C. treatment duration will initially be 12 weeks with a 52-week open-label extension. The primary endpoint of the study is safety and tolerability. Secondary endpoints include Myasthenia Gravis Activities of Daily Living Scale (MG-ADL) and Quantitative Myasthenia Gravis (QMG) score assessments. Initial top-line results from this trial are anticipated in September 2025.

About Generalized Myasthenia Gravis (gMG)
Generalized Myasthenia Gravis (gMG) is a chronic autoimmune disorder driven by the classical pathway that causes progressive muscle weakness. Over 100,000 people in the U.S. are living with gMG and approximately 85% have AChR autoantibody-driven disease. Despite availability of current treatment options, a significant number of patients remain uncontrolled and are seeking better treatment options which may offer sustained efficacy, lower potential risk for infections, and convenient dosing and administration.

About DNTH103
DNTH103 is an investigational, clinical-stage, potent monoclonal antibody engineered to selectively target the classical pathway by inhibiting only the active form of the C1s protein, a clinically validated complement target. DNTH103 is enhanced with YTE half-life extension technology designed to enable a more convenient subcutaneous, self-administered injection dosed as infrequently as once every two weeks. Additionally, selective inhibition of the classical complement pathway may lower patient risk of infection from encapsulated bacteria by preserving immune activity of the lectin and alternative pathways. As the classical pathway plays a significant role in disease pathology, DNTH103 has the potential to be a best-in-class pipeline-in-a-product across a range of autoimmune disorders with high unmet need. Dianthus is building a neuromuscular franchise with DNTH103 and anticipates reporting top-line data from the Phase 2 MaGic trial in generalized Myasthenia Gravis in September 2025, the interim responder analysis of the Phase 3 CAPTIVATE trial in Chronic Inflammatory Demyelinating Polyneuropathy in 2H’26, and top-line data from the Phase 2 MoMeNtum trial in Multifocal Motor Neuropathy in 2H’26.

DNTH103 is an investigational agent that is not approved as a therapy in any indication in any jurisdiction worldwide.

About Dianthus Therapeutics
Dianthus Therapeutics is a clinical-stage biotechnology company dedicated to designing and delivering novel, best-in-class monoclonal antibodies with improved selectivity and potency. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who are leading the development of next-generation antibody complement therapeutics, aiming to deliver transformative medicines for people living with severe autoimmune and inflammatory diseases.

To learn more, please visit www.dianthustx.com and follow us on LinkedIn

Cautionary Statement Regarding Forward-Looking Statements
Certain statements in this press release, other than purely historical information, may constitute “forward-looking statements” within the meaning of the federal securities laws, including for purposes of the safe harbor provisions under the United States Private Securities Litigation Reform Act of 1995, express or implied statements regarding future plans and prospects, including statements regarding the expectations or plans for discovery, preclinical studies, clinical trials and research and development programs, in particular with respect to DNTH103, and any developments or results in connection therewith, including the target product profile and administration of DNTH103; the anticipated timing of the initiation and results from those studies and trials; expectations regarding the time period over which the Company’s capital resources are expected to be sufficient to fund its anticipated operations; and expectations regarding the market and potential opportunities for complement therapies, in particular with respect to DNTH103. The words “opportunity,” “potential,” “milestones,” “runway,” “will,” “anticipate,” “achieve,” “near-term,” “catalysts,” “pursue,” “pipeline,” “believe,” “continue,” “could,” “estimate,” “expect,” “intend,” “may,” “might,” “plan,” “possible,” “predict,” “project,” “should,” “strive,” “would,” “aim,” “target,” “commit,” and similar expressions (including the negatives of these terms or variations of them) generally identify forward-looking statements, but the absence of these words does not mean that statement is not forward looking.

Actual results could differ materially from those included in the forward-looking statements due to various factors, risks and uncertainties, including, but not limited to, that preclinical testing of DNTH103 and data from clinical trials may not be predictive of the results or success of ongoing or later clinical trials, that the development of DNTH103 or the Company’s other compounds may take longer and/or cost more than planned, that the Company may be unable to successfully complete the clinical development of the Company’s compounds, that the Company may be delayed in initiating, enrolling or completing its planned clinical trials, and that the Company’s compounds may not receive regulatory approval or become commercially successful products. These and other risks and uncertainties are identified under the heading “Risk Factors” included in the Company’s Annual Report on Form 10-K for the period ended December 31, 2024, and other filings that the Company has made and may make with the SEC in the future. Nothing in this press release should be regarded as a representation by any person that the forward-looking statements set forth herein will be achieved or that any of the contemplated results of such forward-looking statements will be achieved.

The forward-looking statements in this press release speak only as of the date they are made and are qualified in their entirety by reference to the cautionary statements herein. Dianthus undertakes no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future events or otherwise, except as required by law.

Contact
Jennifer Davis Ruff
Dianthus Therapeutics
jdavisruff@dianthustx.com

Apr 29 2025 | Dianthus Therapeutics to Participate in Two Upcoming Investor Events
NEW YORK and WALTHAM, Mass., April 29, 2025 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to advancing the next… READ MORE
News
Apr 29 2025 | Dianthus Therapeutics to Participate in Two Upcoming Investor Events

NEW YORK and WALTHAM, Mass., April 29, 2025 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to advancing the next generation of antibody complement therapeutics to treat severe autoimmune diseases, today announced the company’s participation at two upcoming investor events.

  • Baird Biotech Discovery Series – Marino Garcia, Chief Executive Officer, will participate in a fireside chat webcast on Tuesday, May 6 at 1:30 p.m. EDT.
  • Bank of America 2025 Health Care Conference – Marino Garcia, Chief Executive Officer, will present a corporate overview on Wednesday, May 14 at 5:35 p.m. EDT / 2:35 p.m. PDT and will host one-on-one meetings with investors.

Webcasts of these presentations may be accessed under “News and Events” in the Investors section of the Dianthus Therapeutics website.

About Dianthus Therapeutics
Dianthus Therapeutics is a clinical-stage biotechnology company dedicated to designing and delivering novel, best-in-class monoclonal antibodies with improved selectivity and potency. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who are leading the development of next-generation antibody complement therapeutics, aiming to deliver transformative medicines for people living with severe autoimmune and inflammatory diseases.

To learn more, please visit www.dianthustx.com and follow us on LinkedIn

Contact
Jennifer Davis Ruff
Dianthus Therapeutics
jdavisruff@dianthustx.com

Mar 11 2025 | Dianthus Therapeutics Highlights Recent Business Achievements and Reports Q4 and FY 2024 Financial Results
Phase 2 MaGic trial of DNTH103 in generalized Myasthenia Gravis (gMG) ongoing; top-line results on track for 2H’25 Phase 3 CAPTIVATE trial of DNTH103 in… READ MORE
News
Mar 11 2025 | Dianthus Therapeutics Highlights Recent Business Achievements and Reports Q4 and FY 2024 Financial Results

Phase 2 MaGic trial of DNTH103 in generalized Myasthenia Gravis (gMG) ongoing; top-line results on track for 2H’25

Phase 3 CAPTIVATE trial of DNTH103 in Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) ongoing; interim responder analysis anticipated in 2H’26

Phase 2 MoMeNtum trial of DNTH103 in Multifocal Motor Neuropathy (MMN) ongoing;
top-line results anticipated in 2H’26

$357.0 million of cash provides runway into 2H’27

NEW YORK and WALTHAM, Mass., March 11, 2025 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to advancing the next generation of antibody complement therapeutics to treat severe autoimmune diseases, today reported financial results for the fourth quarter and full year ending December 31, 2024 and provided an update on recent business achievements.

“We remain on track to report top-line data in 2H’25 from our Phase 2 clinical trial of DNTH103 in gMG, an indication where a best-in-class, potent active C1s and classical pathway inhibitor with the potential for effective and consistent symptom control along with improved safety and convenience could meaningfully advance the standard of care,” said Marino Garcia, Chief Executive Officer of Dianthus Therapeutics. “We are excited to have initiated our pivotal Phase 3 CAPTIVATE trial in CIDP, which is on track for an interim responder analysis in 2H’26, along with top-line results from our Phase 2 trial in MMN.”

DNTH103 Clinical Development

DNTH103 is an investigational, clinical-stage, potent monoclonal antibody engineered to selectively target the classical pathway by inhibiting only the active form of the C1s protein, a clinically validated complement target. DNTH103 is enhanced with YTE half-life extension technology designed to enable a more convenient subcutaneous, self-administered injection dosed as infrequently as once every two weeks. DNTH103 has the potential to be a best-in-class pipeline-in-a-product across a range of autoimmune disorders with high unmet need.

Generalized Myasthenia Gravis (gMG)

  • Phase 2 MaGic gMG trial ongoing: The MaGic trial is a global, randomized, double-blind, placebo-controlled Phase 2 trial in patients with gMG who are acetylcholine receptor (AChR) antibody positive, and it remains on track to report top-line results in 2H’25.

Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

  • Phase 3 CAPTIVATE CIDP trial ongoing: The CAPTIVATE trial is a single, global, two-part, randomized withdrawal Phase 3 trial in patients with CIDP, and it remains on track for an interim responder analysis in 2H’26. The Company believes this single pivotal trial will support a BLA filing in adult patients with CIDP.

Multifocal Motor Neuropathy (MMN)

  • Phase 2 MoMeNtum MMN trial ongoing: The MoMeNtum trial is a global, randomized, double-blind, placebo-controlled Phase 2 trial in patients with MMN, and it remains on track to report top-line results in 2H’26.

Corporate Updates

Full Year 2024 Financial Results

  • Cash Position – $357.0 million of cash, cash equivalents and investments as of December 31, 2024 is projected to provide runway into the second half of 2027.
  • R&D Expenses – Research and development (R&D) expenses for the year ended December 31, 2024 were $83.1 million, inclusive of $5.6 million of stock-based compensation, compared to $32.8 million for the year ended December 31, 2023, which included $0.9 million of stock-based compensation. This increase in R&D expenses was primarily driven by higher clinical costs, chemistry, manufacturing and controls (CMC) costs and increased headcount to support DNTH103 Phase 2 and Phase 3 development.
  • G&A Expenses – General and administrative (G&A) expenses for the year ended December 31, 2024 totaled $25.0 million, inclusive of stock-based compensation of $7.3 million, compared to $18.2 million for the year ended December 31, 2023, which included $2.0 million of stock-based compensation. This increase in G&A expenses was primarily due to increased headcount and higher professional services costs.
  • Net Loss – Net loss for the year ended December 31, 2024 was $85.0 million or $2.55 per share (basic and diluted) compared to $43.6 million or $8.45 per share (basic and diluted) for the year ended December 31, 2023.
  • Additional Information – For additional information on the Company’s financial results for the year ended December 31, 2024, please refer to the Form 10-K filed with the SEC.

About DNTH103
DNTH103 is an investigational, clinical-stage, potent monoclonal antibody engineered to selectively target the classical pathway by inhibiting only the active form of the C1s protein, a clinically validated complement target. DNTH103 is enhanced with YTE half-life extension technology designed to enable a more convenient subcutaneous, self-administered injection dosed as infrequently as once every two weeks. Additionally, selective inhibition of the classical complement pathway may lower patient risk of infection from encapsulated bacteria by preserving immune activity of the lectin and alternative pathways. As the classical pathway plays a significant role in disease pathology, DNTH103 has the potential to be a best-in-class pipeline-in-a-product across a range of autoimmune disorders with high unmet need. Dianthus is building a neuromuscular franchise with DNTH103 and anticipates reporting top-line data from the Phase 2 MaGic trial in generalized Myasthenia Gravis in 2H’25, the interim responder analysis of the Phase 3 CAPITIVATE trial in Chronic Inflammatory Demyelinating Polyneuropathy in 2H’26, and top-line data from the Phase 2 MoMeNtum trial in Multifocal Motor Neuropathy in 2H’26.

DNTH103 is an investigational agent that is not approved as a therapy in any indication in any jurisdiction worldwide.

About Dianthus Therapeutics
Dianthus Therapeutics is a clinical-stage biotechnology company dedicated to designing and delivering novel, best-in-class monoclonal antibodies with improved selectivity and potency. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who are leading the development of next-generation antibody complement therapeutics, aiming to deliver transformative medicines for people living with severe autoimmune and inflammatory diseases.

To learn more, please visit www.dianthustx.com and follow us on LinkedIn

Cautionary Statement Regarding Forward-Looking Statements
Certain statements in this press release, other than purely historical information, may constitute “forward-looking statements” within the meaning of the federal securities laws, including for purposes of the safe harbor provisions under the United States Private Securities Litigation Reform Act of 1995, express or implied statements regarding future plans and prospects, including statements regarding the expectations or plans for discovery, preclinical studies, clinical trials and research and development programs, in particular with respect to DNTH103, and any developments or results in connection therewith, including the target product profile of DNTH103; the anticipated timing of the initiation and results from those studies and trials; expectations regarding the time period over which the Company’s capital resources are expected to be sufficient to fund its anticipated operations; and expectations regarding the market and potential opportunities for complement therapies, in particular with respect to DNTH103. The words “opportunity,” “potential,” “milestones,” “runway,” “will,” “anticipate,” “achieve,” “near-term,” “catalysts,” “pursue,” “pipeline,” “believe,” “continue,” “could,” “estimate,” “expect,” “intend,” “may,” “might,” “plan,” “possible,” “predict,” “project,” “should,” “strive,” “would,” “aim,” “target,” “commit,” and similar expressions (including the negatives of these terms or variations of them) generally identify forward-looking statements, but the absence of these words does not mean that statement is not forward looking.

Actual results could differ materially from those included in the forward-looking statements due to various factors, risks and uncertainties, including, but not limited to, that preclinical testing of DNTH103 and data from clinical trials may not be predictive of the results or success of ongoing or later clinical trials, that the development of DNTH103 or the Company’s other compounds may take longer and/or cost more than planned, that the Company may be unable to successfully complete the clinical development of the Company’s compounds, that the Company may be delayed in initiating, enrolling or completing its planned clinical trials, and that the Company’s compounds may not receive regulatory approval or become commercially successful products. These and other risks and uncertainties are identified under the heading “Risk Factors” included in the Company’s Annual Report on Form 10-K for the period ended December 31, 2024, and other filings that the Company has made and may make with the SEC in the future. Nothing in this press release should be regarded as a representation by any person that the forward-looking statements set forth herein will be achieved or that any of the contemplated results of such forward-looking statements will be achieved.

The forward-looking statements in this press release speak only as of the date they are made and are qualified in their entirety by reference to the cautionary statements herein. Dianthus undertakes no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future events or otherwise, except as required by law.

Contact
Jennifer Davis Ruff
Dianthus Therapeutics
jdavisruff@dianthustx.com

 
Dianthus Therapeutics, Inc.
Consolidated Balance Sheets
(in thousands, except share and per share data)
(unaudited)
       
ASSETS December 31,
2024
  December 31,
2023
Current assets:      
Cash and cash equivalents $ 22,792     $ 132,325  
Short-term investments   252,449       41,393  
Receivable from related party   807       294  
Unbilled receivable from related party         184  
Prepaid expenses and other current assets   4,856       3,255  
Total current assets   280,904       177,451  
       
Long-term investments   81,728        
Property and equipment, net   194       185  
Right-of-use operating lease assets   1,553       615  
Other assets and restricted cash   9,629       1,154  
Total assets $ 374,008     $ 179,405  
       
LIABILITIES AND STOCKHOLDERS’ EQUITY      
Current liabilities:      
Accounts payable $ 4,579     $ 2,610  
Accrued expenses   13,074       6,504  
Current portion of deferred revenue   479        
Current portion of deferred revenue – related party         100  
Current portion of operating lease liabilities   320       417  
Total current liabilities   18,452       9,631  
       
Deferred revenue   1,908        
Deferred revenue – related party         736  
Long-term operating lease liabilities   1,171       168  
Total liabilities   21,531       10,535  
       
Commitments and contingencies      
Stockholders’ equity:      
Preferred stock          
Common stock   31       15  
Additional paid-in capital   526,732       258,231  
Accumulated deficit   (174,392 )     (89,423 )
Accumulated other comprehensive income   106       47  
Total stockholders’ equity   352,477       168,870  
Total liabilities and stockholders’ equity

$

374,008

   

$

179,405

 
 

 
Dianthus Therapeutics, Inc.
Consolidated Statements of Operations and Comprehensive Loss
(in thousands, except share and per share data)
(unaudited)
               
  Three Months Ended December 31,   Year Ended December 31,
    2024       2023       2024       2023  
Revenues:              
License revenue – related party $ 999     $ 457     $ 5,909     $ 2,826  
License revenue   326             326        
Total revenues   1,325       457       6,235       2,826  
               
Operating expenses:              
Research and development   26,413       8,781       83,105       32,841  
General and administrative   6,828       4,632       24,994       18,159  
Total operating expenses   33,241       13,413       108,099       51,000  
               
Loss from operations   (31,916 )     (12,956 )     (101,864 )     (48,174 )
               
Other income/(expense):              
Interest income   3,991       2,444       17,365       4,764  
Gain/(loss) on investment in related party   (160 )           148        
Gain/(loss) on currency exchange, net   27       (32 )     (64 )     (85 )
Other expense   (380 )     (19 )     (554 )     (60 )
Total other income   3,478       2,393       16,895       4,619  
               
Net loss $ (28,438 )   $ (10,563 )   $ (84,969 )   $ (43,555 )
               
Net loss per share attributable to common stockholders, basic and diluted $ (0.81 )   $ (0.71 )   $ (2.55 )   $ (8.45 )
               
Weighted-average number of shares of common stock outstanding, used in computing net loss per share of common stock, basic and diluted   35,033,773       14,817,676       33,313,849       5,153,423  
               
Comprehensive loss:              
Net Loss $ (28,438 )   $ (10,563 )   $ (84,969 )   $ (43,555 )
Other comprehensive income/(loss):              
Unrealized gains/(losses) on marketable securities   (575 )     51       59       208  
Total other comprehensive income/(loss)   (575 )     51       59       208  
Total comprehensive loss $ (29,013 )   $ (10,512 )   $ (84,910 )   $ (43,347 )

Mar 05 2025 | Dianthus Therapeutics Strengthens Strategic Commercial Leadership With Appointment of John C. King as Chief Commercial Officer and Welcomes Sujay Kango, A Seasoned Commercial Leader, to Board of Directors
Mr. King launched the first approved biologic and C5 complement inhibitor into the Myasthenia Gravis market and helped set the foundation for the multi-billion dollar… READ MORE
News
Mar 05 2025 | Dianthus Therapeutics Strengthens Strategic Commercial Leadership With Appointment of John C. King as Chief Commercial Officer and Welcomes Sujay Kango, A Seasoned Commercial Leader, to Board of Directors

Mr. King launched the first approved biologic and C5 complement inhibitor into the Myasthenia Gravis market and helped set the foundation for the multi-billion dollar C5 franchise of Alexion

Mr. King also led the commercial strategy behind the first FDA-approved, self-administered, subcutaneous biologic for gMG as the Chief Commercial Officer of Ra Pharma, acquired by UCB for $2.5 billion

Mr. Kango has >26 years of industry experience spanning senior executive, commercial and business development roles in the pharmaceutical and biotechnology sector

NEW YORK and WALTHAM, Mass., March 05, 2025 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to advancing the next generation of antibody complement therapeutics to treat severe autoimmune diseases, today announced the appointment of John C. King as Chief Commercial Officer. Mr. King brings more than 25 years of global commercial leadership experience within biotechnology, including complement inhibitor experience in neuromuscular and hematological rare diseases. In this newly created position, Mr. King will play a critical role in the Company’s corporate and commercial strategy.

“I’m excited to welcome John to the Dianthus executive team and I look forward to partnering with him as we move DNTH103 forward across three neuromuscular indications and prepare for our first top-line data in 2H’25 from our Phase 2 clinical trial in gMG,” said Marino Garcia, Chief Executive Officer of Dianthus Therapeutics. “John is a strong, strategic leader who played a key role in establishing the foundation for the blockbuster gMG market and the multi-billion dollar C5 complement inhibitor franchise at Alexion, which continues to grow as first-line gMG therapy today. John then took on the role of CCO of Ra Pharma as it was developing the first FDA-approved, self-administered, subcutaneous biologic for the gMG market, leading to Ra Pharma’s acquisition by UCB for $2.5 billion. This wealth of experience will be highly valued at Dianthus as we continue to build an exciting late-stage biotech company.”

“I strongly believe DNTH103 has the potential to be a highly differentiated, first-line therapy and provide meaningful benefits for patients suffering from classical pathway-driven diseases, including gMG, CIDP and MMN. DNTH103’s best-in-class target profile would provide a unique combination of potency, safety and convenience with a patient-friendly, infrequent, self-administered subcutaneous auto-injector,” said John C. King, Chief Commercial Officer of Dianthus Therapeutics. “This is a transformational time for Dianthus and I’m thrilled to join the executive team ahead of key data readouts starting with gMG later this year.”

Mr. King started his biotech career at Wyeth Pharmaceuticals working on Enbrel® before he joined Alexion Pharmaceuticals, where he was Vice President, U.S. Neurology Business Unit responsible for building and leading the commercial team and strategy that launched Soliris® (eculizumab) into the generalized Myasthenia Gravis market as the first approved biologic and complement inhibitor. At Alexion, he also served as Vice President, Head of Global Hematology Franchise, among other leadership roles. Mr. King then joined Ra Pharma as the Chief Commercial Officer where he played a crucial role as part of the executive team in developing the commercial strategy for its C5 complement inhibitor in gMG and in its acquisition by UCB for $2.5 billion. Most recently, he was the Chief Commercial Officer at Vor Bio where he led commercial planning and business development for engineered cell therapies for patients with blood cancer. Mr. King began his career at Ernst & Young LLP and holds a Bachelor of Science in Business Logistics and a Master of Business Administration from Pennsylvania State University.

In addition, Sujay Kango has joined the Company’s Board of Directors. Mr. Kango is an experienced executive with more than 26 years of experience in the pharmaceutical and biotechnology sector. His vast, results-oriented experience ranges from serving as both public and private company board member to being a C-suite executive of multi-billion dollar public companies. He previously served on the boards of MEI Pharma and Infinity Pharmaceuticals, and currently serves as a board member of Adanate, Inc. Mr. Kango was the President and Chief Executive Officer of Tmunity Therapeutics, a clinical stage research and development CAR-T therapy company that was acquired by Gilead Sciences in February 2023 for an undisclosed amount. From 2018-2021, he served as the EVP, Chief Commercial Officer of Acceleron Pharma, which was acquired by Merck & Co. for over $11.5 billion. Mr. Kango has been responsible for over 5 blockbuster products and launches, including Reblozyl, Nexavar, Kyprolis, Peg-Intron, and Remicade. He earned a B.S. in Microbiology and an M.B.A. from McNeese State University.

Dianthus also announced that Tomas Kiselak will transition from the Board of Directors. Mr. Kiselak is a co-founder of Fairmount Funds and has served as a member of the Board since co-founding Dianthus.

About Dianthus Therapeutics
Dianthus Therapeutics is a clinical-stage biotechnology company dedicated to designing and delivering novel, best-in-class monoclonal antibodies with improved selectivity and potency. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who are leading the development of next-generation antibody complement therapeutics, aiming to deliver transformative medicines for people living with severe autoimmune and inflammatory diseases.

To learn more, please visit www.dianthustx.com and follow us on LinkedIn

Cautionary Statement Regarding Forward-Looking Statements
Certain statements in this press release, other than purely historical information, may constitute “forward-looking statements” within the meaning of the federal securities laws, including for purposes of the safe harbor provisions under the United States Private Securities Litigation Reform Act of 1995, express or implied statements regarding future plans and prospects, including statements regarding the expectations or plans for discovery, preclinical studies, clinical trials and research and development programs, in particular with respect to DNTH103, and any developments or results in connection therewith, including the target product profile of DNTH103; the anticipated timing of the initiation and results from those studies and trials; expectations regarding the time period over which the Company’s capital resources are expected to be sufficient to fund its anticipated operations; and expectations regarding the market and potential opportunities for complement therapies, in particular with respect to DNTH103. The words “opportunity,” “potential,” “milestones,” “runway,” “will,” “anticipate,” “achieve,” “near-term,” “catalysts,” “pursue,” “pipeline,” “believe,” continue,” “could,” “estimate,” “expect,” “ intend,” “may,” “might,” “plan,” “possible,” “predict,” “project,” “ should,” “strive,” “would,” “aim,” “target,” “commit,” and similar expressions (including the negatives of these terms or variations of them) generally identify forward-looking statements, but the absence of these words does not mean that statement is not forward looking.

Actual results could differ materially from those included in the forward-looking statements due to various factors, risks and uncertainties, including, but not limited to, that preclinical testing of DNTH103 and data from clinical trials may not be predictive of the results or success of ongoing or later clinical trials, that the development of DNTH103 or the Company’s other compounds may take longer and/or cost more than planned, that the Company may be unable to successfully complete the clinical development of the Company’s compounds, that the Company may be delayed in initiating, enrolling or completing its planned clinical trials, and that the Company’s compounds may not receive regulatory approval or become commercially successful products. These and other risks and uncertainties are identified under the heading “Risk Factors” included in the Company’s Annual Report on Form 10-K for the period ended December 31, 2023, and other filings that the Company has made and may make with the SEC in the future. Nothing in this press release should be regarded as a representation by any person that the forward-looking statements set forth herein will be achieved or that any of the contemplated results of such forward-looking statements will be achieved.

The forward-looking statements in this press release speak only as of the date they are made and are qualified in their entirety by reference to the cautionary statements herein. Dianthus undertakes no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future events or otherwise, except as required by law.

Contact
Jennifer Davis Ruff
Dianthus Therapeutics
jdavisruff@dianthustx.com

Feb 26 2025 | Dianthus Therapeutics to Participate in Two Upcoming Investor Conferences
NEW YORK and WALTHAM, Mass., Feb. 26, 2025 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to advancing the next… READ MORE
News
Feb 26 2025 | Dianthus Therapeutics to Participate in Two Upcoming Investor Conferences

NEW YORK and WALTHAM, Mass., Feb. 26, 2025 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to advancing the next generation of antibody complement therapeutics to treat severe autoimmune diseases, today announced the company’s participation at the following investor conferences:

  • TD Cowen 45th Annual Health Care Conference – Marino Garcia, Chief Executive Officer, will participate in a fireside chat on Wednesday, March 5 at 11:50 a.m. ET and host one-on-one meetings with investors in Boston. A webcast of this presentation may be accessed under “News and Events” in the Investors section of the Dianthus Therapeutics website.
  • Jefferies Biotech on the Bay Summit – Ryan Savitz, Chief Financial Officer and Chief Business Officer, will host one-on-one investor meetings on Wednesday, March 12 in Miami

About Dianthus Therapeutics
Dianthus Therapeutics is a clinical-stage biotechnology company dedicated to designing and delivering novel, best-in-class monoclonal antibodies with improved selectivity and potency. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who are leading the development of next-generation antibody complement therapeutics, aiming to deliver transformative medicines for people living with severe autoimmune and inflammatory diseases.

To learn more, please visit www.dianthustx.com and follow us on LinkedIn.

Contact
Jennifer Davis Ruff
Dianthus Therapeutics
jdavisruff@dianthustx.com

Jan 30 2025 | Dianthus Therapeutics to Webcast Presentations at Two Investor Conferences
NEW YORK and WALTHAM, Mass., Jan. 30, 2025 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to advancing the next… READ MORE
News
Jan 30 2025 | Dianthus Therapeutics to Webcast Presentations at Two Investor Conferences

NEW YORK and WALTHAM, Mass., Jan. 30, 2025 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to advancing the next generation of antibody complement therapeutics to treat severe autoimmune diseases, today announced the company’s participation and presentations by Marino Garcia, Chief Executive Officer, at the following healthcare investor conferences during the month of February:

  • Guggenheim SMID Cap Biotech Conference – Fireside chat on February 6 at 9:00 a.m. ET in New York City
  • Oppenheimer 35th Annual Healthcare Life Sciences Conference – Fireside chat on February 12 at 3:20 p.m. ET, taking place virtually

Live webcasts of the Company’s presentations may be accessed under “News and Events” in the Investors section of the Dianthus Therapeutics website.

About Dianthus Therapeutics
Dianthus Therapeutics is a clinical-stage biotechnology company dedicated to designing and delivering novel, best-in-class monoclonal antibodies with improved selectivity and potency. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who are leading the development of next-generation antibody complement therapeutics, aiming to deliver transformative medicines for people living with severe autoimmune and inflammatory diseases.

To learn more, please visit www.dianthustx.com and follow us on LinkedIn

Contact
Jennifer Davis Ruff
Dianthus Therapeutics
jdavisruff@dianthustx.com

Jan 08 2025 | Dianthus Therapeutics to Webcast Presentation at the 43rd Annual J.P. Morgan Healthcare Conference
NEW YORK and WALTHAM, Mass., Jan. 08, 2025 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to advancing the next… READ MORE
News
Jan 08 2025 | Dianthus Therapeutics to Webcast Presentation at the 43rd Annual J.P. Morgan Healthcare Conference

NEW YORK and WALTHAM, Mass., Jan. 08, 2025 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to advancing the next generation of antibody complement therapeutics to treat severe autoimmune diseases, today announced the company’s participation at the 43rd Annual J.P. Morgan Healthcare Conference. Marino Garcia, Chief Executive Officer, will present a corporate overview on Wednesday, January 15, 2025 at 9:00 a.m. PST / 12:00 p.m. EST in San Francisco.

A live webcast of the Company’s presentation may be accessed under “News and Events” in the Investors section of the Dianthus Therapeutics website.

About Dianthus Therapeutics
Dianthus Therapeutics is a clinical-stage biotechnology company dedicated to designing and delivering novel, best-in-class monoclonal antibodies with improved selectivity and potency. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who are leading the development of next-generation antibody complement therapeutics, aiming to deliver transformative medicines for people living with severe autoimmune and inflammatory diseases.

To learn more, please visit www.dianthustx.com and follow us on LinkedIn.

Contact
Jennifer Davis Ruff
Dianthus Therapeutics
jdavisruff@dianthustx.com

Nov 07 2024 | Dianthus Therapeutics Highlights Recent Business Achievements and Reports Q3 Financial Results
Initiation of a single, two-part, pivotal Phase 3 trial of DNTH103 in Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) anticipated by YE’24 Phase 2 MaGic trial of… READ MORE
News
Nov 07 2024 | Dianthus Therapeutics Highlights Recent Business Achievements and Reports Q3 Financial Results

Initiation of a single, two-part, pivotal Phase 3 trial of DNTH103 in Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) anticipated by YE’24

Phase 2 MaGic trial of DNTH103 in generalized Myasthenia Gravis (gMG) ongoing;
top-line results anticipated in 2H’25

Phase 2 MoMeNtum trial of DNTH103 in Multifocal Motor Neuropathy (MMN) ongoing;
top-line results anticipated in 2H’26

Approximately $343 million of cash provides runway into 2H’27

NEW YORK and WALTHAM, Mass., Nov. 07, 2024 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to advancing the next generation of antibody complement therapeutics to treat severe autoimmune diseases, today reported financial results for the third quarter ending September 30, 2024 and provided an update on recent business achievements.

“We are excited to expand DNTH103 beyond gMG and MMN into CIDP before year end. Like gMG and MMN, CIDP has significant unmet needs where a best-in-class, potent classical pathway inhibitor can potentially make a meaningful difference in the lives of patients. We believe this single, two-part, pivotal Phase 3 trial will support BLA filing in adult patients with CIDP and we anticipate initiating the trial by year-end 2024,” said Marino Garcia, Chief Executive Officer of Dianthus Therapeutics. “We continue to be confident in the pipeline-in-a-product potential of DNTH103 across multiple autoimmune diseases, supported by our proof-of-concept in vitro data most recently presented at AANEM and ICNMD and competitor clinical data that further validate targeting the classical pathway and active C1s.”

DNTH103 Clinical Development

DNTH103 is an investigational, clinical-stage, potent monoclonal antibody engineered to selectively target the classical pathway by inhibiting only the active form of the C1s protein, a clinically validated complement target. DNTH103 is enhanced with YTE half-life extension technology designed to enable a more convenient subcutaneous, self-administered injection dosed as infrequently as once every two weeks. DNTH103 has the potential to be a best-in-class pipeline-in-a-product across a range of autoimmune disorders with high unmet need.

Generalized Myasthenia Gravis (gMG)

  • Phase 2 MaGic gMG trial ongoing: The MaGic trial is a global, randomized, double-blind, placebo-controlled Phase 2 trial in patients with gMG who are acetylcholine receptor (AChR) antibody positive, and it remains on track to report top-line results in 2H’25.
  • Poster presentations at AANEM and ICNMD: Encore poster presentations at the American Association of Neuromuscular & Electrodiagnostic Medicine (AANEM) Annual Meeting in Savannah, Georgia and at the 18th International Congress on Neuromuscular Diseases (ICNMD) in Perth, Australia highlighted preclinical and in vitro data describing the potentially differentiated profile of DNTH103 in a disease model of gMG.

Multifocal Motor Neuropathy (MMN)

  • Phase 2 MoMeNtum MMN trial ongoing: The MoMeNtum trial is a global, randomized, double-blind, placebo-controlled Phase 2 trial designed to evaluate the safety, tolerability, and efficacy of DNTH103 in patients with MMN, and it remains on track to report top-line results in 2H’26.

Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

  • Initiation of a Phase 3 trial in CIDP anticipated by YE’24: Dianthus plans to initiate a single, two-part, randomized withdrawal Phase 3 trial of DNTH103 in CIDP by YE’24. In the open label Part A of this trial, participants will be administered a loading dose followed by 300mg DNTH103 administered every 2 weeks (Q2W) via subcutaneous (S.C.) injection for up to 13 weeks. Part A includes an interim responder analysis of a pre-defined number of participants. Only participants who respond to DNTH103 in Part A will be randomized into Part B, a double-blind, placebo-controlled treatment period of up to 52 weeks, where they will be assessed for prevention of relapse, safety and tolerability, followed by an open-label extension period. The Company believes this single pivotal trial will support BLA filing in adult patients with CIDP. Additional details regarding Phase 3 trial design and timelines will be provided by YE’24.
  • Poster presentations at AANEM and ICNMD: Encore poster presentations at the American Association of Neuromuscular & Electrodiagnostic Medicine (AANEM) Annual Meeting in Savannah, Georgia and at the 18th International Congress on Neuromuscular Diseases (ICNMD) in Perth, Australia highlighted preclinical and in vitro data describing the potentially differentiated profile of DNTH103 in a disease model of CIDP, in addition to head-to-head affinity and pharmacodynamic (PD) potency data for DNTH103 compared to riliprubart.

Corporate Updates

  • Effective September 16, 2024, Steven Romano, M.D., was appointed to the Dianthus Therapeutics Board of Directors. Dr. Romano is a pharmaceutical executive with more than 28 years of experience in drug development across a wide range of therapeutic and disease areas. He currently serves as Executive Vice President, Chief Research and Development Officer at Silence Therapeutics.

Third-Quarter 2024 Financial Results

  • Cash Position – $342.6 million of cash, cash equivalents and investments as of September 30, 2024 is projected to provide runway into the second half of 2027.
  • R&D Expenses – Research and development (R&D) expenses for the quarter ended September 30, 2024 were $25.5 million, inclusive of $1.7 million of stock-based compensation, compared to $8.0 million for the quarter ended September 30, 2023, which included $0.4 million of stock-based compensation. This increase in R&D expenses was primarily driven by higher clinical costs, chemistry, manufacturing and controls (CMC) costs and increased headcount to support DNTH103 Phase 2 and Phase 3 development.
  • G&A Expenses – General and administrative (G&A) expenses for the quarter ended September 30, 2024 totaled $6.5 million, inclusive of stock-based compensation of $2.2 million, compared to $8.7 million for the quarter ended September 30, 2023, which included $0.8 million of stock-based compensation. This decrease in G&A expenses was primarily due to lower personnel costs.
  • Net Loss – Net loss for the quarter ended September 30, 2024 was $25.2 million or $0.74 per share (basic and diluted) compared to $14.8 million or $3.78 per share (basic and diluted) for the quarter ended September 30, 2023.

About DNTH103
DNTH103 is an investigational, clinical-stage, potent monoclonal antibody engineered to selectively target the classical pathway by inhibiting only the active form of the C1s protein, a clinically validated complement target. DNTH103 is enhanced with YTE half-life extension technology designed to enable a more convenient subcutaneous, self-administered injection dosed as infrequently as once every two weeks. Additionally, selective inhibition of the classical complement pathway may lower patient risk of infection from encapsulated bacteria by preserving immune activity of the lectin and alternative pathways. As the classical pathway plays a significant role in disease pathology, DNTH103 has the potential to be a best-in-class pipeline-in-a-product across a range of autoimmune disorders with high unmet need. Dianthus is building a neuromuscular franchise with DNTH103 following the initiation of the Phase 2 MaGic trial in generalized Myasthenia Gravis in 1Q’24 and the Phase 2 MoMeNtum trial in Multifocal Motor Neuropathy in 3Q’24, and initiation of a Phase 3 trial in Chronic Inflammatory Demyelinating Polyneuropathy anticipated by YE’24.

DNTH103 is an investigational agent that is not approved as a therapy in any indication in any jurisdiction worldwide.

About Dianthus Therapeutics
Dianthus Therapeutics is a clinical-stage biotechnology company dedicated to designing and delivering novel, best-in-class monoclonal antibodies with improved selectivity and potency. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who are leading the development of next-generation antibody complement therapeutics, aiming to deliver transformative medicines for people living with severe autoimmune and inflammatory diseases.

To learn more, please visit www.dianthustx.com and follow us on LinkedIn

Cautionary Statement Regarding Forward-Looking Statements
Certain statements in this press release, other than purely historical information, may constitute “forward-looking statements” within the meaning of the federal securities laws, including for purposes of the safe harbor provisions under the United States Private Securities Litigation Reform Act of 1995, express or implied statements regarding future plans and prospects, including statements regarding the expectations or plans for discovery, preclinical studies, clinical trials and research and development programs, in particular with respect to DNTH103, and any developments or results in connection therewith, including the target product profile of DNTH103; the anticipated timing of the initiation and results from those studies and trials; expectations regarding the time period over which the Company’s capital resources are expected to be sufficient to fund its anticipated operations; and expectations regarding the market and potential opportunities for complement therapies, in particular with respect to DNTH103. The words “opportunity,” “potential,” “milestones,” “runway,” “will,” “anticipate,” “achieve,” “near-term,” “catalysts,” “pursue,” “pipeline,” “believe,” “continue,” “could,” “estimate,” “expect,” “ intend,” “may,” “might,” “plan,” “possible,” “predict,” “project,” “should,” “strive,” “would,” “aim,” “target,” “commit,” and similar expressions (including the negatives of these terms or variations of them) generally identify forward-looking statements, but the absence of these words does not mean that statement is not forward looking.

Actual results could differ materially from those included in the forward-looking statements due to various factors, risks and uncertainties, including, but not limited to, that preclinical testing of DNTH103 and data from clinical trials may not be predictive of the results or success of ongoing or later clinical trials, that the development of DNTH103 or the Company’s other compounds may take longer and/or cost more than planned, that the Company may be unable to successfully complete the clinical development of the Company’s compounds, that the Company may be delayed in initiating, enrolling or completing its planned clinical trials, and that the Company’s compounds may not receive regulatory approval or become commercially successful products. These and other risks and uncertainties are identified under the heading “Risk Factors” included in the Company’s Annual Report on Form 10-K for the period ended December 31, 2023, and other filings that the Company has made and may make with the SEC in the future. Nothing in this press release should be regarded as a representation by any person that the forward-looking statements set forth herein will be achieved or that any of the contemplated results of such forward-looking statements will be achieved.

The forward-looking statements in this press release speak only as of the date they are made and are qualified in their entirety by reference to the cautionary statements herein. Dianthus undertakes no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future events or otherwise, except as required by law.

Contact
Jennifer Davis Ruff
Dianthus Therapeutics
jdavisruff@dianthustx.com

DIANTHUS THERAPEUTICS, INC.
Condensed Consolidated Balance Sheets
(in thousands, except share and per share data)
(unaudited)
 
    September 30,
2024
    December 31,
2023
 
Assets            
Current assets:            
Cash and cash equivalents   $ 33,671     $ 132,325  
Short-term investments     247,452       41,393  
Receivable from related party     1,390       294  
Unbilled receivable from related party     1,293       184  
Prepaid expenses and other current assets     3,683       3,255  
Total current assets     287,489       177,451  
Long-term investments     61,482        
Property and equipment, net     189       185  
Right-of-use operating lease assets     352       615  
Other assets and restricted cash     4,736       1,154  
Total assets   $ 354,248     $ 179,405  
Liabilities and Stockholders’ Equity            
Current liabilities:            
Accounts payable   $ 7,572     $ 2,610  
Accrued expenses     7,727       6,504  
Current portion of deferred revenue – related party     100       100  
Current portion of operating lease liabilities     311       417  
Total current liabilities     15,710       9,631  
Deferred revenue – related party     640       736  
Long-term operating lease liabilities           168  
Total liabilities     16,350       10,535  
Commitments and contingencies            
Stockholders’ equity:            
Preferred stock            
Common stock     29       15  
Additional paid-in capital     483,140       258,231  
Accumulated deficit     (145,952 )     (89,423 )
Accumulated other comprehensive income     681       47  
Total stockholders’ equity     337,898       168,870  
Total liabilities and stockholders’ equity   $ 354,248     $ 179,405  
 

DIANTHUS THERAPEUTICS, INC.
Condensed Consolidated Statements of Operations and Comprehensive Loss
(in thousands, except share and per share data)
(unaudited)
 
    Three Months Ended
September 30,
    Nine Months Ended
September 30,
 
    2024     2023     2024     2023  
Revenues:                        
License revenue – related party   $ 2,172     $ 924     $ 4,909     $ 2,369  
Operating expenses:                        
Research and development     25,544       7,960       56,692       24,060  
General and administrative     6,528       8,723       18,165       13,527  
Total operating expenses     32,072       16,683       74,857       37,587  
Loss from operations     (29,900 )     (15,759 )     (69,948 )     (35,218 )
Other income/(expense):                        
Interest income     4,445       1,027       13,375       2,320  
Gain on investment in related party     307             307        
Loss on currency exchange, net     (48 )     (16 )     (91 )     (53 )
Other income/(expense)     22       (15 )     (172 )     (41 )
Total other income     4,726       996       13,419       2,226  
Net loss   $ (25,174 )   $ (14,763 )   $ (56,529 )   $ (32,992 )
Net loss per share attributable to common stockholders, basic and diluted   $ (0.74 )   $ (3.78 )   $ (1.73 )   $ (17.40 )
Weighted-average number of shares of common stock outstanding including shares issuable under equity classified pre-funded warrants, used in computing net loss per share of common stock, basic and diluted     34,236,728       3,906,886       32,614,771       1,896,605  
Comprehensive loss:                        
Net loss   $ (25,174 )   $ (14,763 )   $ (56,529 )   $ (32,992 )
Other comprehensive income:                        
Change in unrealized gains related to available for-sale debt securities     718       15       634       157  
Total other comprehensive income     718       15       634       157  
Total comprehensive loss   $ (24,456 )   $ (14,748 )   $ (55,895 )   $ (32,835 )
 

Nov 04 2024 | Dianthus Therapeutics to Participate in Three Upcoming Healthcare Investor Conferences
NEW YORK and WALTHAM, Mass., Nov. 04, 2024 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to advancing the next… READ MORE
News
Nov 04 2024 | Dianthus Therapeutics to Participate in Three Upcoming Healthcare Investor Conferences

NEW YORK and WALTHAM, Mass., Nov. 04, 2024 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to advancing the next generation of antibody complement therapeutics to treat severe autoimmune diseases, today announced the company’s participation and corporate overview presentations by Marino Garcia, Chief Executive Officer, at the following healthcare investor conferences during November and December 2024:

  • Guggenheim Healthcare Innovation Conference on November 11 at 1:30 p.m. ET in Boston, MA
  • Jefferies Global Healthcare Conference on November 19 at 9:00 a.m. GMT in London
  • 7th Annual Evercore HealthCONx Conference on December 4 at 10:50 a.m. ET in Coral Gables, FL

Live webcasts of the Company’s presentations at these three conferences may be accessed under “News and Events” in the Investors section of the Dianthus Therapeutics website.

About Dianthus Therapeutics
Dianthus Therapeutics is a clinical-stage biotechnology company dedicated to designing and delivering novel, best-in-class monoclonal antibodies with improved selectivity and potency. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who are leading the development of next-generation antibody complement therapeutics, aiming to deliver transformative medicines for people living with severe autoimmune and inflammatory diseases.

To learn more, please visit www.dianthustx.com and follow us on LinkedIn

Contact
Jennifer Davis Ruff
Dianthus Therapeutics
jdavisruff@dianthustx.com

Oct 15 2024 | Dianthus Therapeutics Announces Two Poster Presentations for DNTH103 at the 2024 American Association of Neuromuscular and Electrodiagnostic Medicine (AANEM) Annual Meeting
NEW YORK and WALTHAM, Mass., Oct. 15, 2024 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to advancing the next… READ MORE
News
Oct 15 2024 | Dianthus Therapeutics Announces Two Poster Presentations for DNTH103 at the 2024 American Association of Neuromuscular and Electrodiagnostic Medicine (AANEM) Annual Meeting

NEW YORK and WALTHAM, Mass., Oct. 15, 2024 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to advancing the next generation of antibody complement therapeutics to treat severe autoimmune diseases, today announced two poster presentations for DNTH103 at the 2024 American Association of Neuromuscular and Electrodiagnostic Medicine (AANEM) Annual Meeting, taking place October 15-18, 2024 in Savannah, Georgia.

DNTH103 is an investigational classical pathway inhibitor that is uniquely specific to the active form of C1s, and is being evaluated for its potential as an effective, low-volume, convenient and safe treatment option for patients with generalized Myasthenia Gravis, Multifocal Motor Neuropathy, and Chronic Inflammatory Demyelinating Polyneuropathy.

Two poster presentations at AANEM will highlight preclinical and in vitro data describing the potentially differentiated profile of DNTH103 in disease models of generalized Myasthenia Gravis (gMG) and Chronic Demyelinating Polyneuropathy (CIDP), in addition to head-to-head affinity and pharmacodynamic (PD) potency data for DNTH103 compared to riliprubart.

Dianthus Presentations at AANEM:

October 16, 2024, 6:15-6:45 PM ET & October 17, 2024, 2:45-3:15 PM ET
DNTH103 Shows Sustainable Inhibition of Complement and Prevents Nerve Conduction Velocity Impairment in a Preclinical Model of CIDP
Poster #201

October 16, 2024, 6:15-6:45 PM ET & October 17, 2024, 9:30-10:00 AM ET
DNTH103, A Potentially Safer and More Convenient Novel, Investigational Therapy for Generalized Myasthenia Gravis
Poster #297

These posters will be made available in the Scientific Publications section of the Dianthus website after they are presented.

About DNTH103
DNTH103 is an investigational, clinical-stage, potent monoclonal antibody engineered to selectively target the classical pathway by inhibiting only the active form of the C1s protein, a clinically validated complement target. DNTH103 is enhanced with YTE half-life extension technology designed to enable a more convenient subcutaneous, self-administered injection dosed as infrequently as once every two weeks. Additionally, selective inhibition of the classical complement pathway may lower patient risk of infection from encapsulated bacteria by preserving immune activity of the lectin and alternative pathways. As the classical pathway plays a significant role in disease pathology, DNTH103 has the potential to be a best-in-class pipeline-in-a-product across a range of autoimmune disorders with high unmet need. Dianthus is building a neuromuscular franchise with DNTH103 following the initiation of the Phase 2 MaGic trial in generalized Myasthenia Gravis in 1Q’24 and the Phase 2 MoMeNtum trial in Multifocal Motor Neuropathy in 3Q’24, and planned initiation of a Phase 2 trial in Chronic Inflammatory Demyelinating Polyneuropathy in 2H’24.

DNTH103 is an investigational agent that is not approved as a therapy in any indication in any jurisdiction worldwide.

About Dianthus Therapeutics
Dianthus Therapeutics is a clinical-stage biotechnology company dedicated to designing and delivering novel, best-in-class monoclonal antibodies with improved selectivity and potency. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who are leading the development of next-generation antibody complement therapeutics, aiming to deliver transformative medicines for people living with severe autoimmune and inflammatory diseases.

To learn more, please visit www.dianthustx.com and follow us on LinkedIn

Cautionary Statement Regarding Forward-Looking Statements
Certain statements in this press release, other than purely historical information, may constitute “forward-looking statements” within the meaning of the federal securities laws, including for purposes of the safe harbor provisions under the United States Private Securities Litigation Reform Act of 1995, express or implied statements regarding future plans and prospects, including statements regarding the expectations or plans for discovery, preclinical studies, clinical trials and research and development programs, in particular with respect to DNTH103, and any developments or results in connection therewith, including the target product profile of DNTH103; the anticipated timing of the initiation and results from those studies and trials; expectations regarding the time period over which the Company’s capital resources are expected to be sufficient to fund its anticipated operations; and expectations regarding the market and potential opportunities for complement therapies, in particular with respect to DNTH103. The words “opportunity,” “potential,” “milestones,” “runway,” “will,” “anticipate,” “achieve,” “near-term,” “catalysts,” “pursue,” “pipeline,” “believe,” continue,” “could,” “estimate,” “expect,” “ intend,” “may,” “might,” “plan,” “possible,” “predict,” “project,” “ should,” “strive,” “would,” “aim,” “target,” “commit,” and similar expressions (including the negatives of these terms or variations of them) generally identify forward-looking statements, but the absence of these words does not mean that statement is not forward looking.

Actual results could differ materially from those included in the forward-looking statements due to various factors, risks and uncertainties, including, but not limited to, that preclinical testing of DNTH103 and data from clinical trials may not be predictive of the results or success of ongoing or later clinical trials, that the development of DNTH103 or the Company’s other compounds may take longer and/or cost more than planned, that the Company may be unable to successfully complete the clinical development of the Company’s compounds, that the Company may be delayed in initiating, enrolling or completing its planned clinical trials, and that the Company’s compounds may not receive regulatory approval or become commercially successful products. These and other risks and uncertainties are identified under the heading “Risk Factors” included in the Company’s Annual Report on Form 10-K for the period ended December 31, 2023, and other filings that the Company has made and may make with the SEC in the future. Nothing in this press release should be regarded as a representation by any person that the forward-looking statements set forth herein will be achieved or that any of the contemplated results of such forward-looking statements will be achieved.

The forward-looking statements in this press release speak only as of the date they are made and are qualified in their entirety by reference to the cautionary statements herein. Dianthus undertakes no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future events or otherwise, except as required by law.

Contact
Jennifer Davis Ruff
Dianthus Therapeutics
jdavisruff@dianthustx.com

Sep 04 2024 | Dianthus Therapeutics to Participate in Three Healthcare Investor Conferences in September
NEW YORK and WALTHAM, Mass., Sept. 04, 2024 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to advancing the next… READ MORE
News
Sep 04 2024 | Dianthus Therapeutics to Participate in Three Healthcare Investor Conferences in September

NEW YORK and WALTHAM, Mass., Sept. 04, 2024 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to advancing the next generation of antibody complement therapeutics to treat severe autoimmune diseases, today announced the company’s participation and corporate overview presentations by Marino Garcia, Chief Executive Officer, at the following healthcare investor conferences during the month of September:

  • Baird 2024 Global Healthcare Conference on September 11 at 2:00 p.m. ET in New York City
  • Cantor 2024 Global Healthcare Conference on September 17 at 10:55 a.m. ET in New York City
  • Stifel 2024 Virtual Immunology and Inflammation Summit on September 18 at 10:30 a.m. ET via Zoom

Live webcasts of the Company’s presentations at the Cantor and Stifel conferences may be accessed under “News and Events” in the Investors section of the Dianthus Therapeutics website.

About Dianthus Therapeutics
Dianthus Therapeutics is a clinical-stage biotechnology company dedicated to designing and delivering novel, best-in-class monoclonal antibodies with improved selectivity and potency. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who are leading the development of next-generation antibody complement therapeutics, aiming to deliver transformative medicines for people living with severe autoimmune and inflammatory diseases.

To learn more, please visit www.dianthustx.com and follow us on LinkedIn.

Contact
Jennifer Davis Ruff
Dianthus Therapeutics
jdavisruff@dianthustx.com

Aug 08 2024 | Dianthus Therapeutics Highlights Recent Business Achievements and Reports Q2 Financial Results
Phase 2 MaGic trial in generalized Myasthenia Gravis (gMG) ongoing; top-line results anticipated in 2H’25 IND for Phase 2 MoMeNtum trial in Multifocal Motor Neuropathy (MMN)… READ MORE
News
Aug 08 2024 | Dianthus Therapeutics Highlights Recent Business Achievements and Reports Q2 Financial Results

Phase 2 MaGic trial in generalized Myasthenia Gravis (gMG) ongoing; top-line results anticipated in 2H’25

IND for Phase 2 MoMeNtum trial in Multifocal Motor Neuropathy (MMN) cleared by FDA in June; top-line results anticipated in 2H’26

Phase 2 trial in Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) to initiate 2H’24 Approximately $361 million of cash provides runway into 2H’27

NEW YORK and WALTHAM, Mass., Aug. 08, 2024 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to advancing the next generation of antibody complement therapeutics to treat severe autoimmune diseases, today reported financial results for the second quarter ending June 30, 2024, and provided an update on recent business achievements.

“The second quarter of 2024 highlighted the Dianthus team’s continued focus on execution and operational excellence as we advance our clinical programs for DNTH103 in generalized Myasthenia Gravis, Multifocal Motor Neuropathy, and Chronic Inflammatory Demyelinating Polyneuropathy,” said Marino Garcia, Chief Executive Officer of Dianthus Therapeutics. “We believe DNTH103 may be a potentially best-in-class, potent classical complement pathway inhibitor with infrequent, subcutaneous self-administration and a differentiated safety profile across our three initial indications of gMG, MMN and CIDP. We continue to be confident in the pipeline-in-a-product potential of DNTH103 across multiple autoimmune diseases, supported by our proof-of-concept in vitro data presented at EAN and recent competitor clinical data that further validate targeting the classical pathway and active C1s.”

Recent Business Highlights and Upcoming Milestones

DNTH103

DNTH103 is an investigational, clinical-stage, potent monoclonal antibody engineered to selectively target the classical pathway by inhibiting only the active form of the C1s protein, a clinically validated complement target. DNTH103 is enhanced with YTE half-life extension technology designed to enable a more convenient subcutaneous, self-administered injection dosed as infrequently as once every two weeks. DNTH103 has the potential to be a best-in-class pipeline-in-a-product across a range of autoimmune disorders with high unmet need.

  • Phase 2 MaGic gMG trial ongoing: The MaGic trial is a global, randomized, double-blind, placebo-controlled Phase 2 study in patients with gMG who are acetylcholine receptor (AChR) antibody positive. Initial top-line results from this trial are anticipated to be available in the second half of 2025.
  • Phase 2 IND cleared for MoMeNtum MMN trial: The MoMeNtum trial is a global, randomized, double-blind, placebo-controlled Phase 2 study designed to evaluate the safety, tolerability, and efficacy of DNTH103 in patients with MMN. Initial top-line results from this trial are anticipated to be available in the second half of 2026.
  • One oral presentation highlighted DNTH103 at AAN 2024: An oral presentation at the American Academy of Neurology (AAN) Annual Meeting in Denver highlighted preclinical and in vitro data describing the differentiated safety profile and neurotransmission activity of DNTH103 and a review of previously released Phase 1 healthy volunteer data.
  • Two DNTH103 posters presented at EAN 2024: Two poster presentations at the 10th Congress of the European Academy of Neurology (EAN) in Helsinki highlighted preclinical and in vitro data describing the potentially differentiated profile of DNTH103 in disease models of gMG and CIDP, in addition to head-to-head affinity and pharmacodynamic (PD) potency data for DNTH103 compared to riliprubart.
  • Planning for CIDP Phase 2 trial ongoing: Dianthus remains on track to initiate a Phase 2 trial of DNTH103 in CIDP in the second half of 2024.

Corporate

  • Effective July 1, 2024, Alison Lawton was appointed Chair of the Dianthus Therapeutics Board of Directors. She succeeded Lonnie Moulder, who remains on the Board of Directors.

Second-Quarter 2024 Financial Results

  • Cash Position – $360.7 million of cash, cash equivalents and short-term investments as of June 30, 2024 is projected to provide runway into the second half of 2027.
  • R&D Expenses – Research and development (R&D) expenses for the quarter ended June 30, 2024 were $18.1 million, inclusive of $1.4 million of stock-based compensation, compared to $10.3 million for the quarter ended June 30, 2023, which included $0.1 million of stock-based compensation. This increase in R&D expenses was primarily driven by higher clinical costs, chemistry, manufacturing and controls (CMC) costs and increased headcount to support DNTH103 Phase 1 and Phase 2 development.
  • G&A Expenses – General and administrative (G&A) expenses for the quarter ended June 30, 2024 totaled $6.0 million, inclusive of stock-based compensation of $1.8 million, compared to $2.5 million for the quarter ended June 30, 2023, which included $0.3 million of stock-based compensation. This increase in G&A expenses was primarily due to higher headcount and consulting and professional fees.
  • Net Loss – Net loss for the quarter ended June 30, 2024 was $17.6 million or $0.51 per share (basic and diluted) compared to $11.1 million or $12.73 per share (basic and diluted) for the quarter ended June 30, 2023.

About DNTH103
DNTH103 is an investigational, clinical-stage, potent monoclonal antibody engineered to selectively target the classical pathway by inhibiting only the active form of the C1s protein, a clinically validated complement target. DNTH103 is enhanced with YTE half-life extension technology designed to enable a more convenient subcutaneous, self-administered injection dosed as infrequently as once every two weeks. Additionally, selective inhibition of the classical complement pathway may lower patient risk of infection from encapsulated bacteria by preserving immune activity of the lectin and alternative pathways. As the classical pathway plays a significant role in disease pathology, DNTH103 has the potential to be a best-in-class pipeline-in-a-product across a range of autoimmune disorders with high unmet need. Dianthus is building a neuromuscular franchise with DNTH103 following the initiation of the Phase 2 MaGic trial in generalized Myasthenia Gravis in 1Q’24, regulatory clearance for Multifocal Motor Neuropathy in 2Q’24, and planned initiation of a Phase 2 trial in Chronic Inflammatory Demyelinating Polyneuropathy in 2H’24.

DNTH103 is an investigational agent that is not approved as a therapy in any indication in any jurisdiction worldwide.

About Dianthus Therapeutics
Dianthus Therapeutics is a clinical-stage biotechnology company dedicated to designing and delivering novel, best-in-class monoclonal antibodies with improved selectivity and potency. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who are leading the development of next-generation antibody complement therapeutics, aiming to deliver transformative medicines for people living with severe autoimmune and inflammatory diseases.

To learn more, please visit www.dianthustx.com and follow us on LinkedIn

Cautionary Statement Regarding Forward-Looking Statements
Certain statements in this press release, other than purely historical information, may constitute “forward-looking statements” within the meaning of the federal securities laws, including for purposes of the safe harbor provisions under the United States Private Securities Litigation Reform Act of 1995, express or implied statements regarding future plans and prospects, including statements regarding the expectations or plans for discovery, preclinical studies, clinical trials and research and development programs, in particular with respect to DNTH103, and any developments or results in connection therewith, including the target product profile of DNTH103; the anticipated timing of the initiation and results from those studies and trials; expectations regarding the time period over which the Company’s capital resources are expected to be sufficient to fund its anticipated operations; and expectations regarding the market and potential opportunities for complement therapies, in particular with respect to DNTH103. The words “opportunity,” “potential,” “milestones,” “runway,” “will,” “anticipate,” “achieve,” “near-term,” “catalysts,” “pursue,” “pipeline,” “believe,” continue,” “could,” “estimate,” “expect,” “ intend,” “may,” “might,” “plan,” “possible,” “predict,” “project,” “ should,” “strive,” “would,” “aim,” “target,” “commit,” and similar expressions (including the negatives of these terms or variations of them) generally identify forward-looking statements, but the absence of these words does not mean that statement is not forward looking.

Actual results could differ materially from those included in the forward-looking statements due to various factors, risks and uncertainties, including, but not limited to, that preclinical testing of DNTH103 and data from clinical trials may not be predictive of the results or success of ongoing or later clinical trials, that the development of DNTH103 or the Company’s other compounds may take longer and/or cost more than planned, that the Company may be unable to successfully complete the clinical development of the Company’s compounds, that the Company may be delayed in initiating, enrolling or completing its planned clinical trials, and that the Company’s compounds may not receive regulatory approval or become commercially successful products. These and other risks and uncertainties are identified under the heading “Risk Factors” included in the Company’s Annual Report on Form 10-K for the period ended December 31, 2023, and other filings that the Company has made and may make with the SEC in the future. Nothing in this press release should be regarded as a representation by any person that the forward-looking statements set forth herein will be achieved or that any of the contemplated results of such forward-looking statements will be achieved.

The forward-looking statements in this press release speak only as of the date they are made and are qualified in their entirety by reference to the cautionary statements herein. Dianthus undertakes no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future events or otherwise, except as required by law.

Contact
Jennifer Davis Ruff
Dianthus Therapeutics
jdavisruff@dianthustx.com

 

 
Dianthus Therapeutics, Inc.
Condensed Consolidated Balance Sheets
(in thousands, except share and per share data)
(unaudited)
       
ASSETS June 30,
2024
  December 31,
2023
Current assets:      
Cash and cash equivalents $ 314,169     $ 132,325  
Short-term investments   46,538       41,393  
Receivable from related party   840       294  
Unbilled receivable from related party   835       184  
Prepaid expenses and other current assets   3,305       3,255  
Total current assets   365,687       177,451  
       
Property and equipment, net   189       185  
Right-of-use operating lease assets   442       615  
Other assets and restricted cash   2,641       1,154  
Total assets $ 368,959     $ 179,405  
       
LIABILITIES AND STOCKHOLDERS’ EQUITY      
Current liabilities:      
Accounts payable $ 3,695     $ 2,610  
Accrued expenses   5,857       6,504  
Current portion of deferred revenue – related party   100       100  
Current portion of operating lease liabilities   377       417  
Total current liabilities   10,029       9,631  
       
Deferred revenue – related party   682       736  
Long-term operating lease liabilities   30       168  
Total liabilities   10,741       10,535  
       
Commitments and contingencies      
       
Stockholders’ equity:      
Preferred stock          
Common stock   29       15  
Additional paid-in capital   479,004       258,231  
Accumulated deficit   (120,778 )     (89,423 )
Accumulated other comprehensive income/(loss)   (37 )     47  
Total stockholders’ equity   358,218       168,870  
Total liabilities and stockholders’ equity $ 368,959     $ 179,405  

 

 
Dianthus Therapeutics, Inc.
Condensed Consolidated Statements of Operations and Comprehensive Loss
(in thousands, except share and per share data)
(unaudited)
 
    Three Months Ended
June 30,
    Six Months Ended
June 30,
 
    2024     2023     2024     2023  
Revenues:                        
License revenue – related party   $ 1,863     $ 969     $ 2,737     $ 1,445  
Operating expenses:                        
Research and development     18,070       10,253       31,148       16,100  
General and administrative     5,997       2,492       11,637       4,804  
Total operating expenses     24,067       12,745       42,785       20,904  
Loss from operations     (22,204 )     (11,776 )     (40,048 )     (19,459 )
Other income/(expense):                        
Interest income     4,708       687       8,930       1,293  
Loss on currency exchange, net     (31 )     (28 )     (43 )     (37 )
Other expense     (80 )     (23 )     (194 )     (26 )
Total other income     4,597       636       8,693       1,230  
Net loss   $ (17,607 )   $ (11,140 )   $ (31,355 )   $ (18,229 )
Net loss per share attributable to common stockholders, basic and diluted   $ (0.51 )   $ (12.73 )   $ (0.99 )   $ (20.84 )
Weighted-average number of shares of common stock outstanding including shares issuable under equity-classified pre-funded warrants, used in computing net loss per share of common stock, basic and diluted     34,227,038       874,900       31,794,881       874,805  
Comprehensive loss:                        
Net loss   $ (17,607 )   $ (11,140 )   $ (31,355 )   $ (18,229 )
Other comprehensive (loss)/income:                        
Change in unrealized (losses)/gains related to available-for-sale debt securities     (10 )     38       (84 )     142  
Total other comprehensive (loss)/income     (10 )     38       (84 )     142  
Total comprehensive loss   $ (17,617 )   $ (11,102 )   $ (31,439 )   $ (18,087 )

Jun 28 2024 | Dianthus Therapeutics Announces Two Poster Presentations for DNTH103 at the 10th Congress of the European Academy of Neurology (EAN)
NEW YORK and WALTHAM, Mass., June 28, 2024 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to advancing the next… READ MORE
News
Jun 28 2024 | Dianthus Therapeutics Announces Two Poster Presentations for DNTH103 at the 10th Congress of the European Academy of Neurology (EAN)

NEW YORK and WALTHAM, Mass., June 28, 2024 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to advancing the next generation of antibody complement therapeutics to treat severe autoimmune diseases, today announced two poster presentations for DNTH103 at the 10th Congress of the European Academy of Neurology (EAN), taking place June 29-July 2, 2024 in Helsinki.

DNTH103 is an investigational classical pathway inhibitor that is uniquely specific to the active form of C1s, and is being evaluated for its potential as an effective, low-volume, convenient and safe treatment option for patients with generalized Myasthenia Gravis, Multifocal Motor Neuropathy, and Chronic Inflammatory Demyelinating Polyneuropathy.

Two poster presentations at EAN will highlight preclinical and in vitro data describing the potentially differentiated profile of DNTH103 in disease models of generalized Myasthenia Gravis (gMG) and Chronic Demyelinating Polyneuropathy (CIDP), in addition to head-to-head affinity and pharmacodynamic (PD) potency data for DNTH103 compared to Riliprubart.

Dianthus Presentations at EAN:

June 29, 2024, 14:10 EEST
DNTH103, a Potentially Safer and More Convenient Novel Therapy for Generalised Myasthenia Gravis
Session: Muscle and Neuromuscular Junction Disorder 1; Presentation Number: EPR-118

June 30, 2024, 14:25 EEST
DNTH103: Preventing Nerve Damage in a CIDP Model via Sustained Complement Inhibition
Session: Muscle and Neuromuscular Junction Disorder 2; Presentation Number: EPR-243

These posters will be made available in the Scientific Publications section of the Dianthus website after they are presented.

“Currently, therapies for patients with generalized Myasthenia Gravis (gMG) are limited to C5 inhibitors or FcRn inhibitors that can be burdensome for patients and caregivers, and the C5 complement inhibitors available today have an increased risk for serious bacterial infections. Similarly, treatment options for patients with CIDP have traditionally been limited to intravenous or subcutaneous infusions of Ig,” said Marino Garcia, Chief Executive Officer of Dianthus Therapeutics. “We aim to demonstrate that DNTH103 may become a best-in-class classical complement pathway inhibitor with infrequent self-administration that provides effective and consistent control of symptoms for people living with neuromuscular conditions, without inhibiting the alternative and lectin pathways that are critical in the defense against infection.”

About DNTH103

DNTH103 is an investigational, clinical-stage, potent monoclonal antibody engineered to selectively target the classical pathway by inhibiting only the active form of the C1s protein, a clinically validated complement target. DNTH103 is enhanced with YTE half-life extension technology designed to enable a more convenient subcutaneous, self-administered injection dosed as infrequently as once every two weeks. Additionally, selective inhibition of the classical complement pathway may lower patient risk of infection from encapsulated bacteria by preserving immune activity of the lectin and alternative pathways. As the classical pathway plays a significant role in disease pathology, DNTH103 has the potential to be a best-in-class pipeline-in-a-product across a range of autoimmune disorders with high unmet need. Dianthus is building a neuromuscular franchise with DNTH103 following the initiation of the Phase 2 MaGic trial in generalized Myasthenia Gravis in 1Q’24, regulatory clearance for Multifocal Motor Neuropathy in 2Q’24, and planned initiation of a Phase 2 trial in Chronic Inflammatory Demyelinating Polyneuropathy in 2H’24.

DNTH103 is an investigational agent that is not approved as a therapy in any indication in any jurisdiction worldwide.

About Dianthus Therapeutics
Dianthus Therapeutics is a clinical-stage biotechnology company dedicated to designing and delivering novel, best-in-class monoclonal antibodies with improved selectivity and potency. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who are leading the development of next-generation antibody complement therapeutics, aiming to deliver transformative medicines for people living with severe autoimmune and inflammatory diseases.

To learn more, please visit www.dianthustx.com and follow us on LinkedIn

Cautionary Statement Regarding Forward-Looking Statements
Certain statements in this press release, other than purely historical information, may constitute “forward-looking statements” within the meaning of the federal securities laws, including for purposes of the safe harbor provisions under the United States Private Securities Litigation Reform Act of 1995, express or implied statements regarding future plans and prospects, including statements regarding the expectations or plans for discovery, preclinical studies, clinical trials and research and development programs, in particular with respect to DNTH103, and any developments or results in connection therewith, including the target product profile of DNTH103; the anticipated timing of the initiation and results from those studies and trials; expectations regarding the time period over which the Company’s capital resources are expected to be sufficient to fund its anticipated operations; and expectations regarding the market and potential opportunities for complement therapies, in particular with respect to DNTH103. The words “opportunity,” “potential,” “milestones,” “runway,” “will,” “anticipate,” “achieve,” “near-term,” “catalysts,” “pursue,” “pipeline,” “believe,” continue,” “could,” “estimate,” “expect,” “ intend,” “may,” “might,” “plan,” “possible,” “predict,” “project,” “ should,” “strive,” “would,” “aim,” “target,” “commit,” and similar expressions (including the negatives of these terms or variations of them) generally identify forward-looking statements, but the absence of these words does not mean that statement is not forward looking.

Actual results could differ materially from those included in the forward-looking statements due to various factors, risks and uncertainties, including, but not limited to, that preclinical testing of DNTH103 and data from clinical trials may not be predictive of the results or success of ongoing or later clinical trials, that the development of DNTH103 or the Company’s other compounds may take longer and/or cost more than planned, that the Company may be unable to successfully complete the clinical development of the Company’s compounds, that the Company may be delayed in initiating, enrolling or completing its planned clinical trials, and that the Company’s compounds may not receive regulatory approval or become commercially successful products. These and other risks and uncertainties are identified under the heading “Risk Factors” included in the Company’s Annual Report on Form 10-K for the period ended December 31, 2023, and other filings that the Company has made and may make with the SEC in the future. Nothing in this press release should be regarded as a representation by any person that the forward-looking statements set forth herein will be achieved or that any of the contemplated results of such forward-looking statements will be achieved.

The forward-looking statements in this press release speak only as of the date they are made and are qualified in their entirety by reference to the cautionary statements herein. Dianthus undertakes no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future events or otherwise, except as required by law.

Contact
Jennifer Davis Ruff
Dianthus Therapeutics
jdavisruff@dianthustx.com

Jun 12 2024 | Dianthus Therapeutics Announces FDA Clearance to Initiate Phase 2 Trial of DNTH103 in Multifocal Motor Neuropathy (MMN)
Top-line results from Phase 2 MoMeNtum trial in Multifocal Motor Neuropathy anticipated in 2H 2026 Building a neuromuscular franchise with DNTH103 following the initiation of… READ MORE
News
Jun 12 2024 | Dianthus Therapeutics Announces FDA Clearance to Initiate Phase 2 Trial of DNTH103 in Multifocal Motor Neuropathy (MMN)

Top-line results from Phase 2 MoMeNtum trial in Multifocal Motor Neuropathy anticipated in 2H 2026

Building a neuromuscular franchise with DNTH103 following the initiation of the Phase 2 MaGic trial in generalized Myasthenia Gravis (gMG) in 1Q’24 and planned initiation of a Phase 2 trial in Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) in 2H’24

Recently disclosed head-to-head affinity and PD potency data reinforce DNTH103 is a highly potent, potential best-in-class active C1s inhibitor designed for self-administration in a low-volume, subcutaneous autoinjector once every two weeks

NEW YORK and WALTHAM, Mass., June 12, 2024 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to advancing the next generation of antibody complement therapeutics to treat severe autoimmune diseases, today announced U.S. Food and Drug Administration (FDA) clearance of its Phase 2 Investigational New Drug (IND) application for the MoMeNtum trial of DNTH103 in patients with Multifocal Motor Neuropathy (MMN).

“Pre-clinical and clinical evidence support the classical pathway’s role in the pathology seen in MMN,” said Simrat Randhawa, MD, Chief Medical Officer of Dianthus Therapeutics. “DNTH103 is a potent and highly selective inhibitor of active C1s resulting in classical pathway inhibition, without inhibiting the alternative and lectin pathways that are critical in the defense against infection. The Dianthus medical team and our MMN steering committee are excited to investigate the potential benefits DNTH103 may bring to MMN patients.”

The MoMeNtum trial is a global, randomized, double-blind, placebo-controlled Phase 2 study designed to evaluate the safety, tolerability, and efficacy of DNTH103 in 36 patients with MMN. Following determination of Ig dependency and responsiveness, patients will be randomized to receive placebo or DNTH103 administered subcutaneously (S.C.) every two weeks (Q2W). The initial S.C. treatment duration is expected to be 17 weeks followed by a 52-week open label extension. The primary endpoint of this study is safety and tolerability. Secondary endpoints include time to IVIg retreatment, time to relapse, and assessments of muscle and grip strength. Initial top-line results from this trial are anticipated to be available in the second half of 2026.

“There is a significant unmet medical need for a targeted biologic to treat patients living with MMN,” said Hans Katzberg, MD, MSc, FRCPC, Associate Professor of Neurology, University of Toronto, Prosserman Centre of Neuromuscular Disease. “Today, treatments for MMN are limited to intravenous or subcutaneous infusions of Ig, which can be both inconvenient for patients and difficult to tolerate. Treating MMN with an active C1s inhibitor, like DNTH103, has the potential to transform the lives of these patients.”

About DNTH103
DNTH103 is an investigational, clinical-stage, potent monoclonal antibody engineered to selectively target the classical pathway by inhibiting only the active form of the C1s protein, a clinically validated complement target. DNTH103 is enhanced with YTE half-life extension technology designed to enable a more convenient subcutaneous, self-administered injection dosed as infrequently as once every two weeks. Additionally, selective inhibition of the classical complement pathway may lower patient risk of infection from encapsulated bacteria by preserving immune activity of the lectin and alternative pathways. As the classical pathway plays a significant role in disease pathology, DNTH103 has the potential to be a best-in-class pipeline-in-a-product across a range of autoimmune disorders with high unmet need. Dianthus is building a neuromuscular franchise with DNTH103 following the initiation of the Phase 2 MaGic trial in generalized Myasthenia Gravis in 1Q’24, regulatory clearance for Multifocal Motor Neuropathy in 2Q’24, and planned initiation of a Phase 2 trial in Chronic Inflammatory Demyelinating Polyneuropathy in 2H’24.

DNTH103 is an investigational agent that is not approved as a therapy in any indication in any jurisdiction worldwide.

About Dianthus Therapeutics
Dianthus Therapeutics is a clinical-stage biotechnology company dedicated to designing and delivering novel, best-in-class monoclonal antibodies with improved selectivity and potency. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who are leading the development of next-generation antibody complement therapeutics, aiming to deliver transformative medicines for people living with severe autoimmune and inflammatory diseases.

To learn more, please visit www.dianthustx.com and follow us on LinkedIn

Cautionary Statement Regarding Forward-Looking Statements
Certain statements in this press release, other than purely historical information, may constitute “forward-looking statements” within the meaning of the federal securities laws, including for purposes of the safe harbor provisions under the United States Private Securities Litigation Reform Act of 1995, express or implied statements regarding future plans and prospects, including statements regarding the expectations or plans for discovery, preclinical studies, clinical trials and research and development programs, in particular with respect to DNTH103, and any developments or results in connection therewith, including the target product profile of DNTH103; the anticipated timing of the initiation and results from those studies and trials; expectations regarding the time period over which the Company’s capital resources are expected to be sufficient to fund its anticipated operations; and expectations regarding the market and potential opportunities for complement therapies, in particular with respect to DNTH103. The words “opportunity,” “potential,” “milestones,” “runway,” “will,” “anticipate,” “achieve,” “near-term,” “catalysts,” “pursue,” “pipeline,” “believe,” continue,” “could,” “estimate,” “expect,” “ intend,” “may,” “might,” “plan,” “possible,” “predict,” “project,” “ should,” “strive,” “would,” “aim,” “target,” “commit,” and similar expressions (including the negatives of these terms or variations of them) generally identify forward-looking statements, but the absence of these words does not mean that statement is not forward looking.

Actual results could differ materially from those included in the forward-looking statements due to various factors, risks and uncertainties, including, but not limited to, that preclinical testing of DNTH103 and data from clinical trials may not be predictive of the results or success of ongoing or later clinical trials, that the development of DNTH103 or the Company’s other compounds may take longer and/or cost more than planned, that the Company may be unable to successfully complete the clinical development of the Company’s compounds, that the Company may be delayed in initiating, enrolling or completing its planned clinical trials, and that the Company’s compounds may not receive regulatory approval or become commercially successful products. These and other risks and uncertainties are identified under the heading “Risk Factors” included in the Company’s Annual Report on Form 10-K for the period ended December 31, 2023, and other filings that the Company has made and may make with the SEC in the future. Nothing in this press release should be regarded as a representation by any person that the forward-looking statements set forth herein will be achieved or that any of the contemplated results of such forward-looking statements will be achieved.

The forward-looking statements in this press release speak only as of the date they are made and are qualified in their entirety by reference to the cautionary statements herein. Dianthus undertakes no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future events or otherwise, except as required by law.

Contact
Jennifer Davis Ruff
Dianthus Therapeutics
jdavisruff@dianthustx.com

May 30 2024 | Dianthus Therapeutics to Participate in the Jefferies Global Healthcare Conference
NEW YORK and WALTHAM, Mass., May 30, 2024 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to advancing the next… READ MORE
News
May 30 2024 | Dianthus Therapeutics to Participate in the Jefferies Global Healthcare Conference

NEW YORK and WALTHAM, Mass., May 30, 2024 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to advancing the next generation of antibody complement therapeutics to treat severe autoimmune diseases, today announced its participation in the Jefferies Global Healthcare Conference. Marino Garcia, Chief Executive Officer, will present a corporate overview on Thursday, June 6, 2024 at 1:30 p.m. ET in New York.

A live webcast of this presentation may be accessed under “News and Events” in the Investors section of the Dianthus Therapeutics website.

About Dianthus Therapeutics
Dianthus Therapeutics is a clinical-stage biotechnology company dedicated to designing and delivering novel, best-in-class monoclonal antibodies with improved selectivity and potency. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who are leading the development of next-generation antibody complement therapeutics, aiming to deliver transformative medicines for people living with severe autoimmune and inflammatory diseases.

Dianthus has initiated a Phase 2 trial of DNTH103, an investigational potential best-in-class active C1s inhibitor, in generalized Myasthenia Gravis and plans to initiate additional Phase 2 trials in other neuromuscular indications, including Multifocal Motor Neuropathy and Chronic Inflammatory Demyelinating Polyneuropathy, in 2024.

To learn more, please visit www.dianthustx.com and follow us on LinkedIn.

Cautionary Statement Regarding Forward-Looking Statements
Certain statements in this press release, other than purely historical information, may constitute “forward-looking statements” within the meaning of the federal securities laws, including for purposes of the safe harbor provisions under the United States Private Securities Litigation Reform Act of 1995, express or implied statements regarding future plans and prospects, including statements regarding the expectations or plans for discovery, preclinical studies, clinical trials and research and development programs, in particular with respect to DNTH103, and any developments or results in connection therewith, including the target product profile of DNTH103; the anticipated timing of the initiation and results from those studies and trials; expectations regarding the time period over which the Company’s capital resources are expected to be sufficient to fund its anticipated operations; and expectations regarding the market and potential opportunities for complement therapies, in particular with respect to DNTH103. The words “opportunity,” “potential,” “milestones,” “runway,” “will,” “anticipate,” “achieve,” “near-term,” “catalysts,” “pursue,” “pipeline,” “believe,” continue,” “could,” “estimate,” “expect,” “ intend,” “may,” “might,” “plan,” “possible,” “predict,” “project,” “ should,” “strive,” “would,” “aim,” “target,” “commit,” and similar expressions (including the negatives of these terms or variations of them) generally identify forward-looking statements, but the absence of these words does not mean that statement is not forward looking.

Actual results could differ materially from those included in the forward-looking statements due to various factors, risks and uncertainties, including, but not limited to, that preclinical testing of DNTH103 and data from clinical trials may not be predictive of the results or success of ongoing or later clinical trials, that the development of DNTH103 or the Company’s other compounds may take longer and/or cost more than planned, that the Company may be unable to successfully complete the clinical development of the Company’s compounds, that the Company may be delayed in initiating, enrolling or completing its planned clinical trials, and that the Company’s compounds may not receive regulatory approval or become commercially successful products. These and other risks and uncertainties are identified under the heading “Risk Factors” included in the Company’s Annual Report on Form 10-K for the period ended December 31, 2023, and other filings that the Company has made and may make with the SEC in the future. Nothing in this press release should be regarded as a representation by any person that the forward-looking statements set forth herein will be achieved or that any of the contemplated results of such forward-looking statements will be achieved.

The forward-looking statements in this press release speak only as of the date they are made and are qualified in their entirety by reference to the cautionary statements herein. Dianthus undertakes no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future events or otherwise, except as required by law.

Contact
Jennifer Davis Ruff
Dianthus Therapeutics
jdavisruff@dianthustx.com

May 09 2024 | Dianthus Therapeutics Highlights Recent Business Achievements and Reports Q1 Financial Results
Phase 2 MaGic trial in generalized Myasthenia Gravis (gMG) ongoing, with top-line results anticipated in 2H’25 Building a neuromuscular franchise with DNTH103; Phase 2 trial… READ MORE
News
May 09 2024 | Dianthus Therapeutics Highlights Recent Business Achievements and Reports Q1 Financial Results

Phase 2 MaGic trial in generalized Myasthenia Gravis (gMG) ongoing, with top-line results anticipated in 2H’25

Building a neuromuscular franchise with DNTH103; Phase 2 trial in Multifocal Motor Neuropathy (MMN) to initiate 2Q’24 and Phase 2 trial in Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) to initiate 2H’24

$377 million of cash, including proceeds from a successful $230 million PIPE financing completed in January 2024, provides runway into 2H 2027

NEW YORK and WALTHAM, Mass., May 09, 2024 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to advancing the next generation of antibody complement therapeutics to treat severe autoimmune diseases, today reported financial results for the first quarter ending March 31, 2024, and provided an update on recent business achievements.

“The first quarter of 2024 was highlighted by the initiation of our Phase 2 MaGic trial of DNTH103 for patients with gMG. We are also encouraged by recently published proof-of-concept clinical trial data that continues to validate active C1s as a target for treating CIDP, enhancing our confidence in the pipeline-in-a-product potential for DNTH103 across multiple autoimmune diseases,” said Marino Garcia, Chief Executive Officer of Dianthus Therapeutics. “We remain on track to initiate our Phase 2 clinical trials in MMN and CIDP this year as well.”

Recent Business Highlights and Upcoming Milestones

DNTH103

DNTH103 is an investigational, clinical-stage, potent monoclonal antibody engineered to selectively target the classical pathway by inhibiting only the active form of the C1s protein, a clinically validated complement target. DNTH103 is enhanced with YTE half-life extension technology designed to enable a more convenient subcutaneous, self-administered injection dosed as infrequently as once every two weeks. DNTH103 has the potential to be a best-in-class pipeline-in-a-product across a range of autoimmune disorders with high unmet need.

  • Phase 2 MaGic gMG trial initiated in February: The MaGic trial is a global, randomized, double-blind, placebo-controlled Phase 2 study in up to 60 patients with gMG who are acetylcholine receptor (AchR) antibody positive. Initial top-line results from this trial are anticipated to be available in the second half of 2025.
  • Oral presentation at the American Academy of Neurology (AAN) 2024 Annual Meeting on April 15, 2024: An oral presentation describing key attributes of DNTH103 and its differentiation in gMG was presented at the AAN 2024 Annual Meeting.
  • Planning for MMN and CIDP Phase 2 trials ongoing: Dianthus expects to initiate additional Phase 2 trials of DNTH103 in MMN in the second quarter of 2024 and CIDP in the second half of 2024.

Corporate

  • Dianthus successfully completed a private investment in public equity (“PIPE”) financing in January 2024 that resulted in gross proceeds of approximately $230 million. This PIPE financing included participation from both new and existing investors, including Bain Capital Life Sciences, RA Capital Management, Avidity Partners, Fairmount, Venrock Healthcare Capital Partners, RTW Investments, Great Point Partners LLC, Octagon Capital, Janus Henderson Investors, Vestal Point Capital, Logos Capital, Catalio Capital Management, Woodline Partners LP, Ally Bridge Group, Tellus BioVentures, StemPoint Capital LP and a large investment management firm. 

First-Quarter 2024 Financial Results

  • Cash Position – $377.0 million of cash, cash equivalents and short-term investments as of March 31, 2024 is projected to provide runway into 2H 2027.
  • R&D Expenses – Research and development (R&D) expenses for the quarter ended March 31, 2024 were $13.1 million, inclusive of $0.8 million of stock-based compensation, compared to $5.8 million for the quarter ended March 31, 2023, which included $0.2 million of stock-based compensation. This increase in R&D expenses was primarily driven by higher clinical costs, chemistry, manufacturing and controls (CMC) costs and increased headcount to support DNTH103 Phase 1 and Phase 2 development, partially offset by lower pre-clinical costs.
  • G&A Expenses – General and administrative (G&A) expenses for the quarter ended March 31, 2024 totaled $5.6 million, inclusive of stock-based compensation of $1.2 million, compared to $2.3 million for the quarter ended March 31, 2023, which included $0.3 million of stock-based compensation. This increase in G&A expenses was primarily due to higher headcount and professional fees.
  • Net Loss – Net loss for the quarter ended March 31, 2024 was $13.7 million or $0.54 net loss per share (basic and diluted) compared to $7.1 million or $8.10 net loss per share (basic and diluted) for the quarter ended March 31, 2023.
  • Additional Information – For additional information on the Company’s financial results for the quarter ended March 31, 2024, please refer to the Form 10-Q filed with the SEC.

About DNTH103
DNTH103 is an investigational, clinical-stage, potent monoclonal antibody engineered to selectively target the classical pathway by inhibiting only the active form of the C1s protein, a clinically validated complement target. DNTH103 is enhanced with YTE half-life extension technology designed to enable a more convenient subcutaneous, self-administered injection dosed as infrequently as once every two weeks. Additionally, selective inhibition of the classical complement pathway may lower patient risk of infection from encapsulated bacteria by preserving immune activity of the lectin and alternative pathways. As the classical pathway plays a significant role in disease pathology, DNTH103 has the potential to be a best-in-class pipeline-in-a-product across a range of autoimmune disorders with high unmet need. Dianthus has initiated a Phase 2 trial in generalized Myasthenia Gravis and plans to initiate additional Phase 2 trials in other neuromuscular indications, including Multifocal Motor Neuropathy and Chronic Inflammatory Demyelinating Polyneuropathy, in 2024.

About Dianthus Therapeutics
Dianthus Therapeutics is a clinical-stage biotechnology company dedicated to designing and delivering novel, best-in-class monoclonal antibodies with improved selectivity and potency. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who are leading the development of next-generation antibody complement therapeutics, aiming to deliver transformative medicines for people living with severe autoimmune and inflammatory diseases.

Dianthus has initiated a Phase 2 trial of DNTH103, a potential best-in-class active C1s inhibitor, in generalized Myasthenia Gravis and plans to initiate additional Phase 2 trials in other neuromuscular indications, including Multifocal Motor Neuropathy and Chronic Inflammatory Demyelinating Polyneuropathy, in 2024.

To learn more, please visit www.dianthustx.com and follow us on LinkedIn

Cautionary Statement Regarding Forward-Looking Statements
Certain statements in this press release, other than purely historical information, may constitute “forward-looking statements” within the meaning of the federal securities laws, including for purposes of the safe harbor provisions under the United States Private Securities Litigation Reform Act of 1995, express or implied statements regarding future plans and prospects, including statements regarding the expectations or plans for discovery, preclinical studies, clinical trials and research and development programs, in particular with respect to DNTH103, and any developments or results in connection therewith, including the target product profile of DNTH103; the anticipated timing of the initiation and results from those studies and trials; expectations regarding the time period over which the Company’s capital resources are expected to be sufficient to fund its anticipated operations; and expectations regarding the market and potential opportunities for complement therapies, in particular with respect to DNTH103. The words “opportunity,” “potential,” “milestones,” “runway,” “will,” “anticipate,” “achieve,” “near-term,” “catalysts,” “pursue,” “pipeline,” “believe,” continue,” “could,” “estimate,” “expect,” “ intend,” “may,” “might,” “plan,” “possible,” “predict,” “project,” “ should,” “strive,” “would,” “aim,” “target,” “commit,” and similar expressions (including the negatives of these terms or variations of them) generally identify forward-looking statements, but the absence of these words does not mean that statement is not forward looking.

Actual results could differ materially from those included in the forward-looking statements due to various factors, risks and uncertainties, including, but not limited to, that preclinical testing of DNTH103 and data from clinical trials may not be predictive of the results or success of ongoing or later clinical trials, that the development of DNTH103 or the Company’s other compounds may take longer and/or cost more than planned, that the Company may be unable to successfully complete the clinical development of the Company’s compounds, that the Company may be delayed in initiating, enrolling or completing its planned clinical trials, and that the Company’s compounds may not receive regulatory approval or become commercially successful products. These and other risks and uncertainties are identified under the heading “Risk Factors” included in the Company’s Annual Report on Form 10-K for the period ended December 31, 2023, and other filings that the Company has made and may make with the SEC in the future. Nothing in this press release should be regarded as a representation by any person that the forward-looking statements set forth herein will be achieved or that any of the contemplated results of such forward-looking statements will be achieved.

The forward-looking statements in this press release speak only as of the date they are made and are qualified in their entirety by reference to the cautionary statements herein. Dianthus undertakes no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future events or otherwise, except as required by law.

Contact
Jennifer Davis Ruff
Dianthus Therapeutics
jdavisruff@dianthustx.com

 
Dianthus Therapeutics, Inc.
Condensed Consolidated Balance Sheets
(in thousands)
(unaudited)
       
ASSETS March 31,
2024
  December 31,
2023
Current assets:      
Cash and cash equivalents $ 329,724     $ 132,325  
Short-term investments   47,312       41,393  
Receivable from related party   435       294  
Unbilled receivable from related party   441       184  
Prepaid expenses and other current assets   3,014       3,255  
Total current assets   380,926       177,451  
       
Property and equipment, net   195       185  
Right-of-use operating lease assets   530       615  
Other assets and restricted cash   811       1,154  
Total assets $ 382,462     $ 179,405  
       
LIABILITIES AND STOCKHOLDERS’ EQUITY      
Current liabilities:      
Accounts payable $ 2,612     $ 2,610  
Accrued expenses   5,847       6,504  
Current portion of deferred revenue – related party   100       100  
Current portion of operating lease liabilities   400       417  
Total current liabilities   8,959       9,631  
       
Deferred revenue – related party   719       736  
Long-term operating lease liabilities   97       168  
Total liabilities   9,775       10,535  
       
Commitments and contingencies      
       
Stockholders’ equity:      
Preferred stock          
Common stock   29       15  
Additional paid-in capital   475,856       258,231  
Accumulated deficit   (103,171 )     (89,423 )
Accumulated other comprehensive (loss)/income   (27 )     47  
Total stockholders’ equity   372,687       168,870  
Total liabilities and stockholders’ equity $ 382,462     $ 179,405  
               

 
Dianthus Therapeutics, Inc.
Condensed Consolidated Statements of Operations and Comprehensive Loss
(in thousands, except share and per share data)
(unaudited)
 
       
  Three Months Ended March 31,
  2024   2023
Revenues:      
License revenue – related party $ 874     $ 476  
       
Operating expenses:      
Research and development   13,078       5,847  
General and administrative   5,640       2,312  
Total operating expenses   18,718       8,159  
       
Loss from operations   (17,844 )     (7,683 )
       
Other income/(expense):      
Interest income   4,222       606  
Loss on currency exchange, net   (12 )     (9 )
Other expense   (114 )     (3 )
Total other income   4,096       594  
       
Net loss $ (13,748 )   $ (7,089 )
       
Net loss per share attributable to common stockholders, basic and diluted $ (0.54 )   $ (8.10 )
       
Weighted-average number of common shares      
outstanding, used in computing net loss per common share, basic and diluted   25,665,475       874,709  
       
Comprehensive loss:      
Net Loss $ (13,748 )   $ (7,089 )
Other comprehensive (loss)/income:      
Change in unrealized (losses)/gains related to available-for-sale debt securities   (74 )     104  
Total other comprehensive (loss)/income   (74 )     104  
Total comprehensive loss $ (13,822 )   $ (6,985 )
               

May 08 2024 | Dianthus Therapeutics to Participate in the Bank of America Securities 2024 Health Care Conference
NEW YORK and WALTHAM, Mass., May 08, 2024 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to advancing the next… READ MORE
News
May 08 2024 | Dianthus Therapeutics to Participate in the Bank of America Securities 2024 Health Care Conference

NEW YORK and WALTHAM, Mass., May 08, 2024 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to advancing the next generation of antibody complement therapeutics to treat severe autoimmune diseases, today announced its participation in the Bank of America Securities 2024 Health Care Conference. Marino Garcia, Chief Executive Officer, will present a corporate overview on Tuesday, May 14, 2024 at 4:20 p.m. PT in Las Vegas.

A live webcast of this presentation may be accessed under “News and Events” in the Investors section of the Dianthus Therapeutics website.

About Dianthus Therapeutics
Dianthus Therapeutics is a clinical-stage biotechnology company dedicated to designing and delivering novel, best-in-class monoclonal antibodies with improved selectivity and potency. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who are leading the development of next-generation antibody complement therapeutics, aiming to deliver transformative medicines for people living with severe autoimmune and inflammatory diseases.

Dianthus has initiated a Phase 2 trial of DNTH103, a potential best-in-class active C1s inhibitor, in generalized Myasthenia Gravis and plans to initiate additional Phase 2 trials in other neuromuscular indications, including Multifocal Motor Neuropathy and Chronic Inflammatory Demyelinating Polyneuropathy, in 2024.

To learn more, please visit www.dianthustx.com and follow us on LinkedIn.

Cautionary Statement Regarding Forward-Looking Statements
Certain statements in this press release, other than purely historical information, may constitute “forward-looking statements” within the meaning of the federal securities laws, including for purposes of the safe harbor provisions under the United States Private Securities Litigation Reform Act of 1995, express or implied statements regarding future plans and prospects, including statements regarding the expectations or plans for discovery, preclinical studies, clinical trials and research and development programs, in particular with respect to DNTH103, and any developments or results in connection therewith, including the target product profile of DNTH103; the anticipated timing of the initiation and results from those studies and trials; expectations regarding the time period over which the Company’s capital resources are expected to be sufficient to fund its anticipated operations; and expectations regarding the market and potential opportunities for complement therapies, in particular with respect to DNTH103. The words “opportunity,” “potential,” “milestones,” “runway,” “will,” “anticipate,” “achieve,” “near-term,” “catalysts,” “pursue,” “pipeline,” “believe,” continue,” “could,” “estimate,” “expect,” “ intend,” “may,” “might,” “plan,” “possible,” “predict,” “project,” “ should,” “strive,” “would,” “aim,” “target,” “commit,” and similar expressions (including the negatives of these terms or variations of them) generally identify forward-looking statements, but the absence of these words does not mean that statement is not forward looking.

Actual results could differ materially from those included in the forward-looking statements due to various factors, risks and uncertainties, including, but not limited to, that preclinical testing of DNTH103 and data from clinical trials may not be predictive of the results or success of ongoing or later clinical trials, that the development of DNTH103 or the Company’s other compounds may take longer and/or cost more than planned, that the Company may be unable to successfully complete the clinical development of the Company’s compounds, that the Company may be delayed in initiating, enrolling or completing its planned clinical trials, and that the Company’s compounds may not receive regulatory approval or become commercially successful products. These and other risks and uncertainties are identified under the heading “Risk Factors” included in the “Risk Factors” section of our Annual Report on Form 10-K for the period ended December 31, 2023, and other filings that the Company has made and may make with the SEC in the future. Nothing in this press release should be regarded as a representation by any person that the forward-looking statements set forth herein will be achieved or that any of the contemplated results of such forward-looking statements will be achieved.

The forward-looking statements in this press release speak only as of the date they are made and are qualified in their entirety by reference to the cautionary statements herein. Dianthus undertakes no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future events or otherwise, except as required by law.  

Contact
Jennifer Davis Ruff
Dianthus Therapeutics
jdavisruff@dianthustx.com

May 03 2024 | Dianthus Therapeutics Announces Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)
NEW YORK and WALTHAM, Mass., May 03, 2024 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (“Dianthus”), a clinical-stage biotechnology company dedicated to advancing the next generation… READ MORE
News
May 03 2024 | Dianthus Therapeutics Announces Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)

NEW YORK and WALTHAM, Mass., May 03, 2024 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (“Dianthus”), a clinical-stage biotechnology company dedicated to advancing the next generation of antibody complement therapeutics to treat severe autoimmune diseases, today announced that it granted equity awards on May 1, 2024, to two newly-hired, non-executive employees. The inducement grants were approved by the Company’s independent Compensation Committee and were made as material inducements to acceptance of employment with Dianthus in accordance with Nasdaq Listing Rule 5635(c)(4).

The inducement grants consist of non-qualified stock options to purchase an aggregate of 52,000 shares of the Company’s common stock with a 10-year term and an exercise price of $22.53 per share. The options vest as to 25% on the first anniversary of the vesting commencement date and in equal monthly installments for the following 36 months. The inducement grants are subject to the terms and conditions of the Dianthus Therapeutics, Inc. Equity Inducement Plan, and the terms and conditions of a stock option agreement.

About Dianthus Therapeutics

Dianthus Therapeutics is a clinical-stage biotechnology company dedicated to designing and delivering novel, best-in-class monoclonal antibodies with improved selectivity and potency. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who are leading the development of next-generation antibody complement therapeutics, aiming to deliver transformative medicines for people living with severe autoimmune and inflammatory diseases.

 To learn more, please visit www.dianthustx.com and follow us on LinkedIn

Contact
Jennifer Davis Ruff
Dianthus Therapeutics
jdavisruff@dianthustx.com

Apr 11 2024 | Dianthus Therapeutics Announces Oral Presentation for DNTH103 at the 2024 American Academy of Neurology (AAN) Annual Meeting
NEW YORK and WALTHAM, Mass., April 11, 2024 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to advancing the next… READ MORE
News
Apr 11 2024 | Dianthus Therapeutics Announces Oral Presentation for DNTH103 at the 2024 American Academy of Neurology (AAN) Annual Meeting

NEW YORK and WALTHAM, Mass., April 11, 2024 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to advancing the next generation of antibody complement therapeutics to treat severe autoimmune diseases, today announced an oral presentation for DNTH103 at the American Academy of Neurology (AAN) Annual Meeting, taking place April 13-18, 2024 in Denver, Colorado and virtually.

DNTH103 is an investigational classical pathway inhibitor that is uniquely specific to the active form of C1s, and is being evaluated for its potential as an effective, low-volume, convenient and safe treatment option for patients with generalized Myasthenia Gravis, Multifocal Motor Neuropathy, and Chronic Inflammatory Demyelinating Polyneuropathy. The oral presentation at AAN will highlight preclinical and in vitro data describing the differentiated safety profile and neurotransmission activity of DNTH103 and a review of previously released Phase 1 healthy volunteer data.

“Currently, therapies for patients with generalized Myasthenia Gravis (gMG) are limited to C5 inhibitors or FcRn inhibitors that can be burdensome for patients and caregivers, and the C5 complement inhibitors available today have an increased risk for serious bacterial infections,” said Marino Garcia, Chief Executive Officer of Dianthus Therapeutics. “We aim to demonstrate that DNTH103 may be a best-in-class treatment option with improved safety and infrequent self-administration that provides effective and consistent control of symptoms for people living with neuromuscular conditions.”

Oral Presentation Details:
April 15, 2024, 1:00 PM MT / 3:00 PM ET
Classical Pathway Inhibition with Anti-Active C1s Antibody DNTH103 Prevents Neurotransmission Impairment in a Preclinical Model of Myasthenia Gravis
Presenter: Sankalp Gokhale, M.D., Head of Clinical Development, Neurology, Dianthus Therapeutics
Session S15: Autoimmune Neuromuscular Diseases: New Observations and Therapeutic Approaches
Program S15.001

Detailed presentation listings for the 2024 AAN Annual Meeting can be found on the meeting website: https://www.aan.com/events/annual-meeting.

About DNTH103
DNTH103 is an investigational, clinical-stage, potent monoclonal antibody engineered to selectively target the classical pathway by inhibiting only the active form of the C1s protein, a clinically validated complement target. DNTH103 is enhanced with YTE half-life extension technology designed to enable a more convenient subcutaneous, self-administered injection dosed as infrequently as once every two weeks. Additionally, selective inhibition of the classical complement pathway may lower patient risk of infection from encapsulated bacteria by preserving immune activity of the lectin and alternative pathways. As the classical pathway plays a significant role in disease pathology, DNTH103 has the potential to be a best-in-class pipeline-in-a-product across a range of autoimmune disorders with high unmet need. Dianthus has initiated a Phase 2 trial in generalized Myasthenia Gravis and plans to initiate additional Phase 2 trials in other neuromuscular indications, including Multifocal Motor Neuropathy and Chronic Inflammatory Demyelinating Polyneuropathy, in 2024.

About Dianthus Therapeutics
Dianthus Therapeutics is a clinical-stage biotechnology company dedicated to designing and delivering novel, best-in-class monoclonal antibodies with improved selectivity and potency. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who are leading the development of next-generation antibody complement therapeutics, aiming to deliver transformative medicines for people living with severe autoimmune and inflammatory diseases.  

Dianthus has initiated a Phase 2 trial of DNTH103, a potential best-in-class active C1s inhibitor, in generalized Myasthenia Gravis and plans to initiate additional Phase 2 trials in other neuromuscular indications, including Multifocal Motor Neuropathy and Chronic Inflammatory Demyelinating Polyneuropathy, in 2024.

To learn more, please visit www.dianthustx.com and follow us on LinkedIn

Cautionary Statement Regarding Forward-Looking Statements
Certain statements in this press release, other than purely historical information, may constitute “forward-looking statements” within the meaning of the federal securities laws, including for purposes of the safe harbor provisions under the United States Private Securities Litigation Reform Act of 1995, express or implied statements regarding future plans and prospects, including statements regarding the expectations or plans for discovery, preclinical studies, clinical trials and research and development programs, in particular with respect to DNTH103, and any developments or results in connection therewith, including the target product profile of DNTH103; the anticipated timing of the initiation and results from those studies and trials; and expectations regarding the market and potential opportunities for complement therapies, in particular with respect to DNTH103. The words “opportunity,” “potential,” “milestones,” “runway,” “will,” “anticipate,” “achieve,” “near-term,” “catalysts,” “pursue,” “pipeline,” “believe,” continue,” “could,” “estimate,” “expect,” “ intend,” “may,” “might,” “plan,” “possible,” “predict,” “project,” “ should,” “strive,” “would,” “aim,” “target,” “commit,” and similar expressions (including the negatives of these terms or variations of them) generally identify forward-looking statements, but the absence of these words does not mean that statement is not forward looking.

Actual results could differ materially from those included in the forward-looking statements due to various factors, risks and uncertainties, including, but not limited to, that preclinical testing of DNTH103 and data from clinical trials may not be predictive of the results or success of ongoing or later clinical trials, that the development of DNTH103 or the Company’s other compounds may take longer and/or cost more than planned, that the Company may be unable to successfully complete the clinical development of the Company’s compounds, that the Company may be delayed in initiating, enrolling or completing its planned clinical trials, and that the Company’s compounds may not receive regulatory approval or become commercially successful products. These and other risks and uncertainties are identified under the heading “Risk Factors” included in the Company’s Annual Report on Form 10-K filed with the SEC on March 21, 2024, and other filings that the Company has made and may make with the SEC in the future. Nothing in this press release should be regarded as a representation by any person that the forward-looking statements set forth herein will be achieved or that any of the contemplated results of such forward-looking statements will be achieved.

The forward-looking statements in this press release speak only as of the date they are made and are qualified in their entirety by reference to the cautionary statements herein. Dianthus undertakes no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future events or otherwise, except as required by law.

Contact
Jennifer Davis Ruff
Dianthus Therapeutics
jdavisruff@dianthustx.com

Apr 05 2024 | Dianthus Therapeutics Announces Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)
NEW YORK and WALTHAM, Mass., April 05, 2024 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (“Dianthus”), a clinical-stage biotechnology company dedicated to advancing the next generation… READ MORE
News
Apr 05 2024 | Dianthus Therapeutics Announces Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)

NEW YORK and WALTHAM, Mass., April 05, 2024 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (“Dianthus”), a clinical-stage biotechnology company dedicated to advancing the next generation of antibody complement therapeutics to treat severe autoimmune diseases, today announced that it granted equity awards on April 1, 2024, to six newly-hired, non-executive employees. The inducement grants were approved by the Company’s independent Compensation Committee and were made as material inducements to acceptance of employment with Dianthus in accordance with Nasdaq Listing Rule 5635(c)(4).

The inducement grants consist of non-qualified stock options to purchase an aggregate of 126,000 shares of the Company’s common stock with a 10-year term and an exercise price of $29.72 per share. The options vest as to 25% on the first anniversary of the vesting commencement date and in equal monthly installments for the following 36 months. The inducement grants are subject to the terms and conditions of the Dianthus Therapeutics, Inc. Equity Inducement Plan, and the terms and conditions of a stock option agreement.

About Dianthus Therapeutics

Dianthus Therapeutics is a clinical-stage biotechnology company dedicated to designing and delivering novel, best-in-class monoclonal antibodies with improved selectivity and potency. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who are leading the development of next-generation antibody complement therapeutics, aiming to deliver transformative medicines for people living with severe autoimmune and inflammatory diseases.  

 To learn more, please visit www.dianthustx.com and follow us on LinkedIn

Contact
Jennifer Davis Ruff
Dianthus Therapeutics
jdavisruff@dianthustx.com

Mar 21 2024 | Dianthus Therapeutics Highlights Recent Business Achievements and Reports Q4 and FY2023 Financial Results
Phase 2 MaGic trial in generalized Myasthenia Gravis (gMG) initiated in Q1’24 with top-line results anticipated in 2H’25 $389 million of pro forma cash, including $216… READ MORE
News
Mar 21 2024 | Dianthus Therapeutics Highlights Recent Business Achievements and Reports Q4 and FY2023 Financial Results

Phase 2 MaGic trial in generalized Myasthenia Gravis (gMG) initiated in Q1’24 with top-line results anticipated in 2H’25

$389 million of pro forma cash, including $216 million of net proceeds from a successful PIPE financing completed in January 2024, provides runway into 2H 2027

Building a neuromuscular franchise with DNTH103 through additional planned Phase 2 trials in Multifocal Motor Neuropathy (MMN) and Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) starting in 2024

NEW YORK and WALTHAM, Mass., March 21, 2024 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to advancing the next generation of antibody complement therapeutics to treat severe autoimmune diseases, today reported financial results for the fourth quarter and full year ending December 31, 2023, and provided an update on recent business achievements.

“2023 was a transformative year for Dianthus, highlighted by becoming a public company, closing on a financing, and reporting out positive top-line data from our Phase 1 study that supports DNTH103 as a potentially best-in-class complement inhibitor,” said Marino Garcia, Chief Executive Officer of Dianthus Therapeutics. “DNTH103 is an investigational potent active C1s inhibitor of the classical pathway with an extended half-life that has the potential to offer a more convenient, safer treatment option for patients with infrequent, subcutaneous self-administration. With our Phase 2 MaGic trial now underway in patients with generalized Myasthenia Gravis (gMG) and cash runway into the second half of 2027 following successful completion of a $230 million PIPE financing in January, we are very well positioned to build a neuromuscular franchise around DNTH103 and reach key data readouts in our three initial indications of gMG, Multifocal Motor Neuropathy (MMN) and Chronic Inflammatory Demyelinating Polyneuropathy (CIDP).”

Recent Business Highlights and Upcoming Milestones

DNTH103

DNTH103 is an investigational, clinical-stage, potent monoclonal antibody engineered to selectively target the classical pathway by inhibiting only the active form of the C1s protein, a clinically validated complement target. DNTH103 is enhanced with YTE half-life extension technology designed to enable a more convenient subcutaneous, self-administered injection dosed as infrequently as once every two weeks. DNTH103 has the potential to be a best-in-class pipeline-in-a-product across a range of autoimmune disorders with high unmet need.

  • Phase 2 MaGic gMG trial initiated in February: The MaGic trial is a global, randomized, double-blind, placebo-controlled Phase 2 study in up to 60 patients with gMG who are acetylcholine receptor (AchR) antibody positive. Initial top-line results from this trial are anticipated to be available in the second half of 2025.
  • Oral presentation at the American Academy of Neurology (AAN) 2024 Annual Meeting on April 15, 2024: An oral presentation describing key attributes of DNTH103 and its differentiation in gMG will be presented by Sankalp Gokhale, M.D., Dianthus Therapeutics’ Head of Clinical Development, Neurology, at the AAN 2024 Annual Meeting, being held April 13-18, 2024, in Denver and online. (Program number S15.001)
  • Planning for MMN and CIDP Phase 2 trials ongoing: Dianthus expects to initiate additional Phase 2 trials of DNTH103 in Multifocal Motor Neuropathy (MMN) in the second quarter of 2024 and Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) in the second half of 2024.

Corporate

  • Dianthus successfully completed a private investment in public equity (“PIPE”) financing in January 2024 that resulted in gross proceeds of approximately $230 million. This PIPE financing included participation from both new and existing investors, including Bain Capital Life Sciences, RA Capital Management, Avidity Partners, Fairmount, Venrock Healthcare Capital Partners, RTW Investments, Great Point Partners LLC, Octagon Capital, Janus Henderson Investors, Vestal Point Capital, Logos Capital, Catalio Capital Management, Woodline Partners LP, Ally Bridge Group, Tellus BioVentures, StemPoint Capital LP and a large investment management firm. 
  • Jeffrey Stavenhagen, Ph.D., was appointed as Chief Scientific Officer in November 2023 to lead the Company’s discovery and preclinical research and translational science initiatives. 

Full-Year 2023 Financial Results

  • Cash Position – $389 million of pro forma cash includes cash, cash equivalents and short-term investments as of December 31, 2023 of $173.7 million plus estimated net proceeds of approximately $216 million from the PIPE offering, which closed in January 2024. Net proceeds from the PIPE are unaudited and preliminary.
  • R&D Expenses – Research and development (R&D) expenses for the year ended December 31, 2023 were $32.8 million, inclusive of $0.9 million of stock-based compensation, compared to $29.4 million for the year ended December 31, 2022, which included $0.4 million of stock-based compensation. This increase in R&D expenses was primarily driven by increased clinical costs and higher headcount to support DNTH103 Phase 1 and Phase 2 development partially offset by lower chemistry, manufacturing and controls (CMC) costs.
  • G&A Expenses – General and administrative (G&A) expenses for the year ended December 31, 2023 were $18.2 million, inclusive of stock-based compensation of $2.0 million, compared to $6.7 million for the year ended December 31, 2022, which included $1.1 million of stock-based compensation. This increase in G&A expenses was primarily due to costs related to the reverse merger with Magenta and higher headcount and professional fees.
  • Net Loss – Net loss for the year ended December 31, 2023 was $43.6 million or $8.45 net loss per share (basic and diluted) compared to $28.5 million or $32.57 net loss for the year ended December 31, 2022.
  • Additional Information – For additional information on the Company’s financial results for the year ended December 31, 2023, please refer to the Form 10-K filed with the SEC.

About DNTH103
DNTH103 is an investigational, clinical-stage, potent monoclonal antibody engineered to selectively target the classical pathway by inhibiting only the active form of the C1s protein, a clinically validated complement target. DNTH103 is enhanced with YTE half-life extension technology designed to enable a more convenient subcutaneous, self-administered injection dosed as infrequently as once every two weeks. Additionally, selective inhibition of the classical complement pathway may lower patient risk of infection from encapsulated bacteria by preserving immune activity of the lectin and alternative pathways. As the classical pathway plays a significant role in disease pathology, DNTH103 has the potential to be a best-in-class pipeline-in-a-product across a range of autoimmune disorders with high unmet need. Dianthus has initiated a Phase 2 trial in generalized Myasthenia Gravis and plans to initiate additional Phase 2 trials in other neuromuscular indications, including Multifocal Motor Neuropathy and Chronic Inflammatory Demyelinating Polyneuropathy, in 2024.

About Dianthus Therapeutics
Dianthus Therapeutics is a clinical-stage biotechnology company dedicated to designing and delivering novel, best-in-class monoclonal antibodies with improved selectivity and potency. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who are leading the development of next-generation antibody complement therapeutics, aiming to deliver transformative medicines for people living with severe autoimmune and inflammatory diseases.

Dianthus has initiated a Phase 2 trial of DNTH103, a potential best-in-class active C1s inhibitor, in generalized Myasthenia Gravis and plans to initiate additional Phase 2 trials in other neuromuscular indications, including Multifocal Motor Neuropathy and Chronic Inflammatory Demyelinating Polyneuropathy, in 2024.

To learn more, please visit www.dianthustx.com and follow us on LinkedIn

Cautionary Statement Regarding Forward-Looking Statements
Certain statements in this press release, other than purely historical information, may constitute “forward-looking statements” within the meaning of the federal securities laws, including for purposes of the safe harbor provisions under the United States Private Securities Litigation Reform Act of 1995, express or implied statements regarding future plans and prospects, including statements regarding the expectations or plans for discovery, preclinical studies, clinical trials and research and development programs, in particular with respect to DNTH103, and any developments or results in connection therewith, including the target product profile of DNTH103; the anticipated timing of the initiation and results from those studies and trials; expectations regarding the time period over which the Company’s capital resources are expected to be sufficient to fund its anticipated operations; and expectations regarding the market and potential opportunities for complement therapies, in particular with respect to DNTH103. The words “opportunity,” “potential,” “milestones,” “runway,” “will,” “anticipate,” “achieve,” “near-term,” “catalysts,” “pursue,” “pipeline,” “believe,” continue,” “could,” “estimate,” “expect,” “ intend,” “may,” “might,” “plan,” “possible,” “predict,” “project,” “ should,” “strive,” “would,” “aim,” “target,” “commit,” and similar expressions (including the negatives of these terms or variations of them) generally identify forward-looking statements, but the absence of these words does not mean that statement is not forward looking.

Actual results could differ materially from those included in the forward-looking statements due to various factors, risks and uncertainties, including, but not limited to, that preclinical testing of DNTH103 and data from clinical trials may not be predictive of the results or success of ongoing or later clinical trials, that the development of DNTH103 or the Company’s other compounds may take longer and/or cost more than planned, that the Company may be unable to successfully complete the clinical development of the Company’s compounds, that the Company may be delayed in initiating, enrolling or completing its planned clinical trials, and that the Company’s compounds may not receive regulatory approval or become commercially successful products. These and other risks and uncertainties are identified under the heading “Risk Factors” included in the “Risk Factors” section of our Annual Report on Form 10-K for the period ended December 31, 2023, and other filings that the Company has made and may make with the SEC in the future. Nothing in this press release should be regarded as a representation by any person that the forward-looking statements set forth herein will be achieved or that any of the contemplated results of such forward-looking statements will be achieved.

The forward-looking statements in this press release speak only as of the date they are made and are qualified in their entirety by reference to the cautionary statements herein. Dianthus undertakes no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future events or otherwise, except as required by law.

Contact
Jennifer Davis Ruff
Dianthus Therapeutics
jdavisruff@dianthustx.com

 
Dianthus Therapeutics, Inc.
Consolidated Balance Sheets
(in thousands, except share and per share data)
(unaudited)
         
ASSETS   December 31,
2023
  December 31,
2022
Current assets:        
Cash and cash equivalents   $ 132,325     $ 15,365  
Short-term investments     41,393       60,125  
Receivable from related party     294       4,700  
Unbilled receivable from related party     184       938  
Prepaid expenses and other current assets     3,255       905  
Total current assets     177,451       82,033  
         
Property and equipment, net     185       142  
Right-of-use operating lease assets     615       814  
Other assets and restricted cash     1,154       121  
Total assets   $ 179,405     $ 83,110  
         
LIABILITIES, CONVERTIBLE PREFERRED STOCK AND STOCKHOLDERS’ EQUITY/(DEFICIT)        
Current liabilities:        
Accounts payable   $ 2,610     $ 1,167  
Accrued expenses     6,504       6,608  
Current portion of deferred revenue – related party     100       100  
Current portion of operating lease liabilities     417       350  
Total current liabilities     9,631       8,225  
         
Deferred revenue – related party     736       791  
Long-term operating lease liabilities     168       438  
Total liabilities     10,535       9,454  
         
Commitments and contingencies        
Convertible preferred stock           118,024  
Stockholders’ equity/(deficit):        
Preferred stock            
Common stock     15        
Additional paid-in capital     258,231       1,661  
Accumulated deficit     (89,423)       (45,868)  
Accumulated other comprehensive income/(loss)     47       (161)  
Total stockholders’ equity/(deficit)     168,870       (44,368)  
Total liabilities, convertible preferred stock and stockholders’ equity/(deficit)   $ 179,405     $ 83,110  

 

Dianthus Therapeutics, Inc.
Consolidated Statements of Operations and Comprehensive Loss
(in thousands, except share and per share data)
(unaudited)
                 
    Three Months Ended December 31,   Year Ended December 31,
      2023       2022       2023       2022  
Revenues:                
License revenue – related party   $ 457     $ 1,175     $ 2,826     $ 6,417  
                 
Operating expenses:                
Research and development     8,781       9,831       32,841       29,379  
General and administrative     4,632       2,037       18,159       6,743  
Total operating expenses     13,413       11,868       51,000       36,122  
                 
Loss from operations     (12,956)       (10,693)       (48,174)       (29,705)  
                 
Other income/(expense):                
Interest income     2,444       640       4,764       1,145  
(Loss)/gain on currency exchange, net     (32)       (20)       (85)       136  
Other expense     (19)       (43)       (60)       (52)  
Total other income     2,393       577       4,619       1,229  
                 
Net loss   $ (10,563)     $ (10,116)     $ (43,555)     $ (28,476)  
                 
Net loss per share attributable to common stockholders, basic and diluted   $ (0.71)     $ (11.57)     $ (8.45)     $ (32.57)  
                 
Weighted-average number of shares of common stock outstanding, used in computing net loss per share of common stock, basic and diluted     14,817,676       874,519       5,153,423       874,234  
                 
Comprehensive loss:                
Net Loss   $ (10,563)     $ (10,116)     $ (43,555)     $ (28,476)  
Other comprehensive income/(loss):                
Change in unrealized gains/(losses) related to available-for-sale debt securities     51       (11)       208       (161)  
Total other comprehensive income/(loss)     51       (11)       208       (161)  
Total comprehensive loss   $ (10,512)     $ (10,127)     $ (43,347)     $ (28,637)  

Mar 07 2024 | Dianthus Therapeutics Announces Inducement Grant Under Nasdaq Listing Rule 5635(c)(4)
NEW YORK and and WALTHAM, Mass., March 07, 2024 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH) (“Dianthus”), a clinical-stage biotechnology company dedicated to advancing the… READ MORE
News
Mar 07 2024 | Dianthus Therapeutics Announces Inducement Grant Under Nasdaq Listing Rule 5635(c)(4)

NEW YORK and and WALTHAM, Mass., March 07, 2024 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH) (“Dianthus”), a clinical-stage biotechnology company dedicated to advancing the next generation of antibody complement therapeutics to treat severe autoimmune diseases, today announced that it granted an equity award on March 2, 2024, to a newly-hired, non-executive employee. The inducement grant was approved by the Company’s independent Compensation Committee and was made as a material inducement to acceptance of employment with Dianthus in accordance with Nasdaq Listing Rule 5635(c)(4).

The inducement grant consists of a non-qualified stock option to purchase an aggregate of 30,000 shares of the Company’s common stock with a 10-year term and an exercise price of $25.75 per share. The option vests as to 25% on the first anniversary of the vesting commencement date and in equal monthly installments for the following 36 months. The inducement grant is subject to the terms and conditions of the Dianthus Therapeutics, Inc. Equity Inducement Plan, and the terms and conditions of the Stock Option Agreement.

About Dianthus Therapeutics

Dianthus Therapeutics is a clinical-stage biotechnology company dedicated to designing and delivering novel, best-in-class monoclonal antibodies with improved selectivity and potency. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who are leading the development of next-generation antibody complement therapeutics, aiming to deliver transformative medicines for people living with severe autoimmune and inflammatory diseases.  

To learn more, please visit www.dianthustx.com and follow us on LinkedIn

Contact
Jennifer Davis Ruff
Dianthus Therapeutics
jdavisruff@dianthustx.com

Feb 26 2024 | Dianthus Therapeutics Announces Initiation of Phase 2 MaGic Trial of DNTH103 In Generalized Myasthenia Gravis (gMG)
Top-line results from gMG MaGic trial anticipated in 2H 2025 Building a neuromuscular franchise with DNTH103 through additional planned Phase 2 trials in Multifocal Motor… READ MORE
News
Feb 26 2024 | Dianthus Therapeutics Announces Initiation of Phase 2 MaGic Trial of DNTH103 In Generalized Myasthenia Gravis (gMG)

Top-line results from gMG MaGic trial anticipated in 2H 2025

Building a neuromuscular franchise with DNTH103 through additional planned Phase 2 trials in Multifocal Motor Neuropathy (MMN) and Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

DNTH103 is a potential best-in-class, potent classical pathway inhibitor planned for self-administration as a low volume, subcutaneous injection once every two weeks

NEW YORK and WALTHAM, Mass., Feb. 26, 2024 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to advancing the next generation of antibody complement therapeutics to treat severe autoimmune diseases, today announced the initiation of the Phase 2 MaGic trial of DNTH103 in patients with generalized Myasthenia Gravis. The initiation follows U.S. Food and Drug Administration (FDA) clearance of the Phase 2 Investigational New Drug (IND) application for DNTH103. Top-line results from this trial are anticipated in the second half of 2025.

“Following our encouraging Phase 1 data demonstrating a 60-day half-life and potent, specific classical pathway inhibition, we are excited to rapidly advance DNTH103, our investigational active C1s inhibitor, into a Phase 2 study in generalized Myasthenia Gravis,” said Simrat Randhawa, M.D., Chief Medical Officer of Dianthus Therapeutics. “DNTH103 provides a unique approach to complement inhibition in gMG, which could result in a more convenient and safer alternative for patients versus current options.”

The MaGic trial is a global, randomized, double-blind, placebo-controlled Phase 2 study in up to 60 patients with generalized Myasthenia Gravis who are acetylcholine receptor (AchR) antibody positive. Following an initial loading dose, DNTH103 will be administered every two weeks (Q2W) via subcutaneous (S.C.) injection. The S.C. treatment duration will initially be 12 weeks with a 52-week open label extension. The primary endpoint of the study is safety and tolerability. Secondary endpoints include Myasthenia Gravis Activities of Daily Living Scale (MG-ADL) and Quantitative Myasthenia Gravis (QMG) score assessments. Initial top-line results from this trial are anticipated to be available in the second half of 2025.

“For patients with AchR-positive gMG, inappropriate activation of the complement classical pathway is a major driver of disease pathology and therefore patient symptoms,” said Mazen M. Dimachkie, M.D., Professor of Neurology and Director of Neuromuscular Division at the University of Kansas Medical Center. “I am excited to collaborate with Dianthus to evaluate this investigational, highly specific classical pathway inhibitor that could fill the need for a more convenient and safe complement inhibitor for my gMG patients.” 

About DNTH103
DNTH103 is an investigational, clinical-stage, potent monoclonal antibody engineered to selectively target the classical pathway by inhibiting only the active form of the C1s protein, a clinically validated complement target. DNTH103 is enhanced with YTE half-life extension technology designed to enable a more convenient subcutaneous, self-administered injection dosed as infrequently as once every two weeks. Additionally, selective inhibition of the classical complement pathway may lower patient risk of infection from encapsulated bacteria by preserving immune activity of the lectin and alternative pathways. As the classical pathway plays a significant role in disease pathology, DNTH103 has the potential to be a best-in-class pipeline-in-a-product across a range of autoimmune disorders with high unmet need. Dianthus has initiated a Phase 2 trial in generalized Myasthenia Gravis and plans to initiate additional Phase 2 trials in other neuromuscular indications, including Multifocal Motor Neuropathy and Chronic Inflammatory Demyelinating Polyneuropathy, in 2024.

About Dianthus Therapeutics
Dianthus Therapeutics is a clinical-stage biotechnology company dedicated to designing and delivering novel, best-in-class monoclonal antibodies with improved selectivity and potency. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who are leading the development of next-generation antibody complement therapeutics, aiming to deliver transformative medicines for people living with severe autoimmune and inflammatory diseases.  

Dianthus has initiated a Phase 2 trial of DNTH103, a potential best-in-class active C1s inhibitor, in generalized Myasthenia Gravis and plans to initiate additional Phase 2 trials in other neuromuscular indications, including Multifocal Motor Neuropathy and Chronic Inflammatory Demyelinating Polyneuropathy, in 2024.

To learn more, please visit www.dianthustx.com and follow us on LinkedIn

Cautionary Statement Regarding Forward-Looking Statements
Certain statements in this press release, other than purely historical information, may constitute “forward-looking statements” within the meaning of the federal securities laws, including for purposes of the safe harbor provisions under the United States Private Securities Litigation Reform Act of 1995, express or implied statements regarding future plans and prospects, including statements regarding the expectations or plans for discovery, preclinical studies, clinical trials and research and development programs, in particular with respect to DNTH103, and any developments or results in connection therewith, including the target product profile of DNTH103; the anticipated timing of the initiation and results from those studies and trials; and expectations regarding the market and potential opportunities for complement therapies, in particular with respect to DNTH103. The words “opportunity,” “potential,” “milestones,” “runway,” “will,” “anticipate,” “achieve,” “near-term,” “catalysts,” “pursue,” “pipeline,” “believe,” continue,” “could,” “estimate,” “expect,” “ intend,” “may,” “might,” “plan,” “possible,” “predict,” “project,” “ should,” “strive,” “would,” “aim,” “target,” “commit,” and similar expressions (including the negatives of these terms or variations of them) generally identify forward-looking statements, but the absence of these words does not mean that statement is not forward looking.

Actual results could differ materially from those included in the forward-looking statements due to various factors, risks and uncertainties, including, but not limited to, that preclinical testing of DNTH103 and data from clinical trials may not be predictive of the results or success of ongoing or later clinical trials, that the development of DNTH103 or the Company’s other compounds may take longer and/or cost more than planned, that the Company may be unable to successfully complete the clinical development of the Company’s compounds, that the Company may be delayed in initiating, enrolling or completing its planned clinical trials, and that the Company’s compounds may not receive regulatory approval or become commercially successful products. These and other risks and uncertainties are identified under the heading “Risk Factors” included in Exhibit 99.1 to the Company’s Current Report on Form 8-K filed with the SEC on September 12, 2023 (as amended on September 21, 2023), and other filings that the Company has made and may make with the SEC in the future. Nothing in this press release should be regarded as a representation by any person that the forward-looking statements set forth herein will be achieved or that any of the contemplated results of such forward-looking statements will be achieved.

The forward-looking statements in this press release speak only as of the date they are made and are qualified in their entirety by reference to the cautionary statements herein. Dianthus undertakes no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future events or otherwise, except as required by law.

Contact
Jennifer Davis Ruff
Dianthus Therapeutics
jdavisruff@dianthustx.com

Feb 23 2024 | Dianthus Therapeutics to Participate in the TD Cowen 44th Annual Health Care Conference
NEW YORK and WALTHAM, Mass., Feb. 23, 2024 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to advancing the next… READ MORE
News
Feb 23 2024 | Dianthus Therapeutics to Participate in the TD Cowen 44th Annual Health Care Conference

NEW YORK and WALTHAM, Mass., Feb. 23, 2024 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to advancing the next generation of antibody complement therapeutics to treat severe autoimmune diseases, today announced its participation in the TD Cowen 44th Annual Health Care Conference. Marino Garcia, Chief Executive Officer, will present a corporate overview on Monday, March 4, 2024, at 2:50 p.m. EST in Boston.

A live webcast of this presentation may be accessed under “News and Events” in the Investors section of the Dianthus Therapeutics website.

About Dianthus Therapeutics
Dianthus Therapeutics is a clinical-stage biotechnology company dedicated to designing and delivering novel, best-in-class monoclonal antibodies with improved selectivity and potency. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who are leading the development of next-generation antibody complement therapeutics, aiming to deliver transformative medicines for people living with severe autoimmune and inflammatory diseases.

The Company is advancing its potential best-in-class active C1s inhibitor, DNTH103, into three Phase 2 trials in 2024, beginning with generalized Myasthenia Gravis in the first quarter, Multifocal Motor Neuropathy in the second quarter, and Chronic Inflammatory Demyelinating Polyneuropathy in the second half.

To learn more, please visit www.dianthustx.com and follow us on LinkedIn.

Cautionary Statement Regarding Forward-Looking Statements
This press release contains “forward-looking statements” within the meaning of the safe harbor provisions of the U.S. Private Securities Litigation Reform Act of 1995, including express or implied statements regarding the Company’s future plans, expectations and prospects for discovery, preclinical studies, clinical trials and research and development programs, in particular with respect to DNTH103, and any developments or results in connection therewith, including the target product profile of DNTH103; the anticipated timing of the initiation and results from those studies and trials; and expectations regarding the market and potential opportunities for complement therapies and specifically DNTH103. The words “opportunity,” “potential,” “milestones,” “runway,” “will,” “anticipate,” “achieve,” “near-term,” “catalysts,” “pursue,” “pipeline,” “believe,” continue,” “could,” “estimate,” “expect,” “ intend,” “may,” “might,” “plan,” “possible,” “predict,” “project,” “ should,” “strive,” “would,” “aim,” “target,” “commit,” and similar expressions (including the negatives of these terms or variations of them) generally identify forward-looking statements, but the absence of these words does not mean that statement is not forward looking.

Actual results could differ materially from those included in the forward-looking statements due to various factors, risks and uncertainties, including, but not limited to, that preclinical testing of DNTH103 and data from clinical trials may not be predictive of the results or success of ongoing or later clinical trials, that the development of DNTH103 or the Company’s other compounds may take longer and/or cost more than planned, that the Company may be unable to successfully complete the clinical development of the Company’s compounds, that the Company may be delayed in initiating, enrolling or completing its planned clinical trials, and that the Company’s compounds may not receive regulatory approval or become commercially successful products. These and other risks and uncertainties are identified under the heading “Risk Factors” included in Exhibit 99.1 to the Company’s Current Report on Form 8-K filed with the SEC on September 12, 2023 (as amended on September 21, 2023), and other filings that the Company has made and may make with the SEC in the future. Nothing in this press release should be regarded as a representation by any person that the forward-looking statements set forth herein will be achieved or that any of the contemplated results of such forward-looking statements will be achieved.

The forward-looking statements in this press release speak only as of the date they are made and are qualified in their entirety by reference to the cautionary statements herein. These statements are based upon the current beliefs and expectations of the Company’s management and the Company undertakes no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future events or otherwise, except as required by law.

Contact
Jennifer Davis Ruff
Dianthus Therapeutics
jdavisruff@dianthustx.com 

Jan 31 2024 | Dianthus Therapeutics to Participate at the Guggenheim 6th Annual Biotechnology Conference
NEW YORK and WALTHAM, Mass., Jan. 31, 2024 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to advancing the next… READ MORE
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Jan 31 2024 | Dianthus Therapeutics to Participate at the Guggenheim 6th Annual Biotechnology Conference

NEW YORK and WALTHAM, Mass., Jan. 31, 2024 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to advancing the next generation of antibody complement therapeutics to treat severe autoimmune diseases, today announced that members of the Company’s senior management team will participate in a fireside chat at the Guggenheim 6th Annual Biotechnology Conference on February 7, 2024, at 10:30 a.m. EST in New York City.

A live webcast of this presentation may be accessed under “News and Events” in the Investors section of the Dianthus Therapeutics website.

About Dianthus Therapeutics
Dianthus Therapeutics is a clinical-stage biotechnology company dedicated to designing and delivering novel, best-in-class monoclonal antibodies with improved selectivity and potency. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who are leading the development of next-generation antibody complement therapeutics, aiming to deliver transformative medicines for people living with severe autoimmune and inflammatory diseases.

The Company is advancing its potential best-in-class active C1s inhibitor, DNTH103, into three Phase 2 trials in 2024, beginning with generalized Myasthenia Gravis in the first quarter, Multifocal Motor Neuropathy in the second quarter, and Chronic Inflammatory Demyelinating Polyneuropathy in the second half.

To learn more, please visit www.dianthustx.com and follow us on LinkedIn.

Cautionary Statement Regarding Forward-Looking Statements
This press release contains “forward-looking statements” within the meaning of the safe harbor provisions of the U.S. Private Securities Litigation Reform Act of 1995, including express or implied statements regarding the Company’s future plans, expectations and prospects for discovery, preclinical studies, clinical trials and research and development programs, in particular with respect to DNTH103, and any developments or results in connection therewith, including the target product profile of DNTH103; the anticipated timing of the initiation and results from those studies and trials; expectations regarding the time period over which the Company’s capital resources are expected to be sufficient to fund its anticipated operations; and expectations regarding the market and potential opportunities for complement therapies and specifically DNTH103. The words “opportunity,” “potential,” “milestones,” “runway,” “will,” “anticipate,” “achieve,” “near-term,” “catalysts,” “pursue,” “pipeline,” “believe,” continue,” “could,” “estimate,” “expect,” “ intend,” “may,” “might,” “plan,” “possible,” “predict,” “project,” “ should,” “strive,” “would,” “aim,” “target,” “commit,” and similar expressions (including the negatives of these terms or variations of them) generally identify forward-looking statements, but the absence of these words does not mean that statement is not forward looking.

Actual results could differ materially from those included in the forward-looking statements due to various factors, risks and uncertainties, including, but not limited to, that preclinical testing of DNTH103 and data from clinical trials may not be predictive of the results or success of ongoing or later clinical trials, that the development of DNTH103 or the Company’s other compounds may take longer and/or cost more than planned, that the Company may be unable to successfully complete the clinical development of the Company’s compounds, that the Company may be delayed in initiating, enrolling or completing its planned clinical trials, and that the Company’s compounds may not receive regulatory approval or become commercially successful products. These and other risks and uncertainties are identified under the heading “Risk Factors” included in Exhibit 99.1 to the Company’s Current Report on Form 8-K filed with the SEC on September 12, 2023 (as amended on September 21, 2023), and other filings that the Company has made and may make with the SEC in the future. Nothing in this press release should be regarded as a representation by any person that the forward-looking statements set forth herein will be achieved or that any of the contemplated results of such forward-looking statements will be achieved.

The forward-looking statements in this press release speak only as of the date they are made and are qualified in their entirety by reference to the cautionary statements herein. These statements are based upon the current beliefs and expectations of the Company’s management and the Company undertakes no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future events or otherwise, except as required by law.

Contact
Jennifer Davis Ruff
Dianthus Therapeutics
jdavisruff@dianthustx.com

Jan 22 2024 | Dianthus Therapeutics Announces $230 Million Private Placement
NEW YORK and WALTHAM, Mass., Jan. 22, 2024 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (“Dianthus” or the “Company”) (NASDAQ: DNTH), a clinical-stage biotechnology company dedicated… READ MORE
News
Jan 22 2024 | Dianthus Therapeutics Announces $230 Million Private Placement

NEW YORK and WALTHAM, Mass., Jan. 22, 2024 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (“Dianthus” or the “Company”) (NASDAQ: DNTH), a clinical-stage biotechnology company dedicated to advancing the next generation of antibody complement therapeutics to treat severe autoimmune diseases, today announced that it has entered into a securities purchase agreement for a private investment in public equity (“PIPE”) financing that is expected to result in gross proceeds of approximately $230 million to the Company, before deducting placement agent fees and offering expenses. The PIPE financing included participation from both new and existing investors, including Bain Capital Life Sciences, RA Capital Management, Avidity Partners, Fairmount, Venrock Healthcare Capital Partners, RTW Investments, Great Point Partners LLC, Octagon Capital, Janus Henderson Investors, Vestal Point Capital, Logos Capital, Catalio Capital Management, Woodline Partners LP, Ally Bridge Group, Tellus BioVentures, StemPoint Capital LP and a large investment management firm. 

Pursuant to the terms of the securities purchase agreement, Dianthus is selling an aggregate of 14,500,500 shares of its common stock at a price of $12.00 per share and, in lieu of common stock to certain investors, pre-funded warrants to purchase up to 4,666,332 shares of common stock at a purchase price of $11.999 per pre-funded warrant, which represents the per share purchase price for the common stock less the $0.001 per share exercise price for each pre-funded warrant. The PIPE financing is expected to close on or about January 24, 2024, subject to satisfaction of customary closing conditions.

The Company intends to use the net proceeds from the PIPE financing, together with the Company’s existing cash, cash equivalents, and marketable securities, for research and development expenditures focused on product development and for general corporate purposes, including capital expenditures, working capital and potential business development activities.

Jefferies, Evercore ISI, Stifel, Guggenheim Securities, and Raymond James are acting as placement agents for the PIPE financing.

The offer and sale of the foregoing securities are being made in a transaction not involving a public offering and the securities have not been registered under the Securities Act of 1933, as amended, and may not be reoffered or resold in the United States except pursuant to an effective registration statement or an applicable exemption from the registration requirements. Concurrently with the execution of the securities purchase agreement, Dianthus and the investors entered into a registration rights agreement pursuant to which the Company has agreed to file a registration statement with the Securities and Exchange Commission (the “SEC”) registering the resale of the shares of common stock sold in the PIPE financing, as well as the shares of common stock underlying the pre-funded warrants sold in the PIPE financing.

This press release shall not constitute an offer to sell or a solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any state or other jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such state or other jurisdiction.

About Dianthus Therapeutics

Dianthus Therapeutics is a clinical-stage biotechnology company dedicated to designing and delivering novel, best-in-class monoclonal antibodies with improved selectivity and potency. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who are leading the development of next-generation antibody complement therapeutics, aiming to deliver transformative medicines for people living with severe autoimmune and inflammatory diseases.

Cautionary Statement Regarding Forward-Looking Statements
Certain statements in this press release, other than purely historical information, may constitute “forward-looking statements” within the meaning of the federal securities laws, including for purposes of the safe harbor provisions under the United States Private Securities Litigation Reform Act of 1995, express or implied statements regarding future plans and prospects, including statements regarding the intended use of net proceeds from the PIPE financing and the expected timing of closing of the PIPE financing. The words “opportunity,” “potential,” “milestones,” “runway,” “will,” “anticipate,” “achieve,” “near-term,” “catalysts,” “pursue,” “pipeline,” “believe,” continue,” “could,” “estimate,” “expect,” “ intend,” “may,” “might,” “plan,” “possible,” “predict,” “project,” “ should,” “strive,” “would,” “aim,” “target,” “commit,” and similar expressions (including the negatives of these terms or variations of them) generally identify forward-looking statements, but the absence of these words does not mean that statement is not forward looking.

Actual results could differ materially from those included in the forward-looking statements due to various factors, risks and uncertainties, including, but not limited to, market conditions and the satisfaction of closing conditions, that preclinical testing of DNTH103 and data from clinical trials may not be predictive of the results or success of ongoing or later clinical trials, that the development of DNTH103 or the Company’s other compounds may take longer and/or cost more than planned, that the Company may be unable to successfully complete the clinical development of the Company’s compounds, that the Company may be delayed in initiating, enrolling or completing its planned clinical trials, and that the Company’s compounds may not receive regulatory approval or become commercially successful products. These and other risks and uncertainties are identified under the heading “Risk Factors” included in the Company’s Quarterly Report on Form 10-Q for the quarter ended September 30, 2023 filed with the SEC on November 9, 2023, and other filings that the Company has made and may make with the SEC in the future. Nothing in this press release should be regarded as a representation by any person that the forward-looking statements set forth herein will be achieved or that any of the contemplated results of such forward-looking statements will be achieved.

The forward-looking statements in this press release speak only as of the date they are made and are qualified in their entirety by reference to the cautionary statements herein. Dianthus undertakes no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future events or otherwise, except as required by law.

Contact
Jennifer Davis Ruff
Dianthus Therapeutics
jdavisruff@dianthustx.com

Jan 02 2024 | Dianthus Therapeutics to Webcast Presentation at the 42nd Annual J.P. Morgan Healthcare Conference
NEW YORK and WALTHAM, Mass., Jan. 02, 2024 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to advancing the next… READ MORE
News
Jan 02 2024 | Dianthus Therapeutics to Webcast Presentation at the 42nd Annual J.P. Morgan Healthcare Conference

NEW YORK and WALTHAM, Mass., Jan. 02, 2024 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to advancing the next generation of antibody complement therapeutics to treat severe autoimmune diseases, today announced its participation in the 42nd Annual J.P. Morgan Healthcare Conference. Marino Garcia, Chief Executive Officer, will present a corporate overview on Thursday, January 11, 2024, at 10:30 a.m. PST / 1:30 p.m. EST in San Francisco, California.

A live webcast of this presentation may be accessed under “News and Events” in the Investors section of the Dianthus Therapeutics website. An archived replay of the webcast will be available for 30 days following the presentation.

About Dianthus Therapeutics
Dianthus Therapeutics is a clinical-stage biotechnology company dedicated to designing and delivering novel, best-in-class monoclonal antibodies with improved selectivity and potency. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who are leading the development of next-generation antibody complement therapeutics, aiming to deliver transformative medicines for people living with severe autoimmune and inflammatory diseases.

The Company is advancing its potential best-in-class active C1s inhibitor, DNTH103, into three Phase 2 trials in 2024, beginning with generalized Myasthenia Gravis in the first quarter, Multifocal Motor Neuropathy in the second quarter, and Chronic Inflammatory Demyelinating Polyneuropathy in the second half.

To learn more, please visit www.dianthustx.com and follow us on LinkedIn.

Cautionary Statement Regarding Forward-Looking Statements
This press release contains “forward-looking statements” within the meaning of the safe harbor provisions of the U.S. Private Securities Litigation Reform Act of 1995, including express or implied statements regarding the Company’s future plans, expectations and prospects for discovery, preclinical studies, clinical trials and research and development programs, in particular with respect to DNTH103, and any developments or results in connection therewith, including the target product profile of DNTH103; the anticipated timing of the initiation and results from those studies and trials; expectations regarding the time period over which the Company’s capital resources are expected to be sufficient to fund its anticipated operations; and expectations regarding the market and potential opportunities for complement therapies and specifically DNTH103. The words “opportunity,” “potential,” “milestones,” “runway,” “will,” “anticipate,” “achieve,” “near-term,” “catalysts,” “pursue,” “pipeline,” “believe,” “continue,” “could,” “estimate,” “expect,” “intend,” “may,” “might,” “plan,” “possible,” “predict,” “project,” “should,” “strive,” “would,” “aim,” “target,” “commit,” and similar expressions (including the negatives of these terms or variations of them) generally identify forward-looking statements, but the absence of these words does not mean that statement is not forward looking.

Actual results could differ materially from those included in the forward-looking statements due to various factors, risks and uncertainties, including, but not limited to, that preclinical testing of DNTH103 and data from clinical trials may not be predictive of the results or success of ongoing or later clinical trials, that the development of DNTH103 or the Company’s other compounds may take longer and/or cost more than planned, that the Company may be unable to successfully complete the clinical development of the Company’s compounds, that the Company may be delayed in initiating, enrolling or completing its planned clinical trials, and that the Company’s compounds may not receive regulatory approval or become commercially successful products. These and other risks and uncertainties are identified under the heading “Risk Factors” included in Exhibit 99.1 to the Company’s Current Report on Form 8-K filed with the SEC on September 12, 2023 (as amended on September 21, 2023), and other filings that the Company has made and may make with the SEC in the future. Nothing in this press release should be regarded as a representation by any person that the forward-looking statements set forth herein will be achieved or that any of the contemplated results of such forward-looking statements will be achieved.

The forward-looking statements in this press release speak only as of the date they are made and are qualified in their entirety by reference to the cautionary statements herein. These statements are based upon the current beliefs and expectations of the Company’s management and the Company undertakes no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future events or otherwise, except as required by law.

Contact
Jennifer Davis Ruff
Dianthus Therapeutics
jdavisruff@dianthustx.com 

 

Dec 04 2023 | Dianthus Therapeutics Announces Inducement Grant Under Nasdaq Listing Rule 5635(c)(4)
NEW YORK and WALTHAM, Mass., Dec. 04, 2023 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (“Dianthus”), a clinical-stage biotechnology company dedicated to advancing the next generation… READ MORE
News
Dec 04 2023 | Dianthus Therapeutics Announces Inducement Grant Under Nasdaq Listing Rule 5635(c)(4)

NEW YORK and WALTHAM, Mass., Dec. 04, 2023 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (“Dianthus”), a clinical-stage biotechnology company dedicated to advancing the next generation of antibody complement therapeutics to treat severe autoimmune diseases, today announced that it granted an equity award on December 1, 2023 as a material inducement to employment of the newly-hired Chief Scientific Officer, Jeffrey Stavenhagen, Ph.D. The inducement grant was approved by the Company’s independent Compensation Committee and was made as a material inducement to Dr. Stavenhagen’s acceptance of employment with Dianthus in accordance with Nasdaq Listing Rule 5635(c)(4).

The inducement grant consists of a non-qualified stock option to purchase an aggregate of 96,000 shares of the Company’s common stock with a 10-year term and an exercise price of $11.27 per share. The options vest as to 25% on the first anniversary of the vesting commencement date and in equal monthly installments for the following 36 months. The inducement grant is subject to the terms and conditions of a stand-alone inducement award agreement outside of the Amended and Restated Dianthus Therapeutics, Inc. Equity Incentive Plan (the “Equity Plan”), but is generally subject to the same terms and conditions that apply to awards granted under the Equity Plan.

About Dianthus Therapeutics
Dianthus Therapeutics is a clinical-stage biotechnology company dedicated to designing and delivering novel, best-in-class monoclonal antibodies with improved selectivity and potency. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who are leading the development of next-generation antibody complement therapeutics, aiming to deliver transformative medicines for people living with severe autoimmune and inflammatory diseases. To learn more, please visit www.dianthustx.com and follow us on LinkedIn.

Contact
Jennifer Davis Ruff
Dianthus Therapeutics
jdavisruff@dianthustx.com

Nov 29 2023 | Dianthus Therapeutics Enhances Leadership Team with Appointment of Jeffrey Stavenhagen, Ph.D., as Chief Scientific Officer
Dr. Stavenhagen brings over 20 years of experience in leading drug discovery initiatives, with a focus on monoclonal antibodies targeting neuro diseases Jennifer Davis Ruff… READ MORE
News
Nov 29 2023 | Dianthus Therapeutics Enhances Leadership Team with Appointment of Jeffrey Stavenhagen, Ph.D., as Chief Scientific Officer

Dr. Stavenhagen brings over 20 years of experience in leading drug discovery initiatives, with a focus on monoclonal antibodies targeting neuro diseases

Jennifer Davis Ruff also named Vice President, Head of Investor Relations & Corporate Affairs with over 20 years of experience at leading public biopharmaceutical companies

NEW YORK and WALTHAM, Mass., Nov. 29, 2023 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to advancing the next generation of antibody complement therapeutics to treat severe autoimmune diseases, today announced the appointment of Jeffrey Stavenhagen, Ph.D., as Chief Scientific Officer. In this role, Dr. Stavenhagen will lead the Company’s discovery and preclinical research and translational science initiatives.

“I’m thrilled to welcome Jeff to the Dianthus team as we advance next-generation antibody therapeutics for patients living with severe autoimmune diseases. Dianthus has made tremendous progress with DNTH103, its active C1s inhibitor, and is on track to initiate three Phase 2 clinical trials in 2024 for generalized Myasthenia Gravis, Multifocal Motor Neuropathy, and Chronic Inflammatory Demyelinating Polyneuropathy,” said Marino Garcia, President and Chief Executive Officer of Dianthus Therapeutics. “Jeff has a proven track record as a leader in early-stage antibody and neuro drug development and has successfully advanced a number of new therapeutics into the clinic. His experience will be invaluable as we strategically expand our discovery initiatives to build a sustainable pipeline.”

Dr. Stavenhagen is a recognized expert in early-stage drug development, with more than 20 years of experience building and leading research teams to advance new therapeutic candidates into clinical development. He was most recently Chief Scientific Officer at Therini Bio, where he directed R&D initiatives leading to the development of a first-in-class monoclonal antibody for the treatment of neurodegenerative diseases. He previously served in leadership roles at Therachon, leading preclinical research and CMC, and Lundbeck, advancing its first internal antibody programs into clinical development for neurodegenerative diseases. Dr. Stavenhagen began his biotech career as the first employee of MacroGenics, where he built a novel antibody engineering platform that resulted in Margenza®, one of the first Fc optimized monoclonal antibodies on the market. Throughout his career, he has authored over 40 scientific patents and publications. Dr. Stavenhagen received his Ph.D. in Molecular Biology from Columbia University and performed post-doctoral studies at the Fred Hutchinson Research Center in Seattle.

“It’s an exciting time to join Dianthus as the Company prepares to initiate three Phase 2 trials in 2024 for its potential best-in-class active C1s inhibitor, DNTH103,” said Dr. Stavenhagen. “I’ve been very impressed by Dianthus’ leadership and scientific teams, and I look forward to working with them to continue developing the Company’s drug discovery and translational research programs as we deliver on our mission of improving the lives of people with severe autoimmune diseases.”

In addition, Dianthus announced that Jennifer Davis Ruff has joined the Company as Vice President and Head of Investor Relations and Corporate Affairs. She has more than 20 years of experience in investor relations and corporate communications in the biopharmaceutical and biotechnology industries. Ms. Ruff most recently served as Vice President, Investor Relations at Pyxis Oncology, where she led communications with investors and analysts. Previously, she held the roles of Vice President, Corporate Communications and Investor Relations at TESARO, Director, Investor Relations at Pfizer, and Director, Investor Relations and Corporate Communications at MGI Pharma. She earned a master’s degree in biotechnology from Northwestern University and a bachelor’s degree in biology from the University of Iowa.

About Dianthus Therapeutics
Dianthus Therapeutics is a clinical-stage biotechnology company dedicated to designing and delivering novel, best-in-class monoclonal antibodies with improved selectivity and potency. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who are leading the development of next-generation antibody complement therapeutics, aiming to deliver transformative medicines for people living with severe autoimmune and inflammatory diseases. To learn more, please visit www.dianthustx.com and follow us on LinkedIn.

Cautionary Statement Regarding Forward-Looking Statements
Certain statements in this press release, other than purely historical information, may constitute “forward-looking statements” within the meaning of the federal securities laws, including for purposes of the safe harbor provisions under the United States Private Securities Litigation Reform Act of 1995, express or implied statements regarding future plans and prospects, including statements regarding the expectations or plans for discovery, preclinical studies, clinical trials and research and development programs, in particular with respect to DNTH103, and any developments or results in connection therewith, including the target product profile of DNTH103; the anticipated timing of the initiation and results from those studies and trials; expectations regarding the time period over which the Company’s capital resources are expected to be sufficient to fund its anticipated operations; and expectations regarding the market and potential opportunities for complement therapies, in particular with respect to DNTH103. The words “opportunity,” “potential,” “milestones,” “runway,” “will,” “anticipate,” “achieve,” “near-term,” “catalysts,” “pursue,” “pipeline,” “believe,” continue,” “could,” “estimate,” “expect,” “ intend,” “may,” “might,” “plan,” “possible,” “predict,” “project,” “ should,” “strive,” “would,” “aim,” “target,” “commit,” and similar expressions (including the negatives of these terms or variations of them) generally identify forward-looking statements, but the absence of these words does not mean that statement is not forward looking.

Actual results could differ materially from those included in the forward-looking statements due to various factors, risks and uncertainties, including, but not limited to, that preclinical testing of DNTH103 and data from clinical trials may not be predictive of the results or success of ongoing or later clinical trials, that the development of DNTH103 or the Company’s other compounds may take longer and/or cost more than planned, that the Company may be unable to successfully complete the clinical development of the Company’s compounds, that the Company may be delayed in initiating, enrolling or completing its planned clinical trials, and that the Company’s compounds may not receive regulatory approval or become commercially successful products. These and other risks and uncertainties are identified under the heading “Risk Factors” included in Exhibit 99.1 to the Company’s Current Report on Form 8-K filed with the SEC on September 12, 2023 (as amended on September 21, 2023), and other filings that the Company has made and may make with the SEC in the future. Nothing in this press release should be regarded as a representation by any person that the forward-looking statements set forth herein will be achieved or that any of the contemplated results of such forward-looking statements will be achieved.

The forward-looking statements in this press release speak only as of the date they are made and are qualified in their entirety by reference to the cautionary statements herein. Dianthus undertakes no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future events or otherwise, except as required by law.

Contact
Jennifer Davis Ruff
Dianthus Therapeutics
jdavisruff@dianthustx.com

Nov 09 2023 | Dianthus Therapeutics Highlights Recent Business Achievements and Third Quarter 2023 Financial Results
Began trading on Nasdaq under the ticker symbol DNTH following the successful completion of our merger with Magenta Therapeutics Completed concurrent $72 million financing with… READ MORE
News
Nov 09 2023 | Dianthus Therapeutics Highlights Recent Business Achievements and Third Quarter 2023 Financial Results

Began trading on Nasdaq under the ticker symbol DNTH following the successful completion of our merger with Magenta Therapeutics

Completed concurrent $72 million financing with a syndicate of leading life-science investors

Announced positive top-line Phase 1 data for lead clinical program, DNTH103, confirming potent classical complement pathway inhibition, extended half-life, and a potentially differentiated safety profile

On track to advance DNTH103 into Phase 2 trials targeting multiple neuromuscular indications in 2024, starting with generalized Myasthenia Gravis in Q1 2024

Robust balance sheet, closing the quarter with over $189 million of cash runway expected to fund operations into Q2 2026

NEW YORK and WALTHAM, Mass., Nov. 09, 2023 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (Nasdaq: DNTH), a clinical-stage biotechnology company dedicated to advancing the next generation of antibody complement therapeutics to treat severe autoimmune diseases, today reported financial results for the third quarter ending September 30, 2023 and provided an update on recent business achievements.

“This was a landmark quarter of progress and momentum for Dianthus, marked by the positive top-line results for our lead clinical program, DNTH103, validating its best-in-class potential as well as our exciting transition to the public markets with a robust balance sheet,” said Marino Garcia, President and Chief Executive Officer of Dianthus Therapeutics. “As we look ahead, we remain on track to progress DNTH103 into Phase 2 trials for multiple neuromuscular indications where we have the potential to develop a new standard of care, beginning with generalized Myasthenia Gravis in the first quarter of 2024, followed by Multifocal Motor Neuropathy and Chronic Inflammatory Demyelinating Polyneuropathy. We’re particularly energized by the high level of engagement and interest we’ve seen from leading clinicians and investigators globally due to DNTH103’s potentially differentiated profile as a potent active C1s inhibitor with infrequent, subcutaneous self-administration. We are encouraged by the potential of DNTH103 to address both the disease and treatment burdens that disrupt the lives of patients suffering from severe autoimmune diseases, and we look forward to providing updates on our progress in the coming months.”

Recent Business Highlights and Upcoming Milestones

DNTH103
DNTH103 is an investigational, potent monoclonal antibody designed to selectively target the active form of the C1s protein, a clinically validated complement target within the classical pathway. Selective inhibition of the classical complement pathway may lower patient risk of infection from encapsulated bacteria by preserving immune activity of the lectin and alternative pathways. Engineered with validated YTE half-life extension technology, DNTH103 is intended to be the first subcutaneous complement therapy that can be self-administered as infrequently as once every two weeks for a range of severe, classical pathway-driven autoimmune disorders, beginning with generalized Myasthenia Gravis (gMG), Multifocal Motor Neuropathy (MMN), and Chronic Inflammatory Demyelinating Polyneuropathy (CIDP).

  • Top-line Phase 1 data across seven single and multiple ascending dose cohorts with 52 healthy volunteers establish DNTH103’s best-in-class potential. Results confirmed:
    • Approximately 60-day half-life and highly potent classical pathway inhibition
    • A potentially differentiated safety profile, with no serious adverse events or complement-related infections
  • In a well-established, functional in vitro AChR-positive model of gMG disease, DNTH103 improved neurotransmission and muscle contraction, providing further scientific rationale and support for targeting the classical pathway with DNTH103 in AChR-positive gMG patients.
  • Dianthus intends to initiate Phase 2 trials of DNTH103 for gMG in the first quarter of 2024, followed by MMN in the first half of 2024 and CIDP in the second half of 2024.

Corporate

  • Successfully completed merger with Magenta Therapeutics and began trading on Nasdaq under the new ticker symbol “DNTH” with over $189 million of cash runway expected to fund operations into Q2 2026.
  • Concurrent with the closing of the merger, completed a $72 million private investment in common stock and pre-funded warrants from a syndicate of healthcare investors led by Fidelity Management & Research Company, Catalio Capital Management, 5AM Ventures, Avidity Partners, Wedbush Healthcare Partners and founding investors Fairmount, Tellus BioVentures and Venrock Healthcare Capital Partners.
  • Further strengthened Board of Directors with appointments of Alison Lawton and Anne McGeorge.

Third Quarter Financial Results

  • Cash, cash equivalents, and investments totaled $189.9 million on September 30, 2023.
  • Research and development expenses for the quarter ended September 30, 2023 were $8.0 million, inclusive of $0.4 million of stock-based compensation.
  • General and administrative expenses for the quarter ended September 30, 2023 were $8.7 million, inclusive of severance costs for legacy Magenta employees of $4.0 million and stock-based compensation of $0.8 million.
  • Net loss for the quarter ended September 30, 2023 was $14.8 million or $3.78 net loss per share (basic and diluted).
  • For additional information on the Company’s financial results for the quarter ended September 30, 2023, please refer to the Form 10-Q filed with the SEC.

About DNTH103
DNTH103 is an investigational, long-acting monoclonal antibody designed to selectively target the active form of the C1s protein, a clinically validated complement target within the classical pathway. DNTH103 is enhanced with YTE half-life extension technology designed to enable a more convenient subcutaneous, self-administered injection dosed as infrequently as once every two weeks. Additionally, selective inhibition of the classical complement pathway may lower patient risk of infection from encapsulated bacteria by preserving immune activity of the lectin and alternative pathways. As the classical pathway plays a significant role in disease pathology, DNTH103 has the potential to be a best-in-class pipeline-in-a-product across a range of autoimmune disorders with high unmet need. Dianthus plans to initiate Phase 2 trials in multiple neuromuscular indications in 2024, starting with generalized Myasthenia Gravis in the first quarter of 2024.

About Dianthus Therapeutics
Dianthus Therapeutics is a clinical-stage biotechnology company dedicated to designing and delivering novel, best-in-class monoclonal antibodies with improved selectivity and potency. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who are leading the development of next-generation antibody complement therapeutics, aiming to deliver transformative medicines for people living with severe autoimmune and inflammatory diseases. To learn more, please visit www.dianthustx.com and follow us on LinkedIn.

Cautionary Statement Regarding Forward-Looking Statements
Certain statements in this press release, other than purely historical information, may constitute “forward-looking statements” within the meaning of the federal securities laws, including for purposes of the safe harbor provisions under the United States Private Securities Litigation Reform Act of 1995, express or implied statements regarding future plans and prospects, including statements regarding the expectations or plans for discovery, preclinical studies, clinical trials and research and development programs, in particular with respect to DNTH103, and any developments or results in connection therewith, including the target product profile of DNTH103; the anticipated timing of the results from those studies and trials; expectations regarding the time period over which the Company’s capital resources are expected to be sufficient to fund its anticipated operations; and expectations regarding the market and potential opportunities for complement therapies, in particular with respect to DNTH103. The words “opportunity,” “potential,” “milestones,” “runway,” “will,” “anticipate,” “achieve,” “near-term,” “catalysts,” “pursue,” “pipeline,” “believe,” continue,” “could,” “estimate,” “expect,” “ intend,” “may,” “might,” “plan,” “possible,” “predict,” “project,” “ should,” “strive,” “would,” “aim,” “target,” “commit,” and similar expressions (including the negatives of these terms or variations of them) generally identify forward-looking statements, but the absence of these words does not mean that statement is not forward looking.

Actual results could differ materially from those included in the forward-looking statements due to various factors, risks and uncertainties, including, but not limited to, that preclinical testing of DNTH103 and data from clinical trials may not be predictive of the results or success of ongoing or later clinical trials, that the development of DNTH103 or the Company’s other compounds may take longer and/or cost more than planned, that the Company may be unable to successfully complete the clinical development of the Company’s compounds, that the Company may be delayed in initiating, enrolling or completing its planned clinical trials, and that the Company’s compounds may not receive regulatory approval or become commercially successful products. These and other risks and uncertainties are identified under the heading “Risk Factors” included in Exhibit 99.1 to the Company’s Form 8-K/A filed on September 21, 2023, and other filings that the Company has made and may make with the SEC in the future. Nothing in this press release should be regarded as a representation by any person that the forward-looking statements set forth herein will be achieved or that any of the contemplated results of such forward-looking statements will be achieved.

The forward-looking statements in this press release speak only as of the date they are made and are qualified in their entirety by reference to the cautionary statements herein. Dianthus undertakes no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future events or otherwise, except as required by law.

Media Contact
Peg Rusconi
Verge Scientific Communications
prusconi@vergescientific.com 

Dianthus Therapeutics, Inc.
Condensed Consolidated Balance Sheets
(in thousands, except share and per share data)
(unaudited)
       
ASSETS September 30,
2023
  December 31,
2022
Current assets:      
Cash and cash equivalents $ 157,282     $ 15,365  
Short-term investments   32,588       60,125  
Receivable from related party   232       4,700  
Unbilled receivable from related party   519       938  
Prepaid expenses and other current assets   832       905  
Total current assets   191,453       82,033  
       
Property and equipment, net   195       142  
Right-of-use lease assets   698       814  
Other assets and restricted cash   116       121  
Total assets $ 192,462     $ 83,110  
             
LIABILITIES, CONVERTIBLE PREFERRED STOCK AND STOCKHOLDERS’ EQUITY/(DEFICIT)      
Current liabilities:      
Accounts payable $ 1,369     $ 1,167  
Accrued expenses   11,197       6,608  
Current portion of deferred revenue – related party   100       100  
Current portion of lease liabilities   413       350  
Total current liabilities   13,079       8,225  
       
Deferred revenue – related party   745       791  
Long-term lease liabilities   257       438  
Total liabilities   14,081       9,454  
       
Commitments and contingencies      
Convertible preferred stock         118,024  
Stockholders’ equity/(deficit):      
Preferred stock          
Common stock   15        
Additional paid-in capital   257,230       1,661  
Accumulated deficit   (78,860 )     (45,868 )
Accumulated other comprehensive loss   (4 )     (161 )
Total stockholders’ equity/(deficit)   178,381       (44,368 )
Total liabilities and stockholders’ equity/(deficit) $ 192,462     $ 83,110  

Dianthus Therapeutics, Inc.
Condensed Consolidated Statements of Operations and Comprehensive Loss
(in thousands, except share and per share data)
(unaudited)
               
  Three Months Ended September 30,   Nine Months Ended September 30,
    2023       2022       2023       2022  
Revenues:              
License revenue – related party $ 924     $ 1,173     $ 2,369     $ 5,242  
               
Operating expenses:              
Research and development   7,960       7,218       24,060       19,548  
General and administrative   8,723       2,209       13,527       4,706  
Total operating expenses   16,683       9,427       37,587       24,254  
               
Loss from operations   (15,759 )     (8,254 )     (35,218 )     (19,012 )
               
Other income/(expense):              
Interest income   1,027       416       2,320       505  
(Loss)/gain on currency exchange, net   (16 )     56       (53 )     156  
Other expense   (15 )     (2 )     (41 )     (9 )
Total other income   996       470       2,226       652  
               
Net loss $ (14,763 )   $ (7,784 )   $ (32,992 )   $ (18,360 )
               
Net loss per share attributable to common stockholders, basic and diluted $ (3.78 )   $ (8.90 )   $ (17.40 )   $ (21.00 )
               
Weighted-average number of common              
shares outstanding used in computing net loss per common share, basic and diluted   3,906,886       874,327       1,896,605       874,138  
               
Comprehensive loss:              
Net Loss $ (14,763 )   $ (7,784 )   $ (32,992 )   $ (18,360 )
Other comprehensive income/(loss):              
Change in unrealized losses related to
available-for-sale debt securities
  15       (150 )     157       (150 )
Total other comprehensive income/(loss)   15       (150 )     157       (150 )
Total comprehensive loss $ (14,748 )   $ (7,934 )   $ (32,835 )   $ (18,510 )

Nov 01 2023 | Dianthus Therapeutics to Participate in Upcoming Investor Healthcare Conferences in November
NEW YORK and WALTHAM, Mass., Nov. 01, 2023 (GLOBE NEWSWIRE) — Dianthus Therapeutics, a clinical-stage biotechnology company dedicated to advancing the next generation of antibody… READ MORE
News
Nov 01 2023 | Dianthus Therapeutics to Participate in Upcoming Investor Healthcare Conferences in November

NEW YORK and WALTHAM, Mass., Nov. 01, 2023 (GLOBE NEWSWIRE) — Dianthus Therapeutics, a clinical-stage biotechnology company dedicated to advancing the next generation of antibody complement therapeutics, today announced that the Company’s senior management team will participate in the following upcoming investor healthcare conferences during the month of November:

  • Guggenheim Securities 5th Annual Inflammation, Neurology & Immunology Conference on November 6 in New York City
  • Jefferies 2023 London Healthcare Conference on November 14-15 in London
  • Evercore ISI 6th Annual HealthCONx Conference on November 28-29 in Miami

About Dianthus Therapeutics
Dianthus Therapeutics is a clinical-stage biotechnology company dedicated to designing and delivering novel, best-in-class monoclonal antibodies with improved selectivity and potency. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who are leading the development of next-generation antibody complement therapeutics, aiming to deliver transformative medicines for people living with severe autoimmune and inflammatory diseases. To learn more, please visit www.dianthustx.com and follow us on LinkedIn.

Media Contact
Peg Rusconi
Verge Scientific Communications
prusconi@vergescientific.com

Sep 12 2023 | Dianthus Therapeutics Announces Positive Top-line Phase 1 Data and Debuts Trading on Nasdaq as DNTH
Positive top-line Phase 1 data for lead clinical program DNTH103 confirm potent classical pathway inhibition, extended half-life, and a potentially differentiated safety profile Results support… READ MORE
News
Sep 12 2023 | Dianthus Therapeutics Announces Positive Top-line Phase 1 Data and Debuts Trading on Nasdaq as DNTH

Positive top-line Phase 1 data for lead clinical program DNTH103 confirm potent classical pathway inhibition, extended half-life, and a potentially differentiated safety profile

Results support DNTH103’s best-in-class potential to be the first subcutaneous, self-administered injection dosed as infrequently as once every two weeks to treat a range of autoimmune disorders

Company plans to initiate multiple Phase 2 trials targeting neuromuscular indications in 2024, starting with generalized Myasthenia Gravis in Q1 2024, followed by Multifocal Motor Neuropathy in Q2 2024, and Chronic Inflammatory Demyelinating Polyneuropathy in second half of 2024

Dianthus Therapeutics, Inc. will begin trading on Nasdaq as DNTH with approximately $184 million of cash runway expected to fund operations into Q2 2026

NEW YORK and WALTHAM, Mass., Sept. 12, 2023 (GLOBE NEWSWIRE) — Dianthus Therapeutics, Inc. (“Dianthus”), a clinical-stage biotechnology company dedicated to advancing the next generation of antibody complement therapeutics to treat severe autoimmune diseases, today announced positive top-line Phase 1 data for DNTH103 validating its best-in-class potential as a selective classical pathway inhibitor targeting only the active form of the C1s protein. Additionally, Dianthus will begin trading on the Nasdaq Capital Market today as DNTH, following the successful completion on September 11, 2023 of the previously announced merger with Magenta Therapeutics (“Magenta”).

The Phase 1 healthy volunteer study was designed to validate the extended half-life, potent classical pathway inhibition, and potentially differentiated safety profile of DNTH103. Top-line data across seven single and multiple ascending dose cohorts with 52 healthy volunteers confirmed its approximately 60-day half-life and highly potent classical pathway inhibition, establishing DNTH103’s best-in-class potential to be the first self-administered subcutaneous injection dosed as infrequently as once every two weeks to treat a range of autoimmune disorders. The results also demonstrated DNTH103 was generally well tolerated with no serious adverse events or complement-related infections. Dianthus plans to initiate multiple Phase 2 studies in 2024 in various neuromuscular indications, starting with generalized Myasthenia Gravis (gMG) in the first quarter of 2024 followed by additional Phase 2 trials for Multifocal Motor Neuropathy (MMN) and Chronic Inflammatory Demyelinating Polyneuropathy (CIDP). Additional information about our Phase 1 data and DNTH103 can be found in our corporate presentation at investor.dianthustx.com.

“This is an exciting and transformative time at Dianthus as we announce top-line Phase 1 data for DNTH103 validating its potential to become a new standard of care with a best-in-class profile for multiple classical pathway-driven autoimmune disorders,” said Marino Garcia, President and Chief Executive Officer of Dianthus Therapeutics. “These results, combined with our transition to the public markets, represent a major milestone in our growth trajectory. We are now well positioned to execute across multiple Phase 2 trials as we continue to maximize the value of DNTH103 as a pipeline-in-a-product.”

“I am very encouraged by the Phase 1 safety and pharmacokinetic/pharmacodynamic data seen with DNTH103, our highly potent and selective upstream classical complement pathway inhibitor. Classical pathway activation plays a significant role in the pathology of various autoimmune disorders such as generalized Myasthenia Gravis, where patients still face significant disease and treatment burden, and we are excited to start the gMG Phase 2 trial early next year,” said Simrat Randhawa, M.D., Chief Medical Officer of Dianthus Therapeutics. “We also look forward to starting Phase 2 trials in both MMN and CIDP in 2024, two neuromuscular autoimmune disorders which currently have no approved targeted biologics and where we believe DNTH103 could benefit patients.”

Concurrent with the closing of the merger, Dianthus completed a $72 million private investment in its common stock and pre-funded warrants from a syndicate of healthcare investors led by Fidelity Management & Research Company, Catalio Capital Management, 5AM Ventures, Avidity Partners, Wedbush Healthcare Partners and founding investors Fairmount, Tellus BioVentures and Venrock Healthcare Capital Partners. The cash and cash equivalents as of the close of the business combination were approximately $184 million, which is expected to provide cash runway into the second quarter of 2026.

About DNTH103
DNTH103 is a clinical-stage, potent monoclonal antibody engineered to selectively target the classical pathway by inhibiting only the active form of the C1s protein, a clinically validated complement target. DNTH103 is enhanced with YTE half-life extension technology designed to enable a more convenient subcutaneous, self-administered injection dosed as infrequently as once every two weeks. Additionally, selective inhibition of the classical complement pathway may lower patient risk of infection from encapsulated bacteria by preserving immune activity of the lectin and alternative pathways. As the classical pathway plays a significant role in disease pathology, DNTH103 has the potential to be a best-in-class pipeline-in-a-product across a range of autoimmune disorders with high unmet need. Dianthus plans to initiate Phase 2 trials in multiple neuromuscular indications in 2024, starting with generalized Myasthenia Gravis in the first quarter of 2024.

About Dianthus Therapeutics
Dianthus Therapeutics is a clinical-stage biotechnology company dedicated to designing and delivering novel, best-in-class monoclonal antibodies with improved selectivity and potency. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who are leading the development of next-generation antibody complement therapeutics, aiming to deliver transformative medicines for people living with severe autoimmune and inflammatory diseases. To learn more, please visit www.dianthustx.com and follow us on LinkedIn.

Cautionary Statement Regarding Forward-Looking Statements
Certain statements in this press release, other than purely historical information, may constitute “forward-looking statements” within the meaning of the federal securities laws, including for purposes of the safe harbor provisions under the United States Private Securities Litigation Reform Act of 1995, express or implied statements regarding future plans and prospects, including statements regarding the expectations or plans for discovery, preclinical studies, clinical trials and research and development programs, in particular with respect to DNTH103, and any developments or results in connection therewith, including the target product profile of DNTH103; the anticipated timing of the results from those studies and trials; expectations regarding the use of proceeds and the time period over which the Company’s capital resources are expected to be sufficient to fund its anticipated operations; and expectations regarding the market and potential opportunities for complement therapies, in particular with respect to DNTH103. The words “opportunity,” “potential,” “milestones,” “runway,” “will,” “anticipate,” “achieve,” “near-term,” “catalysts,” “pursue,” “pipeline,” “believe,” continue,” “could,” “estimate,” “expect,” “ intend,” “may,” “might,” “plan,” “possible,” “predict,” “project,” “ should,” “strive,” “would,” “aim,” “target,” “commit,” and similar expressions (including the negatives of these terms or variations of them) generally identify forward-looking statements, but the absence of these words does not mean that statement is not forward looking.

Actual results could differ materially from those included in the forward-looking statements due to various factors, risks and uncertainties, including, but not limited to, that preclinical testing of DNTH103 and data from clinical trials may not be predictive of the results or success of ongoing or later clinical trials, that the development of DNTH103 or the Company’s other compounds may take longer and/or cost more than planned, that the Company may be unable to successfully complete the clinical development of the Company’s compounds, that the Company may be delayed in initiating, enrolling or completing its planned clinical trials, and that the Company’s compounds may not receive regulatory approval or become commercially successful products. These and other risks and uncertainties are identified under the headings “Risk Factors—Risks related to Dianthus” and “—Risks Related to the Combined Company” included in the Company’s definitive proxy statement/prospectus that was filed with and declared effective by the SEC on August 1, 2023, and other filings that the Company has made and may make with the SEC in the future. Nothing in this press release should be regarded as a representation by any person that the forward-looking statements set forth herein will be achieved or that any of the contemplated results of such forward-looking statements will be achieved.

The forward-looking statements in this press release speak only as of the date they are made and are qualified in their entirety by reference to the cautionary statements herein. Dianthus undertakes no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future events or otherwise, except as required by law. 

Media Contact Peg Rusconi Verge Scientific Communications prusconi@vergescientific.com Investor Relations Contact IR@dianthustx.com

Sep 11 2023 | Magenta Therapeutics Announces Completion of Merger with Dianthus Therapeutics and Implementation of Reverse Stock Split
The combined company will operate as “Dianthus Therapeutics, Inc.” with its common stock traded on Nasdaq under trading symbol “DNTH” effective Tuesday, September 12, 2023… READ MORE
News
Sep 11 2023 | Magenta Therapeutics Announces Completion of Merger with Dianthus Therapeutics and Implementation of Reverse Stock Split

The combined company will operate as “Dianthus Therapeutics, Inc.” with its common stock traded on Nasdaq under trading symbol “DNTH” effective Tuesday, September 12, 2023

CAMBRIDGE, Mass., Sept. 11, 2023 (GLOBE NEWSWIRE) — Magenta Therapeutics, Inc. (Nasdaq: MGTA) (“Magenta”) today announced completion of the merger with Dianthus Therapeutics, Inc. (“Dianthus”) following Magenta’s successful receipt of stockholder approval for all proposals related to the merger at a special meeting of stockholders. Magenta effected a reverse stock split of Magenta’s common stock immediately prior to the merger. Magenta following the merger is referred to herein as the “combined company.”

Steve Mahoney, President and Chief Financial and Operating Officer of Magenta said, “We are pleased with the outcome of the special meeting and appreciate our stockholders’ support for the merger with Dianthus.”

To ensure the combined company’s compliance with the minimum bid price requirement of $4.00 per share for initial listing on The Nasdaq Capital Market, Magenta implemented a reverse split of its common stock at a ratio of 1-for-16 shares. In the reverse stock split, every 16 shares of Magenta common stock outstanding was combined and reclassified into 1 share of Magenta common stock. Immediately thereafter, and pursuant to the terms of the previously announced merger agreement, Dianthus became a wholly owned subsidiary of Magenta upon completion of the merger, and each outstanding share of Dianthus common stock was converted into 0.2181 shares of common stock of Magenta. 

Magenta’s stockholders will receive cash in lieu of any fractional shares resulting from the reverse stock split. Stockholders owning shares of common stock via a bank, broker, or other nominee will have their positions automatically adjusted to reflect the reverse stock split and will not be required to take further action in connection with the reverse stock split, subject to their brokers’ particular processes. The new CUSIP number for the combined company following the reverse stock split, merger and other attendant transactions is 252828 108. 

The reverse stock split became legally effective today at 11:13 a.m. Eastern Time, with the merger effective today at 11:15 a.m. Eastern Time.

The combined company will operate under the name, Dianthus Therapeutics, Inc., and its shares will begin trading on The Nasdaq Capital Market on a post-reverse split, post-merger basis under the ticker symbol “DNTH” effective with the open of business on Tuesday, September 12, 2023.

CONTACT
Peg Rusconi
peg.rusconi@vergescientific.com

Jun 20 2023 | Dianthus Therapeutics Appoints Adam Veness, Esq., as General Counsel
Experienced life sciences executive brings more than a decade of public company expertise in legal, corporate governance and compliance New York City and Waltham, Mass.,… READ MORE
News
Jun 20 2023 | Dianthus Therapeutics Appoints Adam Veness, Esq., as General Counsel

Experienced life sciences executive brings more than a decade of public company expertise in legal, corporate governance and compliance

New York City and Waltham, Mass., June 20, 2023 – Dianthus Therapeutics, a clinical-stage biotechnology company dedicated to advancing the next generation of antibody complement therapeutics, today announced the appointment of Adam Veness, Esq., as General Counsel.

Joining Dianthus most recently from Cyteir Therapeutics, Veness spent much of his career as Senior Vice President, General Counsel and Secretary at Acceleron Pharma Inc. prior to the acquisition by Merck in November 2021. During his tenure at Acceleron, Veness gained experience in roles of increasing responsibility where he served on the Executive Committee responsible for company strategy, and he led all aspects of global legal and compliance, including capital markets and SEC reporting obligations, corporate governance, contracts, intellectual property, employment matters, and data privacy.

“We are excited to welcome Adam to the Dianthus team at such a pivotal time for the company,” said Marino Garcia, President and Chief Executive Officer of Dianthus Therapeutics. “Adam’s proven track record in helping develop and implement corporate strategy and successfully leading the legal and compliance functions in public life science companies will be invaluable as we expect to transition to a public company in the third quarter of this year. I am looking forward to working with Adam and to his contributions as we continue to build an exciting biotech company.”

Prior to moving in-house to the biotechnology industry, Veness was a corporate and securities attorney at the law firm Mintz Levin where he represented and counseled public and private companies in the biopharmaceutical, technology, and healthcare industries. He began his legal career at a boutique litigation firm representing companies and individuals in a variety of civil litigation matters. Veness earned a B.A. in political science and philosophy from Tulane University, and a J.D. from Boston University School of Law.

“I am thrilled to join Dianthus as the company embarks on this exciting chapter of growth,” said Adam Veness, Esq., General Counsel of Dianthus Therapeutics. “I have been impressed with the quality of the science and the caliber of the Dianthus management team, board of directors, and investors. The team’s dedication to improving the lives of people with severe autoimmune disease has been inspiring, and their impressive achievements over a short period of time exemplify their sense of urgency in bringing potentially best-in-class therapies to these patients with high unmet need. I look forward to working with Marino and the entire Dianthus team as we are poised to cross the threshold into the public markets.”

About DNTH103
DNTH103 is an investigational long-acting classical complement pathway inhibitor designed as a less frequent and convenient subcutaneous injection with the potential to treat people living with severe autoimmune diseases. DNTH103, a fully human monoclonal antibody, is designed to selectively target only the active form of the C1s complement protein, inhibiting only the classical complement pathway, with the aim of treating patients with a lower dosing volume as a convenient subcutaneous injection suitable for a self-administered pre-filled pen. Inhibiting the active form of the complement target seeks to address a critical treatment gap in current complement therapies that do not bind selectively to the active protein, wasting a significant amount of the drug on inert proteins. DNTH103 selective inhibition of the classical pathway is engineered to preserve important immune activity of the lectin and alternative complement pathways needed to protect the body against infections from encapsulated bacteria. DNTH103 is also enhanced with YTE half-life extension technology to further reduce dosing frequency.

DNTH103 has a steady cadence of expected clinical milestones including top-line Phase 1 data aiming to confirm potent classical pathway inhibition and favorable, extended pharmacokinetics expected by the end of 2023, initiation of a Phase 2 trial in generalized Myasthenia Gravis expected in the first quarter of 2024 followed by two additional planned Phase 2 trial initiations in Multifocal Motor Neuropathy (MMN) and Chronic inflammatory demyelinating polyneuropathy (CIDP). Dianthus also plans to initiate an open label proof of efficacy trial in Cold Agglutinin Disease (CAD) with patient data anticipated in the second half of 2024.

About Dianthus Therapeutics

Dianthus Therapeutics is a clinical-stage biotechnology company dedicated to designing and delivering novel, best-in-class monoclonal antibodies with improved selectivity and potency over existing complement therapies. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who are leading the next generation of antibody complement therapeutics, aiming to deliver transformative medicines for people living with severe autoimmune diseases. In May 2023, Dianthus announced a merger agreement with Magenta Therapeutics and upon completion of the merger, the combined company is expected to operate under the name Dianthus Therapeutics, Inc. and trade on the Nasdaq under the ticker symbol “DNTH”. To learn more, please visit www.dianthustx.com and follow us on LinkedIn.

Forward-Looking Statements

Certain statements in this press release may constitute “forward-looking statements” for purposes of the federal securities laws concerning Dianthus’s expectations with respect to the proposed transaction between Dianthus and Magenta Therapeutics, Inc. (Magenta) announced in May 2023 and its anticipated closing. These forward-looking statements include express or implied statements relating to Dianthus’s management team’s expectations, hopes, beliefs, intentions or strategies regarding the future. In addition, any statements that refer to projections, forecasts or other characterizations of future events or circumstances, including any underlying assumptions, are forward-looking statements. The words “anticipate,” “believe,” “contemplate,” “continue,” “could,” “estimate,” “expect,” “intends,” “may,” “might,” “plan,” “possible,” “potential,” “predict,” “project,” “should,” “will,” “would” and similar expressions may identify forward-looking statements, but the absence of these words does not mean that a statement is not forward-looking. These forward-looking statements are based on current expectations and beliefs concerning future developments and their potential effects. There can be no assurance that future developments affecting Dianthus, Magenta or the proposed transaction will be those that have been anticipated. These forward-looking statements involve a number of risks, uncertainties (some of which are beyond Dianthus’s control) or other assumptions that may cause actual results or performance to be materially different from those expressed or implied by these forward-looking statements. These risks and uncertainties include, but are not limited to, the risk that the conditions to the closing of the transaction are not satisfied, including the failure to obtain stockholder approval for the transaction; the risk that the concurrent financing is not completed in a timely manner or at all; uncertainties as to the timing of the consummation of the transaction and the ability of each of Magenta and Dianthus to consummate the transaction, including the concurrent financing; the occurrence of any event, change or other circumstance or condition that could give rise to the termination of the merger agreement; the effect of the announcement or pendency of the merger on Magenta’s or Dianthus’s business relationships, operating results and business generally; and the outcome of any legal proceedings that may be instituted against Magenta, Dianthus or any of their respective directors or officers related to the merger agreement or the transactions contemplated thereby. The foregoing list of factors is not exhaustive. You should carefully consider the foregoing factors and the other risks and uncertainties described in the “Risk Factors” section of the proxy statement/prospectus included in the registration statement on Form S-4 which was initially filed with the SEC in May 2023 in connection with the transaction and other documents filed by Magenta from time to time with the SEC. Should one or more of these risks or uncertainties materialize, or should any of Dianthus’s assumptions prove incorrect, actual results may vary in material respects from those projected in these forward-looking statements. Dianthus’s forward-looking statements only speak as of the date they are made, and Magenta and Dianthus do not undertake any obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise, except as may be required under applicable securities laws.

 

Media Contact

Peg Rusconi, Verge Scientific Communications

prusconi@vergescientific.com

May 03 2023 | Magenta Therapeutics and Dianthus Therapeutics Announce Merger Agreement
Merger to create Nasdaq-listed, clinical-stage biotechnology company focused on advancing Dianthus’ portfolio of next-generation antibody complement therapeutics Combined company is expected to have approximately $180… READ MORE
News
May 03 2023 | Magenta Therapeutics and Dianthus Therapeutics Announce Merger Agreement

Merger to create Nasdaq-listed, clinical-stage biotechnology company focused on advancing Dianthus’ portfolio of next-generation antibody complement therapeutics

Combined company is expected to have approximately $180 million of cash or cash equivalents at close, including approximately $70 million from a concurrent private financing by Dianthus’ new and existing investors, which is expected to provide funding into mid-2026

Cash expected to fund lead program DNTH103 through multiple clinical data catalysts including Phase 1 in healthy volunteers, and Phase 2 trials in generalized Myasthenia Gravis and other indications

Companies will host a joint webcast today, May 3, 2023 at 8:30 a.m. ET

 

CAMBRIDGE, Mass., May 3, 2023 – Magenta Therapeutics, Inc. (Nasdaq: MGTA) (“Magenta”) and Dianthus Therapeutics, Inc. (“Dianthus”), a privately-held, clinical-stage biotechnology company dedicated to advancing the next generation of antibody complement therapeutics, announced today that they have entered into a definitive merger agreement to combine the companies in an all-stock transaction. The combined company will focus on advancing Dianthus’ pipeline of next-generation complement inhibitors, including DNTH103 currently in a Phase 1 clinical trial. Upon completion of the merger, the combined company is expected to operate under the name Dianthus Therapeutics, Inc. and trade on the Nasdaq under the ticker symbol “DNTH”.

In support of the merger, Dianthus has secured commitments for a $70 million private investment in its common stock and pre-funded warrants from a syndicate of healthcare investors led by Fidelity Management & Research Company, Catalio Capital Management, 5AM Ventures, Avidity Partners, Wedbush Healthcare Partners and founding investors Fairmount, Tellus BioVentures and Venrock Healthcare Capital Partners, that is expected to close immediately prior to completion of the merger. With the cash expected from both companies at closing and the proceeds of the concurrent private financing, the combined company is expected to have approximately $180 million of cash or cash equivalents immediately post-closing. The cash resources are intended to be used to advance Dianthus’ pipeline through multiple clinical data catalysts and is expected to fund operations into mid-2026. The merger and related financing are expected to close in the third quarter of 2023.

“I’m delighted to announce this planned merger with Magenta, which comes at a pivotal moment in the evolution of our company as we advance our pipeline of next-generation complement therapeutics for people living with severe autoimmune diseases,” said Marino Garcia, President and Chief Executive Officer of Dianthus Therapeutics. “Gaining access to the public capital markets can enhance our financial strength and fuel our growth strategy, enabling us to unlock the full potential of our pipeline, including our plans to address multiple autoimmune disorders with our clinical-stage active C1s inhibitor, DNTH103.”

“After a thorough exploration of our strategic alternatives, management and our Board of Directors believe the transaction with Dianthus Therapeutics will culminate in a successful outcome for our stockholders,” said Steve Mahoney, President, Chief Financial and Operating Officer of Magenta. “Dianthus has made rapid progress in developing and advancing DNTH103 into the clinic where it has the potential to be a transformative classical pathway inhibitor for severe autoimmune diseases. We are extremely grateful to our current and former employees who contributed to Magenta’s efforts to develop its programs and we now look forward to the combined company’s advancement on opportunities for value creation for patients.”

Magenta previously announced a comprehensive review of strategic alternatives in February 2023 and has since completed winding down a majority of its activities and costs associated with its research and development initiatives, including the termination of its lease and the sale of key assets.

About DNTH103

DNTH103 is an investigational long-acting classical complement pathway inhibitor designed as a less frequent and convenient subcutaneous injection with the potential to treat people living with severe autoimmune diseases. DNTH103, a fully human monoclonal antibody, is designed to selectively target only the active form of the C1s complement protein, inhibiting only the classical complement pathway, with the aim of treating patients with a lower dosing volume as a convenient subcutaneous injection suitable for a self-administered pre-filled pen. Inhibiting the active form of the complement target seeks to address a critical treatment gap in current complement therapies that do not bind selectively to the active protein, wasting a significant amount of the drug on inert proteins. DNTH103 selective inhibition of the classical pathway is engineered to preserve important immune activity of the lectin and alternative complement pathways needed to protect the body against infections from encapsulated bacteria. DNTH103 is also enhanced with YTE half-life extension technology to further reduce dosing frequency.

DNTH103 has a steady cadence of clinical milestones including top-line Phase 1 data aiming to confirm potent classical pathway inhibition and favorable, extended pharmacokinetics expected by the end of 2023, initiation of a Phase 2 trial in generalized Myasthenia Gravis expected in the first quarter of 2024 followed by two additional planned Phase 2 trial initiations in other neuro indications, and planned initiation of an open label proof of efficacy trial in Cold Agglutinin Disease with patient data anticipated in the second half of 2024.

About the Proposed Transaction, Management and Organization

Pre-merger Dianthus stockholders (including Dianthus stockholders issued shares of Dianthus common stock and pre-funded warrants in the concurrent private financing) are expected to own approximately 78.7% of the combined company and pre-merger Magenta stockholders are expected to own approximately 21.3% of the combined company. The percentage of the combined company that Magenta’s stockholders will own as of the close of the transaction is subject to adjustment based on the amount of Magenta’s net cash at the closing date. Immediately prior to the closing of the proposed merger, Magenta stockholders will be issued contingent value rights representing the right to receive certain payments from proceeds received by the combined company, if any, related to pre-transaction legacy assets.

Following the merger, the combined company will be led by Marino Garcia, the current CEO and President of Dianthus Therapeutics, and the current members of the Dianthus management team. Magenta Therapeutics, Inc. will be renamed “Dianthus Therapeutics, Inc.” and the corporate headquarters will be co-located in New York, NY and Waltham, MA. The merger agreement provides that the Board of Directors of the combined company will be composed of eight board members, including all six current Dianthus board members and two from Magenta. The transaction has been unanimously approved by the Board of Directors of each company and is expected to close in the third quarter of 2023, subject to customary closing conditions, including, the approvals by the stockholders of each company and other customary closing conditions.

Wedbush PacGrow is serving as lead financial advisor, Houlihan Lokey Financial Advisors is serving as co-financial adviser and Goodwin Procter LLP is serving as legal counsel to Magenta Therapeutics. Jefferies, Evercore ISI, Guggenheim Securities and Raymond James are serving as the placement agents to Dianthus Therapeutics, and Gibson, Dunn & Crutcher LLP is serving as legal counsel to Dianthus Therapeutics.

Webcast Presentation

The companies will host a webcast presentation to discuss the proposed transaction as well as Dianthus’ platform and pipeline assets today, May 3, 2023, at 8:30 a.m. ET. The live webcast can be accessed on the Events & Presentations page of Magenta’s website or by using the participant webcast link. A webcast of the presentation and associated slides will be available on the Investors & Media section of Magenta’s website at https://investor.magentatx.com/ and a replay will be archived for one year following the presentation.

About Magenta Therapeutics

Magenta Therapeutics is a biotechnology company focused on improving stem cell transplantation.

About Dianthus Therapeutics

Dianthus Therapeutics is a clinical-stage biotechnology company dedicated to designing and delivering novel, best-in-class monoclonal antibodies with improved selectivity and potency over existing complement therapies. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who are leading the next generation of antibody complement therapeutics, aiming to deliver transformative medicines for people living with severe autoimmune diseases. Dianthus raised a $100 million Series A in April 2022 co-led by 5AM Ventures, Avidity Partners, and Fidelity Management & Research Company, with participation from additional investors including Wedbush Healthcare Partners and founding investors Fairmount, Tellus BioVentures, and Venrock Healthcare Capital Partners. To learn more, please visit www.dianthustx.com and follow us on LinkedIn.

Forward-Looking Statements

Certain statements in this press release, other than purely historical information, may constitute “forward-looking statements” within the meaning of the federal securities laws, including for purposes of the safe harbor provisions under the United States Private Securities Litigation Reform Act of 1995, concerning Magenta, Dianthus, the proposed concurrent financing and the proposed merger between Magenta and Dianthus (“Proposed Transaction”) and other matters. These forward-looking statements include, but are not limited to, express or implied statements relating to Magenta’s or Dianthus’ management team’s expectations, hopes, beliefs, intentions or strategies regarding the future including, without limitation, statements regarding: the Proposed Transaction and the expected effects, perceived benefits or opportunities and related timing with respect thereto, expectations regarding or plans for discovery, preclinical studies, clinical trials and research and development programs, in particular with respect to DNTH103, and any developments or results in connection therewith, including the target product profile of DNTH103; the anticipated timing of the results from those studies and trials; expectations regarding the use of proceeds and the time period over which Dianthus’ capital resources will be sufficient to fund its anticipated operations; expectations regarding the market and potential opportunities for complement therapies, in particular with respect to DNTH103; and the expected trading of the combined company’s stock on Nasdaq under the ticker symbol “DNTH.” In addition, any statements that refer to projections, forecasts or other characterizations of future events or circumstances, including any underlying assumptions, are forward-looking statements. The words “opportunity,” “potential,” “milestones,” “pipeline,” “can,” “goal,” “aim,” “strategy,” “target,” “seek,” “anticipate,” “achieve,” “believe,” “contemplate,” “continue,” “could,” “estimate,” “expect,” “intends,” “may,” “might,” “plan,” “possible,” “predict,” “project,” “should,” “will,” “would” and similar expressions (including the negatives of these terms or variations of them) may identify forward-looking statements, but the absence of these words does not mean that a statement is not forward-looking. These forward-looking statements are based on current expectations and beliefs concerning future developments and their potential effects. There can be no assurance that future developments affecting Magenta, Dianthus or the Proposed Transaction will be those that have been anticipated. These forward-looking statements involve a number of risks, uncertainties (some of which are beyond Magenta’s control) or other assumptions that may cause actual results or performance to be materially different from those expressed or implied by these forward-looking statements. These risks and uncertainties include, but are not limited to, the risk that the conditions to the closing or consummation of the Proposed Transaction are not satisfied, including the failure to obtain stockholder approval for the Proposed Transaction; the risk that the concurrent financing is not completed in a timely manner or at all; uncertainties as to the timing of the consummation of the Proposed Transaction and the ability of each of Magenta and Dianthus to consummate the transactions contemplated by the Proposed Transaction; risks related to Magenta’s continued listing on Nasdaq until closing of the Proposed Transaction and the combined company’s ability to remain listed following the Proposed Transaction; risks related to Magenta’s and Dianthus’ ability to correctly estimate their respective operating expenses and expenses associated with the Proposed Transaction, as applicable, as well as uncertainties regarding the impact any delay in the closing would have on the anticipated cash resources of the resulting combined company upon closing and other events and unanticipated spending and costs that could reduce the combined company’s cash resources; the occurrence of any event, change or other circumstance or condition that could give rise to the termination of the business combination between Magenta and Dianthus; the effect of the announcement or pendency of the merger on Magenta’s or Dianthus’ business relationships, operating results and business generally; costs related to the merger; the outcome of any legal proceedings that may be instituted against Magenta, Dianthus or any of their respective directors or officers related to the merger agreement or the transactions contemplated thereby; the ability of Magenta or Dianthus to protect their respective intellectual property rights; competitive responses to the Proposed Transaction; unexpected costs, charges or expenses resulting from the Proposed Transaction; potential adverse reactions or changes to business relationships resulting from the announcement or completion of the Proposed Transaction; legislative, regulatory, political and economic developments; and those uncertainties and factors described under the heading “Risk Factors,” “Risk Factor Summary” and “Forward-Looking Statements” in Magenta’s most recent Annual Report on Form 10-K filed with the Securities and Exchange Commission (the “SEC”) on March 23, 2023, as well as discussions of potential risks, uncertainties, and other important factors included in other filings by Magenta from time to time, any risk factors related to Magenta or Dianthus made available to you in connection with the Proposed Transaction, as well as risk factors associated with companies, such as Dianthus, that operate in the biopharma industry. Should one or more of these risks or uncertainties materialize, or should any of Magenta’s or Dianthus’ assumptions prove incorrect, actual results may vary in material respects from those projected in these forward-looking statements. Nothing in this press release should be regarded as a representation by any person that the forward-looking statements set forth herein will be achieved or that any of the contemplated results of such forward-looking statements will be achieved. You should not place undue reliance on forward-looking statements in this press release, which speak only as of the date they are made and are qualified in their entirety by reference to the cautionary statements herein. Neither Magenta nor Dianthus undertakes or accepts any duty to release publicly any updates or revisions to any forward-looking statements. This press release does not purport to summarize all of the conditions, risks and other attributes of an investment in Magenta or Dianthus.

No Offer or Solicitation

This press release and the information contained herein is not intended to and does not constitute (i) a solicitation of a proxy, consent or approval with respect to any securities or in respect of the Proposed Transaction or (ii) an offer to sell or the solicitation of an offer to subscribe for or buy or an invitation to purchase or subscribe for any securities pursuant to the Proposed Transaction or otherwise, nor shall there be any sale, issuance or transfer of securities in any jurisdiction in contravention of applicable law. No offer of securities shall be made except by means of a prospectus meeting the requirements of the Securities Act of 1933, as amended, or an exemption therefrom. Subject to certain exceptions to be approved by the relevant regulators or certain facts to be ascertained, the public offer will not be made directly or indirectly, in or into any jurisdiction where to do so would constitute a violation of the laws of such jurisdiction, or by use of the mails or by any means or instrumentality (including without limitation, facsimile transmission, telephone and the internet) of interstate or foreign commerce, or any facility of a national securities exchange, of any such jurisdiction.

NEITHER THE SEC NOR ANY STATE SECURITIES COMMISSION HAS APPROVED OR DISAPPROVED OF THE SECURITIES OR DETERMINED IF THIS PRESS RELEASE IS TRUTHFUL OR COMPLETE.

Important Additional Information About the Proposed Transaction Will be Filed with the SEC

This press release is not a substitute for the registration statement or for any other document that Magenta may file with the SEC in connection with the Proposed Transaction. In connection with the Proposed Transaction between Magenta and Dianthus, Magenta intends to file relevant materials with the SEC, including a registration statement on Form S-4 that will contain a proxy statement/prospectus of Magenta. MAGENTA URGES INVESTORS AND STOCKHOLDERS TO READ THE REGISTRATION STATEMENT, PROXY STATEMENT/PROSPECTUS AND ANY OTHER RELEVANT DOCUMENTS THAT MAY BE FILED WITH THE SEC, AS WELL AS ANY AMENDMENTS OR SUPPLEMENTS TO THESE DOCUMENTS, CAREFULLY AND IN THEIR ENTIRETY IF AND WHEN THEY BECOME AVAILABLE BECAUSE THEY WILL CONTAIN IMPORTANT INFORMATION ABOUT MAGENTA, DIANTHUS, THE PROPOSED TRANSACTION AND RELATED MATTERS. Investors and stockholders will be able to obtain free copies of the proxy statement/prospectus and other documents filed by Magenta with the SEC (when they become available) through the website maintained by the SEC at www.sec.gov. In addition, investors and stockholders should note that Magenta communicates with investors and the public using its website (www.magentatx.com), the investor relations website (https://investors.magentatx.com/) where anyone will be able to obtain free copies of the proxy statement/prospectus and other documents filed by Magenta with the SEC and stockholders are urged to read the proxy statement/prospectus and the other relevant materials when they become available before making any voting or investment decision with respect to the Proposed Transaction.

Participants in the Solicitation

Magenta, Dianthus and their respective directors and executive officers may be deemed to be participants in the solicitation of proxies from stockholders in connection with the Proposed Transaction. Information about Magenta’s directors and executive officers including a description of their interests in Magenta is included in Magenta’s most recent Annual Report on Form 10-K, including any information incorporated therein by reference, as filed with the SEC. Additional information regarding these persons and their interests in the transaction will be included in the proxy statement/prospectus relating to the Proposed Transaction when it is filed with the SEC. These documents can be obtained free of charge from the sources indicated above.

 

Media Contact

Peg Rusconi, Verge Scientific Communications
prusconi@vergescientific.com

 

Magenta Contact

Investor@magentatx.com

Nov 30 2022 | Dianthus Therapeutics Announces First Participant Dosed in Phase 1 Trial of DNTH103, a Selective Inhibitor of the Classical Complement Pathway
Study of lead program will provide proof-of-concept to enable further clinical development in severe autoimmune diseases; full cohort data available in 2H’23 DNTH103 is a… READ MORE
News
Nov 30 2022 | Dianthus Therapeutics Announces First Participant Dosed in Phase 1 Trial of DNTH103, a Selective Inhibitor of the Classical Complement Pathway

Study of lead program will provide proof-of-concept to enable further clinical development in severe autoimmune diseases; full cohort data available in 2H’23

DNTH103 is a next-generation monoclonal antibody that selectively targets only the active form of the C1s protein in the classical complement pathway

DNTH103 designed as an infrequent and convenient subcutaneous injection to improve upon high dose volume and frequency of currently available complement pathway inhibitors

 

New York City and Waltham, Mass., November 30, 2022 – Dianthus Therapeutics, a biotechnology company dedicated to advancing the next generation of antibody complement therapeutics, today announced that the first healthy volunteers have been dosed in a Phase 1 clinical trial of its lead monoclonal antibody, DNTH103.

“Today marks a pivotal milestone for Dianthus as we transition into a clinical stage company,” said Marino Garcia, President and Chief Executive Officer, Dianthus Therapeutics. “Data from this Phase 1 study will provide important information about the safety, tolerability, pharmacokinetics and pharmacodynamics of DNTH103 in healthy adult volunteers across single and multiple ascending dose cohorts, demonstrating potential proof-of-concept to advance DNTH103 into severe autoimmune diseases where other modalities have not fully addressed the unmet medical need.”

DNTH103 is a selective inhibitor of the active C1s protein in the complement system’s classical pathway. Classical pathway activity is implicated in driving morbidity in a range of autoimmune disorders. Unlike therapies that broadly inhibit the complement system, selective inhibition of the classical pathway preserves immune activity of the lectin and alternative complement pathways against bacterial infections.

“All currently approved complement antibody therapies indiscriminately bind to both active and inactive complement proteins – meaning a large, sometimes frequent dose must be administered while a significant portion of the drug acts unnecessarily on inert proteins,” said Simrat Randhawa, M.D., Chief Medical Officer, Dianthus Therapeutics. “DNTH103 selectively targets the active form of C1s – allowing more of the drug to have a therapeutic effect so we can potentially reduce dose volume and frequency of administration. In addition, by leaving the lectin and alternative pathways intact, the risk of infection from encapsulated bacteria is lower for DNTH103 versus commonly used C5 and C3 inhibitors.”

About Dianthus Therapeutics

Dianthus Therapeutics is a clinical-stage biotechnology company dedicated to designing and delivering novel, best-in-class monoclonal antibodies with improved selectivity and potency over existing complement therapies. Based in New York City and Waltham, Mass. Dianthus is comprised of an expert team of biotech and pharma executives who are leading the next generation of antibody complement therapeutics to deliver transformative medicines for patients with severe autoimmune diseases. Dianthus raised a $100M Series A in April 2022 co-led by 5AM Ventures, Avidity Partners, and Fidelity Management & Research Company, with participation from additional investors including Wedbush Healthcare Partners and founding investors Fairmount, Tellus BioVentures, and Venrock Healthcare Capital Partners. To learn more, please visit www.dianthustx.com and follow us on Twitter and LinkedIn.

  

Media Contact

Amanda Sellers, Verge Scientific Communications

asellers@vergescientific.com

May 03 2022 | Dianthus Therapeutics Launches with $100M to Develop Selective Antibody Complement Therapeutics to Treat Severe and Rare Autoimmune Diseases
Lead program DNTH103 to be accelerated to the clinic this year as a highly differentiated and potent monoclonal antibody designed to selectively target the active… READ MORE
News
May 03 2022 | Dianthus Therapeutics Launches with $100M to Develop Selective Antibody Complement Therapeutics to Treat Severe and Rare Autoimmune Diseases

Lead program DNTH103 to be accelerated to the clinic this year as a highly differentiated and potent monoclonal antibody designed to selectively target the active form of complement C1s

Led by biotech veterans Marino Garcia as Chief Executive Officer and Lonnie Moulder as Chairman of the Board

Financing co-led by 5AM Ventures, Avidity Partners, and Fidelity Management & Research Company with strong investor syndicate

Waltham, Mass. and New York City, May 3, 2022 – Dianthus Therapeutics, a biotechnology company dedicated to advancing the next generation of antibody complement therapeutics, today announced the completion of its $100 million Series A financing led by 5AM Ventures, Avidity Partners, and Fidelity Management & Research Company, with participation from additional investors including Wedbush Healthcare Partners and founding investors Fairmount, Tellus BioVentures, and Venrock Healthcare Capital Partners. The financing will be used to expand leadership and scientific teams, advance the company’s lead program, DNTH103, to the clinic this year, and to accelerate additional discovery pipeline programs for people living with severe and rare autoimmune diseases. DNTH103 is a potent, next-generation monoclonal antibody that selectively targets the active form of complement C1s, potentially enabling a lower dosing volume and a less frequent subcutaneous administration that is further enhanced with half-life extension technology.

Dianthus also announced the appointment of Marino Garcia as President and Chief Executive Officer, joining in November 2021, and Simrat Randhawa, M.D., M.B.A., as Chief Medical Officer. Mr. Garcia, a veteran dealmaker and strategist, brings more than 25 years of industry experience in business development and operational leadership roles at top biotech and pharma companies, most recently as Senior Vice President, Corporate and Business Development at Zealand Pharma. Dr. Randhawa brings over 20 years of clinical practice and pharmaceutical industry experience to Dianthus, including senior leadership roles focused in the autoimmune and rare disease spaces. He most recently served as Senior Vice President of Clinical and Medical Affairs at Aurinia Pharmaceuticals.

“We are committed to improving the lives of people living with severe and rare autoimmune diseases and are confident that our selective antibodies have the potential to be best-in-class therapeutics,” said Marino Garcia, President and Chief Executive Officer, Dianthus Therapeutics. “We are privileged to have a strong syndicate of leading biotech investors, experienced Board members, and accomplished leaders and scientists as we advance our lead candidate into the clinic later this year, further develop our discovery pipeline, and expand our team in the coming months. Dianthus is positioned to become a leading, next-generation complement company guided by a deep understanding of the needs of patients.”

Dianthus harnesses the power of selectivity in complement pathways to create potent monoclonal antibodies with the potential to overcome the limitations of current complement therapeutics. Unlike current antibody therapies that bind to both inactive and active complement proteins, DNTH103 selectively targets only the active form of the C1s complement protein, enabling a lower dosing volume and less frequent administration. Its half-life extension technology also further reduces dosing frequency. With these differentiated attributes and high potency inhibition of C1s, DNTH103 is designed to relieve the burden of high-volume, frequent administration with IV infusions or inconvenient, frequent subcutaneous dosing. Accelerating the development of a more convenient subcutaneous therapy could be transformative in expanding the potential patient populations that could benefit from complement therapies, while reducing the discomfort and disruptions that pervade the lives of patients today – ultimately allowing more patients to live healthier lives to their fullest potential.

“We are proud to support Dianthus Therapeutics in advancing the discovery and development of next-generation, potent, and highly differentiated antibody complement therapeutics,” said Paula Soteropoulos, Board Director of Dianthus and Strategic Advisor to 5AM Ventures. “With the leadership of the recently appointed President and CEO Marino Garcia, and a talented team of seasoned biotech executives and entrepreneurs who hold an extensive track record of success, we look forward to seeing Dianthus bring their novel therapies to patients living with severe and rare autoimmune diseases.”

Dianthus is currently led by an accomplished team of veteran scientists and biotech entrepreneurs, including:

  • Marino Garcia, President and Chief Executive Officer
  • Simrat Randhawa, M.D.,Chief Medical Officer
  • Evan Thompson, Ph.D.,Chief Operating Officer
  • Edward Carr,Chief Accounting Officer
  • Rivka Gluck,Senior Vice President, Head of Clinical Operations
  • Robert McGarr, Ph.D.,Vice President, Program & Alliance Management
  • Kristina Maximenko,Head of Human Resources

 

Dianthus is also supported by an experienced Board of Directors, including:

  • Lonnie Moulder, Chairman of the Board at Dianthus, Founder and Managing Member of Tellus BioVentures
  • Paula Soteropoulos, Chairman of the Board at Ensoma and former CEO of Akcea Therapeutics
  • Lei Meng, Senior Therapeutics Analyst, Avidity Partners
  • Tomas Kiselak, Managing Member of Fairmount
  • Jonathan Violin, Ph.D.,Co-founder and Chief Executive Officer of Viridian Therapeutics
  • Marino Garcia, President and Chief Executive Officer, Dianthus Therapeutics

 

Jefferies LLC served as financial advisor to Dianthus.

About Dianthus Therapeutics

Dianthus Therapeutics is a biotechnology company dedicated to designing and delivering novel, best-in-class monoclonal antibodies with improved selectivity and potency over existing complement therapies. Based in Waltham, Mass. and New York City, Dianthus is comprised of an expert team of biotech and pharma executives who are leading the next generation of antibody complement therapeutics to deliver transformative medicines for patients with severe and rare autoimmune diseases. To learn more, please visit www.dianthustx.com.

 

Media Contact

Amanda Sellers, Verge Scientific Communications
asellers@vergescientific.com

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Privacy Policy

Dianthus Therapeutics (Dianthus) respects the privacy of visitors to its website and is committed to the protection of their personal information. This privacy statement explains data collection and use practices of Dianthus’s website.

Description of the information Dianthus may collect on this website:

Personally Identifiable Information:

Dianthus collects personally identifiable information (i.e., information from which you can be identified, such as name, address, telephone number or e-mail address) only when it is asked for and/or you voluntarily submit it to us on this website. We may use the information to respond to your requests, improve our level of service and the content of our website; provide you with tips, helpful information, product news and updates; notify you of new Dianthus products and services; and for our own internal purposes.

Non-Personally Identifiable Information:

Dianthus also collects non-personally identifiable information in aggregate form to track data such as the total number of visits to our website, the number of visitors to each page of our website and the domain names of our visitors’ internet service providers. We use this information, which remains in aggregate, non-personally identifiable form, to understand how our visitors use our website so that we may improve our website and the services we offer.

Use of IP Addresses:

An Internet Protocol (IP) address is a set of numbers that is automatically assigned to your computer whenever you log on to your internet service provider or through your organization’s local area network (LAN) or wide area network (WAN). Web servers automatically identify your computer by the IP address assigned to it during your session online.

Dianthus or third-party companies acting on behalf of Dianthus may collect IP addresses for the purposes of systems administration and to audit the use of our website. We do not ordinarily link a user’s IP address to personally identifiable information of that user, which means each user’s session will be logged, but the user remains anonymous to us. However, we may use IP addresses to identify users of our website when we feel it is necessary to enforce compliance with the website’s terms of use, or to protect our service, website or other users.

Cookies:

This website uses a technology called “cookies.” A cookie is a small text file that is placed on your hard disk by a web page server. Cookies help provide additional functionality to the website or help us analyze usage of the website more accurately. For instance, our server may set a cookie that keeps you from having to enter a password more than once during a visit to the website. In all cases in which cookies are used, we will not collect personally identifiable information without your explicit permission. The only personally identifiable information Dianthus collects is the information you voluntarily provide.

You have the ability to accept or decline cookies. Most web browsers automatically accept cookies, but you can usually modify your browser setting to decline cookies, or receive a warning before a cookie is stored, if you prefer. Please refer to your internet browser’s instructions or help screen to learn more about these functions. If you choose to decline cookies, you may not be able to fully experience the interactive features of this website or any other websites that you visit.

Sharing Personally Identifiable Information with Third Parties

Dianthus will not sell or rent personally identifiable information to any third party for any purpose. Sometimes selected third parties are used by Dianthus to provide us with support services in connection with our website and such parties may, from time to time, have access to your information to enable them to provide those services to Dianthus. Please rest assured that all companies providing such support services are required by Dianthus to meet certain standards of data protection and are prohibited from using the information for their own marketing purposes.

Links to Other Websites:

This website may provide links to other Dianthus and third-party websites as a service to our users. The privacy statement described here does not apply to those websites. Please ensure you check the legal and privacy statement posted on each website you link to.

Changes:

We may occasionally update this legal and privacy statement. We encourage you to periodically review this legal and privacy statement to stay informed about how we are helping to protect the personal information we collect. Your continued use of our website constitutes your agreement to the terms and conditions for use of our website, our privacy statement and any updates.

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Terms of Service

Terms of Service Dianthus:


1. Acceptance of the Terms and Conditions.

Dianthus Therapeutics (“Dianthus,” “we,” “us” or “our”) provides and makes available this website (the “Website”). All use of the Website is subject to the terms and conditions contained in the Terms of Service (the “Agreement”). Please read this Agreement carefully. By accessing, browsing or otherwise using the Website, you acknowledge that you have read, understood, and agree to be bound by this Agreement. If you do not accept the terms and conditions of this Agreement, you shall not, and are not permitted to, access, browse or use the Website.

You understand and agree that we may change this Agreement at any time without prior notice. You may read a current, effective copy of this Agreement at any time by selecting the “Terms of Service” link on the Website. The revised terms and conditions will become effective at the time of posting. Any use of the Website after such date constitutes your acceptance of such revised terms and conditions. If any change to this Agreement is not acceptable to you, your sole remedy is to cease accessing, browsing or otherwise using the Website.

Your access to and use of the Website is also subject to our Privacy Policy, which is hereby incorporated herein by reference.

Nothing on this Website should be construed as an offer to form a binding contract, or as granting any license or transfer of intellectual property. Your use of this Website is at your own risk.

PLEASE READ THIS AGREEMENT CAREFULLY, AS THEY CONTAIN AN AGREEMENT TO ARBITRATE, WHICH REQUIRES THAT YOU AND DIANTHUS ARBITRATE CERTAIN CLAIMS BY BINDING, INDIVIDUAL ARBITRATION INSTEAD OF GOING TO COURT, AND LIMIT CLASS ACTION CLAIMS, UNLESS YOU OPT OUT OF THE AGREEMENT TO ARBITRATE AS DESCRIBED IN THE ARBITRATION SECTION (SEE SECTION 8 OF THESE TERMS).

2. Use of the Website.

Medical Information/Conditions. Any information posted on this Website related to medical conditions and their treatment is general in nature and is intended only for educational and general information purposes. Should you have a medical condition that may require treatment, or if you have any specific medical questions, promptly see your own doctor or other health care provider. Nothing on this Website is intended to act as professional medical advice. If you are a patient in a medical emergency, please seek emergency treatment from a doctor or other health care provider instead of reviewing information on this Website. We do not offer medical diagnosis or treatment from this Website, and none of the information contained on this Website should be construed as providing medical advice or services of any kind. Only your doctor or other health care provider can determine if a particular medical treatment is appropriate for you.

Always seek the advice of your doctor or other qualified health care provider before starting any new treatment or with any question that you may have about a medical condition.

Content. The structure, code and organization of this Website are proprietary to us. This Website contains material, including but not limited to software, text, graphics and images (collectively, the “Content”). We may own the Content or portions of the Content may be made available to us through arrangements that we have with one or more third parties. The Content is protected by United States and foreign intellectual property laws. Unauthorized use of any Content may violate copyright, trademark or other laws. You have no rights in or to any Content, and you will not use, copy or display the Content except as permitted in this Agreement. No other use is permitted without our prior written consent. You must retain all copyright and other proprietary notices contained in the original Content on any copy you make of the Content. You may not sell, transfer, assign, license, sublicense or modify any Content or reproduce, display, publicly perform, make a derivative work of, distribute or otherwise use any Content in any way for any purpose, including without limitation any public or commercial purpose. The use or posting of any Content on any other website or in a networked computer environment for any purpose is prohibited. If you violate any part of this Agreement, your right to access and/or use any Content or the Website shall automatically terminate and you shall immediately destroy any copies you have made of any Content.

Trademarks. The trademarks, service marks, and logos owned by Dianthus that are used and displayed on this Website, including without limitation all such marks and logos referencing Dianthus are registered and unregistered trademarks or service marks of Dianthus. Other company, product and service names located on the Website may be trademarks or service marks owned by third parties (the “Third-Party Trademarks”, and, collectively with the Dianthus Trademarks, the “Trademarks”). Nothing on this Website or in this Agreement should be construed as granting, by implication, estoppel, or otherwise, any license or right to use any Trademark displayed on this Website without the prior written consent of Dianthus specific for each such use. The Trademarks may not be used to disparage Dianthus or the applicable third party, Dianthus’s or the third party’s products or services, or in any manner (using commercially reasonable judgment) that may damage any goodwill in the Trademarks. Use of any Trademarks as part of a link to or from any website is prohibited without Dianthus’s prior written consent. All goodwill generated from the use of any Dianthus Trademark shall inure to Dianthus’s benefit. All rights are reserved by the owners of each Trademark, except as otherwise described in this Agreement.

Certain Prohibitions. You agree not to: (a) take any action that imposes an unreasonable load on the Website’s infrastructure, (b) use any device, software or routine to interfere or attempt to interfere with the proper working of the Website or any activity being conducted on the Website, (c) attempt to decipher, decompile, disassemble or reverse engineer any of the software comprising or making up the Website, (d) delete or alter any material posted on the Website by Dianthus or any other person or entity, (e) frame or link to any of the materials or information available on the Website or (f) distribute any virus, Trojan horse, disabling device, time bomb or other code that may impact the operation of the Website, or use the Website to distribute any of the foregoing.

Third Party Links. The Website may contain links and/or references to third party websites and/or services (the “External Sites”). These links are provided solely as a convenience to you and not as an endorsement by us of the content on such External Sites. The content of such External Sites is developed and provided by others. You should contact the site administrator or Webmaster for those External Sites if you have any concerns regarding such links or any content located on such External Sites. We are not responsible for the content of any External Site and do not make any representation regarding the content or accuracy of any materials on any such External Site. You should take precautions when downloading files from all websites to protect your computer from viruses and other destructive programs. If you decide to access any External Site, you do so at your own risk.

Links to Us. Links to any document published by us on this Website must be made to the home page only, without deleting any frames, or our URL address.

Our Social Media. We may use social media accounts from time to time. If you use any social media to communicate with us, please be aware that the terms and privacy policies of the applicable social media platform will govern those communications with us, in addition to this Agreement. Information that you make available on a social media platform may be made available publicly, so we recommend that you not provide us with any information via any social media that you do not feel comfortable making available publicly. We welcome your mentions, replies, comments, likes, suggestions or shares, but please note that any content that you provide to us via a social media channel may be used by us without restriction and without any obligation of payment to you. We will use reasonable efforts to respond to your comments. We may remove or not approve a comment for any reason or no reason, including if it the comment includes vulgar, defamatory, racist, pornographic, violent or other content. There are certain questions or comments that we will not respond to, including without limitation financial data or data on progress of our clinical trials. If we follow any other person’s account, that is not an endorsement. We reserve all rights in relation to use of social media platforms. We do not offer medical diagnosis or treatment via our social media accounts.

3. Limitation of Liability and Disclaimer of Warranties.

Disclaimer of Warranties. THE WEBSITE AND CONTENT ARE PROVIDED ON AN “AS IS” AND “AS AVAILABLE” BASIS WITHOUT ANY WARRANTIES OF ANY KIND. DIANTHUS, ITS AFFILIATES, THEIR RESPECTIVE OFFICERS, DIRECTORS, EMPLOYEES, AGENTS, SUPPLIERS, OR LICENSORS (COLLECTIVELY, THE “DIANTHUS PARTIES“) MAKE NO WARRANTIES OR REPRESENTATIONS ABOUT THE CONTENT, INCLUDING BUT NOT LIMITED TO ITS ACCURACY, RELIABILITY, COMPLETENESS, TIMELINESS OR RELIABILITY, OR THAT DIANTHUS WILL UPDATE SUCH CONTENT OR KEEP SUCH CONTENT CURRENT OR UP TO DATE. THE DIANTHUS PARTIES SHALL NOT BE SUBJECT TO LIABILITY FOR THE TRUTH, ACCURACY OR COMPLETENESS OF THE CONTENT OR ANY OTHER INFORMATION CONVEYED TO YOU, FOR ERRORS, MISTAKES OR OMISSIONS THEREIN OR FOR ANY DELAYS OR INTERRUPTIONS OF THE DATA OR INFORMATION STREAM FROM WHATEVER CAUSE. YOU AGREE THAT YOU USE THE WEBSITE AND THE CONTENT AT YOUR OWN RISK. THE DIANTHUS PARTIES DO NOT WARRANT THAT THE WEBSITE WILL OPERATE ERROR-FREE OR THAT THE WEBSITE, ITS SERVER, OR THE CONTENT ARE FREE OF COMPUTER VIRUSES OR SIMILAR CONTAMINATION OR DESTRUCTIVE FEATURES. IF YOUR USE OF THE WEBSITE OR THE CONTENT RESULTS IN THE NEED FOR SERVICING OR REPLACING EQUIPMENT OR DATA, NO DIANTHUS PARTY SHALL BE RESPONSIBLE FOR THOSE COSTS. THE DIANTHUS PARTIES DISCLAIM ALL WARRANTIES, INCLUDING, BUT NOT LIMITED TO ANY WARRANTY OF TITLE, MERCHANTABILITY, NON-INFRINGEMENT OR FITNESS FOR PARTICULAR PURPOSE.

Limitation of Liability. IN NO EVENT SHALL ANY DIANTHUS PARTY BE LIABLE FOR ANY INCIDENTAL, CONSEQUENTIAL, MULTIPLE, PUNITIVE, SPECIAL OR OTHER INDIRECT DAMAGES, LOST PROFITS, LOST REVENUES, OR DAMAGES RESULTING FROM LOST DATA OR BUSINESS INTERRUPTION) RESULTING FROM THE USE OR INABILITY TO USE THE WEBSITE OR ANY CONTENT, WHETHER BASED ON WARRANTY, CONTRACT, TORT (INCLUDING NEGLIGENCE), OR ANY OTHER LEGAL THEORY, EVEN IF SUCH DIANTHUS PARTY HAS BEEN ADVISED OF THE POSSIBILITY OF SUCH DAMAGES. THE DIANTHUS PARTIES’ AGGREGATE LIABILITY FOR ALL CLAIMS ARISING FROM THIS AGREEMENT SHALL NOT EXCEED THE GREATER OF (I) $1.00 OR (II) THE AGGREGATE AMOUNT YOU HAVE PAID TO US FOR THIS WEBSITE, IF ANY, IN THE THEN-PRIOR TWELVE (12) MONTH PERIOD.

Certain States. Some states do not allow exclusion of implied warranties or limitation of liability for incidental or consequential damages, so the above limitations or exclusions may not apply to you. IN SUCH STATES, THE LIABILITY OF THE DIANTHUS PARTIES SHALL BE LIMITED TO THE GREATEST EXTENT PERMITTED BY LAW.

4. Indemnification

You agree to defend, indemnify, and hold harmless the Dianthus Parties from and against any claims, actions or demands, including, without limitation, reasonable legal and accounting fees, arising or resulting from your breach of this Agreement or your access to, use of or misuse of any Content or the Website. Dianthus will provide notice to you of any such claim, suit, or proceeding. Dianthus reserves the right to assume the exclusive defense and control of any matter which is subject to indemnification under this section. In such case, you agree to cooperate with any reasonable requests assisting Dianthus’s defense of such matter.

5. Termination

Dianthus reserves the right, in its sole discretion, to restrict, suspend, or terminate this Agreement and your access to all or any part of the Website or the Content at any time and for any reason without prior notice or liability. Dianthus reserves the right to change, suspend, or discontinue all or any part of the Website or the Content at any time without prior notice or liability.

Sections 2 (Use of the Website), 3 (Limitation of Liability and Warranty), 4 (Indemnification), 5 (Termination of Agreement), and 9 (General) shall survive the termination of this Agreement.

6. User Must Comply with Applicable Laws.

We make no claims concerning whether the Content may be downloaded, viewed, or be appropriate for use outside of the United States. If you access the Website or the Content from outside of the United States, you do so at your own risk. Whether inside or outside of the United States, you are solely responsible for ensuring compliance with the laws of your specific jurisdiction. You understand that if you access this website from another country and provide your personal information to us through this website, your personal information may be transmitted to us, and you consent to such transfer.

The United States controls the export of products and information. You expressly agree to comply with such restrictions and not to export or re-export any of the Content to countries or persons prohibited under the export control laws. By downloading any Content, you are expressly agreeing that you are not in a country where such export is prohibited or are a person or entity for which such export is prohibited. You are solely responsible for compliance with the laws of your specific jurisdiction regarding the import, export, or re-export of any Content.

7. U.S. Government Restricted Rights.

The Content is provided with “RESTRICTED RIGHTS.” Use, duplication, or disclosure by the Government is subject to the restrictions contained in 48 CFR 52.227-19 and 48 CFR 252.227-7013 et seq. or its successor. Use of the Website or any Content by the Government constitutes acknowledgement of our proprietary rights in the Website and Content.

8. Arbitration

At the election of you or Dianthus, any dispute, claim or controversy arising out of or relating to this Agreement that is not resolved by mutual agreement may be resolved by binding arbitration to be conducted before J.A.M.S. or its successor. Dianthus shall advance the costs of such binding arbitration, but you agree that should we prevail in the arbitration, Dianthus is entitled to reimbursement of all costs. Unless otherwise agreed by the parties, arbitration will be held in Boston, MA, USA before a single arbitrator mutually agreed upon by the parties, or if the parties cannot mutually agree, a single arbitrator appointed by J.A.M.S., and will be conducted in accordance with the rules and regulations promulgated by J.A.M.S. unless specifically modified in this Agreement. The arbitration must commence within forty-five (45) days after the date on which a written demand for arbitration is filed by either party. The arbitrator will have the power to order the production of documents by each party and any third-party witnesses. In addition, each party may take up to three (3) depositions as of right, and the arbitrator will not have the power to order the answering of interrogatories or the responses to requests for admission or the inspection of premises. In connection with any arbitration, each party must provide to the other, no later than ten (10) business days before the date of the arbitration, the identity of all persons that may testify at the arbitration, a copy of all documents that may be introduced at the arbitration or considered or used by a party’s witness or expert, and a summary of the expert’s opinions and the basis for said opinions. The arbitrator’s decision and award shall be made and delivered within sixty (60) days of the conclusion of the arbitration and within six (6) months of the selection of the arbitrator. The arbitrator will not have the power to award damages in excess of the limitation of liability set forth in this Agreement and may not multiply actual damages or award punitive damages or any other damages that are specifically excluded under the Agreement, and each party hereby irrevocably waives any claim to such damages. The parties covenant and agree that they will participate in the arbitration in good faith. The arbitrator may, in his or her discretion, assess costs and expenses (including the reasonable legal fees and expenses of the prevailing part) against any party to a proceeding. Any party refusing to comply with an order of the arbitrators will be liable for costs and expenses, including attorneys’ fees, incurred by the other party in enforcing the award. Notwithstanding the foregoing, in the case of temporary or preliminary injunctive relief, any party may proceed in court without prior arbitration for the purpose of avoiding immediate and irreparable harm. The provisions of this arbitration section will be enforceable in any court of competent jurisdiction.

Any claims brought by you or us must be brought in that party’s individual capacity, and not as a plaintiff or class member in any purported class or representative proceeding. Neither you nor we will participate in a class action or class-wide arbitration for any claims covered by these Terms. You hereby waive any and all rights to bring any claims related to this Agreement, including without limitation our Privacy Policy, as a plaintiff or class member in any purported class or representative proceeding. You may bring claims only on your own behalf.

The arbitration procedures described above in in this Section 8 is the “Agreement to Arbitrate”.

You may opt out of this Agreement to Arbitrate. If you do so, neither you nor we can require the other to participate in an arbitration proceeding. To opt out, you must notify us in writing within thirty (30) days of the date that you first became subject to this arbitration provision. The opt out notice must state that you do not agree to the Agreement to Arbitrate and must include your name, address, phone number, and a clear statement that you want to opt out of this Agreement to Arbitrate. You must sign the opt out notice for it to be effective. This procedure is the only way you can opt out of the Agreement to Arbitrate. You must use this address to opt out:

Dianthus Therapeutics, ATTN: Arbitration Opt-out, 203 Crescent Street, Building 17, Suite 102B, Waltham, MA 02453

Notwithstanding any provision in this Agreement to the contrary, you and we agree that if we make any change to this Agreement to Arbitrate (other than a change to any notice address or website link provided herein) in the future, that change shall not apply to any claim that was filed in a legal proceeding against us prior to the effective date of the change. Moreover, if we seek to terminate the Arbitration Procedures from this Agreement, such termination shall not be effective until thirty (30) days after the version of this Agreement not containing this Agreement to Arbitrate is posted to our Website, and shall not be effective as to any claim that was filed in a legal proceeding against us prior to the effective date of removal.

9. General

This Agreement constitutes the entire agreement between you and Dianthus and governs your use of the Website, superseding any prior agreements between you and Dianthus with respect to the Website. You also may be subject to additional terms and conditions that may apply when you use affiliate services, third-party content or third-party software. This Agreement shall be governed by the laws of the Commonwealth of Massachusetts without regard to its conflict of law provisions. With respect to any disputes or claims not subject to arbitration, as set forth above, you and Dianthus agree to submit to the personal and exclusive jurisdiction of the state and federal courts located in Boston, Massachusetts, USA. EACH OF THE PARTIES HEREBY KNOWINGLY, VOLUNTARILY AND INTENTIONALLY WAIVES ANY RIGHT IT MAY HAVE TO A TRIAL BY JURY IN RESPECT OF ANY LITIGATION (INCLUDING BUT NOT LIMITED TO ANY CLAIMS, COUNTERCLAIMS, CROSS-CLAIMS, OR THIRD PARTY CLAIMS) ARISING OUT OF, UNDER OR IN CONNECTION WITH THIS AGREEMENT. FURTHER, EACH PARTY HERETO CERTIFIES THAT NO REPRESENTATIVE OR AGENT OF EITHER PARTY HAS REPRESENTED, EXPRESSLY OR OTHERWISE, THAT SUCH PARTY WOULD NOT IN THE EVENT OF SUCH LITIGATION, SEEK TO ENFORCE THIS WAIVER OF RIGHT TO JURY TRIAL PROVISION. EACH OF THE PARTIES ACKNOWLEDGES THAT THIS SECTION IS A MATERIAL INDUCEMENT FOR THE OTHER PARTY ENTERING INTO THIS AGREEMENT.

The failure of Dianthus to exercise or enforce any right or provision of this Agreement shall not constitute a waiver of such right or provision. If any provision of this Agreement is found by a court of competent jurisdiction to be invalid, the parties nevertheless agree that the court should endeavor to give effect to the parties’ intentions as reflected in the provision, and the other provisions of this Agreement shall remain in full force and effect. You agree that regardless of any statute or law to the contrary, any claim or cause of action arising out of or related to use of the Website or this Agreement must be filed within one (1) year after such claim or cause of action arose or be forever barred. A printed version of this Agreement and of any notice given in electronic form shall be admissible in judicial or administrative proceedings based upon or relating to this agreement to the same extent and subject to the same conditions as other business documents and records originally generated and maintained in printed form. The section titles in this Agreement are for convenience only and have no legal or contractual effect. Notices to you may be made via either email or regular mail. The Website may also provide notices to you of changes to this Agreement or other matters by displaying notices or links to notices generally on the Website.

If you are a California resident, we are required to inform you that you may reach the Complaint Assistance Unit of the Division of Consumer Services of the California Department of Consumer Affairs via mail at 1625 North Market Blvd., Suite N112, Sacramento, CA 95834 or telephone at (916) 445-1254 or (800) 952-5210. Hearing impaired users can reach the Complaint Assistance Unit at TDD (800) 326-2297 or TDD (916) 322-1700.

Copyright © 2023, Dianthus Therapeutics, All Rights Reserved.
Updated: July 21, 2023